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Clinical Significance of B7-H3 and HER2 Co-Expression and Therapeutic Value of Combination Treatment in Gastric Cancer

https://doi.org/10.2139/ssrn.4095072
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1 of 40 checkable references need attention · checked 2026-07-23

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

10 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

References needing attention

marked retracted — notice via Crossref, record curated by Retraction Watch10.3892/or.2014.3405
Aberrant expression of B7-H3 in gastric adenocarcinoma promotes cancer cell metastasis
The 39 checked references that resolve
resolves10.3322/caac.21660
Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries
resolves10.1056/NEJMsb1503104
Precision Medicine — Personalized, Problematic, and Promising
resolves10.1016/S1470-2045(13)70436-4
Management of gastric cancer in Asia: resource-stratified guidelines
resolves10.1093/jnci/djw166
The Efficacy and Safety of First-line Chemotherapy in Advanced Esophagogastric Cancer: A Network Meta-analysis
resolves10.1080/14789450.2016.1246189
Proteomics approach to identify biomarkers for upper gastrointestinal cancer
resolves10.1016/S1470-2045(08)70035-4
S-1 plus cisplatin versus S-1 alone for first-line treatment of advanced gastric cancer (SPIRITS trial): a phase III trial
resolves10.1056/NEJMoa073149
Capecitabine and Oxaliplatin for Advanced Esophagogastric Cancer
resolves10.1016/S0140-6736(10)61121-X
Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial
resolves10.3748/wjg.v22.i23.5406
Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China
resolves10.1007/s10120-013-0252-z
HER2-positive gastric cancer
resolves10.2217/imt.14.86
Current Advances in T-Cell-Based Cancer Immunotherapy
resolves10.1158/1078-0432.CCR-15-2428
Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy
resolves10.1111/j.1349-7006.2011.01877.x
B7‐H3 expression in gastric cancer: A novel molecular blood marker for detecting circulating tumor cells
resolves10.7150/thno.43991
Tandem CAR-T cells targeting CD70 and B7-H3 exhibit potent preclinical activity against multiple solid tumors
resolves10.1016/j.trecan.2018.03.010
B7-H3 in Cancer – Beyond Immune Regulation
resolves10.7150/ijbs.41105
B7-H3, a checkpoint molecule, as a target for cancer immunotherapy
resolves10.3389/fonc.2019.01466
Overexpression of B7-H3 in α-SMA-Positive Fibroblasts Is Associated With Cancer Progression and Survival in Gastric Adenocarcinomas
resolves10.2174/156800908785133141
The Immunoregulatory Protein Human B7H3 is a Tumor-Associated Antigen that Regulates Tumor Cell Migration and Invasion
resolves10.1158/1535-7163.MCT-11-0072
B7-H3 Silencing Increases Paclitaxel Sensitivity by Abrogating Jak2/Stat3 Phosphorylation
resolves10.1002/ijc.26238
B7‐H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis‐associated genes
resolves10.7150/jca.17759
B7-H3 Promotes the Migration and Invasion of Human Bladder Cancer Cells via the PI3K/Akt/STAT3 Signaling Pathway
resolves10.1016/S1470-2045(20)30326-0
Margetuximab plus pembrolizumab in patients with previously treated, HER2-positive gastro-oesophageal adenocarcinoma (CP-MGAH22–05): a single-arm, phase 1b–2 trial
resolves10.1038/s41586-021-04161-3
The KEYNOTE-811 trial of dual PD-1 and HER2 blockade in HER2-positive gastric cancer
resolves10.1158/1078-0432.CCR-16-3107
B7-H3 Expression in NSCLC and Its Association with B7-H4, PD-L1 and Tumor-Infiltrating Lymphocytes
resolves10.1007/s00262-012-1278-5
B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence
resolves10.1038/sj.onc.1210477
The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis
resolves10.1186/bcr327
Intracellular signaling pathways of ErbB2/HER-2 and family members
resolves10.1007/s10911-006-9009-1
The ErbB2 Signaling Network as a Target for Breast Cancer Therapy
resolves10.18632/oncotarget.17847
B7-H3 promotes gastric cancer cell migration and invasion
resolves10.1016/j.drup.2018.03.001
How the Warburg effect supports aggressiveness and drug resistance of cancer cells?
resolves10.1111/j.1582-4934.2008.00540.x
Osteopontin promotes gastric cancer metastasis by augmenting cell survival and invasion through Akt‐mediated HIF‐1α up‐regulation and MMP9 activation
resolves10.1016/S0140-6736(17)31827-5
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial
resolves10.1200/JCO.2019.37.18_suppl.LBA4007
Pembrolizumab with or without chemotherapy versus chemotherapy for advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma: The phase III KEYNOTE-062 study.
resolves10.1007/s10120-018-00909-5
Pembrolizumab alone or in combination with chemotherapy as first-line therapy for patients with advanced gastric or gastroesophageal junction adenocarcinoma: results from the phase II nonrandomized KEYNOTE-059 study
resolves10.2217/fon-2020-0737
First-Line Pembrolizumab/Placebo Plus Trastuzumab and Chemotherapy in Her2-Positive Advanced Gastric Cancer: KEYNOTE-811
resolves10.1038/s41423-019-0305-2
Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy
resolves10.1038/cr.2017.90
Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function
resolves10.1158/1535-7163.MCT-20-0116
Preclinical Development of MGC018, a Duocarmycin-based Antibody–drug Conjugate Targeting B7-H3 for Solid Cancer
resolves10.1016/j.omto.2019.07.002
B7-H3 as a Novel CAR-T Therapeutic Target for Glioblastoma
The 10 references without a DOI — listed, not checked
no DOI — not checkedRelationship between HER2 expression and tumor interstitial angiogenesis in primary gastric cancer and its effect on prognosis
no DOI — not checkedB7-H3 is overexpressed in patients suffering osteosarcoma and associated with tumor aggressiveness and metastasis
no DOI — not checkedB7-H3 regulates KIF15-activated ERK1/2 pathway and contributes to radioresistance in colorectal cancer
no DOI — not checkedDNMT1 recruited by EZH2-mediated silencing of miR-484 contributes to the malignancy of cervical cancer cells through MMP14 and HNF1A
no DOI — not checkedThe clinicopathological parameters and prognostic significance of HER2 expression in gastric cancer patients: a meta-analysis of literature
no DOI — not checkedSoluble B7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-?B pathway
no DOI — not checkedCancer cell-expressed B7-H3 regulates the differentiation of tumor-associated macrophages in human colorectal carcinoma
no DOI — not checkedInhibition of CD133 Overcomes Cisplatin Resistance Through Inhibiting PI3K/AKT/mTOR Signaling Pathway and Autophagy in CD133-Positive Gastric Cancer Cells
no DOI — not checkedImpact of OCT4 and Its Related Signaling Pathways on Gastrointestinal Cancers: Focusing on Targeted Therapy
no DOI — not checkedB7-H3 inhibits the IFN-?-dependent cytotoxicity of V?9V?2 T cells against colon cancer cells
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