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Identification of the First Diphenyl Ether Gene Cluster for Pestheic Acid Biosynthesis in Plant Endophyte Pestalotiopsis fici

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Pilzinhaltsstoffe, 25 Biosynthese der Seco‐anthrachinone Geodin und Dihydrogeodin aus Emodin
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Enzyme reactions and genes in aflatoxin biosynthesis
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Purification and characterization of emodinanthrone oxygenase from Aspergillus terreus
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Identification of the Viridicatumtoxin and Griseofulvin Gene Clusters from Penicillium aethiopicum
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Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites
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Disruption of a glutathione reductase encoding gene in Acremonium chrysogenum leads to reduction of its growth, cephalosporin production and antioxidative ability which is recovered by exogenous methionine
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Diels–Alder reaction of maldoxin with an isopropenylallene
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A Method for Prediction of the Locations of Linker Regions within Large Multifunctional Proteins, and Application to a Type I Polyketide Synthase
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13C-NMR studies on griseofulvin biosynthesis and acetate metabolism in Penicillium patulum
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Structural Perspective on Enzymatic Halogenation
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Plant antitumor agents. VI. Isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia
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Genome-Based Deletion Analysis Reveals the Prenyl Xanthone Biosynthesis Pathway in Aspergillus nidulans
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Comparative Characterization of Fungal Anthracenone and Naphthacenedione Biosynthetic Pathways Reveals an α-Hydroxylation-Dependent Claisen-like Cyclization Catalyzed by a Dimanganese Thioesterase
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Natural Products from Endophytic Microorganisms
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Concise Approach to Pupukeanane Skeleton: Synthetic Study of Chloropupukeananin
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Syntheses of Chloroisosulochrin and Isosulochrin and Biomimetic Elaboration to Maldoxin, Maldoxone, Dihydromaldoxin, and Dechlorodihydromaldoxin
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Chloropupukeananin, the First Chlorinated Pupukeanane Derivative, and Its Precursors from Pestalotiopsis fici
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Hatomarubigin E, a biosynthetic intermediate of hatomarubigins C and a substrate of HrbU O-methyltransferase
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Chromatin-level regulation of biosynthetic gene clusters
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Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels–Alder reaction and then mechanistic diversification
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The biosynthesis of phenols. Part X. Mutation and radioactive tracer studies relating to the biosynthesis of sulochrin
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568. The constitution of geodoxin, a metabolic product of Aspergillus terreus Thom
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The biosynthesis of phenols. Part XXIV. The conversion of the anthraquinone questin into the benzophenone, sulochrin, in cultures of Aspergillus terreus
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Metabolites of the higher fungi. Part 29. Maldoxin, maldoxone, dihydromaldoxin, isodihydromaldoxin and dechlorodihydromaldoxin. A spirocyclohexadienone, a depsidone and three diphenyl ethers: keys in the depsidone biosynthetic pathway from a member of the fungus genus Xylaria
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Studies in the biochemistry of micro-organisms
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The biosynthesis of phenols. 5. The relationships of some phenolic metabolites of mutants of Aspergillus terreus Thom, I.M.I. 16043
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Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis
inferredcites →https://doi.org/10.1074/jbc.270.37.21495openalex-snapshot
Molecular Cloning and Heterologous Expression of the Gene Encoding Dihydrogeodin Oxidase, a Multicopper Blue Enzyme from Aspergillus terreus
inferredcites →https://doi.org/10.1074/jbc.m101225200openalex-snapshot
Deoxysugar Methylation during Biosynthesis of the Antitumor Polyketide Elloramycin by Streptomyces olivaceus
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a121881openalex-snapshot
