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Genetic depletion of Polo‐like kinase 1 leads to embryonic lethality due to mitotic aberrancies

https://doi.org/10.1002/bies.201670908

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/mrd.22188openalex-snapshot

Polo-like kinase 1 is essential for the first mitotic division in the mouse embryo

inferredcites →https://doi.org/10.1007/pl00013778openalex-snapshot

The POLO kinase is required at multiple stages during spermatogenesis in Drosophila melanogaster

inferredcites →https://doi.org/10.1007/s00018-010-0279-9openalex-snapshot

Polo-box domain: a versatile mediator of polo-like kinase function

inferredcites →https://doi.org/10.1016/j.cub.2004.09.049openalex-snapshot

Roles of Polo-like Kinase 1 in the Assembly of Functional Mitotic Spindles

inferredcites →https://doi.org/10.1016/j.cub.2006.12.046openalex-snapshot

The Small-Molecule Inhibitor BI 2536 Reveals Novel Insights into Mitotic Roles of Polo-like Kinase 1

inferredcites →https://doi.org/10.1016/j.devcel.2007.03.013openalex-snapshot

Polo-like Kinase 1 Triggers the Initiation of Cytokinesis in Human Cells by Promoting Recruitment of the RhoGEF Ect2 to the Central Spindle

inferredcites →https://doi.org/10.1016/j.molcel.2004.07.015openalex-snapshot

Polo-like Kinase-1 Controls Recovery from a G2 DNA Damage-Induced Arrest in Mammalian Cells

inferredcites →https://doi.org/10.1016/j.molcel.2006.10.016openalex-snapshot

Self-Regulated Plk1 Recruitment to Kinetochores by the Plk1-PBIP1 Interaction Is Critical for Proper Chromosome Segregation

inferredcites →https://doi.org/10.1016/s0092-8674(03)00725-6openalex-snapshot

The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain

inferredcites →https://doi.org/10.1038/75973openalex-snapshot

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

inferredcites →https://doi.org/10.1038/ncb1474openalex-snapshot

The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity

inferredcites →https://doi.org/10.1038/ncb1742openalex-snapshot

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

inferredcites →https://doi.org/10.1038/ncomms1395openalex-snapshot

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

inferredcites →https://doi.org/10.1038/nrc1841openalex-snapshot

Targeting polo-like kinase 1 for cancer therapy

inferredcites →https://doi.org/10.1038/nrd3184openalex-snapshot

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

inferredcites →https://doi.org/10.1038/nrm1401openalex-snapshot

Polo-like kinases and the orchestration of cell division

inferredcites →https://doi.org/10.1038/sj.emboj.7600569openalex-snapshot

Plk1 docking to GRASP65 phosphorylated by Cdk1 suggests a mechanism for Golgi checkpoint signalling

inferredcites →https://doi.org/10.1038/sj.onc.1208219openalex-snapshot

Differential regulation of polo-like kinase 1, 2, 3, and 4 gene expression in mammalian cells and tissues

inferredcites →https://doi.org/10.1038/sj.onc.1208271openalex-snapshot

Yeast polo-like kinases: functionally conserved multitask mitotic regulators

inferredcites →https://doi.org/10.1038/sj.onc.1208272openalex-snapshot

Polo-like kinases (Plks) and cancer

inferredcites →https://doi.org/10.1038/sj.onc.1208273openalex-snapshot

Polo-like kinases and oncogenesis

inferredcites →https://doi.org/10.1073/pnas.0609131104openalex-snapshot

Molecular and structural basis of polo-like kinase 1 substrate recognition: Implications in centrosomal localization

inferredcites →https://doi.org/10.1073/pnas.0701140104openalex-snapshot

Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells

inferredcites →https://doi.org/10.1073/pnas.1031523100openalex-snapshot

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

inferredcites →https://doi.org/10.1073/pnas.132269599openalex-snapshot

Activation of Cdc2/cyclin B and inhibition of centrosome amplification in cells depleted of Plk1 by siRNA

inferredcites →https://doi.org/10.1073/pnas.90.11.4882openalex-snapshot

Identification and cloning of a protein kinase-encoding mouse gene, Plk, related to the polo gene of Drosophila.

inferredcites →https://doi.org/10.1074/jbc.m112.412544openalex-snapshot

High Mitotic Activity of Polo-like Kinase 1 Is Required for Chromosome Segregation and Genomic Integrity in Human Epithelial Cells

inferredcites →https://doi.org/10.1074/jbc.m202602200openalex-snapshot

A Spindle Checkpoint Arrest and a Cytokinesis Failure by the Dominant-negative Polo-box Domain of Plk1 in U-2 OS Cells

inferredcites →https://doi.org/10.1074/jbc.m313681200openalex-snapshot

Polo-like Kinase-1 Is Required for Bipolar Spindle Formation but Is Dispensable for Anaphase Promoting Complex/Cdc20 Activation and Initiation of Cytokinesis

inferredcites →https://doi.org/10.1074/jbc.m412407200openalex-snapshot

Mapping the Functional Domains of the Golgi Stacking Factor GRASP65

inferredcites →https://doi.org/10.1074/jbc.m707715200openalex-snapshot

Molecular Mechanism of Mitotic Golgi Disassembly and Reassembly Revealed by a Defined Reconstitution Assay

inferredcites →https://doi.org/10.1083/jcb.129.6.1617openalex-snapshot

Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function.

