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Phloroglucinol Derivatives Guttiferone G, Aristoforin, and Hyperforin: Inhibitors of Human Sirtuins SIRT1 and SIRT2

https://doi.org/10.1002/anie.200605207

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbic.200400195openalex-snapshot

Aristoforin, a Novel Stable Derivative of Hyperforin, Is a Potent Anticancer Agent

inferredcites →https://doi.org/10.1006/bbrc.1999.0897openalex-snapshot

Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity

inferredcites →https://doi.org/10.1006/bbrc.2000.3000openalex-snapshot

Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins

inferredcites →https://doi.org/10.1006/bbrc.2000.3854openalex-snapshot

Role of NAD+ in the Deacetylase Activity of the SIR2-like Proteins

inferredcites →https://doi.org/10.1016/j.lfs.2005.12.027openalex-snapshot

Hyperforin: More than an antidepressant bioactive compound?

inferredcites →https://doi.org/10.1016/j.molcel.2004.08.031openalex-snapshot

Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin

inferredcites →https://doi.org/10.1016/j.molcel.2005.02.022openalex-snapshot

Mechanism of Sirtuin Inhibition by Nicotinamide: Altering the NAD+ Cosubstrate Specificity of a Sir2 Enzyme

inferredcites →https://doi.org/10.1016/j.neulet.2004.04.053openalex-snapshot

Hyperforin modifies neuronal membrane properties in vivo

inferredcites →https://doi.org/10.1016/j.tips.2004.12.009openalex-snapshot

The emerging therapeutic potential of sirtuin-interacting drugs: from cell death to lifespan extension

inferredcites →https://doi.org/10.1016/s0040-4020(01)89039-6openalex-snapshot

The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea

inferredcites →https://doi.org/10.1016/s0092-8674(01)00527-xopenalex-snapshot

hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase

inferredcites →https://doi.org/10.1016/s1097-2765(03)00038-8openalex-snapshot

The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase

inferredcites →https://doi.org/10.1021/bi034959lopenalex-snapshot

Sir2 Regulation by Nicotinamide Results from Switching between Base Exchange and Deacetylation Chemistry

inferredcites →https://doi.org/10.1021/cr0500582openalex-snapshot

Polycyclic Polyprenylated Acylphloroglucinols

inferredcites →https://doi.org/10.1021/jm0209782openalex-snapshot

Biosynthesis of Hyperforin in Hypericum perforatum

inferredcites →https://doi.org/10.1021/jm049933mopenalex-snapshot

An In Silico Approach to Discovering Novel Inhibitors of Human Sirtuin Type 2

inferredcites →https://doi.org/10.1021/jm050522vopenalex-snapshot

Discovery of Indoles as Potent and Selective Inhibitors of the Deacetylase SIRT1

inferredcites →https://doi.org/10.1021/jm060118bopenalex-snapshot

Adenosine Mimetics as Inhibitors of NAD+-Dependent Histone Deacetylases, from Kinase to Sirtuin Inhibition

inferredcites →https://doi.org/10.1021/np0000872openalex-snapshot

Structure−Activity Relationship of Polyisoprenyl Benzophenones from Garcinia pyrifera on the Tubulin/Microtubule System

inferredcites →https://doi.org/10.1021/np050045jopenalex-snapshot

Guttiferone I, a New Prenylated Benzophenone from Garcinia humilis as a Liver X Receptor Ligand

inferredcites →https://doi.org/10.1038/227680a0openalex-snapshot

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

inferredcites →https://doi.org/10.1038/35001622openalex-snapshot

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

inferredcites →https://doi.org/10.1038/sj.leu.2404301openalex-snapshot

Hyperforin, a new lead compound against the progression of cancer and leukemia?

