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Understanding the research advances on lumpy skin disease: A comprehensive literature review of experimental evidence

https://doi.org/10.3389/fmicb.2022.1065894
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At the dated check, the references listed below either did not resolve in Crossref or DataCite, or carried a retraction notice. Each one is shown with the registry record that put it there.

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References needing attention

does not resolve to a known work10.7763/IJBBB.2013.V3.235
does not resolve to a known work10.22092/ari.2017.113301
does not resolve to a known work10.1128/JVI.75.15.7122–7130.2001
does not resolve to a known work10.3760/cma.j.cn112150-20200520-00756
The 142 checked references that resolve
resolves10.3855/jidc.5038
Hematological and serum biochemical findings in clinical cases of cattle naturally infected with lumpy skin disease
resolves10.1128/JVI.07162-11
Biological Characterization and Next-Generation Genome Sequencing of the Unclassified Cotia Virus SPAn232 (Poxviridae)
resolves10.1007/s11250-022-03073-2
Assessing machine learning techniques in forecasting lumpy skin disease occurrence based on meteorological and geospatial features
resolves10.1016/j.mcp.2021.101778
A TaqMan probe-based multiplex real-time PCR method for the specific detection of wild type lumpy skin disease virus with beta-actin as internal amplification control
resolves10.1016/j.jviromet.2017.08.011
Development and validation of a TaqMan probe-based real-time PCR method for the differentiation of wild type lumpy skin disease virus from vaccine virus strains
resolves10.1038/s41598-020-64029-w
Non-vector-borne transmission of lumpy skin disease virus
resolves10.1111/j.1865-1682.2011.01240.x
Common, Emerging, Vector-Borne and Infrequent Abortogenic Virus Infections of Cattle
resolves10.1007/s00580-021-03264-7
Prevalence, intensity, and impacts of non-cutaneous lesions of lumpy skin disease among some infected cattle flocks in Nile Delta governorates, Egypt
resolves10.14202/vetworld.2021.2230-2237
Diagnosis of naturally occurring lumpy skin disease virus infection in cattle using virological, molecular, and immunohistopathological assays
resolves10.1111/tbed.12045
Seminal Transmission of Lumpy Skin Disease Virus in Heifers
resolves10.1111/j.1439-0531.2008.01274.x
Sites of Persistence of Lumpy Skin Disease Virus in the Genital Tract of Experimentally Infected Bulls
resolves10.3389/fvets.2021.799065
The First Lumpy Skin Disease Outbreak in Thailand (2021): Epidemiological Features and Spatio-Temporal Analysis
resolves10.1016/S0264-410X(02)00203-7
Immunogenicity of a recombinant lumpy skin disease virus (neethling vaccine strain) expressing the rabies virus glycoprotein in cattle
resolves10.1099/vir.0.19116-0
Evaluation of lumpy skin disease virus, a capripoxvirus, as a replication-deficient vaccine vector
resolves10.1007/s11250-009-9486-5
Evaluation of different diagnostic methods for diagnosis of Lumpy skin disease in cows
resolves10.1111/j.1865-1682.2008.01024.x
Quantification of Lumpy Skin Disease Virus Following Experimental Infection in Cattle
resolves10.3390/vaccines9060621
Investigation of Post Vaccination Reactions of Two Live Attenuated Vaccines against Lumpy Skin Disease of Cattle
resolves10.1006/viro.1995.1342
Distinct Patterns of IFN Sensitivity Observed in Cells Infected with Vaccinia K3L- and E3L- Mutant Viruses
resolves10.1111/tbed.12730
Detection of lumpy skin disease virus in skin lesions, blood, nasal swabs and milk following preventive vaccination
resolves10.1586/erv.12.116
Animal poxvirus vaccines: a comprehensive review
resolves10.1023/b:trop.0000026661.88631.50
