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Repurposing Cyanine NIR‐I Dyes Accelerates Clinical Translation of Near‐Infrared‐II (NIR‐II) Bioimaging

https://doi.org/10.1002/adma.201802546

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What this work says

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Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

inferred← citeshttps://doi.org/10.1002/smll.202107732openalex-snapshot

GSH‐Responsive Metal–Organic Framework for Intratumoral Release of NO and IDO Inhibitor to Enhance Antitumor Immunotherapy

inferred← citeshttps://doi.org/10.1002/smll.202204153openalex-snapshot

A Precipitation‐Enhanced Emission (PEE) Strategy for Increasing the Brightness and Reducing the Liver Retention of NIR‐II Fluorophores

inferred← citeshttps://doi.org/10.1002/smll.202205976openalex-snapshot

Highly Sensitive Broadband Phototransistors Based on Gradient Tin/Lead Mixed Perovskites

inferred← citeshttps://doi.org/10.1002/smll.202206044openalex-snapshot

Second Near‐Infrared (NIR‐II) Window for Imaging‐Navigated Modulation of Brain Structure and Function

inferred← citeshttps://doi.org/10.1002/smll.202206053openalex-snapshot

An Activatable Phototheranostic Nanoplatform for Tumor Specific NIR‐II Fluorescence Imaging and Synergistic NIR‐II Photothermal‐Chemodynamic Therapy

inferred← citeshttps://doi.org/10.1002/smll.202206544openalex-snapshot

Low‐Dose NIR‐II Preclinical Bioimaging Using Liposome‐Encapsulated Cyanine Dyes

inferred← citeshttps://doi.org/10.1002/smm2.1245openalex-snapshot

NIR‐II cyanine@albumin fluorophore for deep tissue imaging and imaging‐guided surgery

inferred← citeshttps://doi.org/10.1002/smsc.202500033openalex-snapshot

Near‐Infrared Emission Perovskites for Multifunctional Bioimaging

inferred← citeshttps://doi.org/10.1002/smtd.202001066openalex-snapshot

Surgical Navigation for Malignancies Guided by Near‐Infrared‐II Fluorescence Imaging

inferred← citeshttps://doi.org/10.1002/viw.20200068openalex-snapshot

Exploiting molecular probes to perform near‐infrared fluorescence‐guided surgery

inferred← citeshttps://doi.org/10.1002/wnan.1734openalex-snapshot

Unlocking the power of optical imaging in the second biological window: Structuring near‐infrared II materials from organic molecules to nanoparticles

inferred← citeshttps://doi.org/10.1007/978-3-030-32036-2_13openalex-snapshot

NIR Fluorescent Nanoprobes and Techniques for Brain Imaging

inferred← citeshttps://doi.org/10.1007/978-981-15-9627-8_3openalex-snapshot

Organic Dyes for NIR Imaging

inferred← citeshttps://doi.org/10.1007/978-981-16-1260-2_4openalex-snapshot

Magnetic and Fluorescent Nanogels for Nanomedicine

inferred← citeshttps://doi.org/10.1007/978-981-96-6875-5_2openalex-snapshot

Advantages and Limitations vs. Other Medical Imaging Techniques

inferred← citeshttps://doi.org/10.1007/s00259-022-05688-xopenalex-snapshot

Molecular fluorophores for in vivo bioimaging in the second near-infrared window

inferred← citeshttps://doi.org/10.1007/s00259-022-05730-yopenalex-snapshot

Intraoperative fluorescence molecular imaging accelerates the coming of precision surgery in China

inferred← citeshttps://doi.org/10.1007/s00259-024-06690-1openalex-snapshot

Near-infrared II theranostic agents for the diagnosis and treatment of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1007/s11307-020-01545-1openalex-snapshot

