Reference health
Melatonin and Microglia
121/121 checkable references clean · checked 2026-07-23
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
9 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 121 checked references that resolve
resolves10.1111/jpi.12090
Melatonin and the theories of aging: a critical appraisal of melatonin's role in antiaging mechanisms
resolves10.1111/jpi.12547
Melatonin in macrophage biology: Current understanding and future perspectives
resolves10.1186/s13195-015-0139-9
Immune phenotypes of microglia in human neurodegenerative disease: challenges to detecting microglial polarization in human brains
resolves10.1016/j.brainres.2014.12.045
Macrophage activation and its role in repair and pathology after spinal cord injury
resolves10.1074/mcp.M115.053926
Novel Molecular Insights into Classical and Alternative Activation States of Microglia as Revealed by Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC)-based Proteomics*
resolves10.3389/fncel.2020.00198
Overview of General and Discriminating Markers of Differential Microglia Phenotypes
resolves10.1111/j.1745-7254.2007.00625.x
From blood to brain: amoeboid microglial cell, a nascent macrophage and its functions in developing brain
resolves10.1111/j.1471-4159.2006.04029.x
Inhibition of neuronal nitric oxide synthase activity by <i>N</i><sup>1</sup>‐acetyl‐5‐methoxykynuramine, a brain metabolite of melatonin
resolves10.1111/j.1600-079X.2005.00281.x
Melatonin counteracts inducible mitochondrial nitric oxide synthase‐dependent mitochondrial dysfunction in skeletal muscle of septic mice
resolves10.1016/j.biocel.2005.09.008
Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic mice
resolves10.1182/blood-2005-09-3691
Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding
resolves10.1016/j.jneuroim.2005.05.002
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
resolves10.1155/2017/1835195
Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
resolves10.1016/j.neulet.2008.05.036
Melatonin inhibits amphetamine-induced nitric oxide synthase mRNA overexpression in microglial cell lines
resolves10.1007/s11481-016-9702-9
Efficacy of N-Acetylserotonin and Melatonin in the EAE Model of Multiple Sclerosis
resolves10.1007/s11064-016-2122-7
Melatonin Attenuates Manganese and Lipopolysaccharide-Induced Inflammatory Activation of BV2 Microglia
resolves10.1002/jnr.24409
Melatonin improves functional recovery in female rats after acute spinal cord injury by modulating polarization of spinal microglial/macrophages
resolves10.1186/s12974-016-0701-9
1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype
resolves10.1155/2016/6986175
Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization
resolves10.3389/fnagi.2018.00378
A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration
resolves10.1080/15287394.2019.1615019
Melatonin attenuates expression of cyclooxygenase-2 (COX-2) in activated microglia induced by lipopolysaccharide (LPS)
resolves10.3389/fimmu.2019.01511
Melatonin Attenuates LPS-Induced Acute Depressive-Like Behaviors and Microglial NLRP3 Inflammasome Activation Through the SIRT1/Nrf2 Pathway
resolves10.3390/antiox9121299
Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux
resolves10.1007/s10753-020-01270-5
Melatonin Attenuates Thrombin-induced Inflammation in BV2 Cells and Then Protects HT22 Cells from Apoptosis
resolves10.1371/journal.pone.0166010
Melatonin Suppresses Toll Like Receptor 4-Dependent Caspase-3 Signaling Activation Coupled with Reduced Production of Proinflammatory Mediators in Hypoxic Microglia
resolves10.1016/j.intimp.2020.106596
Melatonin alleviates intestinal injury, neuroinflammation and cognitive dysfunction caused by intestinal ischemia/reperfusion
resolves10.1096/fj.202002247RR
Melatonin prevents diabetes‐associated cognitive dysfunction from microglia‐mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway
resolves10.1080/14737175.2021.1907182
The second phase of brain trauma can be controlled by nutraceuticals that suppress DAMP-mediated microglial activation
resolves10.1007/s12031-020-01699-1
