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Gambogenic acid inhibits proliferation and ferroptosis by targeting the miR‐1291/FOXA2 and AMPKα/SLC7A11/GPX4 axis in colorectal cancer
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1007/s13238-020-00789-5openalex-snapshot
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
inferredcites →https://doi.org/10.1016/j.abb.2011.08.002openalex-snapshot
AMP-activated protein kinase modulates the gene expression of aquaporin 9 via forkhead box a2
inferredcites →https://doi.org/10.1016/j.biopha.2022.113636openalex-snapshot
Gambogenic acid antagonizes the expression and effects of long non-coding RNA NEAT1 and triggers autophagy and ferroptosis in melanoma
inferredcites →https://doi.org/10.1016/j.canlet.2012.03.004openalex-snapshot
Gambogenic acid induces G1 arrest via GSK3β-dependent cyclin D1 degradation and triggers autophagy in lung cancer cells
inferredcites →https://doi.org/10.1016/j.canlet.2020.02.015openalex-snapshot
Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs
inferredcites →https://doi.org/10.1016/j.cell.2012.03.042openalex-snapshot
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2018.09.043openalex-snapshot
The development of the concept of ferroptosis
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2021.09.008openalex-snapshot
Endoplasmic reticulum stress-mediated autophagy activation is involved in cadmium-induced ferroptosis of renal tubular epithelial cells
inferredcites →https://doi.org/10.1016/j.freeradbiomed.2023.05.008openalex-snapshot
Erianin inhibits the growth and metastasis through autophagy-dependent ferroptosis in KRASG13D colorectal cancer
inferredcites →https://doi.org/10.1016/j.isci.2020.101880openalex-snapshot
Spermatogonial Gene Networks Selectively Couple to Glutathione and Pentose Phosphate Metabolism but Not Cysteine Biosynthesis
inferredcites →https://doi.org/10.1016/j.jid.2018.01.023openalex-snapshot
Regulation of Cancer Stem Cell Self-Renewal by HOXB9 Antagonizes Endoplasmic Reticulum Stress-Induced Melanoma Cell Apoptosis via the miR-765–FOXA2 Axis
inferredcites →https://doi.org/10.1016/j.jid.2021.05.025openalex-snapshot
CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway
inferredcites →https://doi.org/10.1016/j.molcel.2008.03.003openalex-snapshot
AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
inferredcites →https://doi.org/10.1016/j.phymed.2020.153306openalex-snapshot
Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1α/JNK
inferredcites →https://doi.org/10.1016/j.taap.2020.115110openalex-snapshot
Gambogenic acid induces ferroptosis in melanoma cells undergoing epithelial-to-mesenchymal transition
inferredcites →https://doi.org/10.1016/j.tox.2021.153048openalex-snapshot
Resveratrol protected acrolein-induced ferroptosis and insulin secretion dysfunction via ER-stress- related PERK pathway in MIN6 cells
inferredcites →https://doi.org/10.1016/s0891-5849(02)00842-0openalex-snapshot
Ferritin, iron homeostasis, and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.
inferredcites →https://doi.org/10.1016/s1470-2045(20)30110-8openalex-snapshot
Camrelizumab versus investigator's choice of chemotherapy as second-line therapy for advanced or metastatic oesophageal squamous cell carcinoma (ESCORT): a multicentre, randomised, open-label, phase 3 study
inferredcites →https://doi.org/10.1038/s41418-022-01096-8openalex-snapshot
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
inferredcites →https://doi.org/10.1038/s41419-020-2256-zopenalex-snapshot
VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis
inferredcites →https://doi.org/10.1038/s41419-022-05158-0openalex-snapshot
Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes
inferredcites →https://doi.org/10.1038/s41571-020-00462-0openalex-snapshot
Broadening horizons: the role of ferroptosis in cancer
inferredcites →https://doi.org/10.1038/s41573-020-0068-6openalex-snapshot
RAS-targeted therapies: is the undruggable drugged?
