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Loss of Ataxin-1 Elevates BACE1 Expression and Impairs Axonal Targeting in the Cerebrum

https://doi.org/10.2139/ssrn.3155885
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The 13 references without a DOI — listed, not checked
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no DOI — not checkedFRDA genes in schizophrenic patients and a healthy population
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no DOI — not checkedArrow indicates glomeruli, which showed strong immunoreactivity for BACE1. Bottom panel, fluorescence photomicrographs of olfactory glomerulus (arrow) region immunolabeled for Ataxin-1 and BACE1. DAPI was used for nuclear staining. Brain sections from BACE1 KO were used as negative control for the immunofluorescence staining. (C) Analysis of sAPP? (arrow) levels in the cortex and cerebullum of Ataxin-1 WT and KO mouse. Bottom, densitometric quantification of the western blot result (n=3). cerebullum of Ataxin 1 WT and KO mouse
no DOI — not checkedref97
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no DOI — not checkedpostnatal (P0, right top) and adult mouse brains. Horizontal straight lines within a blot indicate that different parts within the same blot were placed together. Ataxin-1 levels in the embryonic/postnatal brains were lower than those of adult brains. In contrast, BACE1 levels were much higher in the embryonic/postnatal brains. (bottom panel) No effect of Ataxin-1 depletion on BACE1 levels in cultured cortical neurons (DIV10) and embryonic fibroblasts
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