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Sustained Release of TPCA‐1 from Silk Fibroin Hydrogels Preserves Keratocyte Phenotype and Promotes Corneal Regeneration by Inhibiting Interleukin‐1β Signaling

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaophthalmol.2015.4776openalex-snapshot
Global Survey of Corneal Transplantation and Eye Banking
inferredcites →https://doi.org/10.1002/adfm.201400526openalex-snapshot
Highly Tunable Elastomeric Silk Biomaterials
inferredcites →https://doi.org/10.1002/adhm.201601238openalex-snapshot
Surface Topography and Mechanical Strain Promote Keratocyte Phenotype and Extracellular Matrix Formation in a Biomimetic 3D Corneal Model
inferredcites →https://doi.org/10.1002/adma.201503986openalex-snapshot
Progress in Corneal Stromal Repair: From Tissue Grafts and Biomaterials to Modular Supramolecular Tissue‐Like Assemblies
inferredcites →https://doi.org/10.1016/j.actbio.2017.08.001openalex-snapshot
Thermosensitive chitosan-based hydrogels releasing stromal cell derived factor-1 alpha recruit MSC for corneal epithelium regeneration
inferredcites →https://doi.org/10.1016/j.actbio.2017.12.006openalex-snapshot
NF-κB signaling is key in the wound healing processes of silk fibroin
inferredcites →https://doi.org/10.1016/j.addr.2012.09.043openalex-snapshot
Silk fibroin biomaterials for tissue regenerations
inferredcites →https://doi.org/10.1016/j.biomaterials.2007.11.003openalex-snapshot
Sonication-induced gelation of silk fibroin for cell encapsulation
inferredcites →https://doi.org/10.1016/j.cell.2008.01.020openalex-snapshot
Shared Principles in NF-κB Signaling
inferredcites →https://doi.org/10.1016/j.cytogfr.2011.10.001openalex-snapshot
Understanding the mechanism of IL-1β secretion
inferredcites →https://doi.org/10.1016/j.ejpb.2014.12.029openalex-snapshot
Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics
inferredcites →https://doi.org/10.1016/j.exer.2014.09.012openalex-snapshot
The corneal fibrosis response to epithelial–stromal injury
inferredcites →https://doi.org/10.1016/j.preteyeres.2015.07.002openalex-snapshot
Progress in corneal wound healing
inferredcites →https://doi.org/10.1016/s0002-9440(10)62357-7openalex-snapshot
Therapeutic Effect of Topical Administration of SN50, an Inhibitor of Nuclear Factor-κB, in Treatment of Corneal Alkali Burns in Mice
inferredcites →https://doi.org/10.1016/s0014-4835(02)00293-2openalex-snapshot
Local suppression of IL-1 by receptor antagonist in the rat model of corneal alkali injury
inferredcites →https://doi.org/10.1016/s1350-9462(01)00008-8openalex-snapshot
The Corneal Wound Healing Response:
inferredcites →https://doi.org/10.1021/jp056350vopenalex-snapshot
Mechanisms of Silk Fibroin Sol−Gel Transitions
inferredcites →https://doi.org/10.1038/nprot.2011.379openalex-snapshot
Materials fabrication from Bombyx mori silk fibroin
inferredcites →https://doi.org/10.1038/onc.2015.472openalex-snapshot
Overexpression of GAB2 in ovarian cancer cells promotes tumor growth and angiogenesis by upregulating chemokine expression
inferredcites →https://doi.org/10.1038/s41420-018-0066-1openalex-snapshot
BRD4 inhibitor JQ1 inhibits and reverses mechanical injury-induced corneal scarring
inferredcites →https://doi.org/10.1038/s41536-018-0061-4openalex-snapshot
Sustained release of decorin to the surface of the eye enables scarless corneal regeneration
inferredcites →https://doi.org/10.1039/c7ra02682jopenalex-snapshot
A silk fibroin hydrogel with reversible sol–gel transition
inferredcites →https://doi.org/10.1074/jbc.m303292200openalex-snapshot
Keratocyte Phenotype Mediates Proteoglycan Structure
inferredcites →https://doi.org/10.1158/1535-7163.mct-13-0464openalex-snapshot
TPCA-1 Is a Direct Dual Inhibitor of STAT3 and NF-κB and Regresses Mutant EGFR-Associated Human Non–Small Cell Lung Cancers
inferredcites →https://doi.org/10.1167/iovs.08-1897openalex-snapshot
Inhibition by a Selective IκB Kinase-2 Inhibitor of Interleukin-1–Induced Collagen Degradation by Corneal Fibroblasts in Three-Dimensional Culture
inferredcites →https://doi.org/10.1167/iovs.11-9305openalex-snapshot
