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Sortase transpeptidases: Insights into mechanism, substrate specificity, and inhibition

https://doi.org/10.1002/bip.21472
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/0471140864.ps1503s56openalex-snapshot
Site‐Specific Protein Labeling via Sortase‐Mediated Transpeptidation
inferredcites →https://doi.org/10.1002/cbic.200700614openalex-snapshot
Site‐Specific Protein Modification on Living Cells Catalyzed by Sortase
inferredcites →https://doi.org/10.1007/978-0-387-73657-0_47openalex-snapshot
Enzymatic ligation of peptides, peptide nucleic acids and proteins by means of sortase A
inferredcites →https://doi.org/10.1007/s00203-008-0425-zopenalex-snapshot
The involvement of sortase A in high virulence of STSS-causing Streptococcus suis serotype 2
inferredcites →https://doi.org/10.1007/s00253-005-0040-8openalex-snapshot
Inhibition of sortase-mediated Staphylococcus aureus adhesion to fibronectin via fibronectin-binding protein by sortase inhibitors
inferredcites →https://doi.org/10.1007/s10529-008-9718-1openalex-snapshot
Immobilization of proteins to biacore sensor chips using Staphylococcus aureus sortase A
inferredcites →https://doi.org/10.1007/s10529-009-0116-0openalex-snapshot
Sortase-mediated protein ligation: an emerging biotechnology tool for protein modification and immobilisation
inferredcites →https://doi.org/10.1007/s10858-008-9296-5openalex-snapshot
Attachment of an NMR-invisible solubility enhancement tag using a sortase-mediated protein ligation method
inferredcites →https://doi.org/10.1016/j.ab.2003.10.023openalex-snapshot
Development of a high-performance liquid chromatography assay and revision of kinetic parameters for the Staphylococcus aureus sortase transpeptidase SrtA
inferredcites →https://doi.org/10.1016/j.bmc.2004.03.066openalex-snapshot
Inhibition of the Staphylococcus aureus sortase transpeptidase SrtA by phosphinic peptidomimetics
inferredcites →https://doi.org/10.1016/j.bmc.2009.02.008openalex-snapshot
Probing of the cis-5-phenyl proline scaffold as a platform for the synthesis of mechanism-based inhibitors of the Staphylococcus aureus sortase SrtA isoform
inferredcites →https://doi.org/10.1016/j.bmc.2009.08.067openalex-snapshot
Discovery and structure–activity relationship analysis of Staphylococcus aureus sortase A inhibitors
inferredcites →https://doi.org/10.1016/j.bmcl.2007.08.007openalex-snapshot
Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos
inferredcites →https://doi.org/10.1016/j.bmcl.2007.10.051openalex-snapshot
Identification of novel inhibitors of bacterial surface enzyme Staphylococcus aureus Sortase A
inferredcites →https://doi.org/10.1016/j.febslet.2004.06.070openalex-snapshot
Localization and mutagenesis of the sorting signal binding site on sortase A from Staphylococcus aureus
inferredcites →https://doi.org/10.1016/j.jbiotec.2005.09.012openalex-snapshot
Establishment of an experimental system allowing immobilization of proteins on the surface of Bacillus subtilis cells
inferredcites →https://doi.org/10.1016/j.jmb.2009.08.058openalex-snapshot
Two Crystal Structures of Pneumococcal Pilus Sortase C Provide Novel Insights into Catalysis and Substrate Specificity
inferredcites →https://doi.org/10.1016/j.micinf.2005.06.009openalex-snapshot
The role of Streptococcus pneumoniae sortase A in colonisation and pathogenesis
inferredcites →https://doi.org/10.1016/j.str.2003.11.021openalex-snapshot
The Structure of Sortase B, a Cysteine Transpeptidase that Tethers Surface Protein to the Staphylococcus aureus Cell Wall
inferredcites →https://doi.org/10.1016/j.str.2004.06.001openalex-snapshot
Structures of Sortase B from Staphylococcus aureus and Bacillus anthracis Reveal Catalytic Amino Acid Triad in the Active Site
inferredcites →https://doi.org/10.1016/j.str.2008.10.007openalex-snapshot
Sortase-Mediated Pilus Fiber Biogenesis in Streptococcus pneumoniae
inferredcites →https://doi.org/10.1016/j.vetmic.2007.08.032openalex-snapshot
Disruption of srtA gene in Streptococcus suis results in decreased interactions with endothelial cells and extracellular matrix proteins
inferredcites →https://doi.org/10.1021/bc060339wopenalex-snapshot
Sortase A as a Novel Molecular “Stapler” for Sequence-Specific Protein Conjugation
inferredcites →https://doi.org/10.1021/bi020078nopenalex-snapshot
A Case for Reverse Protonation: Identification of Glu160 as an Acid/Base Catalyst in Thermoanaerobacterium saccharolyticum β-Xylosidase and Detailed Kinetic Analysis of a Site-Directed Mutant
inferredcites →https://doi.org/10.1021/bi0346345openalex-snapshot
Reverse Protonation Is the Key to General Acid−Base Catalysis in Enolase,
inferredcites →https://doi.org/10.1021/bi035920jopenalex-snapshot
Analysis of the Substrate Specificity of the Staphylococcus aureus Sortase Transpeptidase SrtA
inferredcites →https://doi.org/10.1021/bi050141jopenalex-snapshot
Staphylococcus aureus Sortase Transpeptidase SrtA: Insight into the Kinetic Mechanism and Evidence for a Reverse Protonation Catalytic Mechanism
inferredcites →https://doi.org/10.1021/bi700448eopenalex-snapshot
