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APOE3-R136S Mutation Confers Resilience Against Tau Pathology via cGAS-STING-IFN Inhibition

https://doi.org/10.2139/ssrn.4799775
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46/46 checkable references clean · checked 2026-10-11

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

17 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.

The 46 checked references that resolve
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Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report
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The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
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Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials
resolves10.1038/s12276-019-0250-2
Diagnosis of Alzheimer’s disease utilizing amyloid and tau as fluid biomarkers
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Amyloid-β and Tau
resolves10.1038/34910
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
resolves10.1073/pnas.0600549103
Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease
resolves10.1073/pnas.050004797
Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease
resolves10.1186/s13024-022-00577-1
Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination
resolves10.1038/nature24016
ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
resolves10.1038/s41593-023-01480-8
The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation
resolves10.1016/j.immuni.2017.08.008
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
resolves10.1016/j.cellsig.2009.01.016
Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis
resolves10.1126/scitranslmed.abe3947
AD-linked R47H- <i>TREM2</i> mutation induces disease-enhancing microglial states via AKT hyperactivation
resolves10.1007/s11064-020-03176-y
Single Nucleotide Polymorphism rs11136000 of CLU Gene (Clusterin, ApoJ) and the Risk of Late-Onset Alzheimer’s Disease in a Central European Population
resolves10.1186/s13024-021-00426-7
Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology
resolves10.1016/j.neuron.2009.02.010
Presynaptic Regulation of Astroglial Excitatory Neurotransmitter Transporter GLT1
resolves10.7150/ijbs.7526
Identification of Tmem10 as a Novel Late-stage Oligodendrocytes Marker for Detecting Hypomyelination
resolves10.1111/jnc.15133
The role of Sphingolipids in myelination and myelin stability and their involvement in childhood and adult demyelinating disorders
resolves10.1523/JNEUROSCI.1972-08.2008
Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels
resolves10.3233/JAD-220996
Plasma ApoE4 Levels Are Lower than ApoE2 and ApoE3 Levels, and Not Associated with Plasma Aβ40/42 Ratio as a Biomarker of Amyloid-β Amyloidosis in Alzheimer’s Disease
resolves10.1038/s41380-023-02170-4
Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk
resolves10.1038/nn.2583
Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
resolves10.1002/bies.201500004
Neuronal hyperactivity – A key defect in Alzheimer's disease?
resolves10.1016/j.neuron.2016.12.023
Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer’s Disease
resolves10.1016/j.cell.2012.02.046
Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model
resolves10.1038/s41380-019-0483-4
Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer’s disease
resolves10.1038/s42003-022-04268-x
Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer’s disease
resolves10.1038/nature20587
Gamma frequency entrainment attenuates amyloid load and modifies microglia
resolves10.1073/pnas.1903566116
Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures
resolves10.1002/ana.410400512
Deficient glutamate tranport is associated with neurodegeneration in Alzheimer's disease
resolves10.1172/JCI66163
Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection
resolves10.2174/1567205011666140131120922
Myelin Injury and Degraded Myelin Vesicles in Alzheimer’s Disease
resolves10.1186/s40478-018-0515-3
White matter changes in Alzheimer’s disease: a focus on myelin and oligodendrocytes
resolves10.1038/s41586-022-05439-w
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
resolves10.1038/nn.4132
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
resolves10.1038/s41593-023-01315-6
Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience
resolves10.1038/s41586-023-05788-0
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy
resolves10.1016/j.cmet.2014.09.016
Reducing Macrophage Proteoglycan Sulfation Increases Atherosclerosis and Obesity through Enhanced Type I Interferon Signaling
resolves10.1088/1741-2552/aa5eea
Open Ephys: an open-source, plugin-based platform for multichannel electrophysiology
resolves10.3389/fnbeh.2021.647640
New Open-Source Tools: Using Bonsai for Behavioral Tracking and Closed-Loop Experiments
resolves10.1038/s41593-018-0209-y
DeepLabCut: markerless pose estimation of user-defined body parts with deep learning
resolves10.14806/ej.17.1.200
Cutadapt removes adapter sequences from high-throughput sequencing reads
resolves10.1093/bioinformatics/bts635
STAR: ultrafast universal RNA-seq aligner
resolves10.1038/nbt.1621
Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
resolves10.1093/bioinformatics/btu638
HTSeq—a Python framework to work with high-throughput sequencing data
The 17 references without a DOI — listed, not checked
no DOI — not checkedref1
no DOI — not checkedref2
no DOI — not checkedAPOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge
no DOI — not checkedAPOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia
no DOI — not checkedDistinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia
no DOI — not checkedref17
no DOI — not checkedA Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
no DOI — not checkedCarboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways
no DOI — not checkedBlockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
no DOI — not checkedref29
no DOI — not checkedHigh-Density Lipoprotein Changes in Alzheimer's Disease Are APOE Genotype-Specific
no DOI — not checkedGABAergic Inhibitory Interneuron Deficits in Alzheimer's Disease: Implications for Treatment
no DOI — not checkedAstrocytic response mediated by the CLU risk allele inhibits OPC proliferation and myelination in a human iPSC model
no DOI — not checkedMicroglial NF-?B drives tau spreading and toxicity in a mouse model of tauopathy
no DOI — not checkedModerated estimation of fold change and dispersion for RNA-seq data with DESeq2
no DOI — not checkedRStudio: Integrated Development for R
no DOI — not checkedref64
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