Quantitative Assessment of Ultrastructure and Light Scatter in Mouse Corneal Debridement Wounds
inferredcites →https://doi.org/10.1172/jci23298openalex-snapshot
Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1β–induced neovascularization and tumor growth
inferredcites →https://doi.org/10.1371/journal.pone.0134157openalex-snapshot
Expression Profiles of Neuropeptides, Neurotransmitters, and Their Receptors in Human Keratocytes In Vitro and In Situ
inferredcites →https://doi.org/10.2353/ajpath.2007.070172openalex-snapshot
Dexamethasone Inhibits Interleukin-1β-Induced Corneal Neovascularization
inferredcites →https://doi.org/10.3390/pharmaceutics11030143openalex-snapshot
Hyaluronic Acid-Modified and TPCA-1-Loaded Gold Nanocages Alleviate Inflammation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4631980openalex-extracted
inferred← citeshttps://doi.org/10.1002/adhm.202102770openalex-snapshot
Self‐Delivering Nanodrugs Developed via Small‐Molecule‐Directed Assembly and Macrophage Cloaking for Sonodynamic‐Augmented Immunotherapy
inferred← citeshttps://doi.org/10.1002/adhm.202200602openalex-snapshot
Nanosilicate‐Reinforced Silk Fibroin Hydrogel for Endogenous Regeneration of Both Cartilage and Subchondral Bone
inferred← citeshttps://doi.org/10.1002/adma.202210517openalex-snapshot
Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis
inferred← citeshttps://doi.org/10.1002/adma.202310532openalex-snapshot
Bio‐Responsive Sliver Peroxide‐Nanocarrier Serves as Broad‐Spectrum Metallo‐β‐lactamase Inhibitor for Combating Severe Pneumonia
inferred← citeshttps://doi.org/10.1002/adtp.202500483openalex-snapshot
Silk Fibroin in Medicine: A Review on ISO10993 Biocompatibility, Preclinical Evidence, and Clinical Perspectives
inferred← citeshttps://doi.org/10.1002/biot.202300040openalex-snapshot
Reconstruction of tracheal window‐shape defect by 3D printed polycaprolatone scaffold coated with Silk Fibroin Methacryloyl
inferred← citeshttps://doi.org/10.1002/smll.202409739openalex-snapshot
Cellular Interactions and Biological Effects of Silk Fibroin: Implications for Tissue Engineering and Regenerative Medicine
inferred← citeshttps://doi.org/10.1002/smll.202514957openalex-snapshot
Transparent SilMA Hydrogel: Priming Microstructure Regulation for Real‐Time Cell and Organoid Visualization
inferred← citeshttps://doi.org/10.1007/s00339-025-08655-zopenalex-snapshot
Mechanics and design of metastructured auxetic patches with bio-inspired materials
inferred← citeshttps://doi.org/10.1016/j.addr.2024.115317openalex-snapshot
Corneal fibrosis: From in vitro models to current and upcoming drug and gene medicines
inferred← citeshttps://doi.org/10.1016/j.apmt.2021.101119openalex-snapshot
Wound dressing gel with resisted bacterial penetration and enhanced re-epithelization for corneal epithelial-stromal regeneration
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2024.10.016openalex-snapshot
Controlled TPCA-1 delivery engineers a pro-tenogenic niche to initiate tendon regeneration by targeting IKKβ/NF-κB signaling
inferred← citeshttps://doi.org/10.1016/j.biocel.2026.106994openalex-snapshot
CXCR4 targeting by TPCA‑1 attenuates neuroinflammation in intracerebral hemorrhage through inhibiting NF‑κB and AP‑1 activation
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111622openalex-snapshot
Dual roles and therapeutic potential of ALDH3 family members in cancer
inferred← citeshttps://doi.org/10.1016/j.cis.2025.103413openalex-snapshot
Silk-based biomaterials for tissue engineering
inferred← citeshttps://doi.org/10.1016/j.colsurfa.2025.137123openalex-snapshot
Silk fibroin-enhanced peptide self-assembled biomimetic hydrogel for 3D cell proliferation
inferred← citeshttps://doi.org/10.1016/j.engmed.2026.100162openalex-snapshot
Silk biomaterials for precision medicine: From silk science to medical engineering
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2022.11.021openalex-snapshot
Silk fibroin based interpenetrating network hydrogel for corneal stromal regeneration
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.141039openalex-snapshot
Silk biomaterials for corneal tissue engineering: From research approaches to therapeutic potentials; A review
