On the public citation graph

Designing Multitarget Anti‐inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists–COX‐2 Inhibitors

0 signed · 80 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbdv.200900421openalex-snapshot
Nitrooxymethyl‐Substituted Analogues of Rofecoxib: Synthesis and Pharmacological Characterization
inferredcites →https://doi.org/10.1002/cbic.200800600openalex-snapshot
Development and Biological Evaluation of a Novel Aurora A Kinase Inhibitor
inferredcites →https://doi.org/10.1002/cmdc.201100393openalex-snapshot
Rofecoxib Analogues Possessing a Nitric Oxide Donor Sulfohydroxamic Acid (SO2NHOH) Cyclooxygenase‐2 Pharmacophore: Synthesis, Molecular Modeling, and Biological Evaluation as Anti‐inflammatory Agents
inferredcites →https://doi.org/10.1007/s00018-010-0368-9openalex-snapshot
Superactive mutants of thromboxane prostanoid receptor: functional and computational analysis of an active form alternative to constitutively active mutants
inferredcites →https://doi.org/10.1016/0002-9343(89)90344-6openalex-snapshot
Mechanisms of nonsteroidal anti-inflammatory drug-induced gastric damage
inferredcites →https://doi.org/10.1016/0003-2697(80)90515-1openalex-snapshot
LIGAND: A versatile computerized approach for characterization of ligand-binding systems
inferredcites →https://doi.org/10.1016/j.tet.2004.09.064openalex-snapshot
Synthesis of new N-aryl oxindoles as intermediates for pharmacologically active compounds
inferredcites →https://doi.org/10.1016/j.tibs.2007.09.013openalex-snapshot
Nutritionally essential fatty acids and biologically indispensable cyclooxygenases
inferredcites →https://doi.org/10.1016/j.tips.2009.11.007openalex-snapshot
Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular risk
inferredcites →https://doi.org/10.1016/s0022-3565(24)38195-9openalex-snapshot
Effects of Specific Inhibition of Cyclooxygenase-2 on Sodium Balance, Hemodynamics, and Vasoactive Eicosanoids
inferredcites →https://doi.org/10.1016/s0079-6468(08)70048-1openalex-snapshot
5 Selective Inhibitors of Cyclooxygenase-2 (COT-2)
inferredcites →https://doi.org/10.1016/s0090-6980(02)00029-1openalex-snapshot
Distinct functions of COX-1 and COX-2
inferredcites →https://doi.org/10.1016/s0140-6736(08)60137-3openalex-snapshot
COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs
inferredcites →https://doi.org/10.1016/s0140-6736(11)60600-4openalex-snapshot
Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial
inferredcites →https://doi.org/10.1016/s0165-6147(98)01242-5openalex-snapshot
Ligand-binding studies: old beliefs and new strategies
inferredcites →https://doi.org/10.1021/ac00049a010openalex-snapshot
pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances
inferredcites →https://doi.org/10.1021/cr200008nopenalex-snapshot
Nitric Oxide: A Guardian for Vascular Grafts?
inferredcites →https://doi.org/10.1021/cr950066qopenalex-snapshot
Bioisosterism: A Rational Approach in Drug Design
inferredcites →https://doi.org/10.1021/jm030276sopenalex-snapshot
Synthesis and Selective Cyclooxygenase-2 Inhibitory Activity of a Series of Novel, Nitric Oxide Donor-Containing Pyrazoles
inferredcites →https://doi.org/10.1021/jm0402059openalex-snapshot
Adverse Cardiovascular Effects of the Coxibs
inferredcites →https://doi.org/10.1021/jm058225dopenalex-snapshot
Designed Multiple Ligands. An Emerging Drug Discovery Paradigm
inferredcites →https://doi.org/10.1021/jm0607247openalex-snapshot
NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties
inferredcites →https://doi.org/10.1021/jm0613166openalex-snapshot
Structural and Functional Basis of Cyclooxygenase Inhibition
inferredcites →https://doi.org/10.1021/jm200715nopenalex-snapshot
Novel Analgesic/Anti-Inflammatory Agents: Diarylpyrrole Acetic Esters Endowed with Nitric Oxide Releasing Properties
inferredcites →https://doi.org/10.1021/jm200980uopenalex-snapshot
Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists
inferredcites →https://doi.org/10.1038/sj.bjp.0707518openalex-snapshot
Antagonism of thromboxane receptors by diclofenac and lumiracoxib
inferredcites →https://doi.org/10.1042/0300-5127:0290641openalex-snapshot
Thromboxane A2 Signalling in Humans: a ‘Tail’ of Two Receptors