Recent Advances of Organic Near-Infrared II Fluorophores in Optical Properties and Imaging Functions

inferred← citeshttps://doi.org/10.1007/s11307-021-01642-9openalex-snapshot

Identification of a Suitable Untargeted Agent for the Clinical Translation of ABY-029 Paired-Agent Imaging in Fluorescence-Guided Surgery

inferred← citeshttps://doi.org/10.1007/s11307-023-01840-7openalex-snapshot

2nd Window NIR Imaging of Radiation Injury Mitigation Provided by Reduced Notch-Dll4 Expression on Vasculature

inferred← citeshttps://doi.org/10.1007/s11426-020-9780-8openalex-snapshot

NIR-II probe modified by poly(L-lysine) with efficient ovalbumin delivery for dendritic cell tracking

inferred← citeshttps://doi.org/10.1007/s11426-024-2308-3openalex-snapshot

Carbon dots self-assembly enables near-infrared emission

inferred← citeshttps://doi.org/10.1007/s11426-025-2573-1openalex-snapshot

A cyanine fluorophore for imaging-guided tumor photodynamic and photothermal therapy under NIR-II light activation

inferred← citeshttps://doi.org/10.1007/s11468-024-02749-9openalex-snapshot

Designing Ultrasensitive NIR-II SERS Nanoprobes: Achieved via Plasmonic Engineering

inferred← citeshttps://doi.org/10.1007/s12274-022-4836-yopenalex-snapshot

Near-infrared-II deep tissue fluorescence microscopy and application

inferred← citeshttps://doi.org/10.1007/s12274-022-5033-8openalex-snapshot

In vivo bioorthogonal labeling of rare-earth doped nanoparticles for improved NIR-II tumor imaging by extracellular vesicle-mediated targeting

inferred← citeshttps://doi.org/10.1007/s40843-025-4031-6openalex-snapshot

Donor-acceptor engineered aza-BODIPY fluorophore with intramolecular charge transfer-enhanced NIR-II emission for tumor phototheranostics

inferred← citeshttps://doi.org/10.1016/b978-0-12-814657-6.00011-2openalex-snapshot

Polymer nanomaterials in bioimaging

inferred← citeshttps://doi.org/10.1016/b978-0-323-95171-5.00009-1openalex-snapshot

Nanostructures used in cancer imaging

inferred← citeshttps://doi.org/10.1016/j.aca.2021.338362openalex-snapshot

Individual and successive detection of H2S and HClO in living cells and zebrafish by a dual-channel fluorescent probe with longer emission wavelength

inferred← citeshttps://doi.org/10.1016/j.actbio.2023.04.024openalex-snapshot

Donor-acceptor-donor small molecules for fluorescence/photoacoustic imaging and integrated photothermal therapy

inferred← citeshttps://doi.org/10.1016/j.addr.2022.114637openalex-snapshot

Design strategies and applications of smart optical probes in the second near-infrared window

inferred← citeshttps://doi.org/10.1016/j.apsb.2025.06.023openalex-snapshot

Rapid discovery of drug-introduced multiple organ dysfunction via NIR-II fluorescent imaging

inferred← citeshttps://doi.org/10.1016/j.bioadv.2025.214298openalex-snapshot

A multi-modal embolic gel system for long-term fluorescence imaging and photothermal therapy

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2019.119364openalex-snapshot

Boosting often overlooked long wavelength emissions of rare-earth nanoparticles for NIR-II fluorescence imaging of orthotopic glioblastoma

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2020.120219openalex-snapshot

Novel ultrasmall multifunctional nanodots for dual-modal MR/NIR-II imaging-guided photothermal therapy

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2021.120916openalex-snapshot

Starlike polymer brush-based ultrasmall nanoparticles with simultaneously improved NIR-II fluorescence and blood circulation for efficient orthotopic glioblastoma imaging

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2022.121637openalex-snapshot

An antigen-strengthened dye-modified fully-human-nanobody-based immunoprobe for second near infrared bioimaging of metastatic tumors

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2026.124594openalex-snapshot

