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Amythiamicin D and Related Thiopeptides as Inhibitors of the Bacterial Elongation Factor EF‐Tu: Modification of the Amino Acid at Carbon Atom C2 of Ring C Dramatically Influences Activity

https://doi.org/10.1002/cmdc.201300323

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Total Synthesis of Antibiotics GE2270A and GE2270T

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Totalsynthese des Thiazolylpeptids GE2270 A

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Von Aminosäuren zu Heteroarenen – Thiopeptid‐Antibiotika als heterocyclische Peptide aus der Natur

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Total Synthesis and Stereochemical Assignment of Micrococcin P1

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Wie Thiostrepton im Labor synthetisiert wurde

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The Palladium‐Catalyzed Cross‐Coupling Reactions of Organotin Reagents with Organic Electrophiles [New Synthetic Methods (58)]

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Synthesis of the Heterocyclic Core of the GE 2270 Antibiotics and Structure Elucidation of a Major Degradation Product

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Total Synthesis of Antibiotics GE2270A and GE2270T

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Total Synthesis of the Thiazolyl Peptide GE2270 A

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From Amino Acids to Heteroaromatics—Thiopeptide Antibiotics, Nature's Heterocyclic Peptides

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Total Synthesis and Stereochemical Assignment of Micrococcin P1

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How Thiostrepton Was Made in the Laboratory

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Total Synthesis of Thiopeptide Antibiotics GE2270A, GE2270T, and GE2270C1

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Total Synthesis of Siomycin A: Construction of Synthetic Segments

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Rugulactone and its Analogues Exert Antibacterial Effects through Multiple Mechanisms Including Inhibition of Thiamine Biosynthesis

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Concise Total Synthesis of the Thiazolyl Peptide Antibiotic GE2270 A

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Total Syntheses of the Thiopeptides Amythiamicin C and D

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Elongation Factors EFIA and EF‐Tu: Their Role in Translation and Beyond

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DynaDock: A new molecular dynamics‐based algorithm for protein–peptide docking including receptor flexibility

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GE2270A-resistant Mutations in Elongation Factor Tu Allow Productive Aminoacyl-tRNA Binding to EF-Tu·GTP·GE2270A Complexes

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A highly efficient and economical cell-free protein synthesis system using the S12 extract of Escherichia coli

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Mechanism of inhibition of translocation by kanamycin and viomycin: A comparative study with fusidic acid

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Degradation studies of antibiotic MDL 62,879 (GE2270A) and revision of the structure

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Identification of Distinct Thiopeptide-Antibiotic Precursor Lead Compounds Using Translation Machinery Assays

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Interplay between the Ribosomal Tunnel, Nascent Chain, and Macrolides Influences Drug Inhibition

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Elongation factor Tu‐targeted antibiotics: Four different structures, two mechanisms of action

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Probing the reactivity of the GTP- and GDP-bound conformations of elongation factor Tu in complex with the antibiotic GE2270 A.

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Synthesis of organotrialkylstannanes. The reaction between organic halides and hexaalkyldistannanes in the presence of palladium complexes

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PyBOP® and PyBroP: Two reagents for the difficult coupling of the α,α-dialkyl amino acid, Aib.

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Synthesis of novel proline–thiazole based cyclic hexa- and octapeptides

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Asymmetric synthesis of chiral amines by highly diastereoselective 1,2-additions of organometallic reagents to N-tert-butanesulfinyl imines

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New methods and reagents in organic synthesis, 22,1 diphenyl phosphorazidate as a reagent for c-acylation of methyl isocyanoacetate with carboxylic acids

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A convenient synthesis of macrocyclic lactams

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Perfluoro-enolate chemistry: An “electrophile-coexisting” procedure for carbon-carbon bond forming reactions with an ester lithium f-enolate

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A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

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Mechanisms of EF-Tu, a pioneer GTPase

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Combinatorial modification of natural products: synthesis and in vitro analysis of derivatives of thiazole peptide antibiotic GE2270 A: A-ring modifications

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N-tert-Butanesulfinyl Imines: Versatile Intermediates for the Asymmetric Synthesis of Amines

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Structural Basis of the Action of Pulvomycin and GE2270 A on Elongation Factor Tu ,

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Structure of an EF-Tu Complex with a Thiazolyl Peptide Antibiotic Determined at 2.35 Å Resolution: Atomic Basis for GE2270A Inhibition of EF-Tu ,

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Thiopeptide Antibiotics

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Palladium-catalyzed coupling of tetraorganotin compounds with aryl and benzyl halides. Synthetic utility and mechanism

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Nuclear magnetic resonance enantiomer regents. Configurational correlations via nuclear magnetic resonance chemical shifts of diastereomeric mandelate, O-methylmandelate, and .alpha.-methoxy-.alpha.-trifluoromethylphenylacetate (MTPA) esters

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Total Synthesis of Thiostrepton. Assembly of Key Building Blocks and Completion of the Synthesis

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Total Synthesis of the Thiopeptide Antibiotic Amythiamicin D

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Total Synthesis and Complete Structural Assignment of Thiocillin I

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Catalytic Asymmetric Synthesis of tert-Butanesulfinamide. Application to the Asymmetric Synthesis of Amines

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4-Aminothiazolyl Analogues of GE2270 A: Antibacterial Lead Finding

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Antibacterial Optimization of 4-Aminothiazolyl Analogues of the Natural Product GE2270 A: Identification of the Cycloalkylcarboxylic Acids

