Reference health
Animal models for bone tissue engineering and modelling disease
1 of 94 checkable references need attention · checked 2026-07-22
At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.
6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
References needing attention
does not resolve to a known work10.1002/(SICI)1097-4636(20000305)49:3<328::AID-JBM5>3.0.CO;2-Q
The 93 checked references that resolve
resolves10.1177/0022034510378427
Osteogenic Potential of Mandibular
<i>vs.</i>
Long-bone Marrow Stromal Cells
resolves10.1016/j.actbio.2013.04.035
Autologous vs. allogenic mesenchymal progenitor cells for the reconstruction of critical sized segmental tibial bone defects in aged sheep
resolves10.1002/term.2104
Scaffold-cell bone engineering in a validated preclinical animal model: precursors vs differentiated cell source
resolves10.3109/03008207.2015.1027341
Selection of animal models for pre-clinical strategies in evaluating the fracture healing, bone graft substitutes and bone tissue regeneration and engineering
resolves10.1111/clr.12744
Effect of poly (lactide‐co‐glycolide) (<scp>PLGA</scp>)‐coated beta‐tricalcium phosphate on the healing of rat calvarial bone defects: a comparative study with pure‐phase beta‐tricalcium phosphate
resolves10.1097/00001665-199807000-00004
Importance of the Critical-Size Bone Defect in Testing Bone-Regenerating Materials
resolves10.1038/srep38814
Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells
resolves10.1016/j.biomaterials.2013.09.011
Polycaprolactone scaffold and reduced rhBMP-7 dose for the regeneration of critical-sized defects in sheep tibiae
resolves10.1016/j.actbio.2015.05.015
BMP delivery complements the guiding effect of scaffold architecture without altering bone microstructure in critical-sized long bone defects: A multiscale analysis
resolves10.1002/jor.21474
Quantifying intra‐osseous growth of osteosarcoma in a murine model with radiographic analysis
resolves10.1242/dev.117.2.409
The triple origin of skull in higher vertebrates: a study in quail-chick chimeras
resolves10.1016/j.jbo.2016.02.005
The role of hematopoietic stem cell niche in prostate cancer bone metastasis
resolves10.1002/jor.1100170506
New segmental long bone defect model in sheep: Quantitative analysis of healing with dual energy X‐ray absorptiometry
resolves10.1111/j.1582-4934.2009.00807.x
A clinically relevant model of osteoinduction: a process requiring calcium phosphate and BMP/Wnt signalling
resolves10.1186/1746-6148-10-36
The effect of bone allografts combined with bone marrow stromal cells on the healing of segmental bone defects in a sheep model
resolves10.2174/157488808786733962
Tissue Engineered Bone Grafts: Biological Requirements, Tissue Culture and Clinical Relevance
resolves10.3791/51558
Adjustable Stiffness, External Fixator for the Rat Femur Osteotomy and Segmental Bone Defect Models
resolves10.1258/la.2010.010085
Rodent models in bone-related research: the relevance of calvarial defects in the assessment of bone regeneration strategies
resolves10.1097/00006534-200008000-00018
Osteogenesis in Cranial Defects: Reassessment of the Concept of Critical Size and the Expression of TGF-β Isoforms
resolves10.1371/journal.pone.0145080
In Vivo Assessment of Bone Regeneration in Alginate/Bone ECM Hydrogels with Incorporated Skeletal Stem Cells and Single Growth Factors
resolves10.1002/masy.200750722
New Approaches in the Treatment of Critical‐Size Segmental Defects in Long Bones
resolves10.1016/j.biomaterials.2004.06.016
Ectopic bone formation in rats: the importance of the carrier
resolves10.1007/s10585-014-9638-5
A humanized tissue-engineered in vivo model to dissect interactions between human prostate cancer cells and human bone
resolves10.3791/54472
An Intramedullary Locking Nail for Standardized Fixation of Femur Osteotomies to Analyze Normal and Defective Bone Healing in Mice
resolves10.1097/00001665-199001000-00011
The Critical Size Defect as an Experimental Model To Test Bone Repair Materials
resolves10.1007/s10555-013-9437-5
Humanised xenograft models of bone metastasis revisited: novel insights into species-specific mechanisms of cancer cell osteotropism
resolves10.1016/j.biomaterials.2014.01.062
Species-specific homing mechanisms of human prostate cancer metastasis in tissue engineered bone
resolves10.1016/j.tibtech.2009.12.001
Can tissue engineering concepts advance tumor biology research?
