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Integrated Combination Treatment Using a “Smart” Chemotherapy and MicroRNA Delivery System Improves Outcomes in an Orthotopic Colorectal Cancer Model

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Advanced Materials for Co‐Delivery of Drugs and Genes in Cancer Therapy
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Glutathione‐Induced Intracellular Release of Guests from Mesoporous Silica Nanocontainers with Cyclodextrin Gatekeepers
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Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs
inferredcites →https://doi.org/10.1002/adma.201505524openalex-snapshot
Large Pore‐Sized Hollow Mesoporous Organosilica for Redox‐Responsive Gene Delivery and Synergistic Cancer Chemotherapy
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Rational Design of Cancer Nanomedicine: Nanoproperty Integration and Synchronization
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Integrated Hollow Mesoporous Silica Nanoparticles for Target Drug/siRNA Co‐Delivery
inferredcites →https://doi.org/10.1002/jbm.a.34450openalex-snapshot
Comparative studies of polyethylenimine–doxorubicin conjugates with pH‐sensitive and pH‐insensitive linkers
inferredcites →https://doi.org/10.1002/smll.201301926openalex-snapshot
A Dual‐Responsive Mesoporous Silica Nanoparticle for Tumor‐Triggered Targeting Drug Delivery
inferredcites →https://doi.org/10.1002/smll.201303842openalex-snapshot
Nanoparticle‐Enabled, Image‐Guided Treatment Planning of Target Specific RNAi Therapeutics in an Orthotopic Prostate Cancer Model
inferredcites →https://doi.org/10.1016/j.addr.2014.05.009openalex-snapshot
In vivo delivery of miRNAs for cancer therapy: Challenges and strategies
inferredcites →https://doi.org/10.1016/j.addr.2015.10.014openalex-snapshot
Co-delivery of drugs and plasmid DNA for cancer therapy
inferredcites →https://doi.org/10.1016/j.bbcan.2010.04.004openalex-snapshot
Vascular endothelial growth factor receptor-2 in breast cancer
inferredcites →https://doi.org/10.1016/j.biocel.2013.02.002openalex-snapshot
Cell-surface GRP78 facilitates colorectal cancer cell migration and invasion
inferredcites →https://doi.org/10.1016/j.biomaterials.2005.03.043openalex-snapshot
Covalent conjugation of polyethyleneimine on biodegradable microparticles for delivery of plasmid DNA vaccines
inferredcites →https://doi.org/10.1016/j.biotechadv.2014.05.006openalex-snapshot
Nano carriers that enable co-delivery of chemotherapy and RNAi agents for treatment of drug-resistant cancers
inferredcites →https://doi.org/10.1016/j.ccr.2004.08.018openalex-snapshot
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
inferredcites →https://doi.org/10.1016/j.ctrv.2015.10.012openalex-snapshot
Maintenance strategy in metastatic colorectal cancer: A systematic review
inferredcites →https://doi.org/10.1016/j.jconrel.2011.01.030openalex-snapshot
Glutathione-responsive nano-vehicles as a promising platform for targeted intracellular drug and gene delivery
inferredcites →https://doi.org/10.1016/j.nantod.2015.01.005openalex-snapshot
Core-crosslinked polymeric micelles: Principles, preparation, biomedical applications and clinical translation
inferredcites →https://doi.org/10.1016/s0378-5173(01)00950-4openalex-snapshot
Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly (lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer
inferredcites →https://doi.org/10.1021/acs.chemrev.7b00258openalex-snapshot
Nanotechnology for Multimodal Synergistic Cancer Therapy
inferredcites →https://doi.org/10.1021/bc100346nopenalex-snapshot
Targeted Delivery of siRNA to Hepatocytes and Hepatic Stellate Cells by Bioconjugation
inferredcites →https://doi.org/10.1021/cm3037197openalex-snapshot
Bioresponsive Controlled Drug Release Based on Mesoporous Silica Nanoparticles Coated with Reductively Sheddable Polymer Shell
inferredcites →https://doi.org/10.1021/cr300358bopenalex-snapshot
Disulfide-Cleavage-Triggered Chemosensors and Their Biological Applications
inferredcites →https://doi.org/10.1021/cr5006793openalex-snapshot
Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)
inferredcites →https://doi.org/10.1021/ja056726iopenalex-snapshot
Glutathione-Mediated Delivery and Release Using Monolayer Protected Nanoparticle Carriers
