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Explainability and causability in digital pathology

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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamadermatol.2019.1735openalex-snapshot
Association Between Surgical Skin Markings in Dermoscopic Images and Diagnostic Performance of a Deep Learning Convolutional Neural Network for Melanoma Recognition
inferredcites →https://doi.org/10.1002/path.5331openalex-snapshot
Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association
inferredcites →https://doi.org/10.1002/path.5662openalex-snapshot
Independent real‐world application of a clinical‐grade automated prostate cancer detection system
inferredcites →https://doi.org/10.1002/path.5898openalex-snapshot
Artificial intelligence to identify genetic alterations in conventional histopathology
inferredcites →https://doi.org/10.1002/path.5966openalex-snapshot
The state of the art for artificial intelligence in lung digital pathology
inferredcites →https://doi.org/10.1002/widm.1312openalex-snapshot
Causability and explainability of artificial intelligence in medicine
inferredcites →https://doi.org/10.1007/978-3-030-50402-1_4openalex-snapshot
Survey of XAI in Digital Pathology
inferredcites →https://doi.org/10.1007/978-3-030-65965-3_28openalex-snapshot
Interpretable Machine Learning – A Brief History, State-of-the-Art and Challenges
inferredcites →https://doi.org/10.1007/978-3-030-93736-2_33openalex-snapshot
The Next Frontier: AI We Can Really Trust
inferredcites →https://doi.org/10.1007/978-3-030-99838-7_12openalex-snapshot
Digital and Computational Pathology: A Specialty Reimagined
inferredcites →https://doi.org/10.1007/978-3-031-04083-2_2openalex-snapshot
Explainable AI Methods - A Brief Overview
inferredcites →https://doi.org/10.1007/s40708-016-0038-2openalex-snapshot
Interactive knowledge discovery with the doctor-in-the-loop: a practical example of cerebral aneurysms research
inferredcites →https://doi.org/10.1016/j.compbiomed.2020.103865openalex-snapshot
Concept attribution: Explaining CNN decisions to physicians
inferredcites →https://doi.org/10.1016/j.future.2022.03.009openalex-snapshot
The explainability paradox: Challenges for xAI in digital pathology
inferredcites →https://doi.org/10.1016/j.ijhcs.2022.102839openalex-snapshot
Who needs explanation and when? Juggling explainable AI and user epistemic uncertainty
inferredcites →https://doi.org/10.1016/j.inffus.2021.11.003openalex-snapshot
Counterfactuals and causability in explainable artificial intelligence: Theory, algorithms, and applications
inferredcites →https://doi.org/10.1016/j.inffus.2021.11.008openalex-snapshot
CLEVR-XAI: A benchmark dataset for the ground truth evaluation of neural network explanations
inferredcites →https://doi.org/10.1016/j.media.2019.02.012openalex-snapshot
Predicting breast tumor proliferation from whole-slide images: The TUPAC16 challenge
inferredcites →https://doi.org/10.1016/j.nbt.2022.05.002openalex-snapshot
Explainability and causability for artificial intelligence-supported medical image analysis in the context of the European In Vitro Diagnostic Regulation
inferredcites →https://doi.org/10.1016/s2589-7500(19)30123-2openalex-snapshot
A comparison of deep learning performance against health-care professionals in detecting diseases from medical imaging: a systematic review and meta-analysis
inferredcites →https://doi.org/10.1038/s41374-020-00514-0openalex-snapshot
Artificial intelligence and computational pathology
inferredcites →https://doi.org/10.1038/s41379-022-01147-yopenalex-snapshot
Recommendations on compiling test datasets for evaluating artificial intelligence solutions in pathology
inferredcites →https://doi.org/10.1038/s41467-019-08987-4openalex-snapshot
Unmasking Clever Hans predictors and assessing what machines really learn
inferredcites →https://doi.org/10.1038/s41591-021-01620-2openalex-snapshot
Artificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge
inferredcites →https://doi.org/10.1038/s41746-021-00427-2openalex-snapshot
Interpretable survival prediction for colorectal cancer using deep learning
inferredcites →https://doi.org/10.1038/s42256-020-00257-zopenalex-snapshot