inferredcites →https://doi.org/10.1083/jcb.135.6.1701openalex-snapshot

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

inferredcites →https://doi.org/10.1083/jcb.143.3.659openalex-snapshot

Drosophila Polo Kinase Is Required for Cytokinesis

inferredcites →https://doi.org/10.1083/jcb.153.1.149openalex-snapshot

Regulation of Op18 during Spindle Assembly in Xenopus Egg Extracts

inferredcites →https://doi.org/10.1083/jcb.200306009openalex-snapshot

Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis

inferredcites →https://doi.org/10.1083/jcb.200812045openalex-snapshot

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

inferredcites →https://doi.org/10.1083/jcb.201203091openalex-snapshot

Cdk1 and Plk1 mediate a CLASP2 phospho-switch that stabilizes kinetochore–microtubule attachments

inferredcites →https://doi.org/10.1083/jcb.94.3.718openalex-snapshot

A dependent pathway of gene functions leading to chromosome segregation in Saccharomyces cerevisiae.

inferredcites →https://doi.org/10.1093/emboj/cdg558openalex-snapshot

The crystal structure of the human polo‐like kinase‐1 polo box domain and its phospho‐peptide complex

inferredcites →https://doi.org/10.1093/genetics/110.3.381openalex-snapshot

ALTERED FIDELITY OF MITOTIC CHROMOSOME TRANSMISSION IN CELL CYCLE MUTANTS OF S. CEREVISIAE

inferredcites →https://doi.org/10.1101/gad.486808openalex-snapshot

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

inferredcites →https://doi.org/10.1101/gad.5.12a.2153openalex-snapshot

polo encodes a protein kinase homolog required for mitosis in Drosophila.

inferredcites →https://doi.org/10.1126/science.1079079openalex-snapshot

Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates

inferredcites →https://doi.org/10.1128/mcb.00392-08openalex-snapshot

Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression

inferredcites →https://doi.org/10.1128/mcb.00607-10openalex-snapshot

Plk5, a Polo Box Domain-Only Protein with Specific Roles in Neuron Differentiation and Glioblastoma Suppression

inferredcites →https://doi.org/10.1128/mcb.13.7.4445openalex-snapshot

A multicopy suppressor gene of the Saccharomyces cerevisiae G1 cell cycle mutant gene dbf4 encodes a protein kinase and is identified as CDC5.

inferredcites →https://doi.org/10.1128/mcb.18.7.4262openalex-snapshot

Activated Polo-Like Kinase Plx1 Is Required at Multiple Points during Mitosis in Xenopus laevis

inferredcites →https://doi.org/10.1128/mcb.19.12.8625openalex-snapshot

Mitotic Effects of a Constitutively Active Mutant of the Xenopus Polo-Like Kinase Plx1

inferredcites →https://doi.org/10.1242/bio.20122659openalex-snapshot

Sequential phosphorylation of GRASP65 during mitotic Golgi disassembly

inferredcites →https://doi.org/10.1242/jcs.107.6.1509openalex-snapshot

Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5

inferredcites →https://doi.org/10.1242/jcs.111.12.1751openalex-snapshot

The Polo-like kinase Plx1 is a component of the MPF amplification loop at the G2/M-phase transition of the cell cycle in Xenopus eggs

inferredcites →https://doi.org/10.1242/jcs.89.1.25openalex-snapshot

Polo, a mitotic mutant of Drosophila displaying abnormal spindle poles

inferredcites →https://doi.org/10.1371/journal.pbio.1000110openalex-snapshot

Polo-Like Kinase 1 Directs Assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF Complex to Initiate Cleavage Furrow Formation

inferredcites →https://doi.org/10.1371/journal.pbio.1000111openalex-snapshot

Plk1 Self-Organization and Priming Phosphorylation of HsCYK-4 at the Spindle Midzone Regulate the Onset of Division in Human Cells

inferredcites →https://doi.org/10.1371/journal.pone.0070843openalex-snapshot

Identification of Potential Plk1 Targets in a Cell-Cycle Specific Proteome through Structural Dynamics of Kinase and Polo Box-Mediated Interactions

inferredcites →https://doi.org/10.1371/journal.pone.0116783openalex-snapshot

Multiple Requirements of PLK1 during Mouse Oocyte Maturation

inferredcites →https://doi.org/10.1517/13543780903483191openalex-snapshot

Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics

inferredcites →https://doi.org/10.2174/092986707780362925openalex-snapshot

Targeting Cell Cycle Kinases for Cancer Therapy

inferredcites →https://doi.org/10.4161/cc.10.14.16494openalex-snapshot

From Plk1 to Plk5

inferredcites →https://doi.org/10.4161/cc.3.2.660openalex-snapshot

The Polo-Box Domain: A Molecular Integrator of Mitotic Kinase Cascades and Polo-like Kinase Function