inferredcites →https://doi.org/10.1038/s41575-019-0189-8openalex-snapshot
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
inferredcites →https://doi.org/10.1038/s43018-021-00184-xopenalex-snapshot
The metabolic landscape of RAS-driven cancers from biology to therapy
inferredcites →https://doi.org/10.1042/bcj20200984openalex-snapshot
FoxA2 and RNA Pol II mediate human islet amyloid polypeptide turnover in ER-stressed pancreatic β-cells
inferredcites →https://doi.org/10.1073/pnas.2017152117openalex-snapshot
Oncogenic activation of PI3K-AKT-mTOR signaling suppresses ferroptosis via SREBP-mediated lipogenesis
inferredcites →https://doi.org/10.1080/15384101.2015.1087623openalex-snapshot
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells
inferredcites →https://doi.org/10.1080/15548627.2020.1810918openalex-snapshot
Ferroptosis: machinery and regulation
inferredcites →https://doi.org/10.1080/2162402x.2020.1731072openalex-snapshot
A non-linear association between blood tumor mutation burden and prognosis in NSCLC patients receiving atezolizumab
inferredcites →https://doi.org/10.1080/2162402x.2021.1987636openalex-snapshot
Identification of pyroptosis-related subtypes, the development of a prognosis model, and characterization of tumor microenvironment infiltration in colorectal cancer
inferredcites →https://doi.org/10.1124/dmd.113.052092openalex-snapshot
Small Nucleolar RNA-Derived MicroRNA hsa-miR-1291 Modulates Cellular Drug Disposition through Direct Targeting of ABC Transporter ABCC1
inferredcites →https://doi.org/10.1146/annurev-biochem-060308-103103openalex-snapshot
Regulation of mRNA Translation and Stability by microRNAs
inferredcites →https://doi.org/10.1155/2020/1675613openalex-snapshot
IMCA Induces Ferroptosis Mediated by SLC7A11 through the AMPK/mTOR Pathway in Colorectal Cancer
inferredcites →https://doi.org/10.1158/2159-8290.cd-19-1500openalex-snapshot
The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis
inferredcites →https://doi.org/10.1186/s12935-019-0810-5openalex-snapshot
PGC-1β cooperating with FOXA2 inhibits proliferation and migration of breast cancer cells
inferredcites →https://doi.org/10.1186/s12943-022-01616-7openalex-snapshot
Wnt signaling in colorectal cancer: pathogenic role and therapeutic target
inferredcites →https://doi.org/10.1242/dmm.047662openalex-snapshot
miRNA interplay: mechanisms and consequences in cancer
inferredcites →https://doi.org/10.1248/bpb.b21-00511openalex-snapshot
Gambogenic Acid Inhibits Basal Autophagy of Drug-Resistant Hepatoma Cells and Improves Its Sensitivity to Adriamycin
inferredcites →https://doi.org/10.1261/rna.036483.112openalex-snapshot
MicroRNA-1291-mediated silencing of IRE1α enhances Glypican-3 expression
inferredcites →https://doi.org/10.2147/jir.s389290openalex-snapshot
Ferroptosis: Reviewing CRC with the Third Eye
inferredcites →https://doi.org/10.3389/fcell.2021.736350openalex-snapshot
Gambogenic Acid Induces Endoplasmic Reticulum Stress in Colorectal Cancer via the Aurora A Pathway
inferredcites →https://doi.org/10.3390/ijms20246249openalex-snapshot
Deciphering miRNAs’ Action through miRNA Editing
inferredcites →https://doi.org/10.3892/ijo.2022.5303openalex-snapshot
Functional assessment of miR‑1291 in colon cancer cells
inferredcites →https://doi.org/10.3978/j.issn.2078-6891.2012.030openalex-snapshot
Colorectal carcinoma: Pathologic aspects.
inferredcites →https://doi.org/10.7150/thno.44877openalex-snapshot
A novel miR-1291-ERRα-CPT1C axis modulates tumor cell proliferation, metabolism and tumorigenesis
inferredcites →https://doi.org/10.7554/elife.02523openalex-snapshot
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4844849openalex-extracted
Identification of Ferroptosis-Inducers Targeting Glutathione Peroxidase 4 from Herbal Compounds Using Comprehensive Computational Approaches
inferred← citeshttps://doi.org/10.1002/cbin.70018openalex-snapshot
Induction of Ferroptosis by Shikonin in Gastric Cancer via the DLEU1/mTOR/GPX4 Axis
inferred← citeshttps://doi.org/10.1002/ptr.70337openalex-snapshot
Apigenin Inhibits Triple‐Negative Breast Cancer Growth by Dual Targeting GPX4 / SLC7A11 ‐Mediated Ferroptosis and PKM2 / GLUT1 ‐Mediated Aerobic Glycolysis
inferred← citeshttps://doi.org/10.1007/s00210-025-04324-3openalex-snapshot
NRF2 as a ferroptosis gatekeeper in colorectal cancer: implications for therapy
inferred← citeshttps://doi.org/10.1007/s10495-025-02240-8openalex-snapshot