Shortcut learning in deep neural networks
inferredcites →https://doi.org/10.1093/ajcp/aqab085openalex-snapshot
The Utility of Unsupervised Machine Learning in Anatomic Pathology
inferredcites →https://doi.org/10.1109/access.2021.3051315openalex-snapshot
A Survey of Contrastive and Counterfactual Explanation Generation Methods for Explainable Artificial Intelligence
inferredcites →https://doi.org/10.1109/access.2022.3154776openalex-snapshot
Personas for Artificial Intelligence (AI) an Open Source Toolbox
inferredcites →https://doi.org/10.1109/icdm.2019.00036openalex-snapshot
Efficient Data Representation by Selecting Prototypes with Importance Weights
inferredcites →https://doi.org/10.1109/jproc.2021.3060483openalex-snapshot
Explaining Deep Neural Networks and Beyond: A Review of Methods and Applications
inferredcites →https://doi.org/10.1109/mc.2021.3092610openalex-snapshot
Toward Human–AI Interfaces to Support Explainability and Causability in Medical AI
inferredcites →https://doi.org/10.1111/cup.13954openalex-snapshot
Artificial intelligence in dermatopathology: Diagnosis, education, and research
inferredcites →https://doi.org/10.1111/tbj.13858openalex-snapshot
Review of the current state of digital image analysis in breast pathology
inferredcites →https://doi.org/10.1145/3233231openalex-snapshot
The Mythos of Model Interpretability
inferredcites →https://doi.org/10.1145/3287560.3287574openalex-snapshot
Explaining Explanations in AI
inferredcites →https://doi.org/10.1145/3387166openalex-snapshot
A Multidisciplinary Survey and Framework for Design and Evaluation of Explainable AI Systems
inferredcites →https://doi.org/10.1177/2374289519873088openalex-snapshot
Artificial Intelligence and Machine Learning in Pathology: The Present Landscape of Supervised Methods
inferredcites →https://doi.org/10.1186/s12911-020-01332-6openalex-snapshot
Explainability for artificial intelligence in healthcare: a multidisciplinary perspective
inferredcites →https://doi.org/10.1186/s13075-021-02716-3openalex-snapshot
Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges
inferredcites →https://doi.org/10.1609/aimag.v40i2.2850openalex-snapshot
DARPA's Explainable Artificial Intelligence Program
inferredcites →https://doi.org/10.2196/23436openalex-snapshot
Hidden Variables in Deep Learning Digital Pathology and Their Potential to Cause Batch Effects: Prediction Model Study
inferredcites →https://doi.org/10.3892/mmr.2014.2914openalex-snapshot
Ki67 is a promising molecular target in the diagnosis of cancer (Review)
inferredcites →https://doi.org/10.48550/arxiv.1806.10574openalex-snapshot
This Looks Like That: Deep Learning for Interpretable Image Recognition
inferredcites →https://doi.org/10.48550/arxiv.2102.13076openalex-snapshot
Benchmarking and Survey of Explanation Methods for Black Box Models

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1002/2056-4538.12366openalex-snapshot
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inferred← citeshttps://doi.org/10.1002/2056-4538.70003openalex-snapshot
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The Emerging Role of Artificial Intelligence in Advancing Molecular Precision Medicine for Cancer
inferred← citeshttps://doi.org/10.1007/978-3-032-39388-3_33openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00428-025-04084-8openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s00428-025-04283-3openalex-snapshot
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inferred← citeshttps://doi.org/10.1007/s10462-025-11487-1openalex-snapshot
Artificial intelligence-generated content (AIGC) in biomedical research, healthcare delivery, and clinical practices: technologies, applications, and regulatory considerations
inferred← citeshttps://doi.org/10.1007/s44411-025-00436-7openalex-snapshot
Artificial Intelligence-Based Pathomics: Technological Features and Clinical Applications
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Evaluation of tumor budding with virtual panCK stains generated by novel multi-model CNN framework
inferred← citeshttps://doi.org/10.1016/j.cmpb.2024.108408openalex-snapshot
A time-dependent explainable radiomic analysis from the multi-omic cohort of CPTAC-Pancreatic Ductal Adenocarcinoma
