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Effects of Astragaloside IV on Glucocorticoid-Induced Avascular Necrosis of the Femoral Head Via Multiple Akt-Mediated Pathways

https://doi.org/10.2139/ssrn.4107702
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37/37 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

12 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 37 checked references that resolve
resolves10.1182/blood-2015-05-643601
Genetics of glucocorticoid-associated osteonecrosis in children with acute lymphoblastic leukemia
resolves10.1016/j.rdc.2015.08.006
Glucocorticoids and Rheumatoid Arthritis
resolves10.1016/j.jot.2017.11.001
Herbal Fufang Xian Ling Gu Bao prevents corticosteroid-induced osteonecrosis of the femoral head—A first multicentre, randomised, double-blind, placebo-controlled clinical trial
resolves10.2106/JBJS.20.00847
Musculoskeletal Consequences of COVID-19
resolves10.1007/s00264-015-3061-7
Multicentric epidemiologic study on six thousand three hundred and ninety five cases of femoral head osteonecrosis in China
resolves10.7150/thno.17450
Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway
resolves10.1002/jor.23008
TLR4 stimulation and corticosteroid interactively induce osteonecrosis of the femoral head in rat
resolves10.7150/ijbs.16951
Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
resolves10.1080/15476278.2019.1633869
ATP6V1H facilitates osteogenic differentiation in MC3T3-E1 cells via Akt/GSK3β signaling pathway
resolves10.1039/D0FO00497A
Pea protein-derived tripeptide LRW shows osteoblastic activity on MC3T3-E1 cells <i>via</i> the activation of the Akt/Runx2 pathway
resolves10.1007/s12035-017-0798-6
Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease
resolves10.1111/fcp.12232
Research review on the pharmacological effects of astragaloside<scp>IV</scp>
resolves10.1016/j.lfs.2019.04.040
Astragaloside IV exerts angiogenesis and cardioprotection after myocardial infarction via regulating PTEN/PI3K/Akt signaling pathway
resolves10.1080/13880209.2019.1569697
Astragaloside IV alleviates heart failure by promoting angiogenesis through the JAK-STAT3 pathway
resolves10.1016/j.biopha.2018.09.049
Astragalosides IV protected the renal tubular epithelial cells from free fatty acids-induced injury by reducing oxidative stress and apoptosis
resolves10.1016/j.freeradbiomed.2018.11.033
Astragaloside IV reduces neuronal apoptosis and parthanatos in ischemic injury by preserving mitochondrial hexokinase-II
resolves10.1016/j.phrs.2020.104831
Astragaloside IV acts through multi-scale mechanisms to effectively reduce diabetic nephropathy
resolves10.1016/j.biopha.2019.109729
Combination of tanshinone IIA and astragaloside IV attenuate atherosclerotic plaque vulnerability in ApoE(-/-) mice by activating PI3K/AKT signaling and suppressing TRL4/NF-κB signaling
resolves10.3727/096504018X15344989701565
Astragaloside IV Inhibits the Progression of Non-Small Cell Lung Cancer Through the Akt/GSK-3β/β-Catenin Pathway
resolves10.1093/bib/bbaa379
A comprehensive drug repurposing study for COVID19 treatment: novel putative dihydroorotate dehydrogenase inhibitors show association to serotonin–dopamine receptors
resolves10.1021/acs.jcim.9b00105
Using AMBER18 for Relative Free Energy Calculations
resolves10.1021/acs.chemrev.9b00055
End-Point Binding Free Energy Calculation with MM/PBSA and MM/GBSA: Strategies and Applications in Drug Design
resolves10.7150/ijbs.38713
Silencing MicroRNA-137-3p, which Targets RUNX2 and CXCL12 Prevents Steroid-induced Osteonecrosis of the Femoral Head by Facilitating Osteogenesis and Angiogenesis
resolves10.1016/j.freeradbiomed.2016.12.032
Augmented O-GlcNAc signaling via glucosamine attenuates oxidative stress and apoptosis following contrast-induced acute kidney injury in rats
resolves10.1186/s13287-016-0391-3
Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway
resolves10.1111/jcmm.15103
Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head
resolves10.1016/j.omtn.2020.03.010
miR-26a Attenuated Bone-Specific Insulin Resistance and Bone Quality in Diabetic Mice
resolves10.1038/aps.2014.156
Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway
resolves10.1158/1078-0432.CCR-12-2623
PI3K/AKT Signaling Is Essential for Communication between Tissue-Infiltrating Mast Cells, Macrophages, and Epithelial Cells in Colitis-Induced Cancer
resolves10.1002/ijc.29519
<scp>HIF</scp>‐1 at the crossroads of hypoxia, inflammation, and cancer
resolves10.1016/j.cmet.2017.10.005
Advances in Hypoxia-Inducible Factor Biology
resolves10.1016/j.cell.2019.01.021
VEGF in Signaling and Disease: Beyond Discovery and Development
resolves10.1016/j.canlet.2017.11.017
Bad phosphorylation as a target of inhibition in oncology
resolves10.1016/j.canlet.2004.01.017
Positive correlation between overexpression of phospho-BAD with phosphorylated Akt at serine 473 but not threonine 308 in colorectal carcinoma
resolves10.1038/cdd.2017.186
BCL-2 family proteins: changing partners in the dance towards death
resolves10.1146/annurev-immunol-042617-053010
Apoptosis and Clearance of Apoptotic Cells
resolves10.1021/acs.biomac.8b01802
Engineered Polymeric Micelles for Combinational Oxidation Anticancer Therapy through Concurrent HO-1 Inhibition and ROS Generation
The 12 references without a DOI — listed, not checked
no DOI — not checkedPredictors of osteonecrosis in systemic lupus erythematosus: A prospective cohort study
no DOI — not checkedPolydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/?-catenin signaling pathway
no DOI — not checkedExosomes derived from human CD34(+) stem cells transfected with miR-26a prevent glucocorticoidinduced osteonecrosis of the femoral head by promoting angiogenesis and osteogenesis
no DOI — not checkedSalidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies
no DOI — not checkedThe epigallocatechin gallate derivative Y(6) inhibits human hepatocellular carcinoma by inhibiting angiogenesis in MAPK/ERK1/2 and PI3K/AKT/ HIF-1?/VEGF dependent pathways
no DOI — not checkedTetramethylpyrazine enhances vascularization and prevents osteonecrosis in steroid-treated rats
no DOI — not checkedAstragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms
no DOI — not checkedAstragaloside IV promotes the proliferation and migration of osteoblast-like cells through the hedgehog signaling pathway
no DOI — not checkedEvaluation of the binding performance of flavonoids to estrogen receptor alpha by Autodock, Autodock Vina and Surflex-Dock
no DOI — not checkedAstragaloside IV Prevents Obesity-Associated Hypertension by Improving Pro-Inflammatory Reaction and Leptin Resistance
no DOI — not checkedBCL-2 family isoforms in apoptosis and cancer
no DOI — not checkedNew Insights into the Nrf-2/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases
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