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Effect of Akkermansia Muciniphila on Gut and Metabolic Health: A Meta-Analysis of Preclinical Mouse Model Studies

https://doi.org/10.2139/ssrn.4771341
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Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity
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Akkermansia muciniphila ameliorates the age-related decline in colonic mucus thickness and attenuates immune activation in accelerated aging Ercc1−/Δ7 mice
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Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases
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<i>Akkermansia muciniphila</i> strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice
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A β- <i>N</i> -acetylhexosaminidase Amuc_2109 from <i>Akkermansia muciniphila</i> protects against dextran sulfate sodium-induced colitis in mice by enhancing intestinal barrier and modulating gut microbiota
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Akkermansia muciniphila Reduces Peritonitis and Improves Intestinal Tissue Wound Healing after a Colonic Transmural Defect by a MyD88-Dependent Mechanism
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Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice
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Akkermansia muciniphila and its outer membrane protein Amuc_1100 prophylactically attenuate 5-fluorouracil-induced intestinal mucositis
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Indispensable role of melatonin, a scavenger of reactive oxygen species (ROS), in the protective effect of Akkermansia muciniphila in cadmium-induced intestinal mucosal damage
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Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
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<i>Akkermansia muciniphila</i> and its outer protein Amuc_1100 regulates tryptophan metabolism in colitis
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Pasteurized Akkermansia muciniphila improves glucose metabolism is linked with increased hypothalamic nitric oxide release
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Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease
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A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice
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Akkermansia muciniphila secretes a glucagon-like peptide-1-inducing protein that improves glucose homeostasis and ameliorates metabolic disease in mice
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Diverse effects of different Akkermansia muciniphila genotypes on Brown adipose tissue inflammation and whitening in a high-fat-diet murine model
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Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr−/−.Leiden Mice
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The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury
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Akkermansia muciniphila improves metabolic profiles by reducing inflammation in chow diet-fed mice
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<i>Akkermansia Muciniphila</i> Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in <i>Apoe</i> <sup>−/−</sup> Mice
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Pasteurized <i>Akkermansia muciniphila</i> increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice
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Extracellular vesicles and pasteurized cells derived from Akkermansia muciniphila protect against high-fat induced obesity in mice
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Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice
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Early life treatment with vancomycin propagates Akkermansia muciniphila and reduces diabetes incidence in the NOD mouse
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<i>Akkermansia muciniphila</i>and<i>Helicobacter typhlonius</i>modulate intestinal tumor development in mice
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A Preliminary Study Examining the Binding Capacity of Akkermansia muciniphila and Desulfovibrio spp., to Colonic Mucin in Health and Ulcerative Colitis
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Altered O-glycosylation profile of MUC2 mucin occurs in active ulcerative colitis and is associated with increased inflammation
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Akkermansia muciniphila as a Next-Generation Probiotic in Modulating Human Metabolic Homeostasis and Disease Progression: A Role Mediated by Gut–Liver–Brain Axes?
resolves10.1080/19490976.2021.1880240
<i>Akkermansia muciniphila</i> and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption in rats
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Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids
The 29 references without a DOI — listed, not checked
no DOI — not checkedThe potential of the gut microbiome to reshape the cancer therapy paradigm: A review
no DOI — not checkedHealth and disease: Akkermansia muciniphila, the shining star of the gut flora
no DOI — not checkedRevisiting the role of Akkermansia muciniphila as a therapeutic bacterium
no DOI — not checkedGender differences in the effect of blackberry supplementation in vascular senescence and atherosclerosis in ApoE-/-mice
no DOI — not checkedref26
no DOI — not checkedDaily ingestion of Akkermansia mucciniphila for one month promotes healthy aging and increases lifespan in old female mice
no DOI — not checkedGut microbiota remodeling improves natural aging-related disorders through Akkermansia muciniphila and its derived acetic acid
no DOI — not checkedExtracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis
no DOI — not checkedAkkermansia muciniphila colonization alleviating high fructose and restraint stress-induced jejunal mucosal barrier disruption
no DOI — not checkedAkkermansia muciniphila exerts strain-specific effects on DSS-induced ulcerative colitis in mice
no DOI — not checkedMucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development
no DOI — not checkedAkkermansia muciniphila alleviates dextran sulfate sodium (DSS)-induced acute colitis by NLRP3 activation
no DOI — not checkedAn Akkermansia muciniphila subtype alleviates high-fat diet-induced metabolic disorders and inhibits the neurodegenerative process in mice
no DOI — not checkedAkkermansia muciniphila and bifidobacterium bifidum prevent nafld by regulating fxr expression and gut microbiota
no DOI — not checkedref55
no DOI — not checkedAkkermansia muciniphila prevents fatty liver disease, decreases serum triglycerides, and maintains gut homeostasis
no DOI — not checkedProtective effect of Akkermansia muciniphila against immunemediated liver injury in a mouse model
no DOI — not checkedGut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis
no DOI — not checkedComparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice
no DOI — not checkedref71
no DOI — not checkedFunction of Akkermansia muciniphila in obesity: interactions with lipid metabolism, immune response and gut systems
no DOI — not checkedProtective effects of Akkermansia muciniphila on cognitive deficits and amyloid pathology in a mouse model of Alzheimer's disease
no DOI — not checkedMendelian randomization supports causality between gut microbiota and chronic hepatitis B
no DOI — not checkedGut microbiota differences between psoriatic arthritis and other undifferentiated arthritis: A pilot study
no DOI — not checkedref91
no DOI — not checkedref92
no DOI — not checkedInulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy
no DOI — not checkedAnti-inflammatory activities of pentaherbs formula and its influence on gut microbiota in allergic asthma
no DOI — not checkedGenome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas
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