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Synthesis and antitumor potential of new arylidene ursolic acid derivatives via caspase‐8 activation

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1 of the 55 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1371/journal.pone.0013731 (notice 2020-01-29).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1097-0215(19970304)70:5<587::aid-ijc16>3.0.co;2-aopenalex-snapshot
Reactive oxygen species as mediators of the transformed phenotype
inferredcites →https://doi.org/10.1002/ardp.201300161openalex-snapshot
Syntheses and Biological Activities of New Hybrid Molecules Containing Different Heterocyclic Moieties
inferredcites →https://doi.org/10.1002/cbdv.201900111openalex-snapshot
Synthesis and Antitumor Evaluation in Vitro of NO‐Donating Ursolic Acid‐Benzylidene Derivatives
inferredcites →https://doi.org/10.1002/path.1711630410openalex-snapshot
Apoptosis induced by mild hyperthermia in human and murine tumour cell lines: A study using electron microscopy and DNA gel electrophoresis
inferredcites →https://doi.org/10.1002/pro.2426openalex-snapshot
Redesigning the procaspase‐8 dimer interface for improved dimerization
inferredcites →https://doi.org/10.1002/slct.201701977openalex-snapshot
Novel Benzimidazole‐Containing Heterocyclic Compounds: Synthesis, Physical Properties and OLED Application
inferredcites →https://doi.org/10.1007/978-1-4939-2926-9_13openalex-snapshot
Animal Models for Studying the In Vivo Functions of Cell Cycle CDKs
inferredcites →https://doi.org/10.1007/bf02253342openalex-snapshot
Induction of Apoptosis and c-myc in L1210 Lymphocytic Leukemia Cells by Adenosine
inferredcites →https://doi.org/10.1007/s00044-020-02579-4openalex-snapshot
Uses of dimedone to synthesis pyrazole, isoxazole and thiophene derivatives with antiproliferative, tyrosine kinase and Pim-1 kinase inhibitions
inferredcites →https://doi.org/10.1007/s00280-005-0111-7openalex-snapshot
Role of mitochondria as the gardens of cell death
inferredcites →https://doi.org/10.1007/s00706-020-02612-7openalex-snapshot
2,4-Disubstituted 4-(1,3-thiazol-5-yl)but-3-en-2-ones: synthetic approaches to and consequent chemical modification
inferredcites →https://doi.org/10.1007/s11033-018-4527-7openalex-snapshot
Signaling and physiological activity of the NO-donating agent TNICthio in human blood lymphocytes, Jurkat and MCF7 cell lines
inferredcites →https://doi.org/10.1007/s12272-016-0868-8openalex-snapshot
Synthesis of novel oleanolic acid and ursolic acid in C-28 position derivatives as potential anticancer agents
inferredcites →https://doi.org/10.1016/0022-1759(94)90402-2openalex-snapshot
Evaluation of the MTT and SRB assays for testing LAK cell-mediated growth inhibition of various adherent and non-adherent tumor target cells
inferredcites →https://doi.org/10.1016/0140-6736(93)91154-eopenalex-snapshot
Apoptosis and disease
inferredcites →https://doi.org/10.1016/j.amjsurg.2011.06.019openalex-snapshot
Isoform-specific modulation of pressure-stimulated cancer cell proliferation and adhesion by α-actinin
inferredcites →https://doi.org/10.1016/j.bbcan.2020.188357openalex-snapshot
Caspase-8: The double-edged sword
inferredcites →https://doi.org/10.1016/j.bioorg.2020.104036openalex-snapshot
Synthesis and antitumor activity of α,β-unsaturated carbonyl moiety- containing oleanolic acid derivatives targeting PI3K/AKT/mTOR signaling pathway
inferredcites →https://doi.org/10.1016/j.ejmech.2011.03.050openalex-snapshot
In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives
inferredcites →https://doi.org/10.1016/j.ejmech.2016.01.026openalex-snapshot
Synthesis and screening of ursolic acid-benzylidine derivatives as potential anti-cancer agents
inferredcites →https://doi.org/10.1016/j.ejmech.2017.09.069openalex-snapshot
An insight into the biological activities of heterocyclic–fatty acid hybrid molecules
inferredcites →https://doi.org/10.1016/j.ejphar.2017.06.030openalex-snapshot
Interference of ursolic acid treatment with glioma growth: An in vitro and in vivo study
inferredcites →https://doi.org/10.1016/j.fitote.2020.104670openalex-snapshot
Development of a novel truncated deguelin derivative possessing nitric oxide donor as a potential anti-lung cancer agent
inferredcites →https://doi.org/10.1016/s0014-5793(98)01494-xopenalex-snapshot
BCL‐2 promotes migration and invasiveness of human glioma cells
inferredcites →https://doi.org/10.1016/s0092-8674(02)00704-3openalex-snapshot
Pathways of Apoptosis in Lymphocyte Development, Homeostasis, and Disease
inferredcites →https://doi.org/10.1016/s0960-9822(00)00435-8openalex-snapshot
Cell cycle: To differentiate or not to differentiate?
