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GLP-1R Activation by Liraglutide Promotes Breast Cancer Through NOX4/ROS/VEGF Pathway

https://doi.org/10.2139/ssrn.3977559
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37/37 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

5 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 37 checked references that resolve
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Glucose Metabolism in Cancer
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Hamster preproglucagon contains the sequence of glucagon and two related peptides
resolves10.1152/physrev.00013.2014
Physiology of Proglucagon Peptides: Role of Glucagon and GLP-1 in Health and Disease
resolves10.1007/s40262-015-0343-6
Liraglutide in Type 2 Diabetes Mellitus: Clinical Pharmacokinetics and Pharmacodynamics
resolves10.1053/j.gastro.2011.02.018
Pancreatitis, Pancreatic, and Thyroid Cancer With Glucagon-Like Peptide-1–Based Therapies
resolves10.1016/j.cmet.2015.02.005
GLP-1R Agonists Promote Normal and Neoplastic Intestinal Growth through Mechanisms Requiring Fgf7
resolves10.1055/a-1345-7890
Growth Promotion and Increased ATP-Binding Cassette Transporters Expression by Liraglutide in Triple Negative Breast Cancer Cell Line MDA-MB-231
resolves10.1016/j.freeradbiomed.2016.03.035
Liraglutide protects cardiac microvascular endothelial cells against hypoxia/reoxygenation injury through the suppression of the SR-Ca2+–XO–ROS axis via activation of the GLP-1R/PI3K/Akt/survivin pathways
resolves10.1016/j.bbrc.2013.06.035
LOX-1, a bridge between GLP-1R and mitochondrial ROS generation in human vascular smooth muscle cells
resolves10.1016/j.bbrc.2018.03.142
Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells
resolves10.1111/bph.13575
Improvement of islet graft function using liraglutide is correlated with its anti‐inflammatory properties
resolves10.3390/biom9110735
Role of Reactive Oxygen Species in Cancer Progression: Molecular Mechanisms and Recent Advancements
resolves10.1007/978-1-4939-8549-4_14
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resolves10.1172/JCI75276
The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss
resolves10.1016/j.semcdb.2017.05.023
ROS signalling in the biology of cancer
resolves10.1177/1074248420942007
Liraglutide Attenuates Myocardial Fibrosis via Inhibition of AT1R-Mediated ROS Production in Hypertensive Mice
resolves10.1016/j.cbi.2020.109252
GLP-1 receptor agonist liraglutide protects cardiomyocytes from IL-1β-induced metabolic disturbance and mitochondrial dysfunction
resolves10.20892/j.issn.2095-3941.2018.0253
The PI3K/Akt/GSK-3β/ROS/eIF2B pathway promotes breast cancer growth and metastasis via suppression of NK cell cytotoxicity and tumor cell susceptibility
resolves10.1152/ajpcell.00346.2016
ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis
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resolves10.2147/DMSO.S171503
Is there an association between liraglutide use and female breast cancer in a real-world setting?
resolves10.1007/s10549-011-1585-0
The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells
resolves10.1038/nature22800
Crystal structure of the GLP-1 receptor bound to a peptide agonist
resolves10.3390/ijms151119700
Cell-Surface Receptors Transactivation Mediated by G Protein-Coupled Receptors
resolves10.3389/fphar.2020.01257
Liraglutide Ameliorates Erectile Dysfunction via Regulating Oxidative Stress, the RhoA/ROCK Pathway and Autophagy in Diabetes Mellitus
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Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals
resolves10.1038/sj.bjc.6605847
NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
resolves10.1016/j.freeradbiomed.2012.06.016
Nox4 involvement in TGF-beta and SMAD3-driven induction of the epithelial-to-mesenchymal transition and migration of breast epithelial cells
resolves10.3390/cells9081849
Cross-Talk between NADPH Oxidase and Mitochondria: Role in ROS Signaling and Angiogenesis
resolves10.1074/jbc.M202775200
p38 Signaling-mediated Hypoxia-inducible Factor 1α and Vascular Endothelial Growth Factor Induction by Cr(VI) in DU145 Human Prostate Carcinoma Cells
resolves10.1074/jbc.M001914200
Reactive Oxygen Species Generated at Mitochondrial Complex III Stabilize Hypoxia-inducible Factor-1α during Hypoxia
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HIF-1α stabilization by mitochondrial ROS promotes Met-dependent invasive growth and vasculogenic mimicry in melanoma cells
The 5 references without a DOI — listed, not checked
no DOI — not checkedref4
no DOI — not checkedOxaliplatin reverses the GLP-1R-mediated promotion of intrahepatic cholangiocarcinoma by altering FoxO1 signaling
no DOI — not checkedGlucagon-like peptide-1 receptor agonists and risk of breast cancer
no DOI — not checkedGlucagon-like peptide-1 analogues and risk of breast cancer in women with type 2 diabetes: population based cohort study using the UK Clinical Practice Research Datalink
no DOI — not checkedLiraglutide inhibits the proliferation and promotes the apoptosis of MCF-7 human breast cancer cells through downregulation of microRNA-27a expression
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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