Reference health
Exposure to High Altitude Environment Is Associated With Drug Metabolism Change: miRNA-873-5p-Mediated Alteration of Function and Expression Levels of Drug Transporters Under Hypoxia
49/49 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
18 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 49 checked references that resolve
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The first documented description of mountain sickness: The andean or pariacaca story
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Efficacy of tadalafil in chronic hypobaric hypoxia–induced pulmonary hypertension: possible mechanisms
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Effect of X‐ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of <scp>CES</scp>1 and <scp>CYP</scp>3A1 in rats
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The Enzymatic Basis of Drug-Drug Interactions with Systemic Triazole Antifungals
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Genetic and environmental factors affecting drug disposition in man
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Pharmacokinetics of Lidocaine Hydrochloride Metabolized by CYP3A4 in Chinese Han Volunteers Living at Low Altitude and in Native Han and Tibetan Chinese Volunteers Living at High Altitude
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Comparison of the pharmacokinetics of sulfamethoxazole in male chinese volunteers at low altitude and acute exposure to high altitude versus subjects living chronically at high altitude: An open-label, controlled, prospective study
resolves10.1007/s13318-012-0090-0
Comparison of the pharmacokinetics of sulfamethoxazole in native Han and Tibetan male Chinese volunteers living at high altitude
resolves10.5414/CPP41200
Pharmacokinetics of lithium in healthy volunteers after exposure to high altitude
resolves10.1124/dmd.106.013508
Animal Models of Acute Moderate Hypoxia Are Associated with a Down-Regulation of CYP1A1, 1A2, 2B4, 2C5, and 2C16 and Up-Regulation of CYP3A6 and P-glycoprotein in Liver
resolves10.1038/sj.bjp.0704933
Hypoxia‐induced down‐regulation of CYP1A1/1A2 and up‐regulation of CYP3A6 involves serum mediators
resolves10.1038/sj.bjp.0702795
Effect of hypoxia alone or combined with inflammation and 3‐methylcholanthrene on hepatic cytochrome P450 in conscious rabbits
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The Activity, Protein, and mRNA Expression of CYP2E1 and CYP3A1 in Rats after Exposure to Acute and Chronic High Altitude Hypoxia
resolves10.1111/1440-1681.12693
Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia‐inducible factors <scp>HIF</scp>1α and <scp>HIF</scp>2α
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The effects of micro<scp>RNA</scp> on the absorption, distribution, metabolism and excretion of drugs
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Effects of lipopolysaccharide on intestinal P-glycoprotein expression and activity
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Unique pharmacology of KAR-2, a potential anti-cancer agent: Absorption modelling and selective mitotic spindle targeting
resolves10.1016/j.ejps.2013.08.010
Enhancement effect of P-gp inhibitors on the intestinal absorption and antiproliferative activity of bestatin
resolves10.1124/dmd.111.043513
Combined Contributions of Impaired Hepatic CYP2C11 and Intestinal Breast Cancer Resistance Protein Activities and Expression to Increased Oral Glibenclamide Exposure in Rats with Streptozotocin-Induced Diabetes Mellitus
resolves10.1111/1750-3841.14112
Uptake and Transport Mechanism of Dihydromyricetin Across Human Intestinal Caco‐2 Cells
resolves10.2174/1389200219666180529112913
Hypoxia Plays a Key Role in the Pharmacokinetic Changes of Drugs at High Altitude
resolves10.1016/j.jns.2007.03.004
Neuronal mdr-1 gene expression after experimental focal hypoxia: A new obstacle for neuroprotection?
