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Process Scale Purification of Antibodies

https://doi.org/10.1002/9781119126942
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Streamlined process development procedure incorporating the selection of various stationary phase types established in a mAb aggregate reduction study with different mixed mode ligands
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Statistical Designs to Improve Downstream Processing
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Multi-attribute PAT for UF/DF of Proteins—Monitoring Concentration, particle sizes, and Buffer Exchange
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Exploring the limits of conventional small-scale CHO fed-batch for accelerated on demand monoclonal antibody production
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Competitive Sorption of Low and High Molecular Weight Proteins in Model Mixtures by Q Hyper Z Chromatographic Medium. Part I. Equilibrium Uptake
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Alternative Separation Methods: Flocculation and Precipitation
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Continuous Capture of mAbs—Points to Consider and Case Studies
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Next-Generation Process Design for Monoclonal Antibody Purification
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Recent advances in harvest clarification for antibodies and related products
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Use of Industrial Scale Chromatography in Pharmaceutical Discovery/Manufacturing
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Basic principles for the selection of liquid chromatographic modes for specific applications
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Evaluation of process simulation as a decisional tool for biopharmaceutical contract development and manufacturing organizations
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Technical and economic considerations of cell culture harvest and clarification technologies
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Hydrophobic interaction chromatography as polishing step enables obtaining ultra-pure recombinant antibodies
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Immobilizing calcium-dependent affinity ligand onto iron oxide nanoparticles for mild magnetic mAb separation
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Cation exchange frontal chromatography for the removal of monoclonal antibody aggregates
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In-situ gradient formation by direct solid addition of buffer components
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Behavior of weakly adsorbing protein impurities in flow-through ion-exchange chromatography
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Purification of monoclonal antibodies using novel 3D printed ordered stationary phases
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Development of temperature-controlled batch and 3-column counter-current protein A system for improved therapeutic purification
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Autonomous operation and quality monitoring of a continuous antibody downstream process
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QbD-guided pharmaceutical development of Pembrolizumab biosimilar candidate PSG-024 propelled to industry meeting primary requirements of comparability to Keytruda®
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From cell line development to the formulated drug product: The art of manufacturing therapeutic monoclonal antibodies
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Production of monoclonal antibodies for therapeutic purposes: A review
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Economics and ecology: Modelling of continuous primary recovery and capture scenarios for recombinant antibody production
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Novel peptoid-based adsorbents for purifying IgM and IgG from polyclonal and recombinant sources
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Robustness assessment of cation-exchange chromatography with in-silico peak deconvolution in monoclonal antibody purification
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Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies
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Membrane-based purification of Oncolytic Measles virus
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Plant molecular farming for the production of valuable proteins – Critical evaluation of achievements and future challenges
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The adequate amount of sodium chloride in Protein A wash buffer for effective host cell protein clearance
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The Current Scientific and Regulatory Landscape in Advancing Integrated Continuous Biopharmaceutical Manufacturing
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Application of Formulation Principles to Stability Issues Encountered During Processing, Manufacturing, and Storage of Drug Substance and Drug Product Protein Therapeutics
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Preface
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Introduction to Biopharmaceutical Processes
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Countercurrrent Separation Processes
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Countercurrent Chromatography for the Capture Step
inferred← citeshttps://doi.org/10.1017/9781108332897.006openalex-snapshot
Countercurrent Chromatography for the Polishing Steps
inferred← citeshttps://doi.org/10.1017/9781108332897.007openalex-snapshot
Protein Conjugation
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Protein Aggregation in Biopharmaceutical Processes
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Conclusion
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Bibliography
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Index
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Process Intensification for the Purification of Peptidomimetics: The Case of Icatibant through Multicolumn Countercurrent Solvent Gradient Purification (MCSGP)
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A workflow for the development of template-assisted membrane crystallization downstream processing for monoclonal antibody purification
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Opportunities to debottleneck the downstream processing of the oncolytic measles virus
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