Mutational Analysis of Active Site Residues in the Staphylococcus aureus Transpeptidase SrtA
inferredcites →https://doi.org/10.1021/bi952827popenalex-snapshot
Arazoformyl Dipeptide Substrates for Thermolysin. Confirmation of a Reverse Protonation Catalytic Mechanism
inferredcites →https://doi.org/10.1021/ja0390294openalex-snapshot
Vinyl Sulfones: Inhibitors of SrtA, a Transpeptidase Required for Cell Wall Protein Anchoring and Virulence in Staphylococcus aureus
inferredcites →https://doi.org/10.1021/ja077358gopenalex-snapshot
Peptide−Sugar Ligation Catalyzed by Transpeptidase Sortase: A Facile Approach to Neoglycoconjugate Synthesis
inferredcites →https://doi.org/10.1021/ja806779eopenalex-snapshot
Lipid Modification of Proteins through Sortase-Catalyzed Transpeptidation
inferredcites →https://doi.org/10.1021/ja902681kopenalex-snapshot
Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity
inferredcites →https://doi.org/10.1021/ja903231vopenalex-snapshot
Sortase-Catalyzed Peptide−Glycosylphosphatidylinositol Analogue Ligation
inferredcites →https://doi.org/10.1021/jf051765zopenalex-snapshot
Curcuma longa L. Constituents Inhibit Sortase A and Staphylococcus aureus Cell Adhesion to Fibronectin
inferredcites →https://doi.org/10.1021/jm0498708openalex-snapshot
Discovery of Diarylacrylonitriles as a Novel Series of Small Molecule Sortase A Inhibitors
inferredcites →https://doi.org/10.1021/np040220gopenalex-snapshot
Cyclic Peptides of the Nocardamine Class from a Marine-Derived Bacterium of the GenusStreptomyces
inferredcites →https://doi.org/10.1021/np800321yopenalex-snapshot
Meroditerpenoids from the Brown Alga Sargassum siliquastrum
inferredcites →https://doi.org/10.1021/pr901025wopenalex-snapshot
Identification of Sortase A (SrtA) Substrates in Streptococcus uberis: Evidence for an Additional Hexapeptide (LPXXXD) Sorting Motif
inferredcites →https://doi.org/10.1023/a:1011299500628openalex-snapshot
Letter to the Editor: Assignment of the 1H, 13C and 15N signals of Sortase
inferredcites →https://doi.org/10.1038/nchembio.2007.31openalex-snapshot
Sortagging: a versatile method for protein labeling
inferredcites →https://doi.org/10.1042/bj20020602openalex-snapshot
Irreversible inhibition of the bacterial cysteine protease-transpeptidase sortase (SrtA) by substrate-derived affinity labels
inferredcites →https://doi.org/10.1046/j.1365-2958.2001.02411.xopenalex-snapshot
Sortase‐catalysed anchoring of surface proteins to the cell wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1046/j.1365-2958.2002.02798.xopenalex-snapshot
Inactivation of the srtA gene in Listeria monocytogenes inhibits anchoring of surface proteins and affects virulence
inferredcites →https://doi.org/10.1073/pnas.032523999openalex-snapshot
An iron-regulated sortase anchors a class of surface protein during Staphylococcus aureus pathogenesis
inferredcites →https://doi.org/10.1073/pnas.080520697openalex-snapshot
Staphylococcus aureus sortase mutants defective in the display of surface proteins and in the pathogenesis of animal infections
inferredcites →https://doi.org/10.1073/pnas.101064198openalex-snapshot
Structure of sortase, the transpeptidase that anchors proteins to the cell wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1073/pnas.96.22.12424openalex-snapshot
Purification and characterization of sortase, the transpeptidase that cleaves surface proteins of Staphylococcus aureus at the LPXTG motif
inferredcites →https://doi.org/10.1074/jbc.274.34.24316openalex-snapshot
Anchor Structure of Staphylococcal Surface Proteins
inferredcites →https://doi.org/10.1074/jbc.275.13.9876openalex-snapshot
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m109.022624openalex-snapshot
The Structure of the Staphylococcus aureus Sortase-Substrate Complex Reveals How the Universally Conserved LPXTG Sorting Signal Is Recognized
inferredcites →https://doi.org/10.1074/jbc.m109194200openalex-snapshot
Anchoring of Surface Proteins to the Cell Wall of Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m305245200openalex-snapshot
Sortase from Staphylococcus aureus Does Not Contain a Thiolate-Imidazolium Ion Pair in Its Active Site
inferredcites →https://doi.org/10.1074/jbc.m401374200openalex-snapshot
Crystal Structures of Staphylococcus aureus Sortase A and Its Substrate Complex
inferredcites →https://doi.org/10.1074/jbc.m506123200openalex-snapshot
Staphylococcus aureus Sortase A Transpeptidase
inferredcites →https://doi.org/10.1074/jbc.m701857200openalex-snapshot
Activation of Inhibitors by Sortase Triggers Irreversible Modification of the Active Site
inferredcites →https://doi.org/10.1074/jbc.m800974200openalex-snapshot
Mutagenesis Studies of Substrate Recognition and Catalysis in the Sortase A Transpeptidase from Staphylococcus aureus
inferredcites →https://doi.org/10.1074/jbc.m805406200openalex-snapshot
Crystal Structure of Streptococcus pyogenes Sortase A
inferredcites →https://doi.org/10.1074/jbc.m901752200openalex-snapshot
A Straight Path to Circular Proteins
inferredcites →https://doi.org/10.1086/340503openalex-snapshot
On the Role ofStaphylococcus aureusSortase and Sortase‐Catalyzed Surface Protein Anchoring in Murine Septic Arthritis
