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Ivabradine Treatment Lowers Blood Pressure and Promotes Cardiac and Renal Protection in Spontaneously Hypertensive Rats

https://doi.org/10.2139/ssrn.4156324
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1 of 39 checkable references need attention · checked 2026-07-23

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

7 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

References needing attention

marked retracted by the publisher10.1016/j.biopha.2019.108689
RETRACTED: Experimental study of blood pressure and its impact on spontaneous hypertension in rats with Xin Mai Jia
The 38 checked references that resolve
resolves10.1152/physiologyonline.2002.17.1.32
From Funny Current to HCN Channels: 20 Years of Excitation
resolves10.1159/000072696
Effect of Chronic Heart Rate Reduction with Ivabradine on Carotid and Aortic Structure and Function in Normotensive and Hypertensive Rats
resolves10.1161/HYPERTENSIONAHA.111.183913
Role of Heart Rate Reduction in the Prevention of Experimental Heart Failure
resolves10.1152/ajpcell.00616.2006
A hyperpolarization-activated, cyclic nucleotide-gated, (<i>I</i><sub>h</sub>-like) cationic current and HCN gene expression in renal inner medullary collecting duct cells
resolves10.1016/j.yjmcc.2009.04.009
Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node
resolves10.1007/s11033-013-2862-2
Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications
resolves10.1038/ki.2011.230
The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron
resolves10.1177/1074248415624157
Ivabradine
resolves10.1038/324470a0
Characterization of single pacemaker channels in cardiac sino-atrial node cells
resolves10.1146/annurev.ph.55.030193.002323
Pacemaker Mechanisms in Cardiac Tissue
resolves10.1016/j.phrs.2006.03.006
Funny channels in the control of cardiac rhythm and mode of action of selective blockers
resolves10.1016/j.lfs.2010.05.004
Effect of uric acid on hypertension progression in spontaneously hypertensive rats
resolves10.1161/01.RES.60.4.487
Morphometric analysis of cardiac hypertrophy during development, maturation, and senescence in spontaneously hypertensive rats.
resolves10.1136/hrt.2007.118760
The heart rate hypothesis: ready to be tested
resolves10.1007/s10157-020-01888-7
High-salt intake accelerates functional and histological renal damage associated with renal tissue overexpression of (pro)renin receptors and AT1 receptors in spontaneously hypertensive rats
resolves10.1038/hr.2013.99
Renal inflammatory markers during the onset of hypertension in spontaneously hypertensive rats
resolves10.1536/ihj.19.886
Influence on Blood Pressure of Renal Isografts between Spontaneously Hypertensive and Normotensive Rats, Utilizing the F&lt;sub&gt;1&lt;/sub&gt; Hybrids
resolves10.33549/physiolres.934048
Ivabradine does not Impair Anxiety-Like Behavior and Memory in Both Healthy and L-NAME-Induced Hypertensive Rats
resolves10.1111/1440-1681.12264
Dual effects of amiodarone on pacemaker currents in hypertrophied ventricular myocytes isolated from spontaneously hypertensive rats
resolves10.1111/j.1440-1681.2010.05468.x
Cardiac autonomic balance in rats submitted to protein restriction after weaning
resolves10.1159/000516843
The Long-Term Study of Urinary Biomarkers of Renal Injury in Spontaneously Hypertensive Rats
resolves10.1590/2175-8239-jbn-2019-0234
Brazilian Dialysis Census: analysis of data from the 2009-2018 decade
resolves10.1016/S0008-6363(98)00305-8
Cardiac fibrosis and inflammation interaction with hemodynamic and hormonal factors
resolves10.1016/j.ekir.2016.08.006
Glomerulopathy Associated With Moderate Obesity
resolves10.1253/jcj.27.282
Development of a Strain of Spontaneously Hypertensive Rats
resolves10.1097/HJH.0000000000000865
Management of the hypertensive patient with elevated heart rate
resolves10.1139/y11-120
Blood pressure reducing effects of<i>Phalaris canariensis</i>in normotensive and spontaneously hypertensive rats
resolves10.1159/000355943
Protein Restriction after Weaning Modifies the Calcium Kinetics and Induces Cardiomyocyte Contractile Dysfunction in Rats
resolves10.1161/01.HYP.9.6_Pt_2.III130
Altered pressure-natriuresis relationship in young spontaneously hypertensive rats.
resolves10.4065/mcp.2010.0821
Association of Kidney Function and Metabolic Risk Factors With Density of Glomeruli on Renal Biopsy Samples From Living Donors
resolves10.3389/fphys.2016.00305
Chronic Treatment with Ivabradine Does Not Affect Cardiovascular Autonomic Control in Rats
resolves10.1111/bcp.14020
Chronotherapy as a potential approach to hypertensive patients with elevated heart rate?
resolves10.3389/fcvm.2021.607998
Ivabradine and Blood Pressure Reduction: Underlying Pleiotropic Mechanisms and Clinical Implications
resolves10.3390/ijms19103017
Effect of Ivabradine on a Hypertensive Heart and the Renin-Angiotensin-Aldosterone System in L-NAME-Induced Hypertension
resolves10.3389/fmed.2020.00325
Ivabradine Ameliorates Kidney Fibrosis in L-NAME-Induced Hypertension
resolves10.1080/10641963.2020.1723615
Effects of eplerenone on cerebral aldosterone levels and brain lesions in spontaneously hypertensive rats
resolves10.3389/fphar.2016.00408
The Protective Effects of Ivabradine in Preventing Progression from Viral Myocarditis to Dilated Cardiomyopathy
resolves10.1002/jcp.27070
Inhibition of JNK and p38 MAPK‐mediated inflammation and apoptosis by ivabradine improves cardiac function in streptozotocin‐induced diabetic cardiomyopathy
The 7 references without a DOI — listed, not checked
no DOI — not checkedSelective reduction of heart rate by ivabradine: effect on the visco-elastic arterial properties in rats
no DOI — not checkedExercise training reduces resting heart rate via downregulation of the funny channel HCN4
no DOI — not checkedHeart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease
no DOI — not checkedThe High Refined Carbohydrate Diet Pro-motes Renal Injury in Mice Exposed to Cigarette Smoke
no DOI — not checkedAntihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats
no DOI — not checkedEfeito do D-alfa-Tocoferol sobre a fun��o renal de ratos hipertensos: Universidade Federal de S�o Paulo (UNIFESP); 2006. Roger VL. Epidemiology of Heart Failure: A Contemporary Perspective
no DOI — not checkedAbnormal pressure-diuresis-natriuresis response in spontaneously hypertensive rats
What this badge says. CiteStamped means the CHECKABLE references of this work were clean at the dated check: each resolved to a known work in a public registry, and none carried a retraction notice at that time. It says nothing about the quality, findings, or importance of the work itself, and nothing about references deposited without a DOI.

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