A Classical Live Attenuated Vaccine for Sheep Pox
resolves10.1016/j.cimid.2005.12.001
The current status of sheep pox disease
resolves10.1016/0168-1702(86)90024-9
Genomic relationship between capripoxviruses
resolves10.2307/1591007
Further Comparison of Adjuvants for an Inactivated Infectious Coryza Vaccine
resolves10.1016/j.antiviral.2015.08.016
A lumpy skin disease virus deficient of an IL-10 gene homologue provides protective immunity against virulent capripoxvirus challenge in sheep and goats
resolves10.1016/j.vaccine.2009.01.020
Appearance of skin lesions in cattle populations vaccinated against lumpy skin disease: Statutory challenge
resolves10.4102/jsava.v73i3.568
Ixodid ticks on cattle belonging to small-scale farmers at 4 communal grazing areas in South Africa
resolves10.2903/j.efsa.2019.5638
Lumpy skin disease
resolves10.1017/S0950268800052067
An investigation of possible routes of transmission of lumpy skin disease virus (Neethling)
resolves10.3390/bios12090739
Investigation of the “Antigen Hook Effect” in Lateral Flow Sandwich Immunoassay: The Case of Lumpy Skin Disease Virus Detection
resolves10.1186/s12985-018-0969-8
A gel-based PCR method to differentiate sheeppox virus field isolates from vaccine strains
resolves10.1046/j.1365-2915.2003.00445.x
Attempted mechanical transmission of lumpy skin disease virus by biting insects
resolves10.1017/S0950268801005179
Mechanical transmission of lumpy skin disease virus by <i>Aedes aegypti</i> (Diptera: Culicidae)
resolves10.1111/tbed.14583
Characterization of Lumpy skin disease virus isolated from a giraffe in Vietnam
resolves10.1002/rmv.439
Therapeutic potential of nucleoside/nucleotide analogues against poxvirus infections
resolves10.1016/j.vetmic.2018.05.022
Suitability of group-level oral fluid sampling in ruminant populations for lumpy skin disease virus detection
resolves10.1186/s12917-022-03398-y
Isolation and molecular characterization of lumpy skin disease virus from hard ticks, Rhipicephalus (Boophilus) annulatus in Egypt
resolves10.4102/ojvr.v84i1.1393
Lumpy skin disease in cattle: Frequency of occurrence in a dairy farm and a preliminary assessment of its possible impact on Egyptian buffaloes
resolves10.3390/vaccines9040351
Differentiation of Capripox Viruses by Nanopore Sequencing
resolves10.1016/j.vetmic.2021.109046
Development of an inactivated combined vaccine for protection of cattle against lumpy skin disease and bluetongue viruses
resolves10.2903/j.efsa.2017.4773
Lumpy skin disease: I. Data collection and analysis
resolves10.2903/j.efsa.2018.5176
Lumpy skin disease II. Data collection and analysis
resolves10.4102/jsava.v85i1.1075
Seroprevalence of Rift Valley fever and lumpy skin disease in African buffalo (&lt;i&gt;Syncerus caffer&lt;/i&gt;) in the Kruger National Park and Hluhluwe-iMfolozi Park, South Africa
resolves10.5455/OVJ.2022.v12.i4.6
Molecular Diagnosis of Three Outbreaks During 3 Successive Years (2018, 2019, and 2020) of Lumpy Skin Disease Virus in Cattle in Sharkia Governorate, Egypt
resolves10.1016/j.cvsm.2017.10.002
Recent Advances in Vaccine Technologies
resolves10.1016/j.vaccine.2015.01.035
Evaluation of the safety, immunogenicity and efficacy of three capripoxvirus vaccine strains against lumpy skin disease virus
resolves10.1128/jvi.63.11.4703-4708.1989
A comparison of the genome organization of capripoxvirus with that of the orthopoxviruses
resolves10.1099/0022-1317-70-2-485
Poxvirus Genetic Recombination during Natural Virus Transmission
resolves10.1001/jama.1984.03350030023016
Live Attenuated Varicella Vaccine
resolves10.1111/j.1948-7134.2012.00203.x
Analysis of post-blood meal flight distances in mosquitoes utilizing zoo animal blood meals
resolves10.1111/tbed.13216