An intelligent phototheranostic nanoplatform for controllable FRET-activated NIR-II imaging-guided phototherapy

inferred← citeshttps://doi.org/10.1016/j.bios.2020.112026openalex-snapshot

Ionic fluorescent sensor targeting receptor tyrosine kinases for biosystems imaging and application in flow cytometry

inferred← citeshttps://doi.org/10.1016/j.bios.2022.114371openalex-snapshot

Liver injury long-term monitoring and fluorescent image-guided tumor surgery using self-assembly amphiphilic donor-acceptor NIR-II dyes

inferred← citeshttps://doi.org/10.1016/j.bmcl.2022.128910openalex-snapshot

Water-soluble near-infrared fluorescent heptamethine dye for lymphatic mapping applications

inferred← citeshttps://doi.org/10.1016/j.cclet.2019.03.012openalex-snapshot

A general approach to the design of high-performance near-infrared (NIR) D-π-A type fluorescent dyes

inferred← citeshttps://doi.org/10.1016/j.cclet.2019.05.022openalex-snapshot

Recent advances on small-molecule fluorophores with emission beyond 1000 nm for better molecular imaging in vivo

inferred← citeshttps://doi.org/10.1016/j.ccr.2020.213318openalex-snapshot

Recent advances in the development of NIR-II organic emitters for biomedicine

inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214149openalex-snapshot

Breaking the time and space limitation of point-of-care testing strategies: Photothermometric sensors based on different photothermal agents and materials

inferred← citeshttps://doi.org/10.1016/j.ccr.2022.214438openalex-snapshot

Biomarker-activatable probes based on smart AIEgens for fluorescence and optoacoustic imaging

inferred← citeshttps://doi.org/10.1016/j.ccr.2024.215907openalex-snapshot

Recent advances in NIR-II fluorescence/photoacoustic dual-modality imaging probes

inferred← citeshttps://doi.org/10.1016/j.ccr.2025.216551openalex-snapshot

Advances in organic nano-architectures based on NIR-II small-molecule fluorophores for biomedical imaging and therapy

inferred← citeshttps://doi.org/10.1016/j.ccr.2026.217788openalex-snapshot

Visualized diagnosis in the second near-infrared window

inferred← citeshttps://doi.org/10.1016/j.ccr.2026.217892openalex-snapshot

Advances in near-infrared fluorescence imaging for biomedicine

inferred← citeshttps://doi.org/10.1016/j.ccr.2026.218577openalex-snapshot

Enhancing the efficacy of photothermal therapy with cyanine dyes: From molecule design and delivery to combination therapy

inferred← citeshttps://doi.org/10.1016/j.cej.2021.128805openalex-snapshot

Rapid bacteria capturing and killing by AgNPs/N-CD@ZnO hybrids strengthened photo-responsive xerogel for rapid healing of bacteria-infected wounds

inferred← citeshttps://doi.org/10.1016/j.cej.2022.139504openalex-snapshot

Robust emission in near-infrared II of lanthanide nanoprobes conjugated with Au (LNPs-Au) for temperature sensing and controlled photothermal therapy

inferred← citeshttps://doi.org/10.1016/j.cej.2023.146433openalex-snapshot

Downshifting luminescence amplification by multi-phase energy harvesting

inferred← citeshttps://doi.org/10.1016/j.chempr.2025.102481openalex-snapshot

Cartilage-Targeting Fluorophores for Early Detection of Arthritis in the NIR-II Window

inferred← citeshttps://doi.org/10.1016/j.colsurfa.2022.129813openalex-snapshot

Turn-on fluorescence of davydov-split aggregate particles for protein detection

inferred← citeshttps://doi.org/10.1016/j.colsurfb.2020.111537openalex-snapshot

Albumin-based fluorescence resonance energy transfer nanoprobes for multileveled tumor tissue imaging and dye release imaging

inferred← citeshttps://doi.org/10.1016/j.colsurfb.2024.113796openalex-snapshot

Purification-free synthesis of bright lactoglobulin@dye nanoprobe for second near-infrared fluorescence imaging of kidney dysfunction in vivo

inferred← citeshttps://doi.org/10.1016/j.compmedimag.2023.102216openalex-snapshot