inferredcites →https://doi.org/10.1055/s-0030-1258379openalex-snapshot
Copper-Promoted Carbon-Heteroatom Bond Cross-Coupling with Boronic Acids and Derivatives
inferredcites →https://doi.org/10.1056/nejm199906173402407openalex-snapshot
Gastrointestinal Toxicity of Nonsteroidal Antiinflammatory Drugs
inferredcites →https://doi.org/10.1056/nejmp048288openalex-snapshot
Coxibs and Cardiovascular Disease
inferredcites →https://doi.org/10.1073/pnas.96.1.272openalex-snapshot
Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: The human pharmacology of a selective inhibitor of COX-2
inferredcites →https://doi.org/10.1074/jbc.274.5.2645openalex-snapshot
Phosphorylation of the Thromboxane Receptor α, the Predominant Isoform Expressed in Human Platelets
inferredcites →https://doi.org/10.1074/jbc.m305481200openalex-snapshot
A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385
inferredcites →https://doi.org/10.1096/fj.05-4434fjeopenalex-snapshot
Influence of plasma protein on the potencies of inhibitors of cyclooxygenase‐1 and ‐2
inferredcites →https://doi.org/10.1111/j.1440-1746.2009.05929.xopenalex-snapshot
Rescue strategies against non‐steroidal anti‐inflammatory drug‐induced gastroduodenal damage
inferredcites →https://doi.org/10.1111/j.1440-1746.2011.07036.xopenalex-snapshot
Severe acute liver injury associated with lumiracoxib
inferredcites →https://doi.org/10.1111/j.1476-5381.1981.tb16814.xopenalex-snapshot
COMPARISON OF THE ACTIONS OF U‐46619, A PROSTAGLANDIN H2‐ANALOGUE, WITH THOSE OF PROSTAGLANDIN H2 AND THROMBOXANE A2 ON SOME ISOLATED SMOOTH MUSCLE PREPARATIONS
inferredcites →https://doi.org/10.1111/j.2042-7158.2006.tb01645.xopenalex-snapshot
Assessment and prevention of gastrointestinal toxicity of non-steroidal anti-inflammatory drugs
inferredcites →https://doi.org/10.1113/jphysiol.1963.sp007185openalex-snapshot
The aggregation of blood platelets
inferredcites →https://doi.org/10.1124/mol.104.001487openalex-snapshot
Mutational Analysis of the Highly Conserved ERY Motif of the Thromboxane A2 Receptor: Alternative Role in G Protein-Coupled Receptor Signaling
inferredcites →https://doi.org/10.1124/pr.110.003517openalex-snapshot
International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress
inferredcites →https://doi.org/10.1136/bmj.332.7553.1302openalex-snapshot
Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials
inferredcites →https://doi.org/10.1136/bmj.c7086openalex-snapshot
Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis
inferredcites →https://doi.org/10.1146/annurev.biochem.69.1.145openalex-snapshot
Cyclooxygenases: Structural, Cellular, and Molecular Biology
inferredcites →https://doi.org/10.1161/circulationaha.105.568451openalex-snapshot
Cyclooxygenase Inhibition and Cardiovascular Risk
inferredcites →https://doi.org/10.1172/jci27291openalex-snapshot
Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities
inferredcites →https://doi.org/10.2174/1389557043403693openalex-snapshot
First and Second Generations of COX-2 Selective Inhibitors
inferredcites →https://doi.org/10.2174/138955708783331577openalex-snapshot
Current Status of COX-2 Inhibitors

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4524815openalex-extracted
inferred← citeshttps://doi.org/10.1002/0471266949.bmc284openalex-snapshot
Eicosanoid Pathway Modulators: Prostaglandins, Prostacyclin, and Thromboxane
inferred← citeshttps://doi.org/10.1002/cmdc.202000258openalex-snapshot
Polysubstituted Pyrimidines as mPGES‐1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with Strong Anti‐inflammatory Effects in Carrageenan‐Induced Rat Paw Edema
inferred← citeshttps://doi.org/10.1002/med.21331openalex-snapshot
Recent Developments in Chimeric NSAIDs as Safer Anti‐Inflammatory Agents
inferred← citeshttps://doi.org/10.1007/978-3-030-50621-6_3openalex-snapshot
Druggable Prostanoid Pathway
inferred← citeshttps://doi.org/10.1007/s00044-020-02528-1openalex-snapshot
Selective cyclooxygenase-2 inhibitors: A review of recent chemical scaffolds with promising anti-inflammatory and COX-2 inhibitory activities
inferred← citeshttps://doi.org/10.1007/s00894-018-3620-0openalex-snapshot
Molecular docking, molecular modeling, and molecular dynamics studies of azaisoflavone as dual COX-2 inhibitors and TP receptor antagonists