Using the basic reproduction number to assess the risk of transmission of lumpy skin disease virus by biting insects
resolves10.1016/j.jviromet.2019.113800
An Immunoperoxidase Monolayer Assay (IPMA) for the detection of lumpy skin disease antibodies
resolves10.3390/vaccines9050473
Comparative Evaluation of Lumpy Skin Disease Virus-Based Live Attenuated Vaccines
resolves10.1016/j.vetmic.2020.108689
Development and Evaluation of an Inactivated Lumpy Skin Disease Vaccine for Cattle
resolves10.1128/jvi.67.3.1529-1537.1993
Glycoprotein gp50-negative pseudorabies virus: a novel approach toward a nonspreading live herpesvirus vaccine
resolves10.1016/s0022-1759(99)00072-1
A capripoxvirus detection PCR and antibody ELISA based on the major antigen P32, the homolog of the vaccinia virus H3L gene
resolves10.1177/104063879000200205
The Isolation of Lumpy Skin Disease Virus and Bovine Herpesvirus- from Cattle in Egypt
resolves10.4102/jsava.v72i2.619
Lumpy skin disease in southern Africa : a review of the disease and aspects of control
resolves10.1016/S0166-0934(98)00035-4
Improved detection of capripoxvirus in biopsy samples by PCR
resolves10.1016/j.theriogenology.2004.06.013
Excretion of lumpy skin disease virus in bull semen
resolves10.3390/ani10030477
Mechanical Transmission of Lumpy Skin Disease Virus by Stomoxys spp. (Stomoxys calsitrans, Stomoxys sitiens, Stomoxys indica), Diptera: Muscidae
resolves10.3390/genes13050734
Sensitive and Specific Detection of Lumpy Skin Disease Virus in Cattle by CRISPR-Cas12a Fluorescent Assay Coupled with Recombinase Polymerase Amplification
resolves10.1128/JVI.77.11.6093-6100.2003
Poxvirus Immunomodulatory Strategies: Current Perspectives
resolves10.1016/S0034-5288(18)32635-3
Artificial infection of Rhipicephalm appendiculatus with Theileria parva by percutaneous injection
resolves10.1111/tbed.12926
Economic cost of lumpy skin disease outbreaks in three Balkan countries: Albania, Bulgaria and the Former Yugoslav Republic of Macedonia (2016-2017)
resolves10.1016/j.vaccine.2018.06.017
Characterisation of putative immunomodulatory gene knockouts of lumpy skin disease virus in cattle towards an improved vaccine
resolves10.1111/tbed.12646
Investigation on the incidence of adverse reactions, viraemia and haematological changes following field immunization of cattle using a live attenuated vaccine against lumpy skin disease
resolves10.1016/S0034-5288(18)30655-6
A single vaccine for the control of capripox infection in sheep and goats
resolves10.1007/s11250-021-02872-3
Clinico-molecular diagnosis and characterization of bovine lumpy skin disease virus in Andhra Pradesh, India
resolves10.1111/tbed.12378
Using Synoptic Systems’ Typical Wind Trajectories for the Analysis of Potential Atmospheric Long-Distance Dispersal of Lumpy Skin Disease Virus
resolves10.1016/j.prevetmed.2018.12.001
Neethling vaccine proved highly effective in controlling lumpy skin disease epidemics in the Balkans
resolves10.1128/jvi.66.5.3048-3055.1992
Identification and characterization of pseudorabies virus glycoprotein H
resolves10.1111/tbed.13158
Determination of lumpy skin disease virus in bovine meat and offal products following experimental infection
resolves10.3390/microorganisms10051074
Easy Express Extraction (TripleE)—A Universal, Electricity-Free Nucleic Acid Extraction System for the Lab and the Pen
resolves10.1186/s12864-022-08639-w
An in-depth bioinformatic analysis of the novel recombinant lumpy skin disease virus strains: from unique patterns to established lineage
resolves10.1371/journal.pone.0241022
Isolation and characterization of lumpy skin disease virus from cattle in India
resolves10.1016/j.antiviral.2017.02.017
Co-administration of recombinant major envelope proteins (rA27L and rH3L) of buffalopox virus provides enhanced immunogenicity and protective efficacy in animal models