inferredcites →https://doi.org/10.1039/b600518gopenalex-snapshot

Phloroglucinol compounds of natural origin

inferredcites →https://doi.org/10.1055/s-2001-15465openalex-snapshot

Evaluation of Synaptosomal Uptake Inhibition of most Relevant Constituents of St. John's Wort

inferredcites →https://doi.org/10.1055/s-2001-15512openalex-snapshot

Hyperforin - Antidepressant Activity by a Novel Mechanism of Action

inferredcites →https://doi.org/10.1055/s-2003-43210openalex-snapshot

Preventive Agents against Sepsis and New Phenylpropanoid Glucosides from the Fruits ofIllicium verum

inferredcites →https://doi.org/10.1074/jbc.m106779200openalex-snapshot

Identification of a Class of Small Molecule Inhibitors of the Sirtuin Family of NAD-dependent Deacetylases by Phenotypic Screening

inferredcites →https://doi.org/10.1074/jbc.m402839200openalex-snapshot

Polyisoprenylated Benzophenone, Garcinol, a Natural Histone Acetyltransferase Inhibitor, Represses Chromatin Transcription and Alters Global Gene Expression

inferredcites →https://doi.org/10.1074/jbc.m513741200openalex-snapshot

Metabolite of SIR2 Reaction Modulates TRPM2 Ion Channel

inferredcites →https://doi.org/10.1093/emboj/cdg115openalex-snapshot

HDAC‐6 interacts with and deacetylates tubulin and microtubules in vivo

inferredcites →https://doi.org/10.1101/gad.1412706openalex-snapshot

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

inferredcites →https://doi.org/10.1128/mcb.23.9.3173-3185.2003openalex-snapshot

Role for Human SIRT2 NAD-Dependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle

inferredcites →https://doi.org/10.1146/annurev.biochem.74.082803.133500openalex-snapshot

The Biochemistry of Sirtuins

inferredcites →https://doi.org/10.1158/0008-5472.can-05-3617openalex-snapshot

Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes

inferredcites →https://doi.org/10.1371/journal.pbio.0030041openalex-snapshot

SIRT1 Regulates HIV Transcription via Tat Deacetylation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Hyperforin: A natural lead compound with multiple pharmacological activities

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Catalytic Asymmetric Total Synthesis of ent‐Hyperforin

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Die Chemie der polycyclischen polyprenylierten Acylphloroglucine

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Neurotrophe Naturstoffe – ihre Chemie und Biologie

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Highly Regio‐ and Stereoselective Double Michael Addition–Cyclization of 2,3‐Allenoates with Organozinc Compounds: Efficient Synthesis of 5‐Benzylidenecyclohex‐2‐enones

inferred← citeshttps://doi.org/10.1002/anie.200906678openalex-snapshot

Catalytic Asymmetric Total Synthesis of ent‐Hyperforin

inferred← citeshttps://doi.org/10.1002/anie.201103873openalex-snapshot

The Chemistry of the Polycyclic Polyprenylated Acylphloroglucinols

inferred← citeshttps://doi.org/10.1002/anie.201207325openalex-snapshot

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Indoloquinolizidine Derivatives as Novel and Potent Apoptosis Inducers and Cell‐Cycle Blockers

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Diastereoselective, One‐Pot Synthesis of Polyfunctionalized Bicyclo[3.3.1]nonanes by an Anionic Domino Process

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Thiobarbiturates as Sirtuin Inhibitors: Virtual Screening, Free‐Energy Calculations, and Biological Testing

inferred← citeshttps://doi.org/10.1002/ijc.24295openalex-snapshot

Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor‐induced lymphangiogenesis in vivo

inferred← citeshttps://doi.org/10.1002/med.20178openalex-snapshot

NAD+-dependent histone deacetylases (sirtuins) as novel therapeutic targets

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HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents

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Conspectus of Structurally Distinct Groups of Histone Deacetylase Inhibitors of Classical Histone Deacetylases and Sirtuins

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A current update on phytochemistry, pharmacology and herb–drug interactions of Hypericum perforatum

