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Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Molekularer Mechanismus der Inhibierung des Komplexes aus humanem Hsp90 und humanem Cdc37, einem Kinomchaperon‐Cochaperon‐System, durch das Triterpen Celastrol
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Molecular Mechanism of Inhibition of the Human Protein Complex Hsp90–Cdc37, a Kinome Chaperone–Cochaperone, by Triterpene Celastrol
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Quantum Mechanical Calculation of NMR Parameters in the Stereostructural Determination of Natural Products
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Computational NMR Methods in the Stereochemical Analysis of Organic Compounds: Are Proton or Carbon NMR Chemical Shift Data More Discriminating?
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Cytotoxic Terpenoids from Turraea pubescens
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A new cytotoxic limonoid from Odontadenia macrantha from the Suriname rainforest
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Complete assignments of the 1H and 13C NMR spectra of 15 limonoids
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Comparison of different theory models and basis sets in the calculation of13C NMR chemical shifts of natural products
inferredcites →https://doi.org/10.1006/jmbi.2000.4157openalex-snapshot
C-terminal regions of Hsp90 are important for trapping the nucleotide during the ATPase cycle 1 1Edited by R. Huber
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Targeting multiple signal transduction pathways through inhibition of Hsp90
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Proteasome inhibitors in cancer therapy
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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
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A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry
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Limonoids and protolimonoids from the fruits of Phellodendron amurense
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Tetranortriterpenoids—VII
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The role of heat shock proteins in cancer
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Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators
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Design, synthesis and biological evaluation of biphenylamide derivatives as Hsp90 C-terminal inhibitors
inferredcites →https://doi.org/10.1016/j.phytochem.2004.08.010openalex-snapshot
Phragmalin limonoids from Chukrasia tabularis
inferredcites →https://doi.org/10.1016/j.phytochem.2004.08.041openalex-snapshot
Limonoids from Cedrela sinensis
inferredcites →https://doi.org/10.1016/j.phytochem.2007.12.015openalex-snapshot
Limonoids from the stem bark of Cedrela odorata
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Rings D-seco and B,D-seco tetranortriterpenoids from root bark of Entandrophragma angolense
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Structural characterization of tetranortriterpenes from Pseudrocedrela kotschyi and Trichilia emetica and study of their activity towards the chaperone Hsp90
inferredcites →https://doi.org/10.1016/j.tet.2003.08.033openalex-snapshot
Swietenialides, novel ring D opened phragmalin limonoid orthoesters from Swietenia mahogani JACQ.
inferredcites →https://doi.org/10.1016/j.tet.2005.08.044openalex-snapshot
Triterpenoids from Cedrela sinensis
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Androstane and pregnane 2β,19-hemiketal steroids from Trichilia claussenii
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Delevoyin C, a tetranortriterpenoid from Entandrophragma delevoyi
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(−)-Epigallocatechin-3-gallate Is a Novel Hsp90 Inhibitor
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LC-MS and NMR Techniques for the Analysis and Characterization of Citrus Limonoids
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Natural Products as Chemical Probes
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Elucidation of the Hsp90 C-Terminal Inhibitor Binding Site
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Exploiting Conformational Dynamics in Drug Discovery: Design of C-Terminal Inhibitors of Hsp90 with Improved Activities
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Determination of Relative Configuration in Organic Compounds by NMR Spectroscopy and Computational Methods
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The missing term in effective pair potentials