resolves10.1126/science.1217134
Attenuated Vaccines Can Recombine to Form Virulent Field Viruses
resolves10.1093/nar/gkx932
Virus taxonomy: the database of the International Committee on Taxonomy of Viruses (ICTV)
resolves10.1128/jvi.65.3.1124-1132.1991
Bovine herpesvirus 1 attachment to permissive cells is mediated by its major glycoproteins gI, gIII, and gIV
resolves10.1021/acssynbio.1c00103
Highly Sensitive CRISPR/Cas12a-Based Fluorescence Detection of Porcine Reproductive and Respiratory Syndrome Virus
resolves10.1016/j.micpath.2021.105024
Research progress on live attenuated vaccine against African swine fever virus
resolves10.1007/s10493-013-9722-6
Transovarial passage and transmission of LSDV by Amblyomma hebraeum, Rhipicephalus appendiculatus and Rhipicephalus decoloratus
resolves10.1111/tbed.12102
Evidence of Transstadial and Mechanical Transmission of Lumpy Skin Disease Virus by<i>Amblyomma hebraeum</i>Ticks
resolves10.1186/1297-9716-43-1
Mathematical modelling and evaluation of the different routes of transmission of lumpy skin disease virus
resolves10.1016/j.jvacx.2022.100209
Improved safety profile of inactivated Neethling strain of the Lumpy Skin Disease Vaccine
resolves10.1038/nrmicro1099
Poxvirus tropism
resolves10.1016/j.jviromet.2013.12.013
Development of an assay to differentiate between virulent and vaccine strains of lumpy skin disease virus (LSDV)
resolves10.1038/357455a0
Human gene therapy comes of age
resolves10.1186/s12985-020-01298-x
Suitability of individual and bulk milk samples to investigate the humoral immune response to lumpy skin disease vaccination by ELISA
resolves10.1099/0022-1317-67-4-693
Antigenic and Molecular Evolution of the Vaccine Strain of Type 3 Poliovirus during the Period of Excretion by a Primary Vaccinee
resolves10.1186/s12985-021-01634-9
First molecular characterization of poxviruses in cattle, sheep, and goats in Botswana
resolves10.1016/j.prevetmed.2017.09.003
Economic impact of lumpy skin disease and cost effectiveness of vaccination for the control of outbreaks in Ethiopia
resolves10.1007/s00705-019-04411-w
Experimental lumpy skin disease virus infection of cattle: comparison of a field strain and a vaccine strain
resolves10.4172/2157-7579.1000535
Review: Lumpy Skin Disease
resolves10.1111/vde.12690
Validation of a diagnostic tool for the diagnosis of lumpy skin disease
resolves10.1007/s00580-019-02952-9
Assessing the possible causes of hemolytic anemia associated with lumpy skin disease naturally infected buffaloes
resolves10.1017/S0950268801006513
Long term immunity in African cattle vaccinated with a recombinant capripox-rinderpest virus vaccine
resolves10.1016/j.vaccine.2006.12.010
Absence of lumpy skin disease virus in semen of vaccinated bulls following vaccination and subsequent experimental infection
resolves10.1016/0264-410X(94)90104-X
Non-transmissible pseudorabies virus gp50 mutants: a new generation of safe live vaccines
resolves10.1073/pnas.1515613113
Myxoma virus M156 is a specific inhibitor of rabbit PKR but contains a loss-of-function mutation in Australian virus isolates
resolves10.1002/path.1700780207
The growth in tissue cultures of a virus derived from lumpy‐skin disease of cattle
resolves10.1080/14760584.2018.1522255
Poxvirus-based vector systems and the potential for multi-valent and multi-pathogen vaccines
resolves10.3389/fvets.2022.957306
Spatio-temporal patterns of lumpy skin disease outbreaks in dairy farms in northeastern Thailand
resolves10.1007/s12639-015-0677-x
Clinical management of demodicosis in Ongole cattle
resolves10.1136/vr.114.24.581
Malignant catarrhal fever
resolves10.1016/0264-410X(93)90258-Y
Single capripoxvirus recombinant vaccine for the protection of cattle against rinderpest and lumpy skin disease