resolves10.1111/cas.12483
Krüppel‐like factor 8 contributes to hypoxia‐induced <scp>MDR</scp> in gastric cancer cells
resolves10.1007/s13277-016-4944-y
MicroRNA-873 mediates multidrug resistance in ovarian cancer cells by targeting ABCB1
resolves10.1074/jbc.M709382200
Post-transcriptional Regulation of Human Pregnane X Receptor by Micro-RNA Affects the Expression of Cytochrome P450 3A4
resolves10.3892/mmr.2015.3890
MicroRNA-522 reverses drug resistance of doxorubicin-induced HT29 colon cancer cell by targeting ABCB5
resolves10.1124/jpet.113.203562
Bioimaging Real-Time PXR-Dependent mdr1a Gene Regulation in mdr1a.fLUC Reporter Mice
resolves10.1186/s12906-018-2402-7
Gancao (Glycyrrhizae Radix) provides the main contribution to Shaoyao-Gancao decoction on enhancements of CYP3A4 and MDR1 expression via pregnane X receptor pathway in vitro
resolves10.1124/jpet.117.247296
Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes
resolves10.1016/j.apsb.2019.12.003
Xenobiotic receptors in mediating the effect of sepsis on drug metabolism
resolves10.1152/ajpgi.00330.2018
OATP1B3-1B7, a novel organic anion transporting polypeptide, is modulated by FXR ligands and transports bile acids
resolves10.1016/j.ajg.2020.04.018
The roles and interaction of FXR and PPARs in the pathogenesis of nonalcoholic fatty liver disease
resolves10.3389/fphar.2016.00456
Pregnane X Receptor (PXR)-Mediated Gene Repression and Cross-Talk of PXR with Other Nuclear Receptors via Coactivator Interactions
resolves10.1016/j.isci.2018.10.018
Binding of Drug-Activated CAR/Nr1i3 Alters Metabolic Regulation in the Liver
resolves10.1002/bdd.2172
TGF‐β1 elevates P‐gp and BCRP in hepatocellular carcinoma through HOTAIR/miR‐145 axis
resolves10.1016/j.canlet.2017.08.027
The miR-491-3p/Sp3/ABCB1 axis attenuates multidrug resistance of hepatocellular carcinoma
resolves10.1016/j.taap.2015.07.004
Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver
The 18 references without a DOI — listed, not checked
no DOI — not checkedPA5-37010), and OATP2B1 (1:500, rabbit polyclonal, Novus, NBP-1-59811) were obtained. RNAiso Plus and PrimeScript TM RT Reagent were obtained from Takara Bio Inc
no DOI — not checkedAll experimental procedures were performed strictly according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals. The protocol was approved by the Animal Ethics Committee of The Qinghai University. Ten animals were housed in each cage in separate rooms to ensure that each animal could be restrained within a single space to reduce stress
no DOI — not checkedEffect of intermittent hypobaric hypoxia on efficacy and clearance of drug. Indian
no DOI — not checkedEffect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19
no DOI — not checkedref25
no DOI — not checkedIntestinal absorption of the effective components of Schisandra chinensis Baill by rats singlepass perfusion in situ
no DOI — not checkedIntestinal Absorption Characters of Mosapride Citrate Using Caco-2 Cells and Single-Pass Intestinal Perfusion Methods. Chin
no DOI — not checkedRegulation of High-Altitude Hypoxia on the Transcription of CYP450 and UGT1A1 Mediated by PXR and CAR
no DOI — not checkedA Decade's Review of miRNA: a Center of Transcriptional Regulation of Drug-Metabolizing Enzymes and Transporters Under Hypoxia
no DOI — not checkedref42
no DOI — not checkedChanges of P-gp expression in rats' small intestine and effects on uptake of levofloxacin after acute exposure to hypoxia
no DOI — not checkedRole of PEPT1in the transport of cinnabar in Caco-2 cells
no DOI — not checkedChanges in the intestinal flora of rats under high altitude hypoxia
no DOI — not checkedref48
no DOI — not checkedRegualation of P-glycoprotein gene expression by PKC/NF-?B-PXR
no DOI — not checkedDiurnal expression of ABC and SLC transporters in jejunum is modulated by adrenalectomy
no DOI — not checkedA Network of SLC and ABC Transporter and DME Genes Involved in Remote Sensing and Signaling in the
no DOI — not checkedmiRNA-29a reverses P-glycoprotein-mediated drug resistance and inhibits proliferation via up-regulation of PTEN in colon cancer cells
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