Purification and Properties of Dihydrogeodin Oxidase from Aspergillus terreus
inferredcites →https://doi.org/10.1093/oxfordjournals.jbchem.a122365openalex-snapshot
A Novel Anthraquinone Ring Cleavage Enzyme from Aspergillus terreus
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Contribution of Fungal Loline Alkaloids to Protection from Aphids in a Grass-Endophyte Mutualism
inferredcites →https://doi.org/10.1099/13500872-142-2-435openalex-snapshot
Taxol from Pestalotiopsis microspora, an endophytic fungus of Taxus wallachiana
inferredcites →https://doi.org/10.1111/j.1574-6968.2010.01914.xopenalex-snapshot
Absence of the aflatoxin biosynthesis gene, norA, allows accumulation of deoxyaflatoxin B1 in Aspergillus flavus cultures
inferredcites →https://doi.org/10.1126/science.8097061openalex-snapshot
Taxol and Taxane Production by Taxomyces andreanae , an Endophytic Fungus of Pacific Yew
inferredcites →https://doi.org/10.1128/aem.01743-08openalex-snapshot
Identification and Characterization of the Asperthecin Gene Cluster of Aspergillus nidulans
inferredcites →https://doi.org/10.1128/aem.02187-09openalex-snapshot
Characterization of the Aspergillus nidulans Monodictyphenone Gene Cluster
inferredcites →https://doi.org/10.1128/aem.07710-11openalex-snapshot
Genome-Based Cluster Deletion Reveals an Endocrocin Biosynthetic Pathway in Aspergillus fumigatus
inferredcites →https://doi.org/10.1128/aem.60.7.2408-2414.1994openalex-snapshot
Molecular characterization of aflR, a regulatory locus for aflatoxin biosynthesis
inferredcites →https://doi.org/10.1128/aem.64.10.3713-3717.1998openalex-snapshot
Characterization of aflJ , a Gene Required for Conversion of Pathway Intermediates to Aflatoxin
inferredcites →https://doi.org/10.1128/aem.71.12.8963-8965.2005openalex-snapshot
An Aflatoxin Biosynthesis Cluster Gene Encodes a Novel Oxidase Required for Conversion of Versicolorin A to Sterigmatocystin
inferredcites →https://doi.org/10.1128/aem.72.2.1096-1101.2006openalex-snapshot
The Aflatoxin Biosynthesis Cluster Gene, aflX , Encodes an Oxidoreductase Involved in Conversion of Versicolorin A to Demethylsterigmatocystin
inferredcites →https://doi.org/10.1128/am.30.1.26-28.1975openalex-snapshot
Emodin, a Toxic Metabolite of Aspergillus wentii Isolated from Weevil-Damaged Chestnuts
inferredcites →https://doi.org/10.1248/cpb.30.2283openalex-snapshot
Partial purification and some properties of emodin-O-methyltransferase from (+)-geodin producing strain of Aspergillus terreus.
inferredcites →https://doi.org/10.1248/cpb.31.337openalex-snapshot
Purification and characterization of dihydrogeodin oxidase from a fungal strain of Aspergillus terreus producing (+)-geodin.
inferredcites →https://doi.org/10.1515/znb-2001-0813openalex-snapshot
Chloroisosulochrin, Chloroisosulochrin Dehydrate, And Pestheic Acid, Plant Growth Regulators, Produced By Pestalotiopsis Theae
inferredcites →https://doi.org/10.3390/ijms9091717openalex-snapshot
Are the Genes nadA and norB Involved in Formation of Aflatoxin G1?
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RES-1214-1 and -2, Novel Non-peptidic Endothelin Type A Receptor Antagonists Produced by Pestalotiopsis sp.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113264zenodo-depositor-declared
Undescribed diphenyl ethers betaethrins A-I from a desert plant endophytic strain of the fungus Phoma betae A.B. Frank (Didymellaceae)
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Biosynthesis of Depsides, Depsidones, and Diphenyl Ethers from Fungi and Lichens
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Didepside Formation by the Nonreducing Polyketide Synthase Preu6 of Preussia isomera Requires Interaction of Starter Acyl Transferase and Thioesterase Domains
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Didepside Formation by the Nonreducing Polyketide Synthase Preu6 of Preussia isomera Requires Interaction of Starter Acyl Transferase and Thioesterase Domains
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Identification and engineering on the nonconserved residues of metallo‐β‐lactamase‐type thioesterase to improve the enzymatic activity
inferred← citeshttps://doi.org/10.1002/chem.202503453openalex-snapshot
A Bifunctional Cytochrome P450 Enzyme Catalyzes Hydroxylation and Aryl‐Aryl Ether Formation in the Biosynthesis of Emestrin
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Chlorinated Natural Products and Related Halogenases
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Biological control of wheat powdery mildew disease by the termite‐associated fungus Aspergillus chevalieri BYST01 and potential role of secondary metabolites
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Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134
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Piperazine ring formation by a single-module NRPS and cleavage by an α-KG-dependent nonheme iron dioxygenase in brasiliamide biosynthesis