inferred← citeshttps://doi.org/10.1016/j.msec.2021.112215openalex-snapshot
Enzymatically crosslinked silk-nanosilicate reinforced hydrogel with dual-lineage bioactivity for osteochondral tissue engineering
inferred← citeshttps://doi.org/10.1016/j.neuroscience.2024.01.021openalex-snapshot
Faecal Microbiota Transplantation Alleviates Ferroptosis after Ischaemic Stroke
inferred← citeshttps://doi.org/10.1016/j.pmatsci.2026.101841openalex-snapshot
Silk fibroin as a biomaterial for drug delivery: From gland to clinic
inferred← citeshttps://doi.org/10.1021/acsnano.2c06357openalex-snapshot
Hybrid Biomimetic Nanovesicles to Drive High Lung Biodistribution and Prevent Cytokine Storm for ARDS Treatment
inferred← citeshttps://doi.org/10.1038/s41467-024-54963-yopenalex-snapshot
Dual rectification of metabolism abnormality in pancreatic cancer by a programmed nanomedicine
inferred← citeshttps://doi.org/10.1039/d0nr07176eopenalex-snapshot
Efficient in vivo wound healing using noble metal nanoclusters
inferred← citeshttps://doi.org/10.1039/d1tb02502copenalex-snapshot
Photocurable silk fibroin-based tissue sealants with enhanced adhesive properties for the treatment of corneal perforations
inferred← citeshttps://doi.org/10.1063/5.0060344openalex-snapshot
Silk materials at the convergence of science, sustainability, healthcare, and technology
inferred← citeshttps://doi.org/10.1080/09205063.2021.1958185openalex-snapshot
Natural Polymeric Scaffolds for Tissue Engineering Applications
inferred← citeshttps://doi.org/10.1080/17518253.2021.1998648openalex-snapshot
Gold nanoparticles: synthesis, application in colon cancer therapy and new approaches - review
inferred← citeshttps://doi.org/10.1088/1748-605x/accda9openalex-snapshot
Stiffness-dependent dynamic effect of inflammation on keratocyte phenotype and differentiation
inferred← citeshttps://doi.org/10.1101/2022.09.29.510013openalex-snapshot
Multiomics reveal that silk fibroin and sericin differentially potentiate the paracrine functions of mesenchymal stem cells and enhance tissue regeneration
inferred← citeshttps://doi.org/10.1172/jci161929openalex-snapshot
Aurora A kinase inhibition compromises its antitumor efficacy by elevating PD-L1 expression
inferred← citeshttps://doi.org/10.1186/s13046-024-03050-7openalex-snapshot
Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling
inferred← citeshttps://doi.org/10.18240/ijo.2024.03.05openalex-snapshot
Semaphorin 7A impairs barrier function in cultured human corneal epithelial cells in a manner dependent on nuclear factor-kappa B
inferred← citeshttps://doi.org/10.3389/fbioe.2023.1252499openalex-snapshot
A brief review on the mechanisms and approaches of silk spinning-inspired biofabrication
inferred← citeshttps://doi.org/10.3389/fmats.2024.1390372openalex-snapshot
High-strength and high-elasticity silk fibroin-composite gelatin biomaterial hydrogels for rabbit knee cartilage regeneration
inferred← citeshttps://doi.org/10.3390/biomimetics8080612openalex-snapshot
Advanced Applications of Silk-Based Hydrogels for Tissue Engineering: A Short Review
inferred← citeshttps://doi.org/10.3390/cells11203310openalex-snapshot
Recent Advancements in Molecular Therapeutics for Corneal Scar Treatment
inferred← citeshttps://doi.org/10.3390/ijms231911073openalex-snapshot
Keratocyte Differentiation Is Regulated by NF-κB and TGFβ Signaling Crosstalk
inferred← citeshttps://doi.org/10.3390/molecules27113418openalex-snapshot
Preparation and Characterization of Natural Silk Fibroin Hydrogel for Protein Drug Delivery
inferred← citeshttps://doi.org/10.3390/polym16121717openalex-snapshot
Biopolymeric Innovations in Ophthalmic Surgery: Enhancing Devices and Drug Delivery Systems
inferred← citeshttps://doi.org/10.5772/intechopen.106966openalex-snapshot
Advances in Biomaterials for Corneal Regeneration
inferred← citeshttps://doi.org/10.6084/m9.figshare.25678549openalex-snapshot
Additional file 1 of Chemotherapy-elicited extracellular vesicle CXCL1 from dying cells promotes triple-negative breast cancer metastasis by activating TAM/PD-L1 signaling
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