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Ghrelin Directly Interacts With Neuropeptide-Y-Containing Neurons in the Rat Arcuate Nucleus

https://doi.org/10.2337/diabetes.52.4.948
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41/41 checkable references clean · checked 2026-07-22

Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.

The 41 checked references that resolve
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Ghrelin is a growth-hormone-releasing acylated peptide from stomach
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Ghrelin, an Endogenous Growth Hormone Secretagogue, Is a Novel Orexigenic Peptide That Antagonizes Leptin Action Through the Activation of Hypothalamic Neuropeptide Y/Y1 Receptor Pathway
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Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin
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The Novel Hypothalamic Peptide Ghrelin Stimulates Food Intake and Growth Hormone Secretion
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Ghrelin Enhances Appetite and Increases Food Intake in Humans
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Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.
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Co-Localization of Growth Hormone Secretagogue Receptor and NPY mRNA in the Arcuate Nucleus of the Rat
resolves10.1016/S0304-3940(02)00241-0
Peripheral ghrelin selectively increases Fos expression in neuropeptide Y – synthesizing neurons in mouse hypothalamic arcuate nucleus
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Systemic Administration of Ghrelin Induces Fos and Egr‐1 Proteins in the Hypothalamic Arcuate Nucleus of Fasted and Fed Rats
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Acute Central Ghrelin and GH Secretagogues Induce Feeding and Activate Brain Appetite Centers
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The effects of GH-releasing peptide-6 (GHRP-6) and GHRP-2 on intracellular adenosine 3′,5′-monophosphate (cAMP) levels and GH secretion in ovine and rat somatotrophs
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resolves10.1016/S0304-3940(02)00140-4
Orexin-1 receptor immunoreactivity in chemically identified target neurons in the rat hypothalamus
resolves10.1016/S0167-0115(99)00102-0
Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats
resolves10.1016/S0006-8993(00)02043-6
Orexin-induced food intake involves neuropeptide Y pathway
resolves10.1016/S0196-9781(00)00311-9
Evidence of NPY Y5 receptor involvement in food intake elicited by orexin A in sated rats
resolves10.1016/S0304-3940(99)00185-8
Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y
resolves10.1016/S0304-3940(01)02053-5
Lowering glucose concentrations increases cytosolic Ca2+ in orexin neurons of the rat lateral hypothalamus
resolves10.1016/S0021-9258(17)42256-3
Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet beta-cells.
resolves10.1210/endo.133.4.8404610
Glucagon-like peptide-1-(7-36)amide and a rise in cyclic adenosine 3',5'-monophosphate increase cytosolic free Ca2+ in rat pancreatic beta-cells by enhancing Ca2+ channel activity.
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Low cerebrospinal fluid hypocretin (orexin) and altered energy homeostasis in human narcolepsy
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Leptin enters the brain by a saturable system independent of insulin
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Regulation of Neuropeptide Y Release by Neuropeptide Y Receptor Ligands and Calcium Channel Antagonists in Hypothalamic Slices
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Autoreceptor-induced inhibition of neuropeptide Y release from PC-12 cells is mediated by Y<sub>2</sub>receptors
resolves10.1146/annurev.ph.52.030190.001353
Regulation of Cardiac L-Type Calcium Current by Phosphorylation and G Proteins
resolves10.1523/JNEUROSCI.21-04-01238.2001
Downregulation of Fasting-Induced cAMP Response Element-Mediated Gene Induction by Leptin in Neuropeptide Y Neurons of the Arcuate Nucleus
resolves10.1046/j.0953-816x.2001.01859.x
Orexin receptor‐1 (OX‐R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake
resolves10.1016/S0304-3940(99)00177-9
Neurons containing orexin in the lateral hypothalamic area of the adult rat brain are activated by insulin-induced acute hypoglycemia
resolves10.1046/j.1365-2826.2002.00810.x
Ghrelin Acts on Leptin‐Responsive Neurones in the Rat Arcuate Nucleus
resolves10.1172/JCI3920
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B.
resolves10.1074/jbc.275.15.11348
Leptin Induces Insulin-like Signaling That Antagonizes cAMP Elevation by Glucagon in Hepatocytes
resolves10.1038/nn885
A phosphatidylinositol 3-kinase–phosphodiesterase 3B–cyclic AMP pathway in hypothalamic action of leptin on feeding
resolves10.1038/nn824
Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels
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