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Retinoic acid counteracts developmental defects in the substantia nigra caused by Pitx3 deficiency
48/48 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
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The 48 checked references that resolve
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A Rare Truncating Mutation in ADH1C (G78Stop) Shows Significant Association With Parkinson Disease in a Large International Sample
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Induction of Cell Cycle Arrest and Morphological Differentiation by Nurr1 and Retinoids in Dopamine MN9D Cells
resolves10.1016/j.mcn.2004.09.008
The homeodomain transcription factor Pitx3 facilitates differentiation of mouse embryonic stem cells into AHD2-expressing dopaminergic neurons
resolves10.1002/neu.20241
Role of all‐<i>trans</i> retinoic acid in neurite outgrowth and axonal elongation
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Families of retinoid dehydrogenases regulating vitamin A function
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Cytosolic retinoid dehydrogenases govern ubiquitous metabolism of retinol to retinaldehyde followed by tissue-specific metabolism to retinoic acid
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Targeted Disruption of <i>Aldh1a1</i> (<i>Raldh1</i>) Provides Evidence for a Complex Mechanism of Retinoic Acid Synthesis in the Developing Retina
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ALDH1 mRNA: presence in human dopamine neurons and decreases in substantia nigra in Parkinson's disease and in the ventral tegmental area in schizophrenia
resolves10.1007/s00702-004-0212-1
Gene expression profiling of parkinsonian substantia nigra pars compacta; alterations in ubiquitin-proteasome, heat shock protein, iron and oxidative stress regulated proteins, cell adhesion/cellular matrix and vesicle trafficking genes
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Distinct functions forAldh1 andRaldh2 in the control of ligand production for embryonic retinoid signaling pathways
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Nurr1 regulates dopamine synthesis and storage in MN9D dopamine cells
resolves10.1038/334345a0
Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
resolves10.1042/bj3390387
Molecular analysis of two closely related mouse aldehyde dehydrogenase genes: identification of a role for Aldh1, but not Aldh-pb, in the biosynthesis of retinoic acid
resolves10.1016/S0169-328X(03)00162-1
Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
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Aryl Hydrocarbon Receptor-Mediated Transcription: Ligand-Dependent Recruitment of Estrogen Receptor α to 2,3,7,8-Tetrachlorodibenzo-
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Pitx3 regulates tyrosine hydroxylase expression in the substantia nigra and identifies a subgroup of mesencephalic dopaminergic progenitor neurons during mouse development
resolves10.1073/pnas.91.16.7772
High levels of a retinoic acid-generating dehydrogenase in the meso-telencephalic dopamine system.
resolves10.1046/j.1460-9568.2003.02765.x
Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen
resolves10.1073/pnas.1231422100
Retinoid activation of retinoic acid receptor but not retinoid X receptor is sufficient to rescue lethal defect in retinoic acid synthesis
resolves10.1002/dvdy.20128
<i>Raldh2</i> expression in optic vesicle generates a retinoic acid signal needed for invagination of retina during optic cup formation
resolves10.1073/pnas.082093299
Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase
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resolves10.1242/dev.02328
Retinoic acid guides eye morphogenetic movements via paracrine signaling but is unnecessary for retinal dorsoventral patterning
resolves10.1074/jbc.M112445200
Recombinant Class I Aldehyde Dehydrogenases Specific for All-trans- or 9-cis-Retinal
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Retinaldehyde dehydrogenase 2 (RALDH2)- independent patterns of retinoic acid synthesis in the mouse embryo
resolves10.1016/S0925-4773(01)00561-5
Differential expression of retinoic acid-synthesizing (RALDH) enzymes during fetal development and organ differentiation in the mouse
resolves10.1242/dev.129.15.3563
Embryonic retinoic acid synthesis is required for forelimb growth and anteroposterior patterning in the mouse
resolves10.1073/pnas.0230529100
Pitx3 is required for development of substantia nigra dopaminergic neurons
resolves10.1006/geno.2000.6464
A Double-Deletion Mutation in the Pitx3 Gene Causes Arrested Lens Development in Aphakia Mice
resolves10.1093/hmg/9.11.1575
Deletion in the promoter region and altered expression of Pitx3 homeobox gene in aphakia mice
resolves10.1073/pnas.94.24.13305
A homeodomain gene
<i>Ptx</i>
3 has highly restricted brain expression in mesencephalic dopaminergic neurons
resolves10.1038/73902
A second independent pathway for development of mesencephalic dopaminergic neurons requires Lmx1b
resolves10.1242/dev.01022
Early developmental failure of substantia nigra dopamine neurons in mice lacking the homeodomain gene<i>Pitx3</i>
resolves10.1007/s00441-004-0943-1
Homeobox gene Pitx3 and its role in the development of dopamine neurons of the substantia nigra
resolves10.1046/j.1460-9568.2003.02885.x
Involvement of Nurr1 in specifying the neurotransmitter identity of ventral midbrain dopaminergic neurons
resolves10.1016/j.mcn.2005.07.018
Molecular and cellular alterations in the Pitx3-deficient midbrain dopaminergic system
resolves10.1016/j.pneurobio.2005.12.003
Developmental origin and fate of meso-diencephalic dopamine neurons
resolves10.1242/dev.00464
Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
resolves10.1006/excr.1999.4691
Fate of Mesencephalic AHD2-Expressing Dopamine Progenitor Cells in Nurr1 Mutant Mice
resolves10.1007/s00441-005-0038-7
Tissue- and species-specific expression patterns of class I, III, and IV Adh and Aldh1 mRNAs in rodent embryos
resolves10.1073/pnas.93.14.6886
Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.
resolves10.1093/oxfordjournals.jbchem.a022353
Recognition of Multiple Patterns of DNA Sites by Drosophila Homeodomain Protein Bicoid
resolves10.1111/j.1460-9568.2004.03206.x
Generation of embryonic stem cells and transgenic mice expressing green fluorescence protein in midbrain dopaminergic neurons
The 1 reference without a DOI — listed, not checked
no DOI — not checkedMic, F. A., Haselbeck, R. J., Cuenca, A. E. and Duester, G.(2002). Novel retinoic acid generating activities in the neural tube and heart identified by conditional rescue of Raldh2 null mutant mice. Development129,2271-2282.
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