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Do Drug‐likeness Rules Apply to Oral Prodrugs?

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ange.202004550openalex-snapshot
Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity
inferredcites →https://doi.org/10.1002/anie.202004550openalex-snapshot
Drug‐Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side‐Chain Lipophilicity
inferredcites →https://doi.org/10.1002/bip.22878openalex-snapshot
Cyclic peptide oral bioavailability: Lessons from the past
inferredcites →https://doi.org/10.1002/chem.201905599openalex-snapshot
Solution Conformations Explain the Chameleonic Behaviour of Macrocyclic Drugs
inferredcites →https://doi.org/10.1002/cmdc.201600182openalex-snapshot
A BOILED‐Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules
inferredcites →https://doi.org/10.1002/jcc.21707openalex-snapshot
PaDEL‐descriptor: An open source software to calculate molecular descriptors and fingerprints
inferredcites →https://doi.org/10.1016/b978-0-12-744481-9.x5000-4openalex-snapshot
The Practice of Medicinal Chemistry
inferredcites →https://doi.org/10.1016/j.addr.2016.04.029openalex-snapshot
Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions
inferredcites →https://doi.org/10.1016/j.addr.2016.06.015openalex-snapshot
Peptide–drug conjugates as effective prodrug strategies for targeted delivery
inferredcites →https://doi.org/10.1016/j.addr.2020.05.007openalex-snapshot
Systemic delivery of peptides by the oral route: Formulation and medicinal chemistry approaches
inferredcites →https://doi.org/10.1016/j.bbamcr.2006.08.039openalex-snapshot
Protein oxidation and cellular homeostasis: Emphasis on metabolism
inferredcites →https://doi.org/10.1016/j.cbpa.2004.04.011openalex-snapshot
Natural products and combinatorial chemistry: back to the future
inferredcites →https://doi.org/10.1016/j.chembiol.2014.08.013openalex-snapshot
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
inferredcites →https://doi.org/10.1016/j.drudis.2020.01.012openalex-snapshot
Flexibility in early drug discovery: focus on the beyond-Rule-of-5 chemical space
inferredcites →https://doi.org/10.1016/j.smim.2017.08.007openalex-snapshot
Recent advances in clinical development of leukotriene B4 pathway drugs
inferredcites →https://doi.org/10.1016/s0169-409x(96)00423-1openalex-snapshot
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
inferredcites →https://doi.org/10.1016/s0378-5173(00)00507-xopenalex-snapshot
Species-dependent and site-specific intestinal metabolism of ester prodrugs
inferredcites →https://doi.org/10.1021/acs.jmedchem.7b00717openalex-snapshot
Beyond the Rule of 5: Lessons Learned from AbbVie’s Drugs and Compound Collection
inferredcites →https://doi.org/10.1021/acs.jmedchem.8b00347openalex-snapshot
Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs Beyond the Rule of 5
inferredcites →https://doi.org/10.1021/acs.jmedchem.8b00686openalex-snapshot
Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs
inferredcites →https://doi.org/10.1021/acschembio.0c00218openalex-snapshot
Improving Membrane Permeation in the Beyond Rule-of-Five Space by Using Prodrugs to Mask Hydrogen Bond Donors
inferredcites →https://doi.org/10.1021/cc9800071openalex-snapshot
A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
inferredcites →https://doi.org/10.1021/ci0200467openalex-snapshot
Property Distributions: Differences between Drugs, Natural Products, and Molecules from Combinatorial Chemistry
inferredcites →https://doi.org/10.1021/ci025515jopenalex-snapshot
Application of Associative Neural Networks for Prediction of Lipophilicity in ALOGPS 2.1 Program
inferredcites →https://doi.org/10.1021/ci0340916openalex-snapshot
Drug Discovery Using Support Vector Machines. The Case Studies of Drug-likeness, Agrochemical-likeness, and Enzyme Inhibition Predictions
inferredcites →https://doi.org/10.1021/ci100031xopenalex-snapshot
Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database
inferredcites →https://doi.org/10.1021/ci3001277openalex-snapshot
ZINC: A Free Tool to Discover Chemistry for Biology
inferredcites →https://doi.org/10.1