resolves10.1016/j.tvjl.2015.11.010
Evidence of intrauterine transmission of lumpy skin disease virus
resolves10.1371/journal.pone.0198506
Risk of introduction of lumpy skin disease in France by the import of vectors in animal trucks
resolves10.3390/v14020372
Development and Evaluation of a Combined Contagious Bovine Pleuropneumonia (CBPP) and Lumpy Skin Disease (LSD) Live Vaccine
resolves10.1128/JVI.02239-20
Quantifying and Modeling the Acquisition and Retention of Lumpy Skin Disease Virus by Hematophagus Insects Reveals Clinically but Not Subclinically Affected Cattle Are Promoters of Viral Transmission and Key Targets for Control of Disease Outbreaks
resolves10.1177/0300985820913268
Lumpy Skin Disease Is Characterized by Severe Multifocal Dermatitis With Necrotizing Fibrinoid Vasculitis Following Experimental Infection
resolves10.1128/jvi.00751-22
The Acquisition and Retention of Lumpy Skin Disease Virus by Blood-Feeding Insects Is Influenced by the Source of Virus, the Insect Body Part, and the Time since Feeding
resolves10.1146/annurev.immunol.21.120601.141049
Poxviruses and Immune Evasion
resolves10.1016/j.cimid.2021.101699
Molecular characterization and phylogenetic analysis of lumpy skin disease in Egypt
resolves10.1007/s11250-021-02786-0
Seroprevalence and risk factors for lumpy skin disease in cattle in Northern Egypt
resolves10.1111/tbed.12501
Epidemiological and Molecular Studies on Lumpy Skin Disease Outbreaks in Turkey during 2014-2015
resolves10.1186/s12917-016-0875-5
Recombinase polymerase amplification assay for rapid detection of lumpy skin disease virus
resolves10.1038/s41598-019-56605-6
Experimental evidence of mechanical lumpy skin disease virus transmission by Stomoxys calcitrans biting flies and Haematopota spp. horseflies
resolves10.1111/tbed.12889
Epidemiological characterization of lumpy skin disease outbreaks in Russia in 2016
resolves10.1371/journal.pone.0207480
Analysis and insights into recombination signals in lumpy skin disease virus recovered in the field
resolves10.1111/j.1751-0813.1966.tb07646.x
EMERGING DISEASES OF ANIMALS
resolves10.1016/j.jviromet.2008.05.003
The use of lumpy skin disease virus genome termini for detection and phylogenetic analysis
resolves10.1016/j.virusres.2021.198671
Inhibition of bovine and ovine capripoxviruses (Lumpy skin disease virus and Sheeppox virus) by ivermectin occurs at different stages of propagation in vitro
resolves10.1128/jvi.76.12.6054-6061.2002
The Genomes of Sheeppox and Goatpox Viruses
resolves10.1016/j.ttbdis.2013.01.006
Evidence of vertical transmission of lumpy skin disease virus in Rhipicephalus decoloratus ticks
resolves10.1016/j.antiviral.2014.06.009
Characterization of sheep pox virus vaccine for cattle against lumpy skin disease virus
resolves10.1111/j.1865-1682.2010.01184.x
A Potential Role for Ixodid (Hard) Tick Vectors in the Transmission of Lumpy Skin Disease Virus in Cattle
resolves10.1016/j.ttbdis.2014.11.002
Lumpy skin disease: Attempted propagation in tick cell lines and presence of viral DNA in field ticks collected from naturally-infected cattle
resolves10.1385/1-59259-789-0:347
Poxvirus Bioinformatics
resolves10.1016/j.vaccine.2004.10.006
Immune responses to recombinants of the South African vaccine strain of lumpy skin disease virus generated by using thymidine kinase gene insertion
resolves10.1111/tbed.14570
Isolation, identification and phylogenetic analysis of lumpy skin disease virus strain of outbreak in Guangdong, China
resolves10.1007/978-3-662-39771-8_3
Lumpy Skin Disease Virus
resolves10.1099/0022-1317-83-5-1049
Orf virus-encoded interleukin-10 stimulates the proliferation of murine mast cells and inhibits cytokine synthesis in murine peritoneal macrophages