inferredcites →https://doi.org/10.1093/jac/dkh078openalex-snapshot
Effect of srtA and srtB gene expression on the virulence of Staphylococcus aureus in animal models of infection
inferredcites →https://doi.org/10.1107/s1744309108040025openalex-snapshot
Cloning, expression, purification, crystallization and preliminary X-ray analysis of the pilus-associated sortase C fromStreptococcus pneumoniae
inferredcites →https://doi.org/10.1110/ps.035733.108openalex-snapshot
Single‐step affinity purification of recombinant proteins using a self‐excising module from Neisseria meningitidis FrpC
inferredcites →https://doi.org/10.1111/j.1365-2958.1990.tb02072.xopenalex-snapshot
Conservation of a hexapeptide sequence in the anchor region of surface proteins from Gram‐positive cocci
inferredcites →https://doi.org/10.1111/j.1365-2958.2004.04117.xopenalex-snapshot
Sortases and pilin elements involved in pilus assembly of Corynebacterium diphtheriae
inferredcites →https://doi.org/10.1111/j.1365-2958.2006.05190.xopenalex-snapshot
Assembly and role of pili in group B streptococci
inferredcites →https://doi.org/10.1111/j.1365-2958.2006.05279.xopenalex-snapshot
Pili with strong attachments: Gram‐positive bacteria do it differently
inferredcites →https://doi.org/10.1111/j.1365-2958.2007.05704.xopenalex-snapshot
Streptococcus pyogenes pili promote pharyngeal cell adhesion and biofilm formation
inferredcites →https://doi.org/10.1111/j.1365-2958.2007.05968.xopenalex-snapshot
Housekeeping sortase facilitates the cell wall anchoring of pilus polymers in Corynebacterium diphtheriae
inferredcites →https://doi.org/10.1111/j.1365-2958.2008.06396.xopenalex-snapshot
Sortase‐mediated assembly and surface topology of adhesive pneumococcal pili
inferredcites →https://doi.org/10.1124/pr.107.07110openalex-snapshot
Sortase as a Target of Anti-Infective Therapy
inferredcites →https://doi.org/10.1126/science.1081147openalex-snapshot
Passage of Heme-Iron Across the Envelope of Staphylococcus aureus
inferredcites →https://doi.org/10.1126/science.285.5428.760openalex-snapshot
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
inferredcites →https://doi.org/10.1128/iai.00663-07openalex-snapshot
Relative Contributions of Enterococcus faecalis OG1RF Sortase-Encoding Genes, srtA and bps ( srtC ), to Biofilm Formation and a Murine Model of Urinary Tract Infection
inferredcites →https://doi.org/10.1128/iai.00735-08openalex-snapshot
MgrA Represses Biofilm Formation in Staphylococcus aureus
inferredcites →https://doi.org/10.1128/iai.72.5.2710-2722.2004openalex-snapshot
A Comparative Genome Analysis Identifies Distinct Sorting Pathways in Gram-Positive Bacteria
inferredcites →https://doi.org/10.1128/iai.73.8.5222-5228.2005openalex-snapshot
Importance of srtA and srtB for Growth of Bacillus anthracis in Macrophages
inferredcites →https://doi.org/10.1128/jb.184.8.2141-2147.2002openalex-snapshot
Further Evidence that a Cell Wall Precursor [C 55 -MurNAc-(Peptide)-GlcNAc] Serves as an Acceptor in a Sorting Reaction
inferredcites →https://doi.org/10.1128/jb.186.17.5865-5875.2004openalex-snapshot
A Novel Sortase, SrtC2, from Streptococcus pyogenes Anchors a Surface Protein Containing a QVPTGV Motif to the Cell Wall
inferredcites →https://doi.org/10.1128/mmbr.70.1.192-221.2006openalex-snapshot
Sortases and the Art of Anchoring Proteins to the Envelopes of Gram-Positive Bacteria
inferredcites →https://doi.org/10.1146/annurev.micro.60.080805.142256openalex-snapshot
Surface Proteins of Gram-Positive Bacteria and How They Get There
inferredcites →https://doi.org/10.1248/bpb.29.1751openalex-snapshot
Flavonols Inhibit Sortases and Sortase-Mediated Staphylococcus aureus Clumping to Fibrinogen
inferredcites →https://doi.org/10.1271/bbb.67.2477openalex-snapshot
Inhibition of Sortase, a Bacterial Surface Protein Anchoring Transpeptidase, by β-Sitosterol-3-O-glucopyranoside fromFritillaria verticillata
inferredcites →https://doi.org/10.1271/bbb.68.421openalex-snapshot
Inhibition of the Bacterial Surface Protein Anchoring Transpeptidase Sortase by Isoquinoline Alkaloids
inferredcites →https://doi.org/10.1371/journal.pone.0001409openalex-snapshot
A Potential New Pathway for Staphylococcus aureus Dissemination: The Silent Survival of S. aureus Phagocytosed by Human Monocyte-Derived Macrophages
inferredcites →https://doi.org/10.2174/138955707782110097openalex-snapshot
Recent Advances Towards New Anti-Infective Agents that Inhibit Cell Surface Protein Anchoring in Staphylococcus aureus and Other Gram-Positive Pathogens
inferredcites →https://doi.org/10.3354/dao01859openalex-snapshot
Sortase inhibitor phenyl vinyl sulfone inhibits Renibacterium salmoninarum adherence and invasion of host cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Chemical Synthesis and Semisynthesis of Lipidated Proteins
inferred← citeshttps://doi.org/10.1002/biot.201100213openalex-snapshot
Site‐specific protein labeling with amine‐containing molecules using Lactobacillus plantarum sortase
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Sortase A: A chemoenzymatic approach for the labeling of cell surfaces
