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Nature Inspired Molecular Design: Stereoselective Synthesis of Bicyclic and Polycyclic Ethers for Potent HIV‐1 Protease Inhibitors
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Outgoing claims: the papers this work cites, builds on, or argues with.
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Structure‐Based Design of Drugs and Other Bioactive Molecules
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Naturstoffsynthese im Wandel der Zeit
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Asymmetric Induction in the [2,3] Wittig Rearrangement by Chiral Substituents in the Allyl Moiety
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Enhancing Protein Backbone Binding—A Fruitful Concept for Combating Drug‐Resistant HIV
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Natural Product Synthesis: Changes over Time
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Probing Multidrug‐Resistance and Protein–Ligand Interactions with Oxatricyclic Designed Ligands in HIV‐1 Protease Inhibitors
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Design of gem‐Difluoro‐bis‐Tetrahydrofuran as P2 Ligand for HIV‐1 Protease Inhibitors to Improve Brain Penetration: Synthesis, X‐ray Studies, and Biological Evaluation
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Design of Highly Potent, Dual‐Acting and Central‐Nervous‐System‐Penetrating HIV‐1 Protease Inhibitors with Excellent Potency against Multidrug‐Resistant HIV‐1 Variants
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A history of AIDS: Looking back to see ahead
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Atomic resolution crystal structures of HIV‐1 protease and mutants V82A and I84V with saquinavir
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Darunavir: A Review of Its Use in the Management of HIV-1 Infection
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Synthesis and optical resolution of high affinity P2-ligands for HIV-1 protease inhibitors
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Design of the anti-HIV protease inhibitor darunavir
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Selection and characterization of HIV-1 showing reduced susceptibility to the non-peptidic protease inhibitor tipranavir
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Terpene trilactones from Gingko biloba: From ancient times to the 21st century
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Darunavir, a conceptually new HIV-1 protease inhibitor for the treatment of drug-resistant HIV
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Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis
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The impact of natural products upon modern drug discovery
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Current status and prospects of HIV treatment
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Enantioselective synthesis of cyclopentyltetrahydrofuran (Cp-THF), an important high-affinity P2-ligand for HIV-1 protease inhibitors
inferredcites →https://doi.org/10.1016/j.tetlet.2015.01.019openalex-snapshot
Enantioselective synthesis of dioxatriquinane structural motifs for HIV-1 protease inhibitors using a cascade radical cyclization
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An enantioselective enzymatic desymmetrization route to hexahydro-4H-furopyranol, a high-affinity ligand for HIV-1 protease inhibitors
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Highly stereoselective asymmetric aldol routes to tert-butyl-2-(3,5-difluorophenyl)-1-oxiran-2-yl)ethyl)carbamates: Building blocks for novel protease inhibitors
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Structure-based design of non-peptide HIV protease inhibitors
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Di(2-pyridyl) carbonate promoted alkoxycarbonylation of amines: A convenient synthesis of functionalized carbamates
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TiCl4 promoted three component coupling reaction: A new method for the synthesis of functionalized tetrahydrofurans and tetrahydropyrans
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Cesium promoted O-alkylation of alcohols for the efficient ether synthesis
inferredcites →https://doi.org/10.1016/s0140-6736(95)90699-1openalex-snapshot
Safety and activity of saquinavir in HIV infection
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Darunavir en primeras líneas. Estudio TITAN
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Resolution and stereoselective synthesis of the herpes thymidine kinase inhibitor L-653180
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Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere
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Development of Protease Inhibitors and the Fight with Drug‐Resistant HIV‐1 Variants
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Design of HIV-1 Protease Inhibitors with Amino-bis-tetrahydrofuran Derivatives as P2-Ligands to Enhance Backbone-Binding Interactions: Synthesis, Biological Evaluation, and Protein–Ligand X-ray Studies
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Recent Progress in the Development of HIV-1 Protease Inhibitors for the Treatment of HIV/AIDS
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Design and Development of Highly Potent HIV-1 Protease Inhibitors with a Crown-Like Oxotricyclic Core as the P2-Ligand To Combat Multidrug-Resistant HIV Variants
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Design of HIV Protease Inhibitors Targeting Protein Backbone: An Effective Strategy for Combating Drug Resistance
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Kinetic Characterization and Cross-Resistance Patterns Of HIV-1 Protease Mutants Selected under Drug Pressure
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The Microtubule Stabilizing Agent Laulimalide Does Not Bind in the Taxoid Site, Kills Cells Resistant to Paclitaxel and Epothilones, and May Not Require Its Epoxide Moiety for Activity
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The Assembly-Inducing Laulimalide/Peloruside A Binding Site on Tubulin: Molecular Modeling and Biochemical Studies with [3H]Peloruside A
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Mitsunobu and Related Reactions: Advances and Applications
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Crystal structure of HIV-1 protease in complex with VX-478, a potent and orally bioavailable inhibitor of the enzyme
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Catalytic asymmetric epoxidation and kinetic resolution: modified procedures including in situ derivatization
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The first practical method for asymmetric epoxidation
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Structure of the insect phagorepellent azadirachtin. Application of PRFT/CWD [partially relaxed Fourier transform/continuous wave decoupling] carbon-13 nuclear magnetic resonance
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Potent HIV protease inhibitors: the development of tetrahydrofuranylglycines as novel P2-ligands and pyrazine amides as P3-ligands
inferredcites →https://doi.org/10.1021/jm00115a028openalex-snapshot
Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere
inferredcites →https://doi.org/10.1021/jm040158kopenalex-snapshot
New Approaches toward Anti-HIV Chemotherapy
inferredcites →https://doi.org/10.1021/jm060561mopenalex-snapshot