inferred← citeshttps://doi.org/10.1007/s11883-015-0514-9openalex-snapshot
Prostanoids and NSAIDs in Cardiovascular Biology and Disease
inferred← citeshttps://doi.org/10.1007/s42823-023-00603-2openalex-snapshot
Design, synthesis and biological studies of tetrazole fused imidazopyridines
inferred← citeshttps://doi.org/10.1016/j.advms.2017.06.004openalex-snapshot
A systematic review on the role of eicosanoid pathways in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.bcp.2018.10.007openalex-snapshot
Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105663openalex-snapshot
Inflammation: Biochemistry, cellular targets, anti-inflammatory agents and challenges with special emphasis on cyclooxygenase-2
inferred← citeshttps://doi.org/10.1016/j.cclet.2013.05.026openalex-snapshot
Synthesis of tetrazole containing 1,2,3-thiadiazole derivatives via U-4CR and their anti-TMV activity
inferred← citeshttps://doi.org/10.1016/j.cdc.2023.101092openalex-snapshot
Synthesis and biological evaluation of tetrazole fused imidazopyridine derivatives as anticancer agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115542openalex-snapshot
Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation
inferred← citeshttps://doi.org/10.1016/j.insi.2026.100343openalex-snapshot
Computational exploration of N-Aryl-3-acylindole derivatives targeting COX-2 and the thromboxane A₂ receptor
inferred← citeshttps://doi.org/10.1016/j.phrs.2015.11.012openalex-snapshot
In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition
inferred← citeshttps://doi.org/10.1016/j.prostaglandins.2015.04.003openalex-snapshot
A potential role of PUFAs and COXIBs in cancer chemoprevention
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02068openalex-snapshot
Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4- b ]indol-1-yl)acetic Acid Scaffold to Generate COXTRANs: A New Class of Dual Cyclooxygenase Inhibitors-Thromboxane Receptor Antagonists
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00760openalex-snapshot
Polypharmacology by Design: A Medicinal Chemist’s Perspective on Multitargeting Compounds
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00445openalex-snapshot
Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain
inferred← citeshttps://doi.org/10.1021/acs.joc.5b01074openalex-snapshot
Selective Formation of ortho -Aminobenzylamines by the Copper-Catalyzed Amination of Benzylamine Boronate Esters
inferred← citeshttps://doi.org/10.1021/acsomega.0c04942openalex-snapshot
Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity
inferred← citeshttps://doi.org/10.1039/c6md00569aopenalex-snapshot
Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016)
inferred← citeshttps://doi.org/10.1080/00397911.2024.2331922openalex-snapshot
Synthesis and biological evaluation of tetrazole ring incorporated oxazole-pyrimidine derivatives as anticancer agents
inferred← citeshttps://doi.org/10.1111/bcpt.12134openalex-snapshot
Inhibitors of the Arachidonic Acid Cascade: Interfering with Multiple Pathways
inferred← citeshttps://doi.org/10.1134/s1070363218100250openalex-snapshot
Design, Synthesis, and Anticancer Evaluation of Tetrazole-Fused Benzoxazole Derivatives as Tubulin Binding Agents
inferred← citeshttps://doi.org/10.1155/2014/120173openalex-snapshot
Synthesis, Spectral Analysis, In Vitro Microbiological Evaluation, and Molecular Docking Studies of Some Novel 1-(1-Aryl-1H-tetrazol-5-yl)-2-(piperidin-1-yl)ethanone Derivatives
inferred← citeshttps://doi.org/10.2174/0929867324666170602083428openalex-snapshot
Nonsteroidal Anti-Inflammatory Drugs: Exploiting Bivalent COXIB/ TP Antagonists for the Control of Cardiovascular Risk
inferred← citeshttps://doi.org/10.3892/mmr.2017.7655openalex-snapshot
Dipterocarpus obtusifolius attenuates the effects of lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages
inferred← citeshttps://doi.org/10.4155/fmc-2018-0159openalex-snapshot
Introduction to COX Inhibitors
inferred← citeshttps://doi.org/10.4155/fmc-2023-0192openalex-snapshot
Dual-Target Inhibitors Based on COX-2: A Review from Medicinal Chemistry Perspectives
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.