Reference health
The Role of Vitamin C in Cancer Prevention and Therapy: A Literature Review
69/69 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
6 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 69 checked references that resolve
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Global trends in dietary micronutrient supplies and estimated prevalence of inadequate intakes
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Estimated prevalence and predictors of vitamin C deficiency within UK's low-income population
resolves10.3945/ajcn.2008.27016
Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)
resolves10.1186/s13148-019-0739-5
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes
resolves10.1172/JCI39191
Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice
resolves10.3945/an.110.000109
Vitamin C: A Concentration-Function Approach Yields Pharmacology and Therapeutic Discoveries
resolves10.1146/annurev-nutr-071812-161246
Human Genetic Variation Influences Vitamin C Homeostasis by Altering Vitamin C Transport and Antioxidant Enzyme Function
resolves10.1038/0502-514
Ascorbic-acid transporter Slc23a1 is essential for vitamin C transport into the brain and for perinatal survival
resolves10.1093/carcin/bgp076
Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer
resolves10.3164/jcbn.14-1
Purple grape juice supplementation in smokers and antioxidant status according to different types of GST polymorphisms
resolves10.3390/foods10010198
Vitamin C from Seaweed: A Review Assessing Seaweed as Contributor to Daily Intake
resolves10.1073/pnas.171318198
A new recommended dietary allowance of vitamin C for healthy young women
resolves10.4062/biomolther.2015.044
Vitamin C Stimulates Epidermal Ceramide Production by Regulating Its Metabolic Enzymes
resolves10.3390/ijms17081328
Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies
resolves10.1371/journal.pone.0056803
Effect of Antioxidant Vitamin Supplementation on Cardiovascular Outcomes: A Meta-Analysis of Randomized Controlled Trials
resolves10.3389/fphys.2018.00809
Potential Mechanisms of Action for Vitamin C in Cancer: Reviewing the Evidence
resolves10.1016/j.ejca.2014.02.013
Vitamin C and survival among women with breast cancer: A Meta-analysis
resolves10.1016/j.freeradbiomed.2019.03.015
Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer
resolves10.1038/s41698-017-0044-8
Vitamin C preferentially kills cancer stem cells in hepatocellular carcinoma via SVCT-2
resolves10.1074/jbc.M608300200
Mechanistic Insights and Functional Determinants of the Transport Cycle of the Ascorbic Acid Transporter SVCT2
resolves10.1016/j.tranon.2019.10.017
Enhanced Anticancer Effect of Adding Magnesium to Vitamin C Therapy: Inhibition of Hormetic Response by SVCT-2 Activation
resolves10.1111/jcmm.12188
Vitamin C suppresses cell death in <scp>MCF</scp>‐7 human breast cancer cells induced by tamoxifen
resolves10.1016/j.ccell.2017.02.018
O2⋅− and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate
resolves10.1158/1078-0432.CCR-09-1713
Mechanisms of Ascorbate-Induced Cytotoxicity in Pancreatic Cancer
resolves10.18632/aging.101905
Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)
resolves10.1126/science.aaa5004
Vitamin C selectively kills
<i>KRAS</i>
and
<i>BRAF</i>
mutant colorectal cancer cells by targeting GAPDH
resolves10.1186/1756-8935-6-10
5-hydroxymethylcytosine and its potential roles in development and cancer
resolves10.1200/JCO.2013.49.6968
Dose-Dense Temozolomide for Newly Diagnosed Glioblastoma: A Randomized Phase III Clinical Trial
resolves10.1016/0009-2797(74)90019-2
The orthomolecular treatment of cancer II. Clinical trial of high-dose ascorbic acid supplements in advanced human cancer
resolves10.1073/pnas.73.10.3685
Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.
resolves10.1073/pnas.75.12.6252
Experimental studies designed to evaluate the management of patients with incurable cancer.