Structure-Based Design of Novel HIV-1 Protease Inhibitors To Combat Drug Resistance
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Design and Synthesis of Potent HIV-1 Protease Inhibitors Incorporating Hexahydrofuropyranol-Derived High Affinity P2 Ligands: Structure−Activity Studies and Biological Evaluation
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Highly Potent HIV-1 Protease Inhibitors with Novel Tricyclic P2 Ligands: Design, Synthesis, and Protein–Ligand X-ray Studies
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Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies
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Harnessing Nature’s Insight: Design of Aspartyl Protease Inhibitors from Treatment of Drug-Resistant HIV to Alzheimer’s Disease
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Nonpeptidal P2 Ligands for HIV Protease Inhibitors: Structure-Based Design, Synthesis, and Biological Evaluation
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Viracept (Nelfinavir Mesylate, AG1343): A Potent, Orally Bioavailable Inhibitor of HIV-1 Protease
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New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development
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An extremely simple, convenient, and selective method for acetylating primary alcohols in the presence of secondary alcohols
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Organoselenium chemistry. A facile one-step synthesis of alkyl aryl selenides from alcohols
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Stereoselective Photochemical 1,3-Dioxolane Addition to 5-Alkoxymethyl-2(5H)-furanone: Synthesis of Bis-tetrahydrofuranyl Ligand for HIV Protease Inhibitor UIC-94017 (TMC-114)
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Capturing the Essence of Organic Synthesis: From Bioactive Natural Products to Designed Molecules in Today’s Medicine
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Enantioselective Total Syntheses of FR901464 and Spliceostatin A and Evaluation of Splicing Activity of Key Derivatives
inferredcites →https://doi.org/10.1021/ml100289mopenalex-snapshot
Design, Synthesis, and X-ray Structure of Substituted Bis-tetrahydrofuran (Bis-THF)-Derived Potent HIV-1 Protease Inhibitors
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Modern Natural Products Drug Discovery and Its Relevance to Biodiversity Conservation
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Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010
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Synthesis of 2‘,3‘-Dideoxy-6‘,6‘-difluorocarbocyclic Nucleosides
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[4 + 2] Cycloaddition Reactions Catalyzed by a Chiral Oxazaborolidinium Cation. Reaction Rates and Diastereo-, Regio-, and Enantioselectivity Depend on Whether Both Bonds Are Formed Simultaneously
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An Expedient Procedure for the Oxidative Cleavage of Olefinic Bonds with PhI(OAc)2, NMO, and Catalytic OsO4
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Synthesis of 3‘,3‘-Difluoro-2‘- hydroxymethyl-4‘,5‘-Unsaturated Carbocyclic Nucleosides
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The discovery of first-in-class drugs: origins and evolution
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Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein–ligand X-ray studies
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A facile and enantiospecific synthesis of 2(S)- and 2 (R)[1′(S)-azido-2-phenylethyl]oxirane
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Design, synthesis, biological evaluation and X-ray structural studies of HIV-1 protease inhibitors containing substituted fused-tetrahydropyranyl tetrahydrofuran as P2-ligands
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Chiral Preparation of Polyoxygenated Cyclopentanoids
inferredcites →https://doi.org/10.1055/s-2001-18434openalex-snapshot
Syntheses of FDA Approved HIV Protease Inhibitors
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AIDS — The First 20 Years
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The emergence of HIV/AIDS in the Americas and beyond
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Active human immunodeficiency virus protease is required for viral infectivity.
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An 11-kDa form of human immunodeficiency virus protease expressed in Escherichia coli is sufficient for enzymatic activity.
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L-735,524: an orally bioavailable human immunodeficiency virus type 1 protease inhibitor.
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ABT-538 is a potent inhibitor of human immunodeficiency virus protease and has high oral bioavailability in humans.
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The endeavor of total synthesis and its impact on chemistry, biology and medicine
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Crystal structure of an in vivo HIV‐1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance
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Rational Design of Peptide-Based HIV Proteinase Inhibitors
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Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)
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Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS
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GRL-04810 and GRL-05010, Difluoride-Containing Nonpeptidic HIV-1 Protease Inhibitors (PIs) That Inhibit the Replication of Multi-PI-Resistant HIV-1 In Vitro and Possess Favorable Lipophilicity That May Allow Blood-Brain Barrier Penetration
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GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro
inferredcites →https://doi.org/10.1128/aac.42.12.3218openalex-snapshot
ABT-378, a Highly Potent Inhibitor of the Human Immunodeficiency Virus Protease
inferredcites →https://doi.org/10.1128/aac.47.10.3123-3129.2003openalex-snapshot
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Demonstration of Sustained Drug-Resistant Human Immunodeficiency Virus Type 1 Lineages Circulating among Treatment-Naive Individuals
inferredcites →https://doi.org/10.1128/jvi.76.3.1349-1358.2002openalex-snapshot
A Potent Human Immunodeficiency Virus Type 1 Protease Inhibitor, UIC-94003 (TMC-126), and Selection of a Novel (A28S) Mutation in the Protease Active Site
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INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design
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Polyether ionophores: broad-spectrum and promising biologically active molecules for the control of drug-resistant bacteria and parasites
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Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–2
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Lasonolide A, a potent and reversible inducer of chromosome condensation
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Thirty Years of HIV and AIDS: Future Challenges and Opportunities
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A novel central nervous system-penetrating protease inhibitor overcomes human immunodeficiency virus 1 resistance with unprecedented aM to pM potency
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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