inferred← citeshttps://doi.org/10.1016/j.cmpb.2024.108561openalex-snapshot
Machine learning-based predictive models for perioperative major adverse cardiovascular events in patients with stable coronary artery disease undergoing noncardiac surgery
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Post-hoc vs ante-hoc explanations: xAI design guidelines for data scientists
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Establishment of a machine learning-based prediction framework to assess trade-offs in decisions that affect post-HCT outcomes
inferred← citeshttps://doi.org/10.1016/j.compbiomed.2025.110979openalex-snapshot
Advancements in biomedical rendering: A survey on AI-based denoising techniques
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Exploring transparency in pathological image analysis: A comprehensive review of explainable artificial intelligence (XAI) techniques
inferred← citeshttps://doi.org/10.1016/j.engappai.2024.109561openalex-snapshot
Fine-tuning language model embeddings to reveal domain knowledge: An explainable artificial intelligence perspective on medical decision making
inferred← citeshttps://doi.org/10.1016/j.engmed.2026.100132openalex-snapshot
Data- and knowledge-driven multimodal learning in computational pathology: A comprehensive survey
inferred← citeshttps://doi.org/10.1016/j.esmorw.2026.100737openalex-snapshot
Artificial intelligence in oncology: empowering clinicians for responsible integration
inferred← citeshttps://doi.org/10.1016/j.ijhcs.2024.103315openalex-snapshot
Majority voting of doctors improves appropriateness of AI reliance in pathology
inferred← citeshttps://doi.org/10.1016/j.jbi.2024.104600openalex-snapshot
CLARUS: An interactive explainable AI platform for manual counterfactuals in graph neural networks
inferred← citeshttps://doi.org/10.1016/j.job.2025.100696openalex-snapshot
Deep learning approaches for pathological image classification
inferred← citeshttps://doi.org/10.1016/j.jpi.2023.100347openalex-snapshot
Seeing the random forest through the decision trees. Supporting learning health systems from histopathology with machine learning models: Challenges and opportunities
inferred← citeshttps://doi.org/10.1016/j.jpi.2024.100387openalex-snapshot
Joining forces for pathology diagnostics with AI assistance: The EMPAIA initiative
inferred← citeshttps://doi.org/10.1016/j.jpi.2025.100454openalex-snapshot
Advancing open-source visual analytics in digital pathology: A systematic review of tools, trends, and clinical applications
inferred← citeshttps://doi.org/10.1016/j.jpi.2026.100710openalex-snapshot
An interpretable deep learning framework for multiclass bone marrow cytomorphology classification using EfficientNet and post hoc visualization techniques
inferred← citeshttps://doi.org/10.1016/j.kint.2025.06.029openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.knosys.2025.113333openalex-snapshot
Explainable Artificial Intelligence (XAI) in glaucoma assessment: Advancing the frontiers of machine learning algorithms
inferred← citeshttps://doi.org/10.1016/j.landig.2026.101017openalex-snapshot
Digital pathology, image analysis, and artificial intelligence in liver disease
inferred← citeshttps://doi.org/10.1016/j.measen.2024.101646openalex-snapshot
Trustworthy, self-fulfilling, non-redundant proficiency tests for metrological challenges in medical diagnostics
inferred← citeshttps://doi.org/10.1016/j.media.2025.103491openalex-snapshot
HistoKernel: Whole slide image level Maximum Mean Discrepancy kernels for pan-cancer predictive modelling
inferred← citeshttps://doi.org/10.1016/j.modpat.2025.100754openalex-snapshot
Pathology Asks for Global Regulations in Artificial Intelligence Employment
inferred← citeshttps://doi.org/10.1016/j.modpat.2025.100817openalex-snapshot
Whole Slide Imaging-Free Supporting Tool for Cytotechnologists in Cervical Cytology
inferred← citeshttps://doi.org/10.1016/j.modpat.2025.100932openalex-snapshot
MSAI-Path: Predicting Microsatellite Instability From Routine Histology Slides Without Reinventing the Wheel
inferred← citeshttps://doi.org/10.1016/j.nbt.2024.12.003openalex-snapshot
Is human oversight to AI systems still possible?