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Biological and Biophysical Methods for Evaluation of Inhibitors of Sortase A in Staphylococcus aureus: An Overview
inferred← citeshttps://doi.org/10.1002/cbic.201100002openalex-snapshot
In vitro Sortagging of an Antibody Fab Fragment: Overcoming Unproductive Reactions of Sortase with Water and Lysine Side Chains
inferred← citeshttps://doi.org/10.1002/cbic.201900240openalex-snapshot
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The Complete Assessment of Small Molecule and Peptidomimetic Inhibitors of Sortase A Towards Antivirulence Treatment
inferred← citeshttps://doi.org/10.1002/cmdc.201900687openalex-snapshot
Asymmetric Disulfanylbenzamides as Irreversible and Selective Inhibitors of Staphylococcus aureus Sortase A
inferred← citeshttps://doi.org/10.1002/ddr.21599openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/pro.2168openalex-snapshot
The binding mechanism, multiple binding modes, and allosteric regulation of Staphylococcus aureus Sortase A probed by molecular dynamics simulations
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Sequence variation in the β7–β8 loop of bacterial class A sortase enzymes alters substrate selectivity
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Structures of Streptococcus pyogenes class A sortase in complex with substrate and product mimics provide key details of target recognition
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Substrate recognition in Bacillus anthracis sortase B beyond its canonical pentapeptide binding motif and use in sortase-mediated ligation
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Production of pentaglycine-fused proteins using Escherichia coli expression system without in vitro peptidase treatment
inferred← citeshttps://doi.org/10.1016/j.pep.2023.106295openalex-snapshot
A rapid procedure to generate stably transfected HEK293 suspension cells for recombinant protein manufacturing: Yield improvements, bioreactor production and downstream processing
inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105521openalex-snapshot
Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors—A review
inferred← citeshttps://doi.org/10.1016/j.plasmid.2013.09.005openalex-snapshot
Conjugative type IV secretion systems in Gram-positive bacteria
inferred← citeshttps://doi.org/10.1016/j.plasmid.2020.102516openalex-snapshot
The ever-expanding tcp conjugation locus of pCW3 from Clostridium perfringens
inferred← citeshttps://doi.org/10.1016/j.sajb.2024.04.001openalex-snapshot
In-Silico Investigation on the Inhibitory Effect of Compounds from Essential Oils of Boesenbergia rotunda on Sortase-A of Streptococcus mutans
inferred← citeshttps://doi.org/10.1016/j.sbsr.2025.100886openalex-snapshot
Advances in the detection of Sortase A activity in Staphylococcus aureus
inferred← citeshttps://doi.org/10.1016/j.tcsw.2021.100055openalex-snapshot
The divergent roles of sortase in the biology of Gram-positive bacteria
inferred← citeshttps://doi.org/10.1016/j.tcsw.2022.100077openalex-snapshot
A review on pilus assembly mechanisms in Gram-positive and Gram-negative bacteria
inferred← citeshttps://doi.org/10.1016/j.tibs.2024.04.003openalex-snapshot
Sortases: structure, mechanism, and implications for protein engineering
inferred← citeshttps://doi.org/10.1016/j.tim.2011.11.001openalex-snapshot
Optimizing future treatment of enterococcal infections: attacking the biofilm?
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b04756openalex-snapshot
Transpeptidation-Mediated Assembly of Tripartite Split Green Fluorescent Protein for Label-Free Assay of Sortase Activity
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00163openalex-snapshot
Kinetics and Optimization of the Lysine–Isopeptide Bond Forming Sortase Enzyme from Corynebacterium diphtheriae
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.0c00456openalex-snapshot
Site-Specific Bioconjugation Approaches for Enhanced Delivery of Protein Therapeutics and Protein Drug Carriers
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.3c00319openalex-snapshot
Steric-Deficient Oligoglycine Surrogates Facilitate Multivalent and Bifunctional Nanobody Synthesis via Combined Sortase A Transpeptidation and Click Chemistry
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00485openalex-snapshot
Sortase A-Mediated N-Terminal Modification of Cowpea Chlorotic Mottle Virus for Highly Efficient Cargo Loading
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.7b00087openalex-snapshot
A Novel “Prebinding” Strategy Dramatically Enhances Sortase-Mediated Coupling of Proteins to Liposomes
inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00877openalex-snapshot
Protein Cages: From Fundamentals to Advanced Applications
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00386openalex-snapshot
Chemical Biology of Sortase A Inhibition: A Gateway to Anti-infective Therapeutic Agents
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00551openalex-snapshot
Sortase A-Inhibitory Coumarins from the Folk Medicinal Plant Poncirus trifoliata
inferred← citeshttps://doi.org/10.1021/acs.jproteome.5c01021openalex-snapshot