PSSGAN: Towards spectrum shift based perceptual quality enhancement for fluorescence imaging

inferred← citeshttps://doi.org/10.1016/j.dyepig.2019.107746openalex-snapshot

Benzobisthiadiazoles: From structure to function

inferred← citeshttps://doi.org/10.1016/j.dyepig.2020.108756openalex-snapshot

A short review on NIR-II organic small molecule dyes

inferred← citeshttps://doi.org/10.1016/j.dyepig.2021.109792openalex-snapshot

Design strategies to rhodamine analogue fluorophores for near-infrared II biological imaging applications

inferred← citeshttps://doi.org/10.1016/j.dyepig.2022.110124openalex-snapshot

Fabrication of semiconducting polymer-blend dots with strong near-infrared fluorescence and afterglow luminescence for bioimaging

inferred← citeshttps://doi.org/10.1016/j.dyepig.2024.111965openalex-snapshot

An all-electron acceptor-based semiconducting polymer nanoprobe for in vivo high brightness NIR-II fluorescence imaging

inferred← citeshttps://doi.org/10.1016/j.ebiom.2023.104476openalex-snapshot

NIR-II fluorescence imaging-guided colorectal cancer surgery targeting CEACAM5 by a nanobody

inferred← citeshttps://doi.org/10.1016/j.eng.2021.07.032openalex-snapshot

Structural and Functional NIR-II Fluorescence Bioimaging in Urinary System via Clinically Approved Dye Methylene Blue

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e24390openalex-snapshot

Fluorescence visualization for cancer DETECTION: EXPERIENCE and perspectives

inferred← citeshttps://doi.org/10.1016/j.hlife.2024.06.007openalex-snapshot

Recent advances in surgical management strategies for hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1016/j.inoche.2019.06.013openalex-snapshot

Facile one-pot synthesis of monodispersed NIR-II emissive silver sulfide quantum dots

inferred← citeshttps://doi.org/10.1016/j.jconrel.2023.08.056openalex-snapshot

Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II

inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.101693openalex-snapshot

Constructing J-aggregates of cyanine dye for NIR-II in vivo dynamic vascular imaging and long-term targeting of tumors

inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.102497openalex-snapshot

Triple-synergistic biomimetic nanoplatform orchestrates photothermal immunotherapy through coordinated ICD and STING activation

inferred← citeshttps://doi.org/10.1016/j.mtchem.2025.102766openalex-snapshot

Unexpected acridine-fused aza-BODIPY photosensitizer originated from pyrrole with a –CH2–CH2− chain

inferred← citeshttps://doi.org/10.1016/j.nanoen.2024.109539openalex-snapshot

Printed quantum dot photodetectors for applications from the high-energy to the infrared region

inferred← citeshttps://doi.org/10.1016/j.nantod.2021.101239openalex-snapshot

Activatable luminescent probes for imaging brain diseases

inferred← citeshttps://doi.org/10.1016/j.nantod.2024.102239openalex-snapshot

Protein biomarker detection via differential dynamic microscopy

inferred← citeshttps://doi.org/10.1016/j.pacs.2022.100426openalex-snapshot

Design and application of organic contrast agents for molecular imaging in the second near infrared (NIR-II) window

inferred← citeshttps://doi.org/10.1016/j.saa.2023.122712openalex-snapshot

New cationic spiropyrans with photoswitchable NIR fluorescence

inferred← citeshttps://doi.org/10.1016/j.saa.2025.126490openalex-snapshot

Investigating the efficacy of a photoacoustic probe in liver function assessment for diabetic mellitus

inferred← citeshttps://doi.org/10.1016/j.scib.2022.08.030openalex-snapshot

Supramolecular engineering of cell membrane vesicles for cancer immunotherapy

inferred← citeshttps://doi.org/10.1016/j.scib.2023.08.041openalex-snapshot

Engineering of cyanine-based nanoplatform with tunable response toward reactive species for ratiometric NIR-II fluorescent imaging in mice

inferred← citeshttps://doi.org/10.1016/j.snb.2024.135910openalex-snapshot

Chemogenic albumin-seeking NIR dyes for in vivo site-specific albumin tagging

inferred← citeshttps://doi.org/10.1016/j.snb.2026.139614openalex-snapshot

A highly sensitive and temperature-compensated near-infrared plasmonic biosensing platform for label-free isothermal nucleic-acid amplification