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Synthesis of Enantiomerically Pure N-tert-Butanesulfinyl Imines (tert-Butanesulfinimines) by the Direct Condensation of tert-Butanesulfinamide with Aldehydes and Ketones

inferredcites →https://doi.org/10.1038/365126a0openalex-snapshot

Crystal structure of active elongation factor Tu reveals major domain rearrangements

inferredcites →https://doi.org/10.1038/nprot.2007.354openalex-snapshot

Mosher ester analysis for the determination of absolute configuration of stereogenic (chiral) carbinol carbons

inferredcites →https://doi.org/10.1039/b609282aopenalex-snapshot

Solution structures of thiopeptide antibiotics

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Micrococcin P1: Structure, biology and synthesis

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Separation of three microbial amino acid polymerization factors.

inferredcites →https://doi.org/10.1074/jbc.m100017200openalex-snapshot

Conformational Change of Elongation Factor Tu (EF-Tu) Induced by Antibiotic Binding

inferredcites →https://doi.org/10.1074/jbc.m505951200openalex-snapshot

Enacyloxin IIa Pinpoints a Binding Pocket of Elongation Factor Tu for Development of Novel Antibiotics

inferredcites →https://doi.org/10.1093/jac/41.6.584openalex-snapshot

Over-expression of target genes as a mechanism of antibiotic resistance in bacteria

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Crystal Structure of the Ternary Complex of Phe-tRNA Phe , EF-Tu, and a GTP Analog

inferredcites →https://doi.org/10.1128/aac.00582-11openalex-snapshot

In VitroandIn VivoActivities of Novel, Semisynthetic Thiopeptide Inhibitors of Bacterial Elongation Factor Tu

inferredcites →https://doi.org/10.7164/antibiotics.44.693openalex-snapshot

Antibiotic GE2270 A: A novel inhibitor of bacterial protein synthesis. I. Isolation and characterization.

inferredcites →https://doi.org/10.7164/antibiotics.44.702openalex-snapshot

Antibiotic GE2270 A: A novel inhibitor of bacterial protein synthesis. II. Structure elucidation.

inferredcites →https://doi.org/10.7164/antibiotics.47.1145openalex-snapshot

Novel antibiotics, amythiamicins. II. Structure elucidation of amythiamicin D.

inferredcites →https://doi.org/10.7164/antibiotics.47.1153openalex-snapshot

Novel antibiotic, amythiamicins. III. Structure elucidations of amythiamicins A, B and C.

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Novel antibiotics, amythiamicins. I. Taxonomy, fermentation, isolation, physico-chemical properties, and antimicrobial activity.

inferredcites →https://doi.org/10.7164/antibiotics.48.1039openalex-snapshot

Components of the GE2270 Complex Produced by Planobispora rosea ATCC 53773.

inferredcites →https://doi.org/10.7164/antibiotics.48.182openalex-snapshot

Novel Antibiotics, Amythiamicins. IV. A Mutation in the Elongation Factor Tu Gene in a Resistant Mutant of B. subtilis.

inferredcites →https://doi.org/10.7164/antibiotics.50.22openalex-snapshot

Targeted Screening for Elongation Factor Tu Binding Antibiotics.

inferredcites →https://doi.org/10.7164/antibiotics.50.344openalex-snapshot

Antimicrobial Activities of Chemically Modified Thiazolyl Peptide Antibiotic MDL 62,879 (GE2270A).

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Addition of Non‐Stabilized Carbon‐Based Nucleophilic Reagents to Chiral N ‐Sulfinyl Imines

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Parameterization of the Hamiltonian Dielectric Solvent (HADES) Reaction‐Field Method for the Solvation Free Energies of Amino Acid Side‐Chain Analogs

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Ribosome‐targeting antibacterial agents: Advances, challenges, and opportunities

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Predicting the bioactive conformations of macrocycles: a molecular dynamics-based docking procedure with DynaDock

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Characterization of Nocardithiocin Derivatives Produced by Amino Acid Substitution of Precursor Peptide notG

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Screening inhibitors against the Ef-Tu of Fusobacterium nucleatum: a docking, ADMET and PBPK assessment study

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Antibacterial pathway of cefquinome against Staphylococcus aureus based on label-free quantitative proteomics analysis

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Chemistry and Chemical Biology of Thiopeptide Natural Products

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Introduction to Thiopeptides: Biological Activity, Biosynthesis, and Strategies for Functional Reprogramming

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Unraveling tetracycline and its degradation product: Induction mechanisms of antibiotic resistance in Escherichia coli

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Concise and stereoselective synthesis of 2,5- and 2,4-disubstituted thiazole amino acid subunits for synthesizing thiazole-containing peptides

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YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function

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Heteroaryl Rings in Peptide Macrocycles

inferred← citeshttps://doi.org/10.1021/jacs.5b00940openalex-snapshot

Chemoenzymatic Synthesis of Thiazolyl Peptide Natural Products Featuring an Enzyme-Catalyzed Formal [4 + 2] Cycloaddition

inferred← citeshttps://doi.org/10.1021/jacs.6b05389openalex-snapshot

Identification of Pyridine Synthase Recognition Sequences Allows a Modular Solid-Phase Route to Thiopeptide Variants

inferred← citeshttps://doi.org/10.1021/jm500062gopenalex-snapshot

Dissecting the Structure of Thiopeptides: Assessment of Thiazoline and Tail Moieties of Baringolin and Antibacterial Activity Optimization

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An enantioselective synthesis of the C 24 –C 40 fragment of (−)-pulvomycin

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Medium-sized peptides from microbial sources with potential for antibacterial drug development

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tRNAs as Antibiotic Targets

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Études biophysiques et structurales d'antibiotiques ciblant le ribosome

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