inferredcites →https://doi.org/10.4161/cc.5.3.2392openalex-snapshot

A Functional Interplay Between Aurora-A, Plk1 and TPX2 at Spindle Poles: Plk1 Controls Centrosomal Localization of Aurora-A and TPX2 Spindle Association

inferredcites →https://doi.org/10.4161/cc.7.16.6439openalex-snapshot

A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4654714openalex-extracted

Four Prognostic Related Genes Were Identified by Bio-Informatics Analysis as Key Genes in Lung Adenocarcinoma

inferred← citeshttps://doi.org/10.1007/978-3-030-73572-2_2openalex-snapshot

Par-4 in Cell Cycle Regulation

inferred← citeshttps://doi.org/10.1007/s10815-016-0864-4openalex-snapshot

Plk1 inhibition leads to a failure of mitotic division during the first mitotic division in pig embryos

inferred← citeshttps://doi.org/10.1016/j.celrep.2017.05.031openalex-snapshot

PLK1 Activation in Late G2 Sets Up Commitment to Mitosis

inferred← citeshttps://doi.org/10.1021/acschembio.7b00147openalex-snapshot

Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity

inferred← citeshttps://doi.org/10.1038/nm.4364openalex-snapshot

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

inferred← citeshttps://doi.org/10.1038/s41418-020-0515-2openalex-snapshot

Squamous differentiation requires G2/mitosis slippage to avoid apoptosis

inferred← citeshttps://doi.org/10.1038/s41418-022-00937-wopenalex-snapshot

Genetic interaction between PLK1 and downstream MCPH proteins in the control of centrosome asymmetry and cell fate during neural progenitor division

inferred← citeshttps://doi.org/10.1038/s41467-018-05429-5openalex-snapshot

Plk1 overexpression induces chromosomal instability and suppresses tumor development

inferred← citeshttps://doi.org/10.1096/fj.202501377ropenalex-snapshot

A Mouse Model of Partial Pancreas Agenesis Induced by Polo‐like kinase 1 Mutation

inferred← citeshttps://doi.org/10.1111/gtc.13032openalex-snapshot

The toxicity of dysregulated Plk1 activity revealed by its suppressor mutations

inferred← citeshttps://doi.org/10.1126/sciadv.aaz2129openalex-snapshot

SKP1 drives the prophase I to metaphase I transition during male meiosis

inferred← citeshttps://doi.org/10.1126/sciadv.aeb2915openalex-snapshot

SIRT2 antagonizes MOF function during mitotic entry

inferred← citeshttps://doi.org/10.1126/scisignal.abj4009openalex-snapshot

The kinase PLK1 promotes the development of Kras / Tp53 -mutant lung adenocarcinoma through transcriptional activation of the receptor RET

inferred← citeshttps://doi.org/10.1172/jci162129openalex-snapshot

PLK1 inhibition dampens NLRP3 inflammasome–elicited response in inflammatory disease models

inferred← citeshttps://doi.org/10.1371/journal.pbio.3003490openalex-snapshot

The cell cycle regulator PLK1 promotes murine melanoma progression by regulating the transcription factor BACH1

inferred← citeshttps://doi.org/10.15252/embr.202051030openalex-snapshot

PLK1 regulates centrosome migration and spindle dynamics in male mouse meiosis

inferred← citeshttps://doi.org/10.21037/tcr-20-811openalex-snapshot

shRNA targeting PLK1 inhibits the proliferation and invasion of nasopharyngeal carcinoma cells

inferred← citeshttps://doi.org/10.3389/fcell.2020.00416openalex-snapshot

A Survey of Essential Genome Stability Genes Reveals That Replication Stress Mitigation Is Critical for Peri-Implantation Embryogenesis

inferred← citeshttps://doi.org/10.3390/cells10051176openalex-snapshot

Modelling the Functions of Polo-Like Kinases in Mice and Their Applications as Cancer Targets with a Special Focus on Ovarian Cancer

inferred← citeshttps://doi.org/10.3390/genes10030208openalex-snapshot

The Mitotic Cancer Target Polo-Like Kinase 1: Oncogene or Tumor Suppressor?

inferred← citeshttps://doi.org/10.3390/pharmaceutics15041232openalex-snapshot

Lights and Shadows on the Cancer Multi-Target Inhibitor Rigosertib (ON-01910.Na)

inferred← citeshttps://doi.org/10.4048/jbc.2022.25.e28openalex-snapshot

Polo-Like Kinase 1 Regulates Chromosomal Instability and Paclitaxel Resistance in Breast Cancer Cells

inferred← citeshttps://doi.org/10.64898/2026.05.12.724486openalex-snapshot

Polo-like kinase 1 controls activation of adult neural stem cells and represents a druggable entry-point to boost adult neurogenesis

inferred← citeshttps://doi.org/10.70675/3874748dz05abz45c5za71azcd3f75bc22f8openalex-snapshot

Mécanisme de contrôle de l'entrée en mitose par Polo-like kinase 1 (PlK1)

inferred← citeshttps://doi.org/10.7554/elife.47097openalex-snapshot

A requirement of Polo-like kinase 1 in murine embryonic myogenesis and adult muscle regeneration

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