inferred← citeshttps://doi.org/10.1016/j.trechm.2019.03.002openalex-snapshot

Recent Progress in Small-Molecule Near-IR Probes for Bioimaging

inferred← citeshttps://doi.org/10.1016/j.xinn.2021.100082openalex-snapshot

Small Molecular NIR-II Fluorophores for Cancer Phototheranostics

inferred← citeshttps://doi.org/10.1021/accountsmr.0c00114openalex-snapshot

Rational Design of High Brightness NIR-II Organic Dyes with S-D-A-D-S Structure

inferred← citeshttps://doi.org/10.1021/accountsmr.4c00025openalex-snapshot

Recent Advances in NIR-II Materials for Biomedical Applications

inferred← citeshttps://doi.org/10.1021/acs.accounts.3c00122openalex-snapshot

Surface Engineering of Nanoparticles toward Cancer Theranostics

inferred← citeshttps://doi.org/10.1021/acs.analchem.1c00730openalex-snapshot

Apoferritin-Engineered Nanoprobe for Tumor-Targeted Triple-NIR Imaging and Phototherapy

inferred← citeshttps://doi.org/10.1021/acs.analchem.9b03152openalex-snapshot

Rational Design of a Multifunctional Molecular Dye with Single Dose and Laser for Efficiency NIR-II Fluorescence/Photoacoustic Imaging Guided Photothermal Therapy

inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00175openalex-snapshot

Water-Soluble Aza-BODIPYs: Biocompatible Organic Dyes for High Contrast In Vivo NIR-II Imaging

inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00253openalex-snapshot

Shortwave-Infrared Fluorescent Molecular Imaging Probes Based on π-Conjugation Extended Indocyanine Green

inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.9b00610openalex-snapshot

The Near-Infrared-II Fluorophores and Advanced Microscopy Technologies Development and Application in Bioimaging

inferred← citeshttps://doi.org/10.1021/acs.chemmater.9b04784openalex-snapshot

Clearable Shortwave-Infrared-Emitting NaErF4 Nanoparticles for Noninvasive Dynamic Vascular Imaging

inferred← citeshttps://doi.org/10.1021/acs.chemmater.9b05159openalex-snapshot

Propylenedioxy Thiophene Donor to Achieve NIR-II Molecular Fluorophores with Enhanced Brightness

inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00553openalex-snapshot

Versatile Types of Inorganic/Organic NIR-IIa/IIb Fluorophores: From Strategic Design toward Molecular Imaging and Theranostics

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c01089openalex-snapshot

Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00601openalex-snapshot

Systematic Structural Modification of Squaraine Dye for Near-Infrared Window One and Two Multiplexed In Vivo Imaging and Photothermal Therapy

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c00975openalex-snapshot

Finely Tuned, Meticulously Screened Renal-Clearable Zwitterionic Cyanine Dyes for Targeted NIR-II Tumor Detection, Intraoperative Navigation, and Dual-Color Imaging

inferred← citeshttps://doi.org/10.1021/acs.joc.2c01229openalex-snapshot

Sterically Shielded Hydrophilic Analogs of Indocyanine Green

inferred← citeshttps://doi.org/10.1021/acs.joc.8b03122openalex-snapshot

Meso-Substituent-Directed Aggregation Behavior and Water Solubility: Direct Functionalization of Methine Chain in Thiazole Orange and Biological Applications in Aqueous Buffer

inferred← citeshttps://doi.org/10.1021/acs.jpcb.2c08016openalex-snapshot

Photoisomerization of Heptamethine Cyanine Dyes Results in Red-Emissive Species: Implications for Near-IR, Single-Molecule, and Super-Resolution Fluorescence Spectroscopy and Imaging

inferred← citeshttps://doi.org/10.1021/acs.jpcb.2c08784openalex-snapshot

Cy3 Cyanine Dye with Strong Fluorescence Enhancement for AGRO100 and Its Derivative

inferred← citeshttps://doi.org/10.1021/acs.jpclett.5c03398openalex-snapshot

Indocyanine Green Fluorescence: Quenching by a Twisted Charge-Transfer State Violates the Kasha–Vavilov Rule

inferred← citeshttps://doi.org/10.1021/acs.jpclett.6c01511openalex-snapshot

Zero Phonon Line with Enhanced Debye–Waller Factor and Forster Resonance Energy Transfer Assisted Tunable Broadband NIR Emissions in (Cr3+, Mo4+):Cs4CdSb2Cl12

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