Proteomics-Driven Molecular Mechanism of Cinnamaldehyde against Methicillin-Resistant Staphylococcus aureus Infection: Covalent Modifications of Sortase A and Aconitase
inferred← citeshttps://doi.org/10.1021/acs.orglett.5b03112openalex-snapshot
Thermodynamic Control of Isomerizations of Bicyclic Radicals: Interplay of Ring Strain and Radical Stabilization
inferred← citeshttps://doi.org/10.1021/acscatal.7b01505openalex-snapshot
Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations
inferred← citeshttps://doi.org/10.1021/acschembio.6b00998openalex-snapshot
Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans
inferred← citeshttps://doi.org/10.1021/acsomega.4c05828openalex-snapshot
Site-Specific and Fluorescently Enhanced Installation of Post-Translational Protein Modifications via Bifunctional Biarsenical Linker
inferred← citeshttps://doi.org/10.1021/acsomega.4c09900openalex-snapshot
Site-Specific Functionalization of Recombinant Spider Silk Using Enzymatic Sortase Coupling
inferred← citeshttps://doi.org/10.1021/acsptsci.3c00268openalex-snapshot
Development of a Stable Peptide–Major Histocompatibility Complex (MHC) via Sortase and Click Chemistry
inferred← citeshttps://doi.org/10.1021/acssuschemeng.1c02045openalex-snapshot
Emerging Solutions for in Vivo Biocatalyst Immobilization: Tailor-Made Catalysts for Industrial Biocatalysis
inferred← citeshttps://doi.org/10.1021/bi200844hopenalex-snapshot
Staphylococcus aureus Sortase A Contributes to the Trojan Horse Mechanism of Immune Defense Evasion with Its Intrinsic Resistance to Cys184 Oxidation
inferred← citeshttps://doi.org/10.1021/bi201591nopenalex-snapshot
Association of RrgA and RrgC into the Streptococcus pneumoniae Pilus by Sortases C-2 and C-3
inferred← citeshttps://doi.org/10.1021/bi300867topenalex-snapshot
Solution Structure of the Sortase Required for Efficient Production of Infectious Bacillus anthracis Spores
inferred← citeshttps://doi.org/10.1021/bi4016023openalex-snapshot
Sorting of LPXTG Peptides by Archetypal Sortase A: Role of Invariant Substrate Residues in Modulating the Enzyme Dynamics and Conformational Signature of a Productive Substrate
inferred← citeshttps://doi.org/10.1021/cb4001487openalex-snapshot
Probing the Recognition of Post-Translational Modifications by Combining Sortase-Mediated Ligation and Phage-Assisted Selection
inferred← citeshttps://doi.org/10.1021/ja205630gopenalex-snapshot
Directed Evolution of Sortase A Mutants with Altered Substrate Selectivity Profiles
inferred← citeshttps://doi.org/10.1021/ja302082dopenalex-snapshot
In Vitro Selection of Functional Lantipeptides
inferred← citeshttps://doi.org/10.1021/ja302354vopenalex-snapshot
Protein Thioester Synthesis Enabled by Sortase
inferred← citeshttps://doi.org/10.1021/ol4002174openalex-snapshot
New Polyaromatic Metabolites from a Marine-Derived Fungus Penicillium sp.
inferred← citeshttps://doi.org/10.1021/ol500592mopenalex-snapshot
Synthesis of α-Diketones from Alkylaryl- and Diarylalkynes Using Mercuric Salts
inferred← citeshttps://doi.org/10.1038/ijos.2016.58openalex-snapshot
In silico identification of potential inhibitors targeting Streptococcus mutans sortase A
inferred← citeshttps://doi.org/10.1038/nrmicro2520openalex-snapshot
Architects at the bacterial surface — sortases and the assembly of pili with isopeptide bonds
inferred← citeshttps://doi.org/10.1038/s41417-021-00308-6openalex-snapshot
Streptococcal bacterial components in cancer therapy
inferred← citeshttps://doi.org/10.1038/s41467-025-63819-yopenalex-snapshot
Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A
inferred← citeshttps://doi.org/10.1038/s41557-025-01871-3openalex-snapshot
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini
inferred← citeshttps://doi.org/10.1038/s41598-018-34752-6openalex-snapshot
Conversion of an amide to a high-energy thioester by Staphylococcus aureus sortase A is powered by variable binding affinity for calcium
inferred← citeshttps://doi.org/10.1038/srep20413openalex-snapshot
Exploration of multiple Sortase A protein conformations in virtual screening
inferred← citeshttps://doi.org/10.1039/9781839161148-00076openalex-snapshot
Designing Enzyme-responsive Biomaterials
inferred← citeshttps://doi.org/10.1039/c1cc13322eopenalex-snapshot
Sortase A-catalyzed peptide cyclization for the synthesis of macrocyclic peptides and glycopeptides
inferred← citeshttps://doi.org/10.1039/c3py01193copenalex-snapshot
Proteins as substrates for controlled radical polymerization
inferred← citeshttps://doi.org/10.1039/c5cc01816aopenalex-snapshot
Molecular basis of Streptococcus mutans sortase A inhibition by the flavonoid natural product trans-chalcone
inferred← citeshttps://doi.org/10.1039/c6nr04181gopenalex-snapshot
Highly efficient enzyme encapsulation in a protein nanocage: towards enzyme catalysis in a cellular nanocompartment mimic
inferred← citeshttps://doi.org/10.1039/c7bm00691hopenalex-snapshot
Orthogonal enzymatic reactions for rapid crosslinking and dynamic tuning of PEG–peptide hydrogels
inferred← citeshttps://doi.org/10.1039/c8ra06705hopenalex-snapshot
Broadening the scope of sortagging
inferred← citeshttps://doi.org/10.1039/d3sc01209copenalex-snapshot