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Mining an O-methyltransferase for de novo biosynthesis of physcion in Aspergillus nidulans
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Improved pestalotiollide B production by deleting competing polyketide synthase genes in Pestalotiopsis microspora
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A comprehensive catalogue of polyketide synthase gene clusters in lichenizing fungi
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Recent advances in the discovery of bioactive metabolites from Pestalotiopsis
inferred← citeshttps://doi.org/10.1007/s11427-017-9068-4openalex-snapshot
COP9 signalosome subunit PfCsnE regulates secondary metabolism and conidial formation in Pestalotiopsis fici
inferred← citeshttps://doi.org/10.1007/s11427-018-9511-7openalex-snapshot
Strategy for efficient cloning of biosynthetic gene clusters from fungi
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The Lichen Flavin-Dependent Halogenase, DnHal: Identification, Heterologous Expression and Functional Characterization
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Secondary metabolite gene clusters arrangement and conservation within the genome of Stemphylium lycopersici codes the pathways for the synthesis of specific and non-specific toxins
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Chemistry and biology of marine-derived Trichoderma metabolites
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Polyketides with potential bioactivities from the mangrove-derived fungus Talaromyces sp. WHUF0362
inferred← citeshttps://doi.org/10.1016/b978-0-12-409547-2.14780-8openalex-snapshot
Fungal Non-Reducing Polyketide Synthases
inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.08.047openalex-snapshot
Structural diversification of natural substrates modified by the O-methyltransferase AurJ from Fusarium Graminearum
inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117371openalex-snapshot
Barceloneic acid A enables Metarhizium robertsii to establish parasitism in insects and mutualism in plants by inhibiting farnesyltransferase
inferred← citeshttps://doi.org/10.1016/j.fgb.2015.03.010openalex-snapshot
The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici
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From taxonomy and industry to genetics: Fungal Biology in China
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AcstuA , which encodes an APSES transcription regulator, is involved in conidiation, cephalosporin biosynthesis and cell wall integrity of Acremonium chrysogenum
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Genomic characterization of Parengyodontium americanum sp. nov
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.149057openalex-snapshot
Identification and functional characterization of a regioselective O-methyltransferase involved in physcion biosynthesis in Polygonum cuspidatum
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Antioxidative phenolic compounds from a marine-derived fungus Aspergillus versicolor
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Diaporthols A and B: Bioactive diphenyl ether derivatives from an endophytic fungus Diaporthe sp.
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Microbial production of the plant-derived fungicide physcion
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Characterization and Structural Analysis of Emodin-O-Methyltransferase from Aspergillus terreus
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Naturally Occurring Asterric Acid Analogs: Chemistry and Biology
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Shielding Effects of Aromatic (Indole) Ring for Structural Analysis
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Lichen Biosynthetic Gene Clusters Part II: Homology Mapping Suggests a Functional Diversity
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Polyketide Production of Pestaloficiols and Macrodiolide Ficiolides Revealed by Manipulations of Epigenetic Regulators in an Endophytic Fungus
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Biosynthesis of Diphenyl Ethers in Fungi
inferred← citeshttps://doi.org/10.1021/acschembio.7b01059openalex-snapshot
Characterization of a Prenyltransferase for Iso-A82775C Biosynthesis and Generation of New Congeners of Chloropestolides
inferred← citeshttps://doi.org/10.1021/jacs.2c02813openalex-snapshot
Diaryl Ether Formation by a Versatile Thioesterase Domain
inferred← citeshttps://doi.org/10.1038/s41598-018-28473-zopenalex-snapshot
Genome Sequencing and analyses of Two Marine Fungi from the North Sea Unraveled a Plethora of Novel Biosynthetic Gene Clusters
inferred← citeshttps://doi.org/10.1039/9781837677436-00367openalex-snapshot
Halogenating Enzymes in Chemoenzymatic Synthesis
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Enzymatic dimerization in the biosynthetic pathway of microbial natural products