resolves10.1128/jvi.77.2.1163-1174.2003
Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles
resolves10.3390/microorganisms8122053
Thermal Inactivation of Different Capripox Virus Isolates
resolves10.3390/vaccines9010004
Development of a Safe and Highly Efficient Inactivated Vaccine Candidate against Lumpy Skin Disease Virus
resolves10.1016/j.mcp.2018.08.003
A real time high-resolution melting PCR assay for detection and differentiation among sheep pox virus, goat pox virus, field and vaccine strains of lumpy skin disease virus
resolves10.1136/vr.137.4.91
Spread of lumpy skin disease in Israeli dairy herds
resolves10.1136/vr.135.14.330
Adverse reactions in cattle to a capripox vaccine
resolves10.1006/viro.2000.0792
A Striking Property of Recombinant Poxviruses: Efficient Inducers of in Vivo Expansion of Primed CD8+ T Cells
resolves10.14202/vetworld.2019.1093-1100
Detection of lumpy skin disease virus in cattle using real-time polymerase chain reaction and serological diagnostic assays in different governorates in Egypt in 2017
The 29 references without a DOI — listed, not checked
no DOI — not checkedProduction of goat pox virus vaccine from a live attenuated goat pox virus strain
no DOI — not checkedCytopathogenic agents associated with lumpy skin disease of cattle
no DOI — not checkedClinical and pathological studies on lumpy skin disease in Egypt
no DOI — not checkedLumpy skin disease: review of the literature
no DOI — not checkedAntibodies against some viruses of domestic animals in southern African wild animals
no DOI — not checkedComparison of the efficacy of Neethling lumpy skin disease virus and x10RM65 sheep-pox live attenuated vaccines for the prevention of lumpy skin disease—the results of a randomized controlled field study
no DOI — not checkedref34
no DOI — not checkedObservations on the first outbreak of lumpy skin disease in Kenya
no DOI — not checkedInfectious diseases of livestock
no DOI — not checkedBovine viral diarrhea virus: biotypes and disease
no DOI — not checkedPathologic and immunohistochemical findings of natural lumpy skin disease in Egyptian cattle
no DOI — not checkedAdenovirus-based expression vectors and recombinant vaccines
no DOI — not checkedThe effect of subunit or modified live bovine herpesvirus-1 vaccines on the efficacy of a recombinant Pasteurella haemolytica vaccine for the prevention of respiratory disease in feedlot calves
no DOI — not checkedPoxvirus DNA
no DOI — not checkedLumpy skin disease: Review of the literature
no DOI — not checkedref111
no DOI — not checkedFamily Poxviridae
no DOI — not checkedMedical and Veterinary Entomology
no DOI — not checkedElectron microscopic studies on lumpy skin disease virus type "Neethling"
no DOI — not checkedVirus taxonomy: classification and nomenclature of viruses
no DOI — not checkedAn investigation of the seroprevalence of Crimean Congo hemorrhagic fever and lumpy skin disease in domesticated water buffaloes in northern Turkey
no DOI — not checkedInfectious diseases of livestock with special reference to southern Africa: J.A.W. Coetzer, G.R. Thomson and R.C. Tustin (editors), Oxford university press, 1994, 2 vols, 1, 605 + viiipp, $245.00, ISBN 0-1957-0506-8
no DOI — not checkedNorthern Rhodesia Department of Animal Health
no DOI — not checkedref131
no DOI — not checkedref132
no DOI — not checkedIncidence of lumpy skin disease among Egyptian cattle in Giza governorate
no DOI — not checkedIsolation of Haemophilus somnus antigens and their use as vaccines for prevention of bovine thromboembolic meningoencephalitis
no DOI — not checkedExperimental infection of game animals with lumpy skin disease virus (prototype strain Neethling)
no DOI — not checkedref173
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