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Substrate Stiffness Modulates the Growth, Phenotype, and Chemoresistance of Ovarian Cancer Cells

https://doi.org/10.3389/fcell.2021.718834
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1 of 71 checkable references need attention · checked 2026-07-22

At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

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References needing attention

does not resolve to a known work10.1126/science.aaaa4559
The 70 checked references that resolve
resolves10.1111/boc.201600078
Are cancer cells really softer than normal cells?
resolves10.1016/j.cell.2013.07.042
A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors
resolves10.1038/ncb1037
Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells
resolves10.1016/j.drup.2012.01.006
The tumor microenvironment is a dominant force in multidrug resistance
resolves10.18632/oncotarget.13817
The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer
resolves10.1038/nrc3447
Regulatory networks defining EMT during cancer initiation and progression
resolves10.1016/j.lungcan.2004.01.008
Irinotecan and docetaxel as first line chemotherapy in patients with stage IIIB/IV non-small cell lung cancer—experience from a prematurely closed phase II study
resolves10.1038/nature10137
Role of YAP/TAZ in mechanotransduction
resolves10.1038/nrgastro.2012.115
The role of stroma in pancreatic cancer: diagnostic and therapeutic implications
resolves10.2147/ott.S109979
Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer
resolves10.3233/Ch-131696
Substrate stiffness influences the outcome of antitumor drug screening in vitro
resolves10.3892/mmr.2017.6960
KDM5A promotes proliferation and EMT in ovarian cancer and closely correlates with PTX resistance
resolves10.1038/nature08908
Cell mechanics and the cytoskeleton
resolves10.3390/cancers3011351
Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
resolves10.1002/ijc.23086
Akt promotes cisplatin resistance in human ovarian cancer cells through inhibition of p53 phosphorylation and nuclear function
resolves10.1038/onc.2011.384
Molecular mechanisms of cisplatin resistance
resolves10.3389/fgene.2020.00516
MDR1 Gene Polymorphisms and Its Association With Expression as a Clinical Relevance in Terms of Response to Chemotherapy and Prognosis in Ovarian Cancer
resolves10.1002/1878-0261.12414
Targeting <scp>HER</scp>2 in patient‐derived xenograft ovarian cancer models sensitizes tumors to chemotherapy
resolves10.1111/j.1365-2141.2006.06435.x
<i>β</i>1 integrin mediated adhesion increases Bim protein degradation and contributes to drug resistance in leukaemia cells
resolves10.1038/sj.onc.1203782
Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)
resolves10.1016/0165-6147(92)90048-b
Mechanism of action of taxol
resolves10.1016/j.cell.2005.06.007
The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP
resolves10.3892/ijo.2017.3877
Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells
resolves10.1016/j.biopha.2013.09.004
Expression of MDR1 and MDR3 gene products in paclitaxel-, doxorubicin- and vincristine-resistant cell lines
resolves10.3322/caac.20073
Cancer Statistics, 2010
resolves10.1016/0005-2736(76)90160-7
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
resolves10.3892/ijo.31.2.277
Chemoresistance to paclitaxel induces epithelial-mesenchymal transition and enhances metastatic potential for epithelial ovarian carcinoma cells
resolves10.1006/gyno.2002.6738
Multidrug Resistance Gene-1 Is a Useful Predictor of Paclitaxel-Based Chemotherapy for Patients with Ovarian Cancer
resolves10.1016/j.bbamcr.2017.11.012
Soft drug-resistant ovarian cancer cells migrate via two distinct mechanisms utilizing myosin II-based contractility
resolves10.1016/s0009-9120(99)00026-0
Increased bcl-2 expression is associated with primary resistance to chemotherapy in human epithelial ovarian cancer
resolves10.1186/1475-2867-14-41
The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance
resolves10.1038/sj.onc.1206315
Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells
resolves10.1007/s12668-016-0191-3
Discrimination Between Normal and Cancerous Cells Using AFM
resolves10.1039/b610522j
Soft biological materials and their impact on cell function
resolves10.1016/j.cell.2009.10.027
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
resolves10.1016/j.bbrc.2008.07.078