inferred← citeshttps://doi.org/10.1039/d2np00040gopenalex-snapshot
The ‘emodin family’ of fungal natural products–amalgamating a century of research with recent genomics-based advances
inferred← citeshttps://doi.org/10.1039/d4sc01435aopenalex-snapshot
Novel fungal diphenyl ether biosynthetic gene clusters encode a promiscuous oxidase for elevated antibacterial activities
inferred← citeshttps://doi.org/10.1039/d6ob01032fopenalex-snapshot
Heterologous expression of the Metarhizium anisopliae barc gene cluster reveals a diphenyl ether-to-xanthene transformation in barceloneic acid biosynthesis
inferred← citeshttps://doi.org/10.1055/a-1203-0623openalex-snapshot
Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum
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Linking secondary metabolites to gene clusters through genome sequencing of six diverse Aspergillus species
inferred← citeshttps://doi.org/10.1101/2021.01.29.428829openalex-snapshot
The Functional Order (FunOrder) tool – Identification of essential biosynthetic genes through computational molecular co-evolution
inferred← citeshttps://doi.org/10.1111/1462-2920.14473openalex-snapshot
A new regulator RsdA mediating fungal secondary metabolism has a detrimental impact on asexual development in Pestalotiopsis fici
inferred← citeshttps://doi.org/10.1111/mmi.14281openalex-snapshot
Two transcription factors cooperatively regulate DHN melanin biosynthesis and development in Pestalotiopsis fici
inferred← citeshttps://doi.org/10.1128/aem.03168-15openalex-snapshot
A Fivefold Parallelized Biosynthetic Process Secures Chlorination of Armillaria mellea (Honey Mushroom) Toxins
inferred← citeshttps://doi.org/10.1186/s12864-014-1190-9openalex-snapshot
Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products
inferred← citeshttps://doi.org/10.1186/s12864-019-5567-7openalex-snapshot
Variation in secondary metabolite production potential in the Fusarium incarnatum-equiseti species complex revealed by comparative analysis of 13 genomes
inferred← citeshttps://doi.org/10.1360/n052017-00122openalex-snapshot
COP9信号小体亚基CsnE对无花果拟盘多毛孢生长发育和次级代谢的影响
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FunOrder: A robust and semi-automated method for the identification of essential biosynthetic genes through computational molecular co-evolution
inferred← citeshttps://doi.org/10.1371/journal.pone.0227396openalex-snapshot
Genome mining of the citrus pathogen Elsinoë fawcettii; prediction and prioritisation of candidate effectors, cell wall degrading enzymes and secondary metabolite gene clusters
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Diphenyl Ethers: Isolation, Bioactivities and Biosynthesis
inferred← citeshttps://doi.org/10.3389/fbioe.2021.649906openalex-snapshot
Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts
inferred← citeshttps://doi.org/10.3389/fmicb.2022.819086openalex-snapshot
Cloning and Functional Characterization of the Polyketide Synthases Based on Genome Mining of Preussia isomera XL-1326
inferred← citeshttps://doi.org/10.3390/antibiotics11101304openalex-snapshot
Halogenase-Targeted Genome Mining Leads to the Discovery of (±) Pestalachlorides A1a, A2a, and Their Atropisomers
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Combination Strategy of Genetic Dereplication and Manipulation of Epigenetic Regulators Reveals a Novel Compound from Plant Endophytic Fungus
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An Optimized and Efficient CRISPR/Cas9 System for the Endophytic Fungus Pestalotiopsis fici
inferred← citeshttps://doi.org/10.3390/molecules25030470openalex-snapshot
Pestalotiones A–D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae
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Halogenation in Fungi: What Do We Know and What Remains to Be Discovered?
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Pestalotiopsis Diversity: Species, Dispositions, Secondary Metabolites, and Bioactivities
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Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products
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Activation of cryptic biosynthetic gene clusters by fungal artificial chromosomes to produce novel secondary metabolites
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A CRISPR/Cas9 Cleavage System for Capturing Fungal Secondary Metabolite Gene Clusters
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Analyses de lichens par spectrométrie de masse : déréplication et histolocalisation
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Maîtrise du risque aflatoxique : utilisation d'extraits naturels et mise en évidence de leurs mécanismes d'action
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Elucidation of the interaction mechanisms between Geotrichum candidum and Fusarium spp for a biocontrol optimization to reduce T-2 toxin contamination in the brewing process
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