Substrate-derived Sortase A inhibitors: targeting an essential virulence factor of Gram-positive pathogenic bacteria
inferred← citeshttps://doi.org/10.1042/bj20111397openalex-snapshot
The full-length Streptococcus pneumoniae major pilin RrgB crystallizes in a fibre-like structure, which presents the D1 isopeptide bond and provides details on the mechanism of pilus polymerization
inferred← citeshttps://doi.org/10.1073/pnas.1105380108openalex-snapshot
Functional genome analysis of Bifidobacterium breve UCC2003 reveals type IVb tight adherence (Tad) pili as an essential and conserved host-colonization factor
inferred← citeshttps://doi.org/10.1074/jbc.m113.508135openalex-snapshot
Specificity Determinants for Lysine Incorporation in Staphylococcus aureus Peptidoglycan as Revealed by the Structure of a MurE Enzyme Ternary Complex
inferred← citeshttps://doi.org/10.1074/jbc.m113.509273openalex-snapshot
Structural and Computational Studies of the Staphylococcus aureus Sortase B-Substrate Complex Reveal a Substrate-stabilized Oxyanion Hole
inferred← citeshttps://doi.org/10.1074/jbc.m115.647834openalex-snapshot
A Structural Snapshot of Type II Pilus Formation in Streptococcus pneumoniae
inferred← citeshttps://doi.org/10.1074/jbc.m115.670984openalex-snapshot
Structure of the Bacillus anthracis Sortase A Enzyme Bound to Its Sorting Signal
inferred← citeshttps://doi.org/10.1080/00498254.2024.2339993openalex-snapshot
Emerging conjugation strategies and protein engineering technologies aim to improve ADCs in the fight against cancer
inferred← citeshttps://doi.org/10.1080/07391102.2018.1453380openalex-snapshot
Molecular Modelling reveals the inhibition mechanism and structure–activity relationship of curcumin and its analogues to Staphylococcal aureus Sortase A
inferred← citeshttps://doi.org/10.1080/07391102.2023.2201863openalex-snapshot
Structure-based virtual screening and molecular dynamics approaches to identify new inhibitors of Staphylococcus aureus sortase A
inferred← citeshttps://doi.org/10.1080/08927014.2024.2426167openalex-snapshot
Rolling down the pilus formation of gram-positive bacteria: underlining the importance of Sortase C as a drug target
inferred← citeshttps://doi.org/10.1080/14756366.2016.1178639openalex-snapshot
Chinese herb medicine against Sortase A catalyzed transformations, a key role in gram-positive bacterial infection progress
inferred← citeshttps://doi.org/10.1080/19490976.2020.1831339openalex-snapshot
Molecular insights into probiotic mechanisms of action employed against intestinal pathogenic bacteria
inferred← citeshttps://doi.org/10.1080/21505594.2023.2171641openalex-snapshot
The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus
inferred← citeshttps://doi.org/10.1093/femsle/fny184openalex-snapshot
Characterisation of the Brochothrix thermosphacta sortase A enzyme
inferred← citeshttps://doi.org/10.1093/jac/dkt113openalex-snapshot
Genomic analysis and reconstruction of cefotaxime resistance in Streptococcus pneumoniae
inferred← citeshttps://doi.org/10.1101/2024.05.13.593989openalex-snapshot
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein C termini
inferred← citeshttps://doi.org/10.1101/710251openalex-snapshot
Molecular Insights on exquisitely Selective SrtA inhibitors towards active site loop forming open/close lid conformations in SrtA from Bacillus anthracis
inferred← citeshttps://doi.org/10.1107/s1399004715009219openalex-snapshot
Structural and biochemical analyses of aClostridium perfringenssortase D transpeptidase
inferred← citeshttps://doi.org/10.1107/s1744309111029952openalex-snapshot
Crystallization and preliminary X-ray diffraction studies of sortase A fromStreptococcus pneumoniae
inferred← citeshttps://doi.org/10.1111/1751-7915.70119openalex-snapshot
Disarming the Pathogenicity of Methicillin‐Resistant Staphylococcus aureus via Osmundacetone‐Mediated Inhibition of Sortase A
inferred← citeshttps://doi.org/10.1111/cbdd.12167openalex-snapshot
Discovery of S taphylococcus aureus Sortase A Inhibitors Using Virtual Screening and the Relaxed Complex Scheme
inferred← citeshttps://doi.org/10.1111/febs.13288openalex-snapshot
Molecular features of the sortase enzyme family
inferred← citeshttps://doi.org/10.1111/j.1365-2958.2011.07598.xopenalex-snapshot
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis
inferred← citeshttps://doi.org/10.1111/j.1365-2958.2011.07887.xopenalex-snapshot
Sortase enzymes in Gram‐positive bacteria
inferred← citeshttps://doi.org/10.1111/mmi.13935openalex-snapshot
Conserved residues are critical for Haloferax volcanii archaeosortase catalytic activity: Implications for convergent evolution of the catalytic mechanisms of non‐homologous sortases from archaea and bacteria
inferred← citeshttps://doi.org/10.1111/nyas.12006openalex-snapshot
Viable screening targets related to the bacterial cell wall
inferred← citeshttps://doi.org/10.1128/9781555817404.ch24openalex-snapshot
Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections
inferred← citeshttps://doi.org/10.1128/9781555818982.ch14openalex-snapshot
Conjugation in Gram-Positive Bacteria
inferred← citeshttps://doi.org/10.1128/9781555819316.refsopenalex-snapshot
References
inferred← citeshttps://doi.org/10.1128/aem.00926-13openalex-snapshot