resolves10.1016/j.joms.2016.05.004
In Vivo Evaluation of Commercially Available Gel-Type Polyethylene Glycol Membrane for Carrier of Recombinant Human Bone Morphogenetic Protein-2
resolves10.1002/jbm.a.35710
Repair of rat critical size calvarial defect using osteoblast‐like and umbilical vein endothelial cells seeded in gelatin/hydroxyapatite scaffolds
resolves10.1038/nature04186
VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
resolves10.1016/j.msec.2017.02.097
Acceleration of bone regeneration in bioactive glass/gelatin composite scaffolds seeded with bone marrow-derived mesenchymal stem cells over-expressing bone morphogenetic protein-7
resolves10.1007/s13770-013-1093-x
Rat defect models for bone grafts and tissue engineered bone constructs
resolves10.3390/ma9040259
Microparticles for Sustained Growth Factor Delivery in the Regeneration of Critically-Sized Segmental Tibial Bone Defects
resolves10.1182/blood.V79.7.1704.1704
Implantation and maintenance of functional human bone marrow in SCID-hu mice
resolves10.1089/ten.tec.2017.0147
Warning About the Use of Critical-Size Defects for the Translational Study of Bone Repair: Analysis of a Sheep Tibial Model
resolves10.1073/pnas.1208384109
Implantable microenvironments to attract hematopoietic stem/cancer cells
resolves10.1007/s13770-013-1094-9
Comparison of bone regeneration rate in flat and long bone defects: Calvarial and tibial bone
resolves10.1002/jor.20154
The efficacy of cylindrical titanium mesh cage for the reconstruction of a critical-size canine segmental femoral diaphyseal defect
resolves10.1002/jbm.b.31622
Repairing goat tibia segmental bone defect using scaffold cultured with mesenchymal stem cells
resolves10.1016/j.biomaterials.2016.10.039
Bone regeneration induced by a 3D architectured hydrogel in a rat critical-size calvarial defect
resolves10.1016/j.actbio.2016.10.004
Surface phosphonation enhances hydroxyapatite coating adhesion on polyetheretherketone and its osseointegration potential
resolves10.1002/jor.20231
Mechanical and radiological assessment of the influence of rhTGFβ‐3 on bone regeneration in a segmental defect in the ovine tibia: Pilot study
resolves10.1038/nprot.2017.002
Engineering a humanized bone organ model in mice to study bone metastases
resolves10.1089/ten.2006.12.1261
Reconstruction of Extensive Long Bone Defects in Sheep Using Resorbable Bioceramics Based on Silicon Stabilized Tricalcium Phosphate
resolves10.1038/nm.3647
Hematopoietic stem cell niche maintenance during homeostasis and regeneration
resolves10.1158/0008-5472.CAN-07-2483
Tissue-Engineered Bone Serves as a Target for Metastasis of Human Breast Cancer in a Mouse Model
resolves10.1089/ten.teb.2009.0658
The Design and Use of Animal Models for Translational Research in Bone Tissue Engineering and Regenerative Medicine
resolves10.1007/s00784-017-2069-3
Comparison of the effects of recombinant human bone morphogenetic protein-2 and -9 on bone formation in rat calvarial critical-size defects
resolves10.1016/S8756-3282(95)80121-9
The potential of sheep for the study of osteopenia: Current status and comparison with other animal models
resolves10.1016/j.biomaterials.2010.01.085
Comparison of mesenchymal stem cells from bone marrow and adipose tissue for bone regeneration in a critical size defect of the sheep tibia and the influence of platelet-rich plasma
resolves10.1097/01.blo.0000073347.50837.16
An Evaluation of Human Demineralized Bone Matrices in a Rat Femoral Defect Model
resolves10.2106/JBJS.G.01585
Selection and Development of Preclinical Models in Fracture-Healing Research
resolves10.1038/leu.2012.154
Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ−/− mice
resolves10.1002/term.2446
Tubular open‐porous β‐tricalcium phosphate polycaprolactone scaffolds as guiding structure for segmental bone defect regeneration in a novel sheep model
resolves10.1359/jbmr.091116
Origin matters: Differences in embryonic tissue origin and Wnt signaling determine the osteogenic potential and healing capacity of frontal and parietal calvarial bones
