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Genome Mining and Gene Knockout Approaches Lead to Discovery of the Biosynthetic Pathway of Sclerotiorin and Sclerotiorin-Like Azaphilones in <i>Penicillium Meliponae</i>

https://doi.org/10.2139/ssrn.4096292
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30/30 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

10 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 30 checked references that resolve
resolves10.1042/bj0341418
Sclerotiorine, C20H20O5Cl, a chlorine-containing metabolic product of <i>Penicillium sclerotiorum</i> van Beyma
resolves10.1248/cpb.11.366
(-)-Sclerotiorin, A Major Metabolite of Penicillium hirayamae UDAGAWA.
resolves10.3987/COM-19-14164
Isochromophilol A, a New Azaphilone Isolated from Penicillium sp. RO369, a Leaf Litter Inhabiting Fungus from Tsuga diversifolia
resolves10.3389/fmicb.2019.02186
Antimicrobial Metabolites Produced by Penicillium mallochii CCH01 Isolated From the Gut of Ectropis oblique, Cultivated in the Presence of a Histone Deacetylase Inhibitor
resolves10.1016/j.bcab.2019.101451
The orange-red pigment from Penicillium mallochii: Pigment production, optimization, and pigment efficacy against Glioblastoma cell lines
resolves10.1016/j.procbio.2018.12.009
Submerged culture of marine-derived Penicillium sclerotiorum FS50 to produce sclerotiorin
resolves10.4314/tjpr.v9i4.58930
Improved Production of Pharmacologically-active Sclerotiorin by &lt;i&gt;Penicillium sclerotiorum&lt;/i&gt;
resolves10.1007/s10126-006-6100-y
Antiplasmodial Marine Natural Products in the Perspective of Current Chemotherapy and Prevention of Malaria. A Review
resolves10.3390/md19010012
Preparation, COX-2 Inhibition and Anticancer Activity of Sclerotiorin Derivatives
resolves10.1007/s10529-006-9133-4
Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase
resolves10.1016/j.jmb.2020.01.033
Sclerotiorin Stabilizes the Assembly of Nonfibrillar Abeta42 Oligomers with Low Toxicity, Seeding Activity, and Beta-sheet Content
resolves10.1248/cpb.58.1033
Azaphilone and Isocoumarin Derivatives from the Endophytic Fungus Penicillium sclerotiorum PSU-A13
resolves10.1002/cbic.202100240
Core Steps to the Azaphilone Family of Fungal Natural Products
resolves10.1002/cpbi.102
Using SPAdes De Novo Assembler
resolves10.1093/molbev/msaa015
IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era
resolves10.1080/10635150490264699
Bayesian Phylogenetic Analysis of Combined Data
resolves10.1016/0378-1119(87)90164-8
Transformation of Aspergillus based on the hygromycin B resistance marker from Escherichia coli
resolves10.7164/antibiotics.48.696
Isochromophilones III -VI, Inhibitors of Acyl-CoA: Cholesterol Acyltransferase Produced by Penicillium multicolor FO-3216.
resolves10.1093/nar/gkab941
The Natural Products Atlas 2.0: a database of microbially-derived natural products
resolves10.3390/metabo11070444
Dereplication, Annotation, and Characterization of 74 Potential Antimicrobial Metabolites from Penicillium Sclerotiorum Using t-SNE Molecular Networks
resolves10.7164/antibiotics.27.558
UTILIZATION OF 13C-13C COUPLING IN STRUCTURAL AND BIOSYNTHETIC STUDIES
resolves10.7164/antibiotics.51.1004
New Brominated and Halogen-less Derivatives and Structure-activity Relationship of Azaphilones Inhibiting gp120-CD4 Binding.
resolves10.3390/metabo2010214
Atlantinone A, a Meroterpenoid Produced by Penicillium ribeum and Several Cheese Associated Penicillium Species
resolves10.1021/ja3090498
Identification and Characterization of the Chaetoviridin and Chaetomugilin Gene Cluster in Chaetomium globosum Reveal Dual Functions of an Iterative Highly-Reducing Polyketide Synthase
resolves10.1021/ja8088185
A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in <i>Aspergillus nidulans</i>
resolves10.1039/C8NP00039E
The architectures of iterative type I PKS and FAS
resolves10.1021/jacs.5b11814
Understanding Programming of Fungal Iterative Polyketide Synthases: The Biochemical Basis for Regioselectivity by the Methyltransferase Domain in the Lovastatin Megasynthase
resolves10.1002/anie.201915514
Collaborative Biosynthesis of a Class of Bioactive Azaphilones by Two Separate Gene Clusters Containing Four PKS/NRPSs with Transcriptional Crosstalk in Fungi
resolves10.1016/j.chembiol.2012.07.004
Characterization of a Silent Azaphilone Gene Cluster from Aspergillus niger ATCC 1015 Reveals a Hydroxylation-Mediated Pyran-Ring Formation
resolves10.1021/jo050414g
Synthesis Studies toward Chloroazaphilone and Vinylogous γ-Pyridones:  Two Common Natural Product Core Structures
The 10 references without a DOI — listed, not checked
no DOI — not checkedAntioxidant and antibacterial activities of the chlorine pigment sclerotiorin from Penicillium mallochii and its chemotaxonomic significance
no DOI — not checkedref7
no DOI — not checkedSemisynthesis and biological evaluation of (+)-sclerotiorin derivatives as antitumor agents for the treatment of hepatocellular carcinoma
no DOI — not checkedPenicilones derivative and application thereof as anti-resistant bacteria drug
no DOI — not checkedref18
no DOI — not checkedA rapid DNA isolation procedure for small quantities of fresh leaf tissue
no DOI — not checkedref21
no DOI — not checkedStructures and biological activities of azaphilones produced by Penicillium sp
no DOI — not checkedDiversifying of chemical structure of native Monascus pigments
no DOI — not checkedref40
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