The Highly Autoaggregative and Adhesive Phenotype of the Vaginal Lactobacillus plantarum Strain CMPG5300 Is Sortase Dependent
inferred← citeshttps://doi.org/10.1128/jb.01321-12openalex-snapshot
Impact of Lactobacillus plantarum Sortase on Target Protein Sorting, Gastrointestinal Persistence, and Host Immune Response Modulation
inferred← citeshttps://doi.org/10.1128/microbiolspec.plas-0004-2013openalex-snapshot
Conjugation in Gram-Positive Bacteria
inferred← citeshttps://doi.org/10.1128/microbiolspec.uti-0013-2012openalex-snapshot
Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections
inferred← citeshttps://doi.org/10.1128/mmbr.00073-15openalex-snapshot
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway
inferred← citeshttps://doi.org/10.1128/spectrum.02327-25openalex-snapshot
Targeted sortase A inhibition by novel peptidomimetic antivirulents against staphylococcal infections
inferred← citeshttps://doi.org/10.1139/cjm-2021-0093openalex-snapshot
Effects of ketamine in methicillin-resistant Staphylococcus aureus and in silico interaction with sortase A
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-19-0633openalex-snapshot
High-Throughput Generation of Bispecific Binding Proteins by Sortase A–Mediated Coupling for Direct Functional Screening in Cell Culture
inferred← citeshttps://doi.org/10.1186/1471-2164-13-141openalex-snapshot
Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient
inferred← citeshttps://doi.org/10.1186/1475-2859-10-s1-s21openalex-snapshot
The fast milk acidifying phenotype of Streptococcus thermophilus can be acquired by natural transformation of the genomic island encoding the cell-envelope proteinase PrtS
inferred← citeshttps://doi.org/10.1186/2191-0855-1-22openalex-snapshot
Analysis and application of Bacillus subtilis sortases to anchor recombinant proteins on the cell wall
inferred← citeshttps://doi.org/10.1186/s12575-021-00160-wopenalex-snapshot
Evaluation of the Function of Probiotics, Emphasizing the Role of their Binding to the Intestinal Epithelium in the Stability and their Effects on the Immune System
inferred← citeshttps://doi.org/10.1186/s12903-024-04069-0openalex-snapshot
Newly discovered clouting interplay between matrix metalloproteinases structures and novel quaternary Ammonium K21: computational and in-vivo testing
inferred← citeshttps://doi.org/10.1186/s12934-015-0385-3openalex-snapshot
In vivo polyester immobilized sortase for tagless protein purification
inferred← citeshttps://doi.org/10.1186/s12934-023-02134-xopenalex-snapshot
Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3
inferred← citeshttps://doi.org/10.1186/s12951-017-0289-yopenalex-snapshot
A versatile papaya mosaic virus (PapMV) vaccine platform based on sortase-mediated antigen coupling
inferred← citeshttps://doi.org/10.1186/s13068-016-0526-xopenalex-snapshot
Production of a functional cell wall-anchored minicellulosome by recombinant Clostridium acetobutylicum ATCC 824
inferred← citeshttps://doi.org/10.1186/s13568-018-0638-8openalex-snapshot
Engineering E. coli cell surface in order to develop a one-step purification method for recombinant proteins
inferred← citeshttps://doi.org/10.1201/b19224-12openalex-snapshot
Protease inhibitors from marine organisms
inferred← citeshttps://doi.org/10.1201/b19224-14openalex-snapshot
Marine cyanobacteria: A prolific source of antimicrobial natural products
inferred← citeshttps://doi.org/10.13005/ojc/350216openalex-snapshot
Structure-Based Discovery of Inhibitors Against MurE in Methicillin-Resistant Staphylococcus Aureus
inferred← citeshttps://doi.org/10.1371/journal.pone.0140784openalex-snapshot
Streptococcus pyogenes Sortase Mutants Are Highly Susceptible to Killing by Host Factors Due to Aberrant Envelope Physiology
inferred← citeshttps://doi.org/10.1371/journal.pone.0153373openalex-snapshot
The N-Terminal GYPSY Motif Is Required for Pilin-Specific Sortase SrtC1 Functionality in Lactobacillus rhamnosus Strain GG
inferred← citeshttps://doi.org/10.1371/journal.pone.0167763openalex-snapshot
Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal
inferred← citeshttps://doi.org/10.1371/journal.pone.0205057openalex-snapshot
Ca2+ binding induced sequential allosteric activation of sortase A: An example for ion-triggered conformational selection
inferred← citeshttps://doi.org/10.1371/journal.pone.0302717openalex-snapshot
Antibacterial activities of Miang extracts against selected pathogens and the potential of the tannin-free extracts in the growth inhibition of Streptococcus mutans
inferred← citeshttps://doi.org/10.1515/znc-2024-0270openalex-snapshot
Flavonoid derivatives from red propolis: In silico predictions of their interactions with Staphylococcus aureus sortase A and studies on their antibiofilm potential
inferred← citeshttps://doi.org/10.18174/232424openalex-snapshot
Molecular analysis of candidate probiotic effector molecules of Lactobacillus plantarum
inferred← citeshttps://doi.org/10.20381/ruor-22316openalex-snapshot
Development of Novel Chemical Probes for the Elucidation of Bacterial and Viral Pathogenesis and Mechanisms of Infection
inferred← citeshttps://doi.org/10.20535/ibb.2021.5.2.228970openalex-snapshot
