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Serum neurofilament light chain is a useful biomarker in pediatric multiple sclerosis

https://doi.org/10.1212/nxi.0000000000000749
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40/40 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

2 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 40 checked references that resolve
resolves10.1001/archneurol.2008.505
Increased Relapse Rate in Pediatric-Onset Compared With Adult-Onset Multiple Sclerosis
resolves10.1055/s-0030-1267155
A Practical Guide to Pediatric Multiple Sclerosis
resolves10.1056/NEJMoa067597
Natural History of Multiple Sclerosis with Childhood Onset
resolves10.1186/s12974-017-0831-8
Relationship of acute axonal damage, Wallerian degeneration, and clinical disability in multiple sclerosis
resolves10.1016/S0140-6736(08)61620-7
Multiple sclerosis
resolves10.1111/bpa.12516
Axonal loss in the multiple sclerosis spinal cord revisited
resolves10.1016/j.neuint.2013.10.008
Cerebrospinal fluid light and heavy neurofilaments in neuromyelitis optica
resolves10.1001/jamaneurol.2016.6117
Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease
resolves10.1212/WNL.0000000000004667
Serum neurofilament light in familial Alzheimer disease
resolves10.1002/acn3.325
Neurofilament light chain: a biomarker for genetic frontotemporal dementia
resolves10.1136/jnnp-2013-307454
Serum neurofilament light chain is a biomarker of human spinal cord injury severity and outcome
resolves10.1136/jnnp-2018-320106
Neurofilament light chain as a biomarker in neurological disorders
resolves10.1080/14767058.2017.1344964
Increase of neuronal injury markers Tau and neurofilament light proteins in umbilical blood after intrapartum asphyxia
resolves10.3389/fneur.2018.00086
Raised Plasma Neurofilament Light Protein Levels Are Associated with Abnormal MRI Outcomes in Newborns Undergoing Therapeutic Hypothermia
resolves10.1016/j.jneuroim.2013.11.004
CSF neurofilament light chain is elevated in OMS (decreasing with immunotherapy) and other pediatric neuroinflammatory disorders
resolves10.1016/j.pediatrneurol.2013.02.015
Cerebrospinal Fluid Brain Injury Biomarkers in Children: A Multicenter Study
resolves10.1016/j.msard.2018.05.017
Increased cerebrospinal fluid chitinase 3-like 1 and neurofilament light chain in pediatric acquired demyelinating syndromes
resolves10.1055/s-2001-20406
Glial Fibrillary Acidic Protein and Neurofilament in Children with Cerebral White Matter Abnormalities
resolves10.1002/ana.24954
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis
resolves10.1212/NXI.0000000000000422
Neurofilament light chain predicts disease activity in relapsing-remitting MS
resolves10.1212/WNL.0000000000003653
Serum neurofilament is associated with progression of brain atrophy and disability in early MS
resolves10.1038/s41582-018-0058-z
Neurofilaments as biomarkers in neurological disorders
resolves10.1212/WNL.0000000000007032
Blood neurofilament light chain as a biomarker of MS disease activity and treatment response
resolves10.1177/1352458518765666
Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis
resolves10.1093/brain/awy154
Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis
resolves10.1093/brain/awy021
Neurofilament light chain and oligoclonal bands are prognostic biomarkers in radiologically isolated syndrome
resolves10.1177/1352458518775303
High neurofilament levels are associated with clinically definite multiple sclerosis in children and adults with clinically isolated syndrome
resolves10.1177/1352458517715132
Plasma neurofilament light chain levels in patients with MS switching from injectable therapies to fingolimod
resolves10.1002/acn3.779
Neurofilament as a potential biomarker for spinal muscular atrophy
resolves10.1111/j.1469-8749.1983.tb13738.x
Development of the Blood‐CSF Barrier
resolves10.1002/ana.24364
Extensive acute axonal damage in pediatric multiple sclerosis lesions
resolves10.1212/WNL.0000000000002823
Pediatric multiple sclerosis
resolves10.1177/1352458517732843
Therapy of highly active pediatric multiple sclerosis
resolves10.1056/NEJMoa1800149
Trial of Fingolimod versus Interferon Beta-1a in Pediatric Multiple Sclerosis
resolves10.1177/2055217318778610
Relapse Rate and MRI Activity in Young Adult Patients With Multiple Sclerosis: A Post Hoc Analysis of Phase 3 Fingolimod Trials
resolves10.1002/acn3.638
Neurofilament light chain serum levels correlate with 10‐year <scp>MRI</scp> outcomes in multiple sclerosis
resolves10.1038/nbt.1641
Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations
resolves10.1515/cclm-2015-1195
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa
resolves10.1371/journal.pone.0075091
Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases
resolves10.1177/1352458515623365
Serum neurofilament light chain in early relapsing remitting MS is increased and correlates with CSF levels and with MRI measures of disease severity
The 2 references without a DOI — listed, not checked
no DOI — not checkedHyun J-W, Kim Y, Kim G, Kim S-H, Kim HJ. Longitudinal analysis of serum neurofilament light chain: a potential therapeutic monitoring biomarker for multiple sclerosis. Mult Scler J 2019 Epub 2019 Mar 26.
no DOI — not checkedReiber H. Proteins in cerebrospinal fluid and blood: barriers, CSF flow rate and source-related dynamics. Restor Neurol Neurosci 2003;21:79–96.
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