Autophagy regulation of pyroptosis and ferroptosis: a new strategy for colorectal cancer treatment
inferred← citeshttps://doi.org/10.1007/s12010-025-05256-7openalex-snapshot
Relationship Between Activating Transcription Factor 3 and Forkhead Box Protein A2 in Spinal Cord Injury and the Underlying Mechanism
inferred← citeshttps://doi.org/10.1007/s12013-024-01287-9openalex-snapshot
Molecular Mechanisms of Tumorgenesis and Metastasis of Long Non-coding RNA (lncRNA) NEAT1 in Human Solid Tumors; An Update
inferred← citeshttps://doi.org/10.1016/j.abb.2024.110231openalex-snapshot
Computational discovery of novel GPX4 inhibitors from herbal sources as potential ferroptosis inducers in cancer therapy
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.153905openalex-snapshot
Curcumin and its nano formulation inhibit proliferation and FGF21 expression in esophageal squamous cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.biopha.2026.119748openalex-snapshot
Iron biomarkers for prognosis, diagnosis, and therapeutic insight in colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116255openalex-snapshot
Neogambogic acid promotes M-MDSC differentiation into M1 macrophages to inhibit peritoneal metastasis of colorectal cancer
inferred← citeshttps://doi.org/10.1016/j.redox.2026.104222openalex-snapshot
Limited Nrf2 activation and heterogeneous thyroidal effects in a 424-compound multi-assay screen call for rigorous testing of purported antioxidant and health-promoting supplements
inferred← citeshttps://doi.org/10.1021/acsami.5c19528openalex-snapshot
Self-Assembly Albumin Nanoparticles for Improved Anticancer Effect and Reinforced Ferroptosis in Metastatic Colorectal Cancer Treatment
inferred← citeshttps://doi.org/10.1039/d4tb02701aopenalex-snapshot
Zwitterionic polymer-coated magnetic nanoparticle induced chemotherapy and ferroptosis for triple-negative breast cancer therapy
inferred← citeshttps://doi.org/10.1055/a-2258-6663openalex-snapshot
Unveiling Gambogenic Acid as a Promising Antitumor Compound: A Review
inferred← citeshttps://doi.org/10.1089/ars.2024.0807openalex-snapshot
Small Molecules Targeting Non-Coding RNAs Regulating Ferroptosis: New Opportunities in Precision Cancer Therapy
inferred← citeshttps://doi.org/10.1111/cpr.70065openalex-snapshot
Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications
inferred← citeshttps://doi.org/10.1142/s0192415x25500363openalex-snapshot
Gambogic Acid Induces Ferroptosis via miR-1291/FOXA2 Axis in Gastric Cancer
inferred← citeshttps://doi.org/10.1186/s13062-024-00530-wopenalex-snapshot
RETRACTED ARTICLE: Regulating ferroptosis by non-coding RNAs in hepatocellular carcinoma
inferred← citeshttps://doi.org/10.14670/hh-18-793openalex-snapshot
ACAT2 negatively modulated by FOXA2 suppresses ferroptosis to expedite the aggressive phenotypes of endometrial cancer cells.
inferred← citeshttps://doi.org/10.2147/ijn.s604452openalex-snapshot
Microenvironment-Activated Fe-MOF Nanoplatform Enables Controlled Doxorubicin Release and Ferroptosis-Associated Oxidative Damage in MCF-7 Breast Cancer Cells
inferred← citeshttps://doi.org/10.3389/fmed.2024.1478153openalex-snapshot
Regulation of ferroptosis in osteoarthritis and osteoarthritic chondrocytes by typical MicroRNAs in chondrocytes
inferred← citeshttps://doi.org/10.3389/fonc.2026.1854448openalex-snapshot
FOXA2 in cancer: from fundamental biology to clinical translation
inferred← citeshttps://doi.org/10.3389/fphar.2024.1374722openalex-snapshot
Targeting ferroptosis regulators by natural products in colorectal cancer
inferred← citeshttps://doi.org/10.3390/antiox13030334openalex-snapshot
Beyond Mortality: Exploring the Influence of Plant Phenolics on Modulating Ferroptosis—A Systematic Review
inferred← citeshttps://doi.org/10.3390/biology14010061openalex-snapshot
Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma
inferred← citeshttps://doi.org/10.3390/cancers15174342openalex-snapshot
MiR-148a-3p Promotes Colorectal Cancer Cell Ferroptosis by Targeting SLC7A11
inferred← citeshttps://doi.org/10.3390/ph18030374openalex-snapshot
Gambogenic Acid Suppresses Malignant Progression of Non-Small Cell Lung Cancer via GCH1-Mediated Ferroptosis
inferred← citeshttps://doi.org/10.3748/wjg.v31.i26.106113openalex-snapshot
Chinese medicine monomers for hepatocellular carcinoma: New ideas related to autophagy
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