inferredcites →https://doi.org/10.1016/s1054-3589(08)61052-2openalex-snapshot
Apoptosis: An Overview of the Process and Its Relevance in Disease
inferredcites →https://doi.org/10.1016/s1097-2765(03)00059-5openalex-snapshot
Insights into the Regulatory Mechanism for Caspase-8 Activation
inferredcites →https://doi.org/10.1021/bp9800891openalex-snapshot
Molecular Regulation of Cell-Cycle Progression and Apoptosis in Mammalian Cells: Implications for Biotechnology
inferredcites →https://doi.org/10.1023/a:1022945107762openalex-snapshot
The mitochondrial membrane potential (Δψm) in apoptosis; an update
inferredcites →https://doi.org/10.1038/35037710openalex-snapshot
The biochemistry of apoptosis
inferredcites →https://doi.org/10.1038/nrgastro.2015.113openalex-snapshot
MPTP pore opening proves crucial for experimental pancreatitis
inferredcites →https://doi.org/10.1038/nrm3999openalex-snapshot
Live to die another way: modes of programmed cell death and the signals emanating from dying cells
inferredcites →https://doi.org/10.1038/s41586-019-1770-6openalex-snapshot
Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis
inferredcites →https://doi.org/10.1038/sj.cdd.4401296openalex-snapshot
A serine protease is involved in the initiation of DNA damage-induced apoptosis
inferredcites →https://doi.org/10.1038/sj.onc.1203824openalex-snapshot
Caspase-8/FLICE functions as an executioner caspase in anticancer drug-induced apoptosis
inferredcites →https://doi.org/10.1039/c5ra08958aopenalex-snapshot
Limitations of MTT and CCK-8 assay for evaluation of graphene cytotoxicity
inferredcites →https://doi.org/10.1039/d0qo00050gopenalex-snapshot
Synthesis and biological evaluation of suffrutines A, B and their N-fused analogues
inferredcites →https://doi.org/10.1039/d0ra02432eopenalex-snapshot
Synthesis and biological evaluation of dehydroabietic acid-pyrimidine hybrids as antitumor agents
inferredcites →https://doi.org/10.1046/j.1365-2184.2003.00266.xopenalex-snapshot
The cell cycle: a review of regulation, deregulation and therapeutic targets in cancer
inferredcites →https://doi.org/10.1073/pnas.96.4.1457openalex-snapshot
Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
inferredcites →https://doi.org/10.1074/jbc.m204497200openalex-snapshot
Inactivation of p21Sensitizes Cells to Apoptosis via an Increase of Both p14ARF and p53 Levels and an Alteration of the Bax/Bcl-2 Ratio
inferredcites →https://doi.org/10.1080/01635581.2010.492092openalex-snapshot
Antitumor Effects of Ursolic Acid in a Mouse Model of Postmenopausal Breast Cancer
inferredcites →https://doi.org/10.1080/10286020.2019.1571488openalex-snapshot
Synthesis and antitumor activity evaluation of ursolic acid derivatives
inferredcites →https://doi.org/10.1080/21691401.2019.1600529openalex-snapshot
Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy
inferredcites →https://doi.org/10.1111/j.1365-2249.2007.03331.xopenalex-snapshot
Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopes
inferredcites →https://doi.org/10.1111/j.1745-7270.2005.00108.xopenalex-snapshot
Caspase Family Proteases and Apoptosis
inferredcites →https://doi.org/10.1111/jmi.12133openalex-snapshot
Cell‐death assessment by fluorescent and nonfluorescent cytosolic and nuclear staining techniques
inferredcites →https://doi.org/10.1134/s0022093019020029openalex-snapshot
