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Revisiting the Rule of Five on the Basis of Pharmacokinetic Data from Rat
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The First Orally Active Low Molecular Weight Agonists for the LH Receptor: Thienopyr(im)idines with Therapeutic Potential for Ovulation Induction
inferredcites →https://doi.org/10.1002/cmdc.201000355openalex-snapshot
Development of Specific “Drug‐Like Property” Rules for Carboxylate‐Containing Oral Drug Candidates
inferredcites →https://doi.org/10.1007/s00210-008-0318-3openalex-snapshot
A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor
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Oral lipid-based formulations
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Defining optimum lipophilicity and molecular weight ranges for drug candidates—Molecular weight dependent lower logD limits based on permeability
inferredcites →https://doi.org/10.1016/j.drudis.2009.07.014openalex-snapshot
The impact of aromatic ring count on compound developability – are too many aromatic rings a liability in drug design?
inferredcites →https://doi.org/10.1016/j.ijpharm.2005.01.022openalex-snapshot
Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium
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Annual Reports in Medicinal Chemistry
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Intestinal lymphatic drug transport: an update
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
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ADME Evaluation in Drug Discovery. 6. Can Oral Bioavailability in Humans Be Effectively Predicted by Simple Molecular Property-Based Rules?
inferredcites →https://doi.org/10.1021/jm020017nopenalex-snapshot
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
inferredcites →https://doi.org/10.1021/jm0306529openalex-snapshot
Influence of Molecular Flexibility and Polar Surface Area Metrics on Oral Bioavailability in the Rat
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The Influence of Target Family and Functional Activity on the Physicochemical Properties of Pre-Clinical Compounds
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Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
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Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
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The Properties of Known Drugs. 1. Molecular Frameworks
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Linear Correlation of the Fraction of Oral Dose Absorbed of 64 Drugs Between Humans and Rats
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Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs
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Comparison of the Use of Liver Models for Predicting Drug Clearance Using in Vitro Kinetic Data from Hepatic Microsomes and Isolated Hepatocytes
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Can the pharmaceutical industry reduce attrition rates?
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Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs
inferredcites →https://doi.org/10.1038/nrd3187openalex-snapshot
Coexistence of passive and carrier-mediated processes in drug transport
inferredcites →https://doi.org/10.1093/humrep/den412openalex-snapshot
Induction of ovulation by a potent, orally active, low molecular weight agonist (Org 43553) of the luteinizing hormone receptor
inferredcites →https://doi.org/10.1111/j.1742-7843.2005.pto960304.xopenalex-snapshot
Which in vitro Screens Guide the Prediction of Oral Absorption and Volume of Distribution?
inferredcites →https://doi.org/10.2174/1389200023337135openalex-snapshot
The Influence of DMPK as an Integrated Partner in Modern Drug Discovery
inferredcites →https://doi.org/10.2174/138920007782109733openalex-snapshot
Prediction of Intestinal First-Pass Drug Metabolism
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Automated Annotation of Microbial and Human Flavonoid-Derived Metabolites
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Quantitative Structure–Activity Relationships
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Computational Approaches and Resources in Single Amino Acid Substitutions Analysis Toward Clinical Research
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Virtual Libraries for Docking Methods: Guidelines for the Selection and the Preparation
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In vitro and in silico evaluation of the acaricidal activity of ethanol extract from Xylopia emarginata Mart. on Rhipicephalus microplus
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Established and Emerging Trends in Computational Drug Discovery in the Structural Genomics Era
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Synthesis, characterization, and anticancer evaluation of N-Heterocyclic entities: ADME profiling and In Silico predictions
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In Silico Prediction and Automatic LC–MSn Annotation of Green Tea Metabolites in Urine
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Finding novel pharmaceuticals in the systems biology era using multiple effective drug targets, phenotypic screening and knowledge of transporters: where drug discovery went wrong and how to fix it
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VIRTUAL SCREENING STATEGIES IN DRUG DISCOVERY – A BRIEF OVERVIEW
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Unraveling the Potential of Marchantia Polymorpha L.-Derived Compounds as Innovative Therapeutic Candidates for Cervical Cancer Via in Silico Analysis
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Virtual Screening Strategies in Drug Discovery: A Critical Review
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New Pharmacokinetic and Microbiological Prediction Equations to Be Used as Models for the Search of Antibacterial Drugs
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Exploration of the binding pocket of histone deacetylases: the design of potent and isoform-selective inhibitors
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A Review of Ligand-Based Virtual Screening Web Tools and Screening Algorithms in Large Molecular Databases in the Age of Big Data
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