inferredcites →https://doi.org/10.1021/ja211035wopenalex-snapshot
Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated Monodisperse Mesoporous Silica Nanoparticles
inferredcites →https://doi.org/10.1021/ja905793qopenalex-snapshot
Uniform Mesoporous Dye-Doped Silica Nanoparticles Decorated with Multiple Magnetite Nanocrystals for Simultaneous Enhanced Magnetic Resonance Imaging, Fluorescence Imaging, and Drug Delivery
inferredcites →https://doi.org/10.1021/mp400596vopenalex-snapshot
Inorganic Nanoparticle-Based Drug Codelivery Nanosystems To Overcome the Multidrug Resistance of Cancer Cells
inferredcites →https://doi.org/10.1021/nl801596aopenalex-snapshot
Improved Biocompatibility and Pharmacokinetics of Silica Nanoparticles by Means of a Lipid Coating: A Multimodality Investigation
inferredcites →https://doi.org/10.1021/nn100690mopenalex-snapshot
Engineered Design of Mesoporous Silica Nanoparticles to Deliver Doxorubicin and P-Glycoprotein siRNA to Overcome Drug Resistance in a Cancer Cell Line
inferredcites →https://doi.org/10.1021/nn1015117openalex-snapshot
Core/Shell Structured Hollow Mesoporous Nanocapsules: A Potential Platform for Simultaneous Cell Imaging and Anticancer Drug Delivery
inferredcites →https://doi.org/10.1021/nn200809topenalex-snapshot
Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model
inferredcites →https://doi.org/10.1021/nn2033105openalex-snapshot
Controlled Intracellular Release of Doxorubicin in Multidrug-Resistant Cancer Cells by Tuning the Shell-Pore Sizes of Mesoporous Silica Nanoparticles
inferredcites →https://doi.org/10.1021/nn3044066openalex-snapshot
Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo
inferredcites →https://doi.org/10.1021/nn900918wopenalex-snapshot
Polyethyleneimine Coating Enhances the Cellular Uptake of Mesoporous Silica Nanoparticles and Allows Safe Delivery of siRNA and DNA Constructs
inferredcites →https://doi.org/10.1038/nm.2537openalex-snapshot
Tumor angiogenesis: molecular pathways and therapeutic targets
inferredcites →https://doi.org/10.1038/nmat2442openalex-snapshot
Understanding biophysicochemical interactions at the nano–bio interface
inferredcites →https://doi.org/10.1038/nmat3819openalex-snapshot
A nanoparticle-based strategy for the imaging of a broad range of tumours by nonlinear amplification of microenvironment signals
inferredcites →https://doi.org/10.1039/c7nr00377copenalex-snapshot
Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles
inferredcites →https://doi.org/10.1056/nejmoa1403108openalex-snapshot
Initial Therapy with FOLFOXIRI and Bevacizumab for Metastatic Colorectal Cancer
inferredcites →https://doi.org/10.1074/jbc.m114.618736openalex-snapshot
Characterization and Mechanism of Stress-induced Translocation of 78-Kilodalton Glucose-regulated Protein (GRP78) to the Cell Surface
inferredcites →https://doi.org/10.1093/annonc/mdu260openalex-snapshot
Metastatic colorectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
inferredcites →https://doi.org/10.1093/nar/gkr730openalex-snapshot
MiR-145 directly targets p70S6K1 in cancer cells to inhibit tumor growth and angiogenesis
inferredcites →https://doi.org/10.1097/sla.0000000000001624openalex-snapshot
Colorectal Cancer Liver Metastases and Concurrent Extrahepatic Disease Treated With Resection
inferredcites →https://doi.org/10.1126/science.6093249openalex-snapshot
Adriamycin-Induced DNA Damage Mediated by Mammalian DNA Topoisomerase II
inferredcites →https://doi.org/10.1136/gutjnl-2011-301585openalex-snapshot
Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved preclinical orthotopic and adjuvant therapy colon cancer models
inferredcites →https://doi.org/10.1158/0008-5472.can-15-3196openalex-snapshot
An Integrated Nanotechnology-Enabled Transbronchial Image-Guided Intervention Strategy for Peripheral Lung Cancer
inferredcites →https://doi.org/10.1172/jci65385openalex-snapshot
Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer
inferredcites →https://doi.org/10.1172/jci89212openalex-snapshot
HIF-1α promotes autophagic proteolysis of Dicer and enhances tumor metastasis
inferredcites →https://doi.org/10.1200/jco.2007.11.0833openalex-snapshot
Actual 10-Year Survival After Resection of Colorectal Liver Metastases Defines Cure
inferredcites →https://doi.org/10.2174/1567201813666151231094056openalex-snapshot
