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Bio‐Orthogonal, Site‐Selective Conjugation of Recombinant Proteins to Microporous Annealed Particle Hydrogels for Tissue Engineering

https://doi.org/10.1002/adtp.201900148

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/ trans ‐Cyclooctene Cycloaddition

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A comprehensive clinical review of recombinant human bone morphogenetic protein-2 (INFUSE® Bone Graft)

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Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: Delivery systems for BMPs in orthopaedic and craniofacial tissue engineering

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Covalently tethered transforming growth factor beta in PEG hydrogels promotes chondrogenic differentiation of encapsulated human mesenchymal stem cells

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Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility

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Strategies to reduce dendritic cell activation through functional biomaterial design

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Versatile click alginate hydrogels crosslinked via tetrazine–norbornene chemistry

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Residue-specific incorporation of non-canonical amino acids into proteins: recent developments and applications

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Matrix Elasticity Directs Stem Cell Lineage Specification

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Protein Chemical Modification on Endogenous Amino Acids

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Spray dried hyaluronic acid microparticles for adhesion controlled aggregation and potential stimulation of stem cells

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Pathways Governing Polyethylenimine Polyplex Transfection in Microporous Annealed Particle Scaffolds

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Covalent Modification of Synthetic Hydrogels with Bioactive Proteins via Sortase-Mediated Ligation

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Sequential Thiol–Ene and Tetrazine Click Reactions for the Polymerization and Functionalization of Hydrogel Microparticles

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Injectable Macroporous Hydrogel Formed by Enzymatic Cross-Linking of Gelatin Microgels

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A Reversible and Repeatable Thiol–Ene Bioconjugation for Dynamic Patterning of Signaling Proteins in Hydrogels

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Site-Specific PEGylation of Protein Disulfide Bonds Using a Three-Carbon Bridge

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Site-Specific PEGylation at Histidine Tags

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Synthetically Tractable Click Hydrogels for Three-Dimensional Cell Culture Formed Using Tetrazine–Norbornene Chemistry

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Green Fluorescent Protein (GFP): Applications, Structure, and Related Photophysical Behavior

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Designing Peptide and Protein Modified Hydrogels: Selecting the Optimal Conjugation Strategy

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Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway

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One-step site-specific modification of native proteins with 2-pyridinecarboxyaldehydes

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Site-specific PEGylation of native disulfide bonds in therapeutic proteins

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Spatially controlled simultaneous patterning of multiple growth factors in three-dimensional hydrogels

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Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance

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Bioactive site-specifically modified proteins for 4D patterning of gel biomaterials

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Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic β-cells

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Inverse electron demand Diels–Alder (iEDDA)-initiated conjugation: a (high) potential click chemistry scheme

inferredcites →https://doi.org/10.1039/c8sc03355bopenalex-snapshot

Site-selective protein conjugation at histidine

inferredcites →https://doi.org/10.1039/c8tb01399copenalex-snapshot

Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors

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Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition

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A BMP/activin A chimera is superior to native BMPs and induces bone repair in nonhuman primates when delivered in a composite matrix

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Recent advances in covalent, site-specific protein immobilization

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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Conjugation of IL‐33 to Microporous Annealed Particle Scaffolds Enhances Type 2‐Like Immune Responses In Vitro and In Vivo

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Covalent Network Formation Rate Controls Depletion‐Induced Supramolecular Assembly in Hybrid Double Network Hydrogels

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4D Printing of Extrudable and Degradable Poly(Ethylene Glycol) Microgel Scaffolds for Multidimensional Cell Culture

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Pectin-based self-healing hydrogel with NaHCO3 degradability for drug loading and release

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Impact of Annealing Chemistry on the Properties and Performance of Microporous Annealed Particle Hydrogels

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Covalent Attachment of Functional Proteins to Microfiber Surfaces via a General Strategy for Site-Selective Tetrazine Ligation

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Methods to Characterize Granular Hydrogel Rheological Properties, Porosity, and Cell Invasion

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Green Chemistry Principles In Advancing Hierarchical Functionalization of Polymer-Based Nanomedicines

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Tetrazine-based inverse-electron-demand Diels–Alder reaction: a powerful tool for fabrication and functionalization of polymeric materials

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Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

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Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

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Microporous annealed particle hydrogels in cell culture, tissue regeneration, and emerging application in cancer immunotherapy

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