resolves10.1002/term.2517
A humanised tissue‐engineered bone model allows species‐specific breast cancer‐related bone metastasis in vivo
resolves10.1038/nrrheum.2015.160
Navigating the bone marrow niche: translational insights and cancer-driven dysfunction
resolves10.1016/j.biomaterials.2008.12.050
The challenge of establishing preclinical models for segmental bone defect research
resolves10.1089/ten.teb.2009.0455
Establishment of a Preclinical Ovine Model for Tibial Segmental Bone Defect Repair by Applying Bone Tissue Engineering Strategies
resolves10.1002/term.276
Ovine bone- and marrow-derived progenitor cells and their potential for scaffold-based bone tissue engineering applications in vitro and in vivo
resolves10.1007/s00264-010-1146-x
Custom-made composite scaffolds for segmental defect repair in long bones
resolves10.1126/scitranslmed.3003720
A Tissue Engineering Solution for Segmental Defect Regeneration in Load-Bearing Long Bones
resolves10.1016/j.gene.2013.04.026
Mesodermal and neural crest derived ovine tibial and mandibular osteoblasts display distinct molecular differences
resolves10.1182/blood-2014-04-572255
Epigenetic and in vivo comparison of diverse MSC sources reveals an endochondral signature for human hematopoietic niche formation
resolves10.1038/nm.4103
A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells
resolves10.1097/PRS.0000000000001637
Repair of a Critical Porcine Tibial Defect by Means of Allograft Revitalization
resolves10.1172/JCI41495
Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/SCID/IL2Rγc-deficient mice
resolves10.1073/pnas.1220108110
Engineering of a functional bone organ through endochondral ossification
resolves10.1016/j.biomaterials.2015.01.076
Tissue engineering a surrogate niche for metastatic cancer cells
resolves10.1182/blood-2004-06-2480
Blood and bone: two tissues whose fates are intertwined to create the hematopoietic stem-cell niche
resolves10.1242/dmm.014076
A tissue-engineered humanized xenograft model of human breast cancer metastasis to bone
resolves10.18632/oncotarget.2788
New mechanistic insights of integrin β1 in breast cancer bone colonization
resolves10.1182/blood.V90.2.754
The Development of a Model for the Homing of Multiple Myeloma Cells to Human Bone Marrow
resolves10.3109/17453679809117623
Effects of lesion between bone, periosteum and muscle on fracture healing in rats
resolves10.1186/s13045-016-0234-9
An engineered multicomponent bone marrow niche for the recapitulation of hematopoiesis at ectopic transplantation sites
resolves10.1002/jbm.a.32347
Repair of segmental bone‐defect of goat's tibia using a dynamic perfusion culture tissue engineering bone
resolves10.1089/ten.tea.2015.0337
Evaluation of
<i>In Vivo</i>
Osteogenic Potential of Bone Morphogenetic Protein 2-Overexpressing Human Periodontal Ligament Stem Cells Combined with Biphasic Calcium Phosphate Block Scaffolds in a Critical-Size Bone Defect Model
resolves10.1080/14686996.2016.1145532
Three dimensional printed macroporous polylactic acid/hydroxyapatite composite scaffolds for promoting bone formation in a critical-size rat calvarial defect model
The 6 references without a DOI — listed, not checked
no DOI — not checkedStandard guide for pre-clinical in vivo evaluation in critical size segmental bone defects
no DOI — not checkedOvine model for critical-size tibial segmental defects
no DOI — not checkedComprehensive Biomaterials
no DOI — not checkedA clarion call for additive biomanufacturing in orthopaedic surgery
no DOI — not checkedSevere combined immunodeficient-hu model of human prostate cancer metastasis to human bone
no DOI — not checkedEstablishment of a novel species- and tissue-specific metastasis model of human prostate cancer in humanized non-obese diabetic/severe combined immunodeficient mice engrafted with human adult lung and bone
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or importance of the work itself, and nothing about references deposited without a DOI.
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