AFM indentation study of breast cancer cells
resolves10.1002/bab.1302
Role of three‐dimensional matrix stiffness in regulating the chemoresistance of hepatocellular carcinoma cells
resolves10.1002/smll.201601365
Porous Matrix Stiffness Modulates Response to Targeted Therapy in Breast Carcinoma
resolves10.1101/gad.192856.112
Genetic and pharmacological disruption of the TEAD–YAP complex suppresses the oncogenic activity of YAP
resolves10.3390/cancers11060838
The Role of Epithelial-to-Mesenchymal Plasticity in Ovarian Cancer Progression and Therapy Resistance
resolves10.1038/s41598-018-25589-0
The mechanical microenvironment regulates ovarian cancer cell morphology, migration, and spheroid disaggregation
resolves10.5041/RMMJ.10106
The Duplicitous Origin of Ovarian Cancer
resolves10.1038/nm.2492
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
resolves10.1038/nm.2938
The tumor microenvironment controls drug sensitivity
resolves10.15430/JCP.2016.21.2.73
Nano-mechanical Phenotype as a Promising Biomarker to Evaluate Cancer Development, Progression, and Anti-cancer Drug Efficacy
resolves10.1152/physrev.00005.2014
The Biology of YAP/TAZ: Hippo Signaling and Beyond
resolves10.1371/journal.pone.0126107
An Atomic Force Microscope Study Revealed Two Mechanisms in the Effect of Anticancer Drugs on Rate-Dependent Young’s Modulus of Human Prostate Cancer Cells
resolves10.1038/oncsis.2017.54
Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells
resolves10.1002/hep.24108
Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells
resolves10.1248/bpb.b14-00604
Nano-mechanical Reinforcement in Drug-Resistant Ovarian Cancer Cells
resolves10.1038/9511
Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo
resolves10.1039/c3ib40246k
The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells
resolves10.2741/e161
AFM and fluorescence imaging of nanomechanical response in periodontal ligament cells
resolves10.1038/Nmat4729
Transcription upregulation via force-induced direct stretching of chromatin
resolves10.1073/pnas.1004900107
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
resolves10.1158/0008-5472.CAN-05-0616
Carcinoma Invasion and Metastasis: A Role for Epithelial-Mesenchymal Transition?
resolves10.1371/journal.pone.0012905
Matrix Rigidity Regulates Cancer Cell Growth and Cellular Phenotype
resolves10.1038/ncomms15206
YAP/TAZ link cell mechanics to Notch signalling to control epidermal stem cell fate
resolves10.1016/0959-8049(94)90132-5
Expression of P-glycoprotein and in vitro or in vivo resistance to doxorubicin and cisplatin in breast and ovarian cancers
resolves10.1002/cncr.29321
<scp>S</scp>ociety of <scp>G</scp>ynecologic <scp>O</scp>ncology recommendations for the prevention of ovarian cancer
resolves10.1002/sca.1998.4950200504
Mechanical properties of L929 cells measured by atomic force microscopy: Effects of anticytoskeletal drugs and membrane crosslinking
resolves10.3389/fcell.2021.641469
Adaptive Mechanisms of Tumor Therapy Resistance Driven by Tumor Microenvironment
resolves10.1371/journal.pone.0046609
Cell Stiffness Is a Biomarker of the Metastatic Potential of Ovarian Cancer Cells
resolves10.1016/j.cell.2004.06.006
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
resolves10.1038/s41598-019-49649-1
Adipocytes promote ovarian cancer chemoresistance
resolves10.1038/bjc.2014.136
Acquisition of epithelial–mesenchymal transition is associated with Skp2 expression in paclitaxel-resistant breast cancer cells
resolves10.1158/0008-5472.Can-05-0425
Akt-Mediated Cisplatin Resistance in Ovarian Cancer: Modulation of p53 Action on Caspase-Dependent Mitochondrial Death Pathway
resolves10.1016/j.biopha.2018.07.059
MiR-1294 confers cisplatin resistance in ovarian Cancer cells by targeting IGF1R
resolves10.1101/gad.173435.111
Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis
resolves10.1038/onc.2015.84
miR-186 regulation of Twist1 and ovarian cancer sensitivity to cisplatin
The 3 references without a DOI — listed, not checked
no DOI — not checkedExpression of a human multidrug resistance gene in ovarian carcinomas.
no DOI — not checkedMiR-181a upregulation is associated with epithelial-To-mesenchymal transition (EMT) and multidrug resistance (MDR) of ovarian cancer cells.
no DOI — not checkedExpression of twist and wnt in human breast cancer.
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