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Applications of Artificial Intelligence in Lung Pathology
inferred← citeshttps://doi.org/10.1038/s41523-025-00857-1openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41698-025-01065-7openalex-snapshot
Enhanced metastasis risk prediction in cutaneous squamous cell carcinoma using deep learning and computational histopathology
inferred← citeshttps://doi.org/10.1038/s41698-025-01119-wopenalex-snapshot
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inferred← citeshttps://doi.org/10.1093/neuonc/noag149openalex-snapshot
Inferring DNA methylation class from digitized pathology images and artificial intelligence: A worthy and timely application with room for improved clinical performance
inferred← citeshttps://doi.org/10.1097/pap.0000000000000536openalex-snapshot
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inferred← citeshttps://doi.org/10.1101/2025.09.04.674077openalex-snapshot
Pathologist-interpretable breast cancer subtyping and stratification from AI-inferred nuclear features
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inferred← citeshttps://doi.org/10.1177/22799036241284898openalex-snapshot
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inferred← citeshttps://doi.org/10.1186/s12967-026-08829-0openalex-snapshot
Agentic systems in computational pathology: architectures, evidence, and translational challenges
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Explanatory argumentation in natural language for correct and incorrect medical diagnoses
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Information maximization-based clustering of histopathology images using deep learning
inferred← citeshttps://doi.org/10.1515/cclm-2023-1124openalex-snapshot
Computational pathology: an evolving concept
inferred← citeshttps://doi.org/10.1631/jzus.a2500360openalex-snapshot
Deep-learning-enabled automatic gene abnormality detection via fluorescence in situ hybridization
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A Comprehensive Survey of ArtificialIntelligence in Precision Healthcare:Shedding Light on Interpretability
inferred← citeshttps://doi.org/10.21203/rs.3.rs-5302339/v1openalex-snapshot
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inferred← citeshttps://doi.org/10.21203/rs.3.rs-9249572/v1openalex-snapshot
Integrating Explainable Artificial Intelligence into Histopathological Risk Assessment: A Scoping Review and Meta-analysis
inferred← citeshttps://doi.org/10.2147/bctt.s605985openalex-snapshot
Artificial Intelligence-Driven Quantitative HER2 Scoring and Spatial Bystander Effect Modeling for ADC Response Stratification in HER2-Low Breast Cancer
inferred← citeshttps://doi.org/10.3389/fmed.2023.1337335openalex-snapshot
AI and professional liability assessment in healthcare. A revolution in legal medicine?
inferred← citeshttps://doi.org/10.3389/fneur.2024.1345687openalex-snapshot
Computational pathology-based weakly supervised prediction model for MGMT promoter methylation status in glioblastoma
inferred← citeshttps://doi.org/10.3389/fnins.2024.1304191openalex-snapshot
Prognostic stratification of glioblastoma patients by unsupervised clustering of morphology patterns on whole slide images furthering our disease understanding
inferred← citeshttps://doi.org/10.3389/fonc.2023.1325271openalex-snapshot
Histopathology image classification: highlighting the gap between manual analysis and AI automation
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The Quest for the Application of Artificial Intelligence to Whole Slide Imaging: Unique Prospective from New Advanced Tools
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Digital Pathology: A Comprehensive Review of Open-Source Histological Segmentation Software
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Artificial Intelligence in Dermatopathology: An Update and Review of the Current Literature
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A Combined MobileNetV2 and CBAM Model to Improve Classifying the Breast Cancer Ultrasound Images
inferred← citeshttps://doi.org/10.4018/979-8-2600-1358-8.ch010openalex-snapshot
Cross-Species Diagnostic Translation in Volumetric Tissue Profiling
inferred← citeshttps://doi.org/10.4103/joc.joc_158_24openalex-snapshot
Machine Learning of Urine Cytology Highlights Increased Neutrophil Count in Muscle-Invasive Urothelial Carcinoma
inferred← citeshttps://doi.org/10.4324/9781032634487-16openalex-snapshot
Powerful AI
inferred← citeshttps://doi.org/10.48550/arxiv.2409.03080openalex-snapshot
Explainable AI for computational pathology identifies model limitations and tissue biomarkers
inferred← citeshttps://doi.org/10.64898/2026.02.23.26346491openalex-snapshot
Morphological set enrichment enables interpretable prognostication and molecular profiling of meningiomas
inferred← citeshttps://doi.org/10.64898/2026.02.25.707931openalex-snapshot
Transforming Histology into Virtual Multiplex Immunofluorescence to Decode Prognostic Spatial Immunity in Hepatocellular Carcinoma
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The ethics of using artificial intelligence in medical research
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The Role of Machine Learning Models in Predicting Cirrhosis Mortality: A Systematic Review
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