Co-Delivery of Epirubicin and siRNA Using Functionalized Mesoporous Silica Nanoparticles Enhances In vitro and In vivo Drug Efficacy
inferredcites →https://doi.org/10.3109/1061186x.2011.622404openalex-snapshot
Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1038/s41565-024-01785-0openalex-extracted
Direct cytosolic delivery of siRNA via cell membrane fusion using cholesterol-enriched exosomes
inferred← citeshttps://doi.org/10.1002/adfm.201803286openalex-snapshot
Unique SiO2 Nanourchins Enable Amplification in Living Cells for In Situ Imaging of mRNAs
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Targeting of CXCR1 on Osteosarcoma Circulating Tumor Cells and Precise Treatment via Cisplatin Nanodelivery
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Biomimetic Nanomedicine Coupled with Neoadjuvant Chemotherapy to Suppress Breast Cancer Metastasis via Tumor Microenvironment Remodeling
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Emerging 2D Nanomaterials‐Integrated Hydrogels: Advancements in Designing Theragenerative Materials for Bone Regeneration and Disease Therapy
inferred← citeshttps://doi.org/10.1002/smll.201902242openalex-snapshot
New Advances in In Vivo Applications of Gated Mesoporous Silica as Drug Delivery Nanocarriers
inferred← citeshttps://doi.org/10.1002/smll.201903473openalex-snapshot
Surface Plasmon Resonance–Enhanced Photoacoustic Imaging and Photothermal Therapy of Endogenous H2S‐Triggered Au@Cu2O
inferred← citeshttps://doi.org/10.1002/smll.202006223openalex-snapshot
Calixarene‐Embedded Nanoparticles for Interference‐Free Gene–Drug Combination Cancer Therapy
inferred← citeshttps://doi.org/10.1002/smll.202100789openalex-snapshot
Metal Phenolic Network‐Integrated Multistage Nanosystem for Enhanced Drug Delivery to Solid Tumors
inferred← citeshttps://doi.org/10.1002/smtd.202300812openalex-snapshot
Engineered Silica Nanoparticles for Nucleic Acid Delivery
inferred← citeshttps://doi.org/10.1007/s40820-021-00666-8openalex-snapshot
Targeted Micellar Phthalocyanine for Lymph Node Metastasis Homing and Photothermal Therapy in an Orthotopic Colorectal Tumor Model
inferred← citeshttps://doi.org/10.1016/j.actbio.2020.09.009openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.actbio.2024.07.012openalex-snapshot
An acid-activatable fluorouracil prodrug for colorectal cancer synergistic therapy
inferred← citeshttps://doi.org/10.1016/j.addr.2023.114977openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.119923openalex-snapshot
Ru@CeO2 yolk shell nanozymes: Oxygen supply in situ enhanced dual chemotherapy combined with photothermal therapy for orthotopic/subcutaneous colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.120031openalex-snapshot
Genetically multimodal therapy mediated by one polysaccharides-based supramolecular nanosystem
inferred← citeshttps://doi.org/10.1016/j.bone.2020.115789openalex-snapshot
MicroRNA function in craniofacial bone formation, regeneration and repair
inferred← citeshttps://doi.org/10.1016/j.cej.2019.01.074openalex-snapshot
A redox prodrug micelle co-delivering camptothecin and curcumin for synergetic B16 melanoma cells inhibition
inferred← citeshttps://doi.org/10.1016/j.engreg.2021.09.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.eurpolymj.2022.111331openalex-snapshot
Construction of a dual-drug delivery system based on oxidized alginate and carboxymethyl chitosan for chemo-photothermal synergistic therapy of osteosarcoma
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.127060openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ijpharm.2019.04.067openalex-snapshot
New insights towards mesoporous silica nanoparticles as a technological platform for chemotherapeutic drugs delivery
inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.10.055openalex-snapshot
Cell surface GRP78: An emerging imaging marker and therapeutic target for cancer
inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.102223openalex-snapshot
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Enhanced Drug Delivery by Nanoscale Integration of a Nitric Oxide Donor To Induce Tumor Collagen Depletion
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inferred← citeshttps://doi.org/10.1038/s41467-022-29309-1openalex-snapshot
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