Melatonin Ameliorates Lipopolysaccharide-Induced Microglial Inflammation via Triggering SIRT1/HMGB1 Signaling Axis
resolves10.1111/j.1600-079X.2008.00570.x
Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid‐β<sub>1–42</sub>
resolves10.1155/2013/895975
JNK and NADPH Oxidase Involved in Fluoride-Induced Oxidative Stress in BV-2 Microglia Cells
resolves10.1016/j.brainres.2019.146401
Melatonin regulates neuroinflammation ischemic stroke damage through interactions with microglia in reperfusion phase
resolves10.1016/j.neulet.2005.01.003
Melatonin attenuates amyloid beta25–35-induced apoptosis in mouse microglial BV2 cells
resolves10.1111/j.1600-079X.2011.00943.x
Inhibitory effects of melatonin on the lipopolysaccharide‐induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt‐induced NF‐κB and STAT/GAS activity
resolves10.1111/jpi.12667
Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation
resolves10.1007/s12640-019-00156-1
Protective Effects of Melatonin on Methamphetamine-Induced Blood–Brain Barrier Dysfunction in Rat Model
resolves10.3390/biom10030364
SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence
resolves10.3390/biomedicines9050466
SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin
resolves10.5665/sleep.4002
Sleep Deprivation Aggravates Median Nerve Injury-Induced Neuropathic Pain and Enhances Microglial Activation by Suppressing Melatonin Secretion
resolves10.1016/S0009-2797(00)00319-7
Melatonin reduces interleukin secretion in amyloid-β stressed mouse brain slices
resolves10.1111/j.1600-079X.2010.00761.x
Melatonin attenuates methamphetamine‐induced overexpression of pro‐inflammatory cytokines in microglial cell lines
resolves10.1080/00207454.2017.1398156
Postnatal melatonin treatment protects against affective disorders induced by early-life immune stimulation by reducing the microglia cell activation and oxidative stress
resolves10.1177/1759091420981204
Melatonin Reduces GSK3β-Mediated Tau Phosphorylation, Enhances Nrf2 Nuclear Translocation and Anti-Inflammation
resolves10.1016/j.neuint.2020.104827
Melatonin reduces neuropathic pain behavior and glial activation through MT2 melatonin receptor modulation in a rat model of lysophosphatidylcholine-induced demyelination neuropathy
resolves10.1155/2020/1241894
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
resolves10.1016/j.neuroscience.2020.05.014
Melatonin Reverses the Depression-associated Behaviour and Regulates Microglia, Fractalkine Expression and Neurogenesis in Adult Mice Exposed to Chronic Mild Stress
resolves10.1111/jpi.12660
Melatonin attenuates choroidal neovascularization by regulating macrophage/microglia polarization via inhibition of RhoA/ROCK signaling pathway
resolves10.3390/jcm9051328
ROCK (RhoA/Rho Kinase) in Cardiovascular–Renal Pathophysiology: A Review of New Advancements
resolves10.1111/jpi.12473
Melatonin attenuated retinal neovascularization and neuroglial dysfunction by inhibition of <scp>HIF</scp>‐1α‐<scp>VEGF</scp> pathway in oxygen‐induced retinopathy mice
resolves10.1016/S0165-5728(01)00419-2
Assessment of melatonin's ability to regulate cytokine production by macrophage and microglia cell types
resolves10.1203/01.pdr.0000252546.20451.1a
Melatonin Reduces Inflammation and Cell Death in White Matter in the Mid-Gestation Fetal Sheep Following Umbilical Cord Occlusion
resolves10.1002/jnr.22430
Melatonin's protective action against ischemic neuronal damage is associated with up‐regulation of the MT2 melatonin receptor
resolves10.1016/j.neuint.2014.06.015
Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway
resolves10.1016/j.lfs.2016.03.032
Melatonin reverses morphine tolerance by inhibiting microglia activation and HSP27 expression
resolves10.1111/jpi.12584
Melatonin alleviates cognition impairment by antagonizing brain insulin resistance in aged rats fed a high‐fat diet
resolves10.1007/s11064-018-02713-0
Long-term Therapeutic Effects of Extracorporeal Shock Wave-Assisted Melatonin Therapy on Mononeuropathic Pain in Rats
resolves10.1007/s12035-018-1275-6
Disruption of Brain Redox Homeostasis, Microglia Activation and Neuronal Damage Induced by Intracerebroventricular Administration of S-Adenosylmethionine to Developing Rats
resolves10.1007/s12031-020-01531-w
Mechanisms of Inhibition of Excessive Microglial Activation by Melatonin
resolves10.1007/s10787-020-00750-2
Melatonin ameliorates spatial memory and motor deficits via preserving the integrity of cortical and hippocampal dendritic spine morphology in mice with neurotrauma
resolves10.1111/jpi.12029
Melatonin reduces median nerve injury‐induced mechanical hypersensitivity via inhibition of microglial p38 mitogen‐activated protein kinase activation in rat cuneate nucleus
resolves10.1016/j.freeradbiomed.2018.12.014
Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway
resolves10.1111/acel.13375
Microglial MT1 activation inhibits LPS‐induced neuroinflammation via regulation of metabolic reprogramming
resolves10.2174/1871524918666180531083944
Recent Findings in Melatonin Research and Their Relevance to the CNS
resolves10.1177/0004867418796955
Leaky brain in neurological and psychiatric disorders: Drivers and consequences
resolves10.1007/s10787-019-00580-x
Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease
resolves10.1186/s12974-018-1313-3
Inflammation: the link between comorbidities, genetics, and Alzheimer’s disease
resolves10.1016/S1474-4422(18)30490-3
The role of astroglia in Alzheimer's disease: pathophysiology and clinical implications
resolves10.1038/jcbfm.2013.227
Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury
resolves10.1097/ALN.0000000000002130
Neuroinflammation and Central Sensitization in Chronic and Widespread Pain
resolves10.1007/s12035-015-9355-3
Pathophysiological Roles of Cyclooxygenases and Prostaglandins in the Central Nervous System
resolves10.1111/j.1460-9568.2011.07738.x
Astrocytes in the aging brain express characteristics of senescence-associated secretory phenotype
resolves10.1146/annurev-pathol-121808-102144
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
resolves10.3390/molecules26134105
Melatonin, Its Metabolites and Their Interference with Reactive Nitrogen Compounds
resolves10.1152/physrev.00044.2005
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
resolves10.12688/f1000research.2-148.v1
Extracellular histone H1 is neurotoxic and drives a pro-inflammatory response in microglia
resolves10.1093/toxsci/kfz071
HMGB1-RAGE Signaling Plays a Role in Organic Dust-Induced Microglial Activation and Neuroinflammation
resolves10.1186/s12974-020-01973-4
Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages/microglia polarization and affords neuroprotection after spinal cord injury
resolves10.1186/s40035-020-00221-2
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
resolves10.1111/j.1600-079X.2007.00420.x
Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats
resolves10.1034/j.1600-079X.2003.00010.x
Melatonin attenuates kainic acid‐induced hippocampal neurodegeneration and oxidative stress through microglial inhibition
resolves10.1111/j.1365-2990.1984.tb00360.x
KAINIC ACID SEIZURES AND THE REVERSIBILITY OF CALCIUM LOADING IN VULNERABLE NEURONS IN THE HIPPOCAMPUS
resolves10.3389/fnins.2020.00848
Melatonin Enhances the Therapeutic Effect of Plasma Exosomes Against Cerebral Ischemia-Induced Pyroptosis Through the TLR4/NF-κB Pathway
resolves10.7150/ijbs.19642
Exosomes from Melatonin Treated Hepatocellularcarcinoma Cells Alter the Immunosupression Status through STAT3 Pathway in Macrophages
resolves10.1371/journal.pone.0040142
Glia-Pinealocyte Network: The Paracrine Modulation of Melatonin Synthesis by Tumor Necrosis Factor (TNF)
resolves10.1111/bph.14083
Immune‐pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
resolves10.1016/j.jneuroim.2020.577232
The induction of Neuron-Glial2 (NG2) expressing cells in methamphetamine toxicity-induced neuroinflammation in rat brain are averted by melatonin
resolves10.1111/cns.12588
Melatonin Stimulates the <scp>SIRT</scp>1/Nrf2 Signaling Pathway Counteracting Lipopolysaccharide (<scp>LPS</scp>)‐Induced Oxidative Stress to Rescue Postnatal Rat Brain
resolves10.1016/j.intimp.2019.105779
SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury
resolves10.1152/ajprenal.00119.2018
SIRT1-mediated HMGB1 deacetylation suppresses sepsis-associated acute kidney injury
resolves10.3389/fimmu.2018.02751
Neuroinvasive Listeria monocytogenes Infection Triggers IFN-Activation of Microglia and Upregulates Microglial miR-155
resolves10.1371/journal.pone.0212039
miRNA expression profiles and molecular networks in resting and LPS-activated BV-2 microglia—Effect of cannabinoids
resolves10.1080/00207454.2019.1707817
Resveratrol promoted the M2 polarization of microglia and reduced neuroinflammation after cerebral ischemia by inhibiting miR-155
resolves10.3390/cells9010186
Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing
resolves10.1016/j.biomaterials.2018.07.026
Melatonin improves quality and longevity of chronic neural recording
resolves10.1371/journal.pone.0212138
Melatonin decreases M1 polarization via attenuating mitochondrial oxidative damage depending on UCP2 pathway in prorenin-treated microglia
resolves10.1111/cns.13261
Melatonin protects against ischemic stroke by modulating microglia/macrophage polarization toward anti‐inflammatory phenotype through STAT3 pathway
resolves10.3389/fimmu.2019.01236
Individual in vivo Profiles of Microglia Polarization After Stroke, Represented by the Genes iNOS and Ym1
resolves10.1096/fasebj.13.12.1537
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide‐induced multiple organ dysfunction syndrome in rats
resolves10.1677/JOE-07-0260
Melatonin administration prevents cardiac and diaphragmatic mitochondrial oxidative damage in senescence-accelerated mice
resolves10.3390/epigenomes2020009
On the Relationships between LncRNAs and Other Orchestrating Regulators: Role of the Circadian System
The 9 references without a DOI — listed, not checked
no DOI — not checkedCatalà, A. (2017). Melatonin and neuroinflammation: Encouraging findings vs. fundamental problems. Pineal Gland: Research Advances and Clinical Challenges, Nova Science.
no DOI — not checkedExtended signaling by melatonin
no DOI — not checkedSenescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and p53 tumor suppressor
no DOI — not checkedThe role of neuroinflammation in age-related dementias
no DOI — not checkedHardeland, R. (2017). Melatonin and microRNAs: An emerging field. Mini-Reviews in Recent Melatonin Research, Cuvillier.
no DOI — not checkedHardeland, R. (2017). Intercellular communication via exosomal and ectosomal microRNAs: Facing a jungle of countless microRNAs and targets. Mini-Reviews in Recent Melatonin Research, Cuvillier.
no DOI — not checkedExosomal and ectosomal noncoding RNAs in cancer—More than diagnostic and prognostic markers
no DOI — not checkedMaiese, K. (2021). Sirtuins, melatonin, and the relevance of circadian oscillators. Sirtuin Biology in Medicine. Targeting New Avenues of Care in Development, Aging, and Disease, Academic Press.
no DOI — not checkedmiR-155 mediates inflammatory injury of hippocampal neuronal cells via the activation of microglia
What this badge says. CiteStamped means the CHECKABLE references of this
work were clean at the dated check: each resolved to a known work in a public registry, and none
carried a retraction notice at that time. It says nothing about the quality, findings,
or importance of the work itself, and nothing about references deposited without a DOI.
checked 2026-07-23 — re-checked daily as this page is visited; titles and statuses come from Crossref and DataCite and are not part of the signed record
Embed this badge
Both snippets point at the live badge image and link back to this page. The badge re-renders from the daily check, so an embed never goes stale by more than a day of visits.
<a href="https://citestamp.com/citestamped/10.3390/ijms22158296"><img src="https://citestamp.com/citestamped/10.3390/ijms22158296/badge.svg" alt="CiteStamped reference-health badge" width="460" height="64"></a>
[](https://citestamp.com/citestamped/10.3390/ijms22158296)