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Synthesis and Biological Evaluation of Five‐Atom‐Linker‐Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Arch. Pharm. Chem. Life Sci. (11/2013)
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Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies
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Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice
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A short history of the 5-HT2C receptor: from the choroid plexus to depression, obesity and addiction treatment
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Serotonin 5-HT1A Receptors as Targets for Agents to Treat Psychiatric Disorders: Rationale and Current Status of Research
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Second Generation Antipsychotic-Induced Type 2 Diabetes: A Role for the Muscarinic M3 Receptor
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QTc Interval Prolongation and Torsade de Pointes Associated with Second-Generation Antipsychotics and Antidepressants: A Comprehensive Review
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Quipazine-induced head-twitch in mice
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Serotonin and negative symptoms
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Synthesis and biological investigation of tetrahydropyridopyrimidinone derivatives as potential multireceptor atypical antipsychotics
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Synthesis and biological evaluation of a series of novel pyridinecarboxamides as potential multi-receptor antipsychotic drugs
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Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect
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Antipsychotics-induced metabolic alterations: Recounting the mechanistic insights, therapeutic targets and pharmacological alternatives
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Validation of a fluorescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity
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Involvement of presynaptic 5-HT 1A receptors in the low propensity of brexpiprazole to induce extrapyramidal side effects in rats
inferredcites →https://doi.org/10.1016/j.pharmthera.2012.04.003openalex-snapshot
Cardiovascular side-effects of antipsychotic drugs: The role of the autonomic nervous system
inferredcites →https://doi.org/10.1016/j.pneurobio.2016.03.011openalex-snapshot
Polypharmacology of dopamine receptor ligands
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Hypothalamic histamine H1 receptor-AMPK signaling time-dependently mediates olanzapine-induced hyperphagia and weight gain in female rats
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Definition and description of schizophrenia in the DSM-5
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(1-(2,5-dimethoxy-4 iodophenyl)-2-aminopropane)-induced head-twitches in the rat are mediated by 5-hydroxytryptamine (5-HT) 2A receptors: modulation by novel 5-HT2A/2C antagonists, D1 antagonists and 5-HT1A agonists.
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Preclinical Behavioral Models for Predicting Antipsychotic Activity
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Classics in Chemical Neuroscience: Aripiprazole
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Rotarod Impairment: Catalepsy-Like Screening Test for Antipsychotic Side Effects
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5-HT1A receptor ligands and their therapeutic applications: review of new patents
inferredcites →https://doi.org/10.1080/14656566.2016.1274972openalex-snapshot
Brexpiprazole for the treatment of schizophrenia
inferredcites →https://doi.org/10.1080/14656566.2018.1543409openalex-snapshot
Resistance is not futile: treatment-refractory schizophrenia – overview, evaluation and treatment
inferredcites →https://doi.org/10.1080/14740338.2016.1201475openalex-snapshot
An update of safety of clinically used atypical antipsychotics
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5-HT1A receptor-dependent control of nigrostriatal dopamine neurotransmission in the pharmacotherapy of Parkinson’s disease and schizophrenia
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Therapeutic Role of 5-HT1A Receptors in The Treatment of Schizophrenia and Parkinson's Disease
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The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies
inferredcites →https://doi.org/10.1124/jpet.114.213793openalex-snapshot
Brexpiprazole I: In Vitro and In Vivo Characterization of a Novel Serotonin-Dopamine Activity Modulator
inferredcites →https://doi.org/10.1124/mol.118.113290openalex-snapshot
Involvement of 5-HT1A and 5-HT2A Receptors but Not α2-Adrenoceptors in the Acute Electrophysiological Effects of Cariprazine in the Rat Brain In Vivo
inferredcites →https://doi.org/10.1177/2045125315614739openalex-snapshot
Brexpiprazole: so far so good
inferredcites →https://doi.org/10.1186/s12859-017-1895-2openalex-snapshot
Development of models for predicting Torsade de Pointes cardiac arrhythmias using perceptron neural networks
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Efficacy of antidepressants in treating the negative symptoms of chronic schizophrenia: meta-analysis
inferredcites →https://doi.org/10.1210/en.2014-1326openalex-snapshot
Olanzapine-Activated AMPK Signaling in the Dorsal Vagal Complex Is Attenuated by Histamine H1 Receptor Agonist in Female Rats
inferredcites →https://doi.org/10.2165/11591710-000000000-00000openalex-snapshot
Antipsychotic Pharmacotherapy and Orthostatic Hypotension
inferredcites →https://doi.org/10.2174/092986712801215883openalex-snapshot
Designed Multiple Ligands: Basic Research vs Clinical Outcomes
inferredcites →https://doi.org/10.2174/1381612821666150605105215openalex-snapshot
Serotonin 5-HT1A Receptors and Antipsychotics - An Update in Light of New Concepts and Drugs
inferredcites →https://doi.org/10.2174/1568026616666160608084834openalex-snapshot
Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future
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Psychiatric Polypharmacy, Etiology and Potential Consequences
inferredcites →https://doi.org/10.3389/fncir.2014.00013openalex-snapshot
Dopamine control of pyramidal neuron activity in the primary motor cortex via D2 receptors
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Advances in drug design and therapeutic potential of selective or multitarget 5‐HT1A receptor ligands
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Synthesis, antibacterial evaluation, and mechanism study of piperazine‐bearing oxime ether derivatives
inferred← citeshttps://doi.org/10.1002/slct.202304489openalex-snapshot
Total Synthesis of 1”‐ and 2”‐Hydroxycannabidiol Metabolites
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inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116564openalex-snapshot
Synthesis and biological evaluation of multimodal monoaminergic arylpiperazine derivatives with potential antidepressant profile
inferred← citeshttps://doi.org/10.1016/j.tetlet.2024.154913openalex-snapshot
Selective C–H acylation of quinolin-2(1H)-one with α-oxocarboxylic acids at the C3 position by sliver catalysis and its application in the synthesis of palbociclib
inferred← citeshttps://doi.org/10.1080/17568919.2026.2665466openalex-snapshot
Quinoline-piperazine molecular hybrids as potential antimalarial agents
inferred← citeshttps://doi.org/10.2174/0115701786403432260129211331openalex-snapshot
Advances in Synthesis of Piperazine Analogues and Molecular Targets: Unlocking Their Potential in CNS Disorder Therapy
inferred← citeshttps://doi.org/10.2174/0115734072304305240802093232openalex-snapshot
Recent Trends in Chemistry and Biological Activity of Antipsychotics
inferred← citeshttps://doi.org/10.3390/ijms232415929openalex-snapshot
Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents
inferred← citeshttps://doi.org/10.3390/pharmaceutics16010028openalex-snapshot
Long-Acting Injectable Antipsychotics—A Review on Formulation and In Vitro Dissolution
inferred← citeshttps://doi.org/10.3892/ijmm.2025.5646openalex-snapshot
Quinazolinone derivatives as potential anti‑tumor agents: Structural features and molecular mechanisms in inducing cell death (Review)
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