Nosocomial Infections: Pathogenicity, Resistance and Novel Antimicrobials
inferred← citeshttps://doi.org/10.2174/1389203721666200212100255openalex-snapshot
Plant Virus Nanoparticles for Vaccine Applications
inferred← citeshttps://doi.org/10.22141/2224-0551.12.5.2017.109278openalex-snapshot
Етіологічна терапія бактеріальних пневмоній сьогодні та в майбутньому 3. Антибактеріальні препарати, що розробляються
inferred← citeshttps://doi.org/10.22159/ijpps.2017v9i3.16264openalex-snapshot
POTENT BIOACTIVE METABOLITES OF CASUARINA JUNGHUHNIANA MIQ. ROOTS–A THERAPEUTIC APPROACH
inferred← citeshttps://doi.org/10.2217/fmb-2019-0219openalex-snapshot
Characterization of Sortase A in Lactobacillus Acidophilus ATCC 4356 Involved in Adherence to Intestinal Cells
inferred← citeshttps://doi.org/10.32657/10356/72495openalex-snapshot
Novel imaging approaches to track the movement of proteins and small molecules within bacterial cells and biofilms
inferred← citeshttps://doi.org/10.3389/fcimb.2016.00160openalex-snapshot
Structural Insights into Substrate Recognition by Clostridium difficile Sortase
inferred← citeshttps://doi.org/10.3389/fmicb.2013.00073openalex-snapshot
Relevance and application of sortase and sortase-dependent proteins in lactic acid bacteria
inferred← citeshttps://doi.org/10.3389/fmicb.2015.00039openalex-snapshot
Archaeal membrane-associated proteases: insights on Haloferax volcanii and other haloarchaea
inferred← citeshttps://doi.org/10.3389/fmicb.2015.01031openalex-snapshot
The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition
inferred← citeshttps://doi.org/10.3389/fmicb.2017.01715openalex-snapshot
Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin
inferred← citeshttps://doi.org/10.3389/fmicb.2019.00711openalex-snapshot
Application of a Dual Internally Quenched Fluorogenic Substrate in Screening for D-Arginine Specific Proteases
inferred← citeshttps://doi.org/10.3389/fmolb.2021.804970openalex-snapshot
2-Sulfonylpyrimidines as Privileged Warheads for the Development of S. aureus Sortase A Inhibitors
inferred← citeshttps://doi.org/10.3390/gels9030230openalex-snapshot
Research Progress in Enzymatically Cross-Linked Hydrogels as Injectable Systems for Bioprinting and Tissue Engineering
inferred← citeshttps://doi.org/10.3390/ijms21228601openalex-snapshot
In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation
inferred← citeshttps://doi.org/10.3390/ijms25147727openalex-snapshot
Exploring Plant-Based Compounds as Alternatives for Targeting Enterococcus faecalis in Endodontic Therapy: A Molecular Docking Approach
inferred← citeshttps://doi.org/10.3390/md18070359openalex-snapshot
Sortase A-Inhibitory Metabolites from a Marine-Derived Fungus Aspergillus sp.
inferred← citeshttps://doi.org/10.3390/molecules21101285openalex-snapshot
Acacetin Protects Mice from Staphylococcus aureus Bloodstream Infection by Inhibiting the Activity of Sortase A
inferred← citeshttps://doi.org/10.3390/molecules21111591openalex-snapshot
Structural Analysis of Sortase A Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules28031338openalex-snapshot
Recognition Site Modifiable Macrocycle: Synthesis, Functional Group Variation and Structural Inspection
inferred← citeshttps://doi.org/10.3390/plants13243491openalex-snapshot
Comprehensive In Vitro Evaluation of Antibacterial, Antioxidant, and Computational Insights into Blepharis ciliaris (L.) B. L. Burtt from Hail Mountains, Saudi Arabia
inferred← citeshttps://doi.org/10.3390/polym10020151openalex-snapshot
Sortase-Mediated Ligation of Purely Artificial Building Blocks
inferred← citeshttps://doi.org/10.3390/toxins12110721openalex-snapshot
Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia
inferred← citeshttps://doi.org/10.3390/vaccines7020049openalex-snapshot
Increased Immunogenicity of Full-Length Protein Antigens through Sortase-Mediated Coupling on the PapMV Vaccine Platform
inferred← citeshttps://doi.org/10.4995/thesis/10251/14013openalex-snapshot
Caracterización de factores de adhesión a proteínas de la matriz extracelular en Lactobacillus casei
inferred← citeshttps://doi.org/10.5255/ukda-sn-857295openalex-snapshot
E-Drone: Interviews With NHS Practitioners About Logistics Drone Use in the NHS, 2022
inferred← citeshttps://doi.org/10.6084/m9.figshare.26603485openalex-snapshot
Additional file 1 of Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3
inferred← citeshttps://doi.org/10.6084/m9.figshare.26697710openalex-snapshot
Additional file 1 of Newly discovered clouting interplay between matrix metalloproteinases structures and novel quaternary Ammonium K21: computational and in-vivo testing
inferred← citeshttps://doi.org/10.6084/m9.figshare.26697713openalex-snapshot
Additional file 2 of Newly discovered clouting interplay between matrix metalloproteinases structures and novel quaternary Ammonium K21: computational and in-vivo testing
inferred← citeshttps://doi.org/10.70675/0756f3edz1fb5z4efez86edzb36410dd71c9openalex-snapshot
Caracterisation fonctionnelle des sortases de lactococcus lactis : de l’ancrage de protéines à la biogénèse de pili
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