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PI3K/AKT/NFATc1 and ROS Signal Axes are Involved in AZD1390-Mediated Inhibitory Effects on Osteoclast and OVX-Induced Osteoporosis

https://doi.org/10.2139/ssrn.4071617
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35/35 checkable references clean · checked 2026-07-24

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

15 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 35 checked references that resolve
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Osteoporosis
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Novel population of human monocyte and osteoclast progenitors from pluripotent stem cells and peripheral blood
resolves10.1016/j.molmed.2014.06.001
Osteoclasts: more than ‘bone eaters’
resolves10.1002/jcp.26596
MicroRNA‐224 suppresses osteoblast differentiation by inhibiting <i>SMAD4</i>
resolves10.1089/ten.teb.2016.0454
Osteoblast Differentiation and Bone Matrix Formation <i>In Vivo</i> and <i>In Vitro</i>
resolves10.1093/neuonc/noaa238
Brain exposure of the ATM inhibitor AZD1390 in humans—a positron emission tomography study
resolves10.1080/15384101.2015.1084205
ATM serine-1981 phosphorylation is a plausible biomarker
resolves10.1038/s41577-019-0135-6
At the intersection of DNA damage and immune responses
resolves10.1371/journal.pone.0244060
ATM inhibition enhances Auranofin-induced oxidative stress and cell death in lung cell lines
resolves10.1126/scisignal.2001959
ATM Is a Redox Sensor Linking Genome Stability and Carbon Metabolism
resolves10.1038/cdd.2011.88
Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice
resolves10.1016/j.bbrc.2016.05.019
Osteoclast function and bone-resorbing activity: An overview
resolves10.1111/jcmm.15229
Triptolide prevents bone loss via suppressing osteoclastogenesis through inhibiting PI3K‐AKT‐NFATc1 pathway
resolves10.1182/blood-2004-09-3662
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
resolves10.1096/fj.201600826R
RANKL induces Bach1 nuclear import and attenuates Nrf2‐mediated antioxidant enzymes, thereby augmenting intracellular reactive oxygen species signaling and osteoclastogenesis in mice
resolves10.1080/13697137.2018.1551347
Hormone replacement therapy and prevention of chronic conditions
resolves10.1002/ctm2.392
A novel RANKL‐targeted flavonoid glycoside prevents osteoporosis through inhibiting NFATc1 and reactive oxygen species
resolves10.5152/eurjrheum.2016.048
An overview and management of osteoporosis
resolves10.1001/jama.2019.15781
Bisphosphonates for Postmenopausal Osteoporosis
resolves10.1016/j.trecan.2021.06.002
Targeting the replication stress response through synthetic lethal strategies in cancer medicine
resolves10.1016/j.drudis.2019.01.015
Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery
resolves10.1242/jcs.00609
The phosphoinositide (PI) 3-kinase family
resolves10.1016/j.bbamcr.2020.118664
Glycogen synthase kinase-3 signaling in Alzheimer's disease
resolves10.1016/j.brainres.2010.03.007
Minocycline treatment reduces white matter damage after excitotoxic striatal injury
resolves10.1186/s13058-019-1125-0
GSK3β regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer
resolves10.4161/15384101.2014.973330
ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels
resolves10.1093/nar/gkp100
Oxidative stress induces degradation of mitochondrial DNA
resolves10.1002/jbmr.2974
SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS
resolves10.1359/JBMR.050324
Thapsigargin Modulates Osteoclastogenesis Through the Regulation of RANKL-Induced Signaling Pathways and Reactive Oxygen Species Production
resolves10.1016/j.yexcr.2004.07.035
Reactive oxygen species mediate RANK signaling in osteoclasts
resolves10.1016/j.cub.2014.03.034
ROS Function in Redox Signaling and Oxidative Stress
resolves10.1002/jbm4.10080
CSF‐1 in Osteocytes Inhibits Nox4‐mediated Oxidative Stress and Promotes Normal Bone Homeostasis
resolves10.3390/ijms20143576
Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases
resolves10.1038/s41598-020-80536-2
Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice
The 15 references without a DOI — listed, not checked
no DOI — not checked(L) Western Blot test for the expression levels of nfatc1 and osteoclast-associated proteins (including NFATc1, c-Fos, CTSK, and D2) during osteoclast formation. 0, 1, 3, and 5 days were stimulated with RANKL in the absence or presence of 2 ?M AZD before collecting proteins for Western Blot
no DOI — not checkedref2
no DOI — not checkedref3
no DOI — not checkedref4
no DOI — not checkedref6
no DOI — not checkedManagement of osteoporosis with calcitriol in elderly Chinese patients: a systematic review
no DOI — not checkedATM in DNA repair in cancer
no DOI — not checkedref19
no DOI — not checkedOvariectomized rat model of osteoporosis: a practical guide
no DOI — not checkedSesamolin Protects Mice From Ovariectomized Bone Loss by Inhibiting Osteoclastogenesis and RANKL-Mediated NF-kappaB and MAPK Signaling Pathways
no DOI — not checkedSchisandrin A restrains osteoclastogenesis by inhibiting reactive oxygen species and activating Nrf2 signalling
no DOI — not checkedPromoter Hypermethylation of the ATM Gene as a Novel Biomarker for Breast Cancer
no DOI — not checkedPI3K/Akt signaling transduction pathway, erythropoiesis and glycolysis in hypoxia (Review)
no DOI — not checkedGSK-3beta in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer
no DOI — not checkedref46
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