resolves10.3945/ajcn.114.085480
Vitamin E and C supplementation and risk of cancer in men: posttrial follow-up in the Physicians’ Health Study II randomized trial , , ,
resolves10.21037/tau.2017.04.42
Weekly ascorbic acid infusion in castration-resistant prostate cancer patients: a single-arm phase II trial
resolves10.1111/bcpt.12323
Elimination of Ascorbic Acid After High‐Dose Infusion in Prostate Cancer Patients: A Pharmacokinetic Evaluation
resolves10.1371/journal.pone.0120228
High-Dose Intravenous Vitamin C Combined with Cytotoxic Chemotherapy in Patients with Advanced Cancer: A Phase I-II Clinical Trial
resolves10.1007/s00280-013-2070-8
Pharmacological ascorbate with gemcitabine for the control of metastatic and node-positive pancreatic cancer (PACMAN): results from a phase I clinical trial
resolves10.1038/s41598-017-17568-8
High Dose Parenteral Ascorbate Inhibited Pancreatic Cancer Growth and Metastasis: Mechanisms and a Phase I/IIa study
resolves10.1371/journal.pone.0029794
Phase I Evaluation of Intravenous Ascorbic Acid in Combination with Gemcitabine and Erlotinib in Patients with Metastatic Pancreatic Cancer
resolves10.1182/blood.V98.3.805
Ascorbic acid enhances arsenic trioxide–induced cytotoxicity in multiple myeloma cells
resolves10.1016/j.freeradbiomed.2014.02.021
Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2
resolves10.1016/j.jcyt.2015.01.004
Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy
resolves10.4082/kjfm.2015.36.6.278
Efficacy of Vitamin C Supplements in Prevention of Cancer: A Meta-Analysis of Randomized Controlled Trials
resolves10.1093/ajcn/nqy097
Dietary intake and blood concentrations of antioxidants and the risk of cardiovascular disease, total cancer, and all-cause mortality: a systematic review and dose-response meta-analysis of prospective studies
resolves10.3390/nu11050977
The Effect of Vitamin C (Ascorbic Acid) in the Treatment of Patients with Cancer: A Systematic Review
resolves10.1093/fampra/cmq115
The effect of supplemental vitamins and minerals on the development of prostate cancer: a systematic review and meta-analysis
resolves10.1080/01635581.2010.494335
Efficacy of Antioxidant Vitamins and Selenium Supplement in Prostate Cancer Prevention: A Meta-Analysis of Randomized Controlled Trials
resolves10.7150/jca.12162
Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects
resolves10.1002/ijc.21441
Intakes of vitamins A, C and E and folate and multivitamins and lung cancer: A pooled analysis of 8 prospective studies
resolves10.1038/srep06161
Association between vitamin C intake and lung cancer: a dose-response meta-analysis
resolves10.1007/s10552-011-9811-y
Retinol, vitamins A, C, and E and breast cancer risk: a meta-analysis and meta-regression
resolves10.1007/s00432-014-1852-7
The plasma level of retinol, vitamins A, C and α-tocopherol could reduce breast cancer risk? A meta-analysis and meta-regression
resolves10.18632/aging.103769
Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies
resolves10.1186/s12916-021-02041-1
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
The 6 references without a DOI — listed, not checked
no DOI — not checkedVitamin C in health and disease: A current perspective
no DOI — not checkedClemetson, C.A.B. (1989). Vitamin C, CRC Press.
no DOI — not checkedSchedule dependence in cancer therapy: Intravenous Vitamin C and the systemic saturation hypothesis
no DOI — not checkedSymmetrical mental neuropathy in breast cancer
no DOI — not checkedFeasibility and correlates of arsenic trioxide combined with ascorbic acid-mediated depletion of intracellular glutathione for the treatment of relapsed/refractory multiple myeloma
no DOI — not checkedHigh 15-F2t-isoprostane levels in patients with a previous history of melanoma skin cancer: The effects of supplementary antioxidant therapy
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