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Citrus Limonoids and Their Semisynthetic Derivatives as Antifeedant Agents Against Spodoptera frugiperda Larvae. A Structure−Activity Relationship Study
inferredcites →https://doi.org/10.1021/jf049474yopenalex-snapshot
New Mosquito Larvicidal Tetranortriterpenoids from Turraea wakefieldii and Turraea floribunda
inferredcites →https://doi.org/10.1021/jf071797hopenalex-snapshot
Citrus Limonoids: Analysis, Bioactivity, and Biomedical Prospects
inferredcites →https://doi.org/10.1021/jm050540copenalex-snapshot
Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects
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A Chemical–Biological Study Reveals C9-type Iridoids as Novel Heat Shock Protein 90 (Hsp90) Inhibitors
inferredcites →https://doi.org/10.1021/jm501893kopenalex-snapshot
9 H -Purine Scaffold Reveals Induced-Fit Pocket Plasticity of the BRD9 Bromodomain
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Sesterterpenes as Tubulin Tyrosine Ligase Inhibitors. First Insight of Structure−Activity Relationships and Discovery of New Lead
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Three New Tetranortriterpenoids from Neem Seed Oil
inferredcites →https://doi.org/10.1038/leu.2014.300openalex-snapshot
Anti-tumor activities of selective HSP90α/β inhibitor, TAS-116, in combination with bortezomib in multiple myeloma
inferredcites →https://doi.org/10.1038/nature04716openalex-snapshot
Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex
inferredcites →https://doi.org/10.1038/nprot.2014.042openalex-snapshot
A guide to small-molecule structure assignment through computation of (1H and 13C) NMR chemical shifts
inferredcites →https://doi.org/10.1039/c4cc07284gopenalex-snapshot
N-terminal and C-terminal modulation of Hsp90 produce dissimilar phenotypes
inferredcites →https://doi.org/10.1039/c4cc10074copenalex-snapshot
Targeting the Hsp90 C-terminal domain by the chemically accessible dihydropyrimidinone scaffold
inferredcites →https://doi.org/10.1039/c5cc03245hopenalex-snapshot
The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90
inferredcites →https://doi.org/10.1055/s-0035-1546251openalex-snapshot
Hsp90 Activity Modulation by Plant Secondary Metabolites
inferredcites →https://doi.org/10.1074/jbc.270.13.7288openalex-snapshot
Transient Interaction of Hsp90 with Early Unfolding Intermediates of Citrate Synthase
inferredcites →https://doi.org/10.1074/jbc.270.24.14412openalex-snapshot
Structural Organization of Procaryotic and Eucaryotic Hsp90. INFLUENCE OF DIVALENT CATIONS ON STRUCTURE AND FUNCTION
inferredcites →https://doi.org/10.1074/jbc.m105568200openalex-snapshot
A Nucleotide-dependent Molecular Switch Controls ATP Binding at the C-terminal Domain of Hsp90
inferredcites →https://doi.org/10.1074/jbc.m512406200openalex-snapshot
Modulation of Chaperone Function and Cochaperone Interaction by Novobiocin in the C-terminal Domain of Hsp90
inferredcites →https://doi.org/10.1074/jbc.m800046200openalex-snapshot
Intra- and Intermonomer Interactions Are Required to Synergistically Facilitate ATP Hydrolysis in Hsp90
inferredcites →https://doi.org/10.1080/10286020801948367openalex-snapshot
Two new pregnanes fromAglaia perviridisHiern
inferredcites →https://doi.org/10.1111/j.1747-0285.2005.00327.xopenalex-snapshot
Use of an Induced Fit Receptor Structure in Virtual Screening
inferredcites →https://doi.org/10.1158/0008-5472.can-05-2029openalex-snapshot
Formation of 17-Allylamino-Demethoxygeldanamycin (17-AAG) Hydroquinone by NAD(P)H:Quinone Oxidoreductase 1: Role of 17-AAG Hydroquinone in Heat Shock Protein 90 Inhibition
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-1000openalex-snapshot
Hsp90 Molecular Chaperone Inhibitors: Are We There Yet?
inferredcites →https://doi.org/10.1158/1535-7163.mct-07-0484openalex-snapshot
A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
inferredcites →https://doi.org/10.1186/1475-2867-13-11openalex-snapshot
Targeted inhibition of heat shock protein 90 disrupts multiple oncogenic signaling pathways, thus inducing cell cycle arrest and programmed cell death in human urinary bladder cancer cell lines
inferredcites →https://doi.org/10.1248/bpb.29.191openalex-snapshot
Limonoids: Overview of Significant Bioactive Triterpenes Distributed in Plants Kingdom
inferredcites →https://doi.org/10.1371/journal.pone.0019961openalex-snapshot
The Hexameric Structures of Human Heat Shock Protein 90
inferredcites →https://doi.org/10.2174/156802609789895728openalex-snapshot
Update on Hsp90 Inhibitors in Clinical Trial
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Telomerase as a Target for Cancer Immunotherapy
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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