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Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor

inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105144openalex-snapshot

Polycyclic polyprenylated acylphloroglucinols with immunosuppressive activity from Hypericum perforatum and absolute configurations assignment of previously reported analogues

inferred← citeshttps://doi.org/10.1016/j.bmc.2008.07.059openalex-snapshot

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone

inferred← citeshttps://doi.org/10.1016/j.bmc.2009.07.073openalex-snapshot

Identification and characterization of novel sirtuin inhibitor scaffolds

inferred← citeshttps://doi.org/10.1016/j.bmc.2009.10.003openalex-snapshot

Development and characterization of lysine based tripeptide analogues as inhibitors of Sir2 activity

inferred← citeshttps://doi.org/10.1016/j.bmc.2011.01.025openalex-snapshot

Simplification of the tetracyclic SIRT1-selective inhibitor MC2141: Coumarin- and pyrimidine-based SIRT1/2 inhibitors with different selectivity profile

inferred← citeshttps://doi.org/10.1016/j.bmc.2015.08.028openalex-snapshot

Isolation and anticancer, anthelminthic, and antiviral (HIV) activity of acylphloroglucinols, and regioselective synthesis of empetrifranzinans from Hypericum roeperianum

inferred← citeshttps://doi.org/10.1016/j.bmcl.2012.03.030openalex-snapshot

Novel acridinedione derivatives: Design, synthesis, SIRT1 enzyme and tumor cell growth inhibition studies

inferred← citeshttps://doi.org/10.1016/j.canlet.2009.01.040openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.cbpa.2008.01.019openalex-snapshot

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inferred← citeshttps://doi.org/10.1016/j.chembiol.2007.06.001openalex-snapshot

Selective Inhibition of CBP/p300 HAT

inferred← citeshttps://doi.org/10.1016/j.drudis.2010.07.001openalex-snapshot

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Hyperatins A–D, highly oxidized polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum L. with hypoglycemic potential in liver cells

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Guttiferones Q-S, cytotoxic polyisoprenylated benzophenones from the pericarp of Garcinia cochinchinensis

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Polyisoprenylated benzophenone and xanthone constituents of the bark of Garcinia cochinchinensis

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The anti-cancer agent guttiferone-A permeabilizes mitochondrial membrane: Ensuing energetic and oxidative stress implications

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The first catalytic asymmetric total synthesis of ent-hyperforin

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The Claisen rearrangement in the syntheses of bioactive natural products

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Synthetic studies towards the phloroglucin natural product hyperforin: construction of the fully prenylated bicyclic core

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The antidepressant hyperforin increases the phosphorylation of CREB and the expression of TrkB in a tissue-specific manner

inferred← citeshttps://doi.org/10.1021/acs.chemrev.7b00551openalex-snapshot

Research Progress of Polycyclic Polyprenylated Acylphloroglucinols

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Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity

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Tricyclic Polyprenylated Acylphloroglucinols from St John’s Wort, Hypericum perforatum

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Pd-Catalyzed Enantioselective Dearomative Allylic Annulation to Access PPAPs Analogues

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Total Synthesis of (−)-Nemorosone and (+)-Secohyperforin

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Transannular Acylation Facilitates C5–C9 Bond Formation in Hyperforin Total Synthesis

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Rapid Synthesis of Polyprenylated Acylphloroglucinol Analogs via Dearomative Conjunctive Allylic Annulation

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A Photoalkylative Fluorogenic Probe of Guttiferone A for Live Cell Imaging and Proteome Labeling in Plasmodium falciparum

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One-pot Diels–Alder cycloaddition/gold(I)-catalyzed 6-endo-dig cyclization for the synthesis of the complex bicyclo[3.3.1]alkenone framework

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Hyperforin induces apoptosis of chronic lymphocytic leukemia cells through upregulation of the BH3-only protein Noxa

inferred← citeshttps://doi.org/10.3892/ijo.2014.2639openalex-snapshot

Identification of a novel polyprenylated acylphloroglucinol-derived SIRT1 inhibitor with cancer-specific anti-proliferative and invasion-suppressing activities

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inferred← citeshttps://doi.org/10.70675/ebe78adcz9cd7z41b0zaff6z48ab13fa68aeopenalex-snapshot

"BH3-only" Noxa, cible spécifique de l'induction d'apoptose pour la thérapie des leucémies lymphoïdes chronique

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Etude du rôle des canaux TRPC6 et de l'antidépresseur hyperforine dans l'homéostasie du zinc dans les neurones corticaux de souris

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