Activation of Fas Receptors, Caspase-8 and Caspase-3 by Fluoride Ions in Rat Erythrocytes in vitro
inferredcites →https://doi.org/10.1371/journal.pone.0013731openalex-snapshot
Downregulation of uPAR and Cathepsin B Induces Apoptosis via Regulation of Bcl-2 and Bax and Inhibition of the PI3K/Akt Pathway in Gliomas
inferredcites →https://doi.org/10.2174/1871520619666190319142934openalex-snapshot
Design, Synthesis, Anti-Proliferative Evaluation and Cell Cycle Analysis of Hybrid 2-Quinolones
inferredcites →https://doi.org/10.3390/molecules201119684openalex-snapshot
Synthesis of Novel β-Keto-Enol Derivatives Tethered Pyrazole, Pyridine and Furan as New Potential Antifungal and Anti-Breast Cancer Agents
inferredcites →https://doi.org/10.3892/ijmm.2013.1361openalex-snapshot
α-lipoic acid protects dopaminergic neurons against MPP+-induced apoptosis by attenuating reactive oxygen species formation
inferredcites →https://doi.org/10.3892/ol.2016.4125openalex-snapshot
Reduced expression of caspase-8 and cleaved caspase-3 in pancreatic ductal adenocarcinoma cells
inferredcites →https://doi.org/10.3892/ol.2017.7578openalex-snapshot
A novel synthetic ursolic acid derivative inhibits growth and induces apoptosis in breast cancer cell lines

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4647946openalex-extracted
inferred← citeshttps://doi.org/10.1002/cbdv.202401953openalex-snapshot
Application of Chalcone in the Structural Modification of Natural Products: An Overview
inferred← citeshttps://doi.org/10.1002/cmdc.202200234openalex-snapshot
Sinomenine Derivatives: Synthesis, Antitumor Activity, and Apoptotic Induction in MCF‐7 Cells via IL‐6/PI3K/Akt/NF‐κB Signaling Pathway
inferred← citeshttps://doi.org/10.1002/slct.202102784openalex-snapshot
Cholesterol‐Based Conjugates: Synthesis, Characterization and In Vitro Biological Studies
inferred← citeshttps://doi.org/10.1007/s00044-023-03147-2openalex-snapshot
Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers
inferred← citeshttps://doi.org/10.1007/s11030-024-10833-9openalex-snapshot
In vitro anticancer study of novel curcumin derivatives via targeting PI3K/Akt/p53 signaling pathway
inferred← citeshttps://doi.org/10.1007/s11596-024-2922-yopenalex-snapshot
Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118078openalex-snapshot
New curcumin derivative induces ferroptosis in MCF-7 cells through activating SLC7A11/GPX4 axis
inferred← citeshttps://doi.org/10.1016/j.steroids.2024.109379openalex-snapshot
An unexpected conversion of 2E-furfurylidene-3-oxo-24-nor-allobetulin to 23-nor-allobetulins
inferred← citeshttps://doi.org/10.1021/acsomega.5c02553openalex-snapshot
The Synergistic Cytotoxic Effect of the Two Enantiomers of 6-Prenylflavanones in the HeLa Cell Line
inferred← citeshttps://doi.org/10.3390/ijms22189796openalex-snapshot
Novel A-Ring Chalcone Derivatives of Oleanolic and Ursolic Amides with Anti-Proliferative Effect Mediated through ROS-Triggered Apoptosis
inferred← citeshttps://doi.org/10.3390/molecules27248981openalex-snapshot
Ursolic Acid Analogs as Potential Therapeutics for Cancer
inferred← citeshttps://doi.org/10.3390/molecules28176208openalex-snapshot
Synthesis of Tricyclic Pterolobirin H Analogue: Evaluation of Anticancer and Anti-Inflammatory Activities and Molecular Docking Investigations
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