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Functional Multi-Omics Reveals Noncanonical Function of G9a in Translational Regulation of Chronic Inflammation

https://doi.org/10.2139/ssrn.3962440
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42/42 checkable references clean · checked 2026-07-25

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

27 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 42 checked references that resolve
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FOXO1 degradation via G9a-mediated methylation promotes cell proliferation in colon cancer
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SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function
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<scp>METTL</scp>3 regulates alternative splicing of MyD88 upon the lipopolysaccharide‐induced inflammatory response in human dental pulp cells
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Gene-specific control of inflammation by TLR-induced chromatin modifications
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The MYC-Associated Protein CDCA7 Is Phosphorylated by AKT To Regulate MYC-Dependent Apoptosis and Transformation
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NUSAP1 promotes invasion and metastasis of prostate cancer
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BIRC5 (survivin): a pejorative prognostic marker in stage II/III breast cancer with no response to neoadjuvant chemotherapy
resolves10.1038/ni.1699
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
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Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer
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Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma
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An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
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Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
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The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells
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Recent advances in endotoxin tolerance
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Curcumin Attenuates Lipopolysaccharide‐Induced Hepatic Lipid Metabolism Disorder by Modification of m<sup>6</sup>A RNA Methylation in Piglets
resolves10.1016/j.imbio.2007.09.015
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Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX
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Time-resolved Analysis of Proteome Dynamics by Tandem Mass Tags and Stable Isotope Labeling in Cell Culture (TMT-SILAC) Hyperplexing
The 27 references without a DOI — listed, not checked
no DOI — not checkedPD-L1 Overexpression During Endotoxin Tolerance Impairs the Adaptive Immune Response in Septic Patients via HIF1alpha
no DOI — not checkedInhibition of EZH2 prevents acute respiratory distress syndrome (ARDS)-associated pulmonary fibrosis by regulating the macrophage polarization phenotype
no DOI — not checkedref6
no DOI — not checkedAssociation of COVID-19 inflammation with activation of the C5a-C5aR1 axis
no DOI — not checkedref13
no DOI — not checkedReduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19)
no DOI — not checkedLabel-free Quantitative Proteomics Reveals a Role for the Mycobacterium tuberculosis SecA2 Pathway in Exporting Solute Binding Proteins and Mce Transporters to the Cell Wall
no DOI — not checkedSKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway
no DOI — not checkedBioorthogonal profiling of protein methylation using azido derivative of S-adenosyl-L-methionine
no DOI — not checkedTargeting translation regulators improves cancer therapy
no DOI — not checkedref33
no DOI — not checkedref34
no DOI — not checkedSingle-cell landscape of bronchoalveolar immune cells in patients with COVID-19
no DOI — not checkedA chromatin activitybased chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing
no DOI — not checkedViral sepsis is a complication in patients with Novel Corona Virus Disease (COVID-19)
no DOI — not checkedMETTL3 plays multiple functions in biological processes
no DOI — not checkedMYBL2 (B-Myb): a central regulator of cell proliferation, cell survival and differentiation involved in tumorigenesis
no DOI — not checkedImmune complement and coagulation dysfunction in adverse outcomes of SARS-CoV-2 infection
no DOI — not checkedThe trinity of COVID-19: immunity, inflammation and intervention
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no DOI — not checkedNovel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of
no DOI — not checkedref62
no DOI — not checkedref63
no DOI — not checkedref65
no DOI — not checkedHA-G9a and Flag-Mettl3 were over-expressed in 293T cells, and purified by Flag IP, cell lysate and IP elute were subjected to western blotting analysis with antibodies recognizing pan mono-and di-or Tri-methylated lysine. Mettl3 was methylated. (B) LC-MS/MS of Mettl3 protein in the Flag IP product. Flag-Mettl3 IP sample was further fractionated on 8% SDS-PAGE gel, and protein band around 70 kDa was cut, in-gel digested with trypsin and sent for LC-MS/MS analysis. Red color indicates covered Mettl3 sequence, modified lysine or serine were highlighted in green and underlined. (C) A summary of identified methylation (4 sites) and phosphorylation sites (2 sites) of Mettl3 protein. MS raw files were subjected to database search (Maxquant software) with oxidation(O), protein N-terminus acetylation, acetyl (K), methyl(KR), dimethyl (K), tri-methyl (K) as variable modifications. A separate search with only oxidation(O), protein N-term acetylation and phosphorylation (STY) was also done simultaneously
no DOI — not checkedA quantitative spatial proteomics analysis of proteome turnover in human cells
no DOI — not checkedProteome-wide analysis of protein abundance and turnover remodelling during oncogenic transformation of human breast epithelial cells
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