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Adenosine and 2′‐Deoxyadenosine Modified with Boron Cluster Pharmacophores as New Classes of Human Blood Platelet Function Modulators

https://doi.org/10.1002/cmdc.201000075

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Nucleoside Modification with Boron Clusters and Their Metal Complexes

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Nucleoside–Metallacarborane Conjugates for Base‐Specific Metal Labeling of DNA

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Evidence for an anti-aggregatory effect of adenosine at physiological concentrations and for its role in the action of dipyridamole

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Rapid photometric method for estimation of platelet count in blood plasma or platelet suspension

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Platelet aggregation monitored in a 96 well microplate reader is useful for evaluation of platelet agonists and antagonists

inferredcites →https://doi.org/10.1016/0076-6879(89)69045-3openalex-snapshot

[1] Isolation of human platelets from plasma by centrifugation and washing

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2-Substituted adenosine derivatives: affinity and efficacy at four subtypes of human adenosine receptors

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Synthesis and biological activity of 2-alkylated deoxyadenosine bisphosphate derivatives as P2Y1 receptor antagonists

inferredcites →https://doi.org/10.1016/j.cardiores.2004.11.008openalex-snapshot

Adenosine-mediated cardioprotection in the aging myocardium

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Adenosine: an endogenous regulator of innate immunity

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Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation

inferredcites →https://doi.org/10.1016/j.tetlet.2005.04.046openalex-snapshot

General method for the synthesis of 2′-O-carboranyl-nucleosides

inferredcites →https://doi.org/10.1016/s0010-8545(00)00262-9openalex-snapshot

Metallacarboranes in the new millennium

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The medicinal chemistry of carboranes

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Modulation of the chemotactic peptide- and immunoglobulin G-triggered respiratory burst in human neutrophils by exogenous and endogenous adenosine

inferredcites →https://doi.org/10.1016/s0049-3848(01)00412-1openalex-snapshot

Adenosine increases human platelet levels of 3′,5′-cGMP through nitric oxide

inferredcites →https://doi.org/10.1016/s0960-894x(01)00438-3openalex-snapshot

Utility of boron clusters for drug design. Hansch–fujita hydrophobic parameters π of dicarba-closo-dodecaboranyl groups

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Adenosine receptors: new opportunities for future drugs

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Announcement

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Iodination Reactions of Icosahedral para-Carborane and the Synthesis of Carborane Derivatives with Boron-Carbon Bonds

inferredcites →https://doi.org/10.1021/jm049029uopenalex-snapshot

Design, Synthesis, and Antiviral Activity of Adenosine 5‘-Phosphonate Analogues as Chain Terminators against Hepatitis C Virus

inferredcites →https://doi.org/10.1021/jm9707737openalex-snapshot

2‘-C-Methyl Analogues of Selective Adenosine Receptor Agonists: Synthesis and Binding Studies

inferredcites →https://doi.org/10.1023/a:1005756929011openalex-snapshot

Chemistry and biology of some low molecular weight boron compounds for Boron Neutron Capture Therapy

inferredcites →https://doi.org/10.1038/nrd1983openalex-snapshot

Adenosine receptors as therapeutic targets

inferredcites →https://doi.org/10.1038/sj.bjp.0703045openalex-snapshot

A2A adenosine receptors in human peripheral blood cells

inferredcites →https://doi.org/10.1053/euhj.2000.2515openalex-snapshot

Platelet activation: assessment and quantification

inferredcites →https://doi.org/10.1080/15257770701548733openalex-snapshot

2′-Deoxyadenosine Bearing Hydrophobic Carborane Pharmacophore

inferredcites →https://doi.org/10.1093/cvr/27.1.18openalex-snapshot

Role of adenosine and its interaction with adrenoceptor activity in ischaemic and reperfusion injury of the myocardium

inferredcites →https://doi.org/10.1093/jac/dkg405openalex-snapshot

Ribavirin, viramidine and adenosine-deaminase-catalysed drug activation: implication for nucleoside prodrug design

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A3 adenosine receptor as a target for cancer therapy

inferredcites →https://doi.org/10.1111/j.1474-8673.1996.tb00051.xopenalex-snapshot

Purinoceptors and platelet aggregation

inferredcites →https://doi.org/10.1135/cccc20071646openalex-snapshot

Boron Units as Pharmacophores - New Applications and Opportunities of Boron Cluster Chemistry

inferredcites →https://doi.org/10.1139/v73-569openalex-snapshot

The tert-Butyldimethylsilyl Group as a Protecting Group in Deoxynucleosides

inferredcites →https://doi.org/10.1152/jappl.1994.76.1.5openalex-snapshot

Adenosine, an endogenous anti-inflammatory agent

inferredcites →https://doi.org/10.1161/01.cir.85.3.893openalex-snapshot

Protective effects of adenosine in myocardial ischemia.

inferredcites →https://doi.org/10.1248/cpb.18.2441openalex-snapshot

Studies of Nucleosides and Nucleotides. XLIV. Purine Cyclonucleosides. (2). Synthesis of Cyclonucleosides having 8, 3'-O- and -S-Anhydro Linkage derived from 2'-Deoxyadenosine

inferredcites →https://doi.org/10.2174/1568026033392200openalex-snapshot

Pharmacology of Adenosine A2A Receptors and Therapeutic Applications

inferredcites →https://doi.org/10.2174/1568026033392282openalex-snapshot

Medicinal Chemistry of Adenosine A2A Receptor Agonists

inferredcites →https://doi.org/10.3109/10428190009053539openalex-snapshot

Vidarabine and 2-Deoxycoformycin as Antileukemic Agents Against Monocytic Leukemia

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Synthesis and evaluation of carbaborane derivatives of indomethacin as cyclooxygenase inhibitors

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Effect of adenosine modified with a boron cluster pharmacophore on reactive oxygen species production by human neutrophils

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In vitro antileukemic activity of novel adenosine derivatives bearing boron cluster modification

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Modulation of human neutrophil activity by adenosine modified with a carborane pharmacophore

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Host–guest supramolecular chemistry of carboranes: structural features and emerging applications in nanotechnology and nanomedicine

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Synthesis and evaluation of adenosine derivatives as A1, A2A, A2B and A3 adenosine receptor ligands containing boron clusters as phenyl isosteres and selective A3 agonists

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Insight into lipophilicity of deoxyribonucleoside‑boron cluster conjugates

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A convenient approach towards boron cluster modifications with adenosine and 2′-deoxyadenosine

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Glycoconjugates of polyhedral boron clusters

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Reactions of closo-dodecaborate amines. Towards novel bis-(closo-dodecaborates) and closo-dodecaborate conjugates with lipids and non-natural nucleosides

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Phosphorylation of Nucleoside-Metallacarborane and Carborane Conjugates by Nucleoside Kinases

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