Reference health
N-Nitrosodimethylamine Contamination in the Metformin Finished Products
22/22 checkable references clean · checked 2026-07-22
Every reference with a DOI in the deposited reference list resolved to a known work in Crossref or DataCite at the dated check, and none carried a retraction, withdrawal, or removal notice.
11 without a DOI — not checked. A reference deposited without a DOI is never matched by title or guessed at; it stays outside the checked set, and this line discloses that.
The 22 checked references that resolve
resolves10.1016/j.yrtph.2019.01.007
Short commentary on NDMA (N-nitrosodimethylamine) contamination of valsartan products
resolves10.1016/j.watres.2013.02.017
NDMA formation from amine-based pharmaceuticals – Impact from prechlorination and water matrix
resolves10.1093/carcin/13.12.2435
<i>In vivo</i> and <i>in vitro</i> genotoxicity of several <i>N</i>-nitrosamines in extrahepatic tissues of the rat
resolves10.7150/ijms.20121
Genotoxicity of a Low-Dose Nitrosamine Mixture as Drinking Water Disinfection Byproducts in NIH3T3 Cells
resolves10.1002/(SICI)1097-0215(19990315)80:6<852::AID-IJC9>3.0.CO;2-S
Risk of colorectal and other gastro-intestinal cancers after exposure to nitrate, nitrite andN-nitroso compounds: a follow-up study
resolves10.1016/j.foodcont.2014.05.030
Occurrence of volatile and non-volatile N-nitrosamines in processed meat products and the role of heat treatment
resolves10.1016/j.jpba.2019.05.022
The contamination of valsartan and other sartans, part 1: New findings
resolves10.1016/j.jpba.2018.11.010
NDMA impurity in valsartan and other pharmaceutical products: Analytical methods for the determination of N-nitrosamines
resolves10.1007/s13340-017-0309-z
Long-term treatment study of global standard dose metformin in Japanese patients with type 2 diabetes mellitus
resolves10.3390/separations7010003
Determination of N-Nitrosamines by Gas Chromatography Coupled to Quadrupole–Time-of-Flight Mass Spectrometry in Water Samples
resolves10.1016/j.jpba.2020.113460
Determination of N-nitrosodimethylamine and N-nitrosomethylethylamine in drug substances and products of sartans, metformin and ranitidine by precipitation and solid phase extraction and gas chromatography–tandem mass spectrometry
resolves10.1016/j.cdc.2019.100231
Method development for the identification and quantitative analysis of seven nitrosamines using gas chromatography mass spectrometry
resolves10.1016/j.talanta.2008.04.060
Analysis of nitrosamines in water by automated SPE and isotope dilution GC/HRMSOccurrence in the different steps of a drinking water treatment plant, and in chlorinated samples from a reservoir and a sewage treatment plant effluent
resolves10.1016/j.talanta.2011.10.042
Pressurised hot water extraction followed by headspace solid-phase microextraction and gas chromatography–tandem mass spectrometry for the determination of N-nitrosamines in sewage sludge
resolves10.1016/j.foodchem.2013.06.070
GC/CI–MS/MS method for the identification and quantification of volatile N-nitrosamines in meat products
resolves10.1016/j.talanta.2012.04.027
A new method for quantifying N-nitrosamines in wastewater samples by gas chromatography—triple quadrupole mass spectrometry
resolves10.1007/s00217-014-2343-4
Rapid determination of nitrosamines in sausage and salami using microwave-assisted extraction and dispersive liquid–liquid microextraction followed by gas chromatography–mass spectrometry
resolves10.1016/j.watres.2010.09.036
Demonstration of 20 pharmaceuticals and personal care products (PPCPs) as nitrosamine precursors during chloramine disinfection
resolves10.1007/s00204-014-1341-4
The influence of chronic l-carnitine supplementation on the formation of preneoplastic and atherosclerotic lesions in the colon and aorta of male F344 rats
The 11 references without a DOI — listed, not checked
no DOI — not checkedUse of N-nitrosodimethylamine (NDMA) contaminated valsartan products and risk of cancer: Danish nationwide cohort study
no DOI — not checkedWorld Health Organization (1993). Guidelines for Drinking-Water Quality, World Health Organization.
no DOI — not checkedUnited States Environmental Protection Agency (2020, September 10). Technical Fact Sheet—N-Nitroso-dimethylamine (NDMA); 2014, Available online: https://www.epa.gov/sites/production/files/2014-03/documents/ffrrofactsheet_contaminant_ndma_january2014_final.pdf.
no DOI — not checkedBuckingham, L. (2020, September 10). Suspension of Ranitidine Medicines in the EU. Available online: https://www.ema.europa.eu/en/news/suspension-ranitidine-medicines-eu.
no DOI — not checkedMunch, J.W., and Bassett, M.V. (2020, June 17). Determination of Nitrosamines in Drinking Water by Solid Phase Extraction and Capillary Column Gas Chromatography with Large Volume Injection and Chemical Ionization Tandem Mass Spectrometry (MS/MS), Available online: https://cfpub.epa.gov/si/si_public_record_report.cfm?Lab=NERL&dirEntryId=103912.
no DOI — not checked(2020, June 17). Common Heart Drug Recalled in 22 Countries for Possible Cancer Link—CNN. Available online: https://edition.cnn.com/2018/07/06/health/valsartan-heart-drug-recall-intl/index.html.
no DOI — not checkedFrancisco, E.M. (2020, June 20). EMA Update on Metformin Diabetes Medicines. Available online: https://www.ema.europa.eu/en/news/ema-update-metformin-diabetes-medicines.
no DOI — not checkedMetformin: Current knowledge
no DOI — not checkedMethod development for the analysis of N-nitrosodimethylamine and other N-nitrosamines in drinking water at low nanogram/liter concentrations using solid-phase extraction and gas chromatography with chemical ionization tandem mass spectrometry
no DOI — not checkedUS Food and Drug Administration (2020, September 10). GC/MS Headspace Method for Detection of NDMA in Valsartan Drug Substance and Drug Products, Available online: https://www.fda.gov/drugs/drug-safety-and-availability.
no DOI — not checked(2020, November 08). Update on Impurities in Metformin Products, Available online: https://www.hsa.gov.sg/announcements/safety-alert/update-on-impurities-in-metformin-products.
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