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Mechanism of Action of Bu Zhong Yi Qi Decoction in the Treatment of Chronic Fatigue Syndrome Based on Network Pharmacology and Molecular Docking

https://doi.org/10.2139/ssrn.4144060
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28/28 checkable references clean · checked 2026-07-23

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

14 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 28 checked references that resolve
resolves10.1146/annurev.med.49.1.1
Chronic Fatigue Syndrome: An Update
resolves10.7326/0003-4819-121-12-199412150-00009
The Chronic Fatigue Syndrome: A Comprehensive Approach to Its Definition and Study
resolves10.1017/S0033291705005222
Twin analyses of chronic fatigue in a Swedish national sample
resolves10.1017/thg.2017.22
Familiality and Heritability of Fatigue in an Australian Twin Sample
resolves10.4161/viru.1.5.12486
Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome
resolves10.1159/000336803
Inflammatory and Cell-Mediated Immune Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Depression: Inflammatory Markers Are Higher in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome than in Depression
resolves10.1016/j.jad.2011.09.004
Evidence for inflammation and activation of cell-mediated immunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Increased interleukin-1, tumor necrosis factor-α, PMN-elastase, lysozyme and neopterin
resolves10.1016/j.autrev.2020.102527
A Unifying Hypothesis of the Pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Recognitions from the finding of autoantibodies against ß2-adrenergic receptors
resolves10.1016/j.jchromb.2017.01.023
Simultaneous determination of multiple bioactive components of Bu-zhong-yi-qi-tang in rat tissues by LC–MS/MS: Application to a tissue distribution study
resolves10.1186/s13063-022-06287-9
Effectiveness of modified Buzhong Yiqi decoction in treating myasthenia gravis: study protocol for a series of N-of-1 trials
resolves10.1016/S0002-9343(98)00157-0
Chronic fatigue and chronic fatigue syndrome: shifting boundaries and attributions
resolves10.1007/s00787-020-01646-w
How common are depression and anxiety in adolescents with chronic fatigue syndrome (CFS) and how should we screen for these mental health co-morbidities? A clinical cohort study
resolves10.1007/s12035-013-8553-0
The Emerging Role of Autoimmunity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/cfs)
resolves10.1016/j.biopha.2018.10.076
Chronic fatigue syndrome (CFS): Suggestions for a nutritional treatment in the therapeutic approach
resolves10.7326/ACPJC-2016-164-10-055
Review: Exercise therapy reduces fatigue in chronic fatigue syndrome
resolves10.1111/jfbc.13968
Anti‐fatigue effect of quercetin on enhancing muscle function and antioxidant capacity
resolves10.1016/j.jnutbio.2022.108949
Kaempferol increases intracellular ATP content in C2C12 myotubes under hypoxic conditions by suppressing the HIF-1α stabilization and/or by enhancing the mitochondrial complex IV activity
resolves10.1007/s00702-017-1732-9
The IL-1β phenomena in neuroinflammatory diseases
resolves10.1186/s12865-016-0142-3
Illness progression in chronic fatigue syndrome: a shifting immune baseline
resolves10.1016/j.bbih.2020.100067
MCP-1 is increased in patients with CFS and FM, whilst several other immune markers are significantly lower than healthy controls
resolves10.1016/j.cyto.2015.11.018
Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome
resolves10.1074/jbc.M115.704361
Inhibitor of Differentiation/DNA Binding 1 (ID1) Inhibits Etoposide-induced Apoptosis in a c-Jun/c-Fos-dependent Manner
resolves10.1002/jcp.21635
The epidermal growth factor receptor ligands at a glance
resolves10.1002/art.1780341123
Antineuronal antibody levels in chronic fatigue syndrome patients with neurologic abnormalities
resolves10.1016/j.bbi.2015.09.013
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome
resolves10.1017/S0033291701003580
Decreased tryptophan availability but normal post-synaptic 5-HT<sub>2c</sub> receptor sensitivity in chronic fatigue syndrome
resolves10.1128/MMBR.68.2.320-344.2004
ERK and p38 MAPK-Activated Protein Kinases: a Family of Protein Kinases with Diverse Biological Functions
resolves10.1128/MMBR.00031-10
Activation and Function of the MAPKs and Their Substrates, the MAPK-Activated Protein Kinases
The 14 references without a DOI — listed, not checked
no DOI — not checkedReview of case definitions for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
no DOI — not checkedKnowledge Centre for the Health Services at The Norwegian Institute of Public Health (NIPH) Copyright �2006 by The Norwegian Institute of Public Health (NIPH)
no DOI — not checkedEffect of Buzhong Yiqi decoction on anti-acetylcholine receptor antibody and clinical status in juvenile ocular myasthenia gravis
no DOI — not checkedBuzhongyiqi Decoction Protects Against Loperamide-Induced Constipation by Regulating the Arachidonic Acid Pathway in Rats
no DOI — not checkedThe National Academies Collection: Reports funded by National Institutes of Health
no DOI — not checkedOnset Patterns and Course of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
no DOI — not checkedChronic fatigue syndrome. Clinical practice guidelines--2002
no DOI — not checkedref20
no DOI — not checkedThe extracellular stress response to pediatric cardiopulmonary bypass
no DOI — not checkedNonmicrobial Activation of TLRs Controls Intestinal Growth, Wound Repair, and Radioprotection
no DOI — not checkedAutoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome
no DOI — not checkedref40
no DOI — not checkedEffects of glutamine on exercise-induced fatigue, skeletal muscle oxidation and liver cell apoptosis in rats
no DOI — not checkedEstrogen weakens muscle endurance via estrogen receptor-p38 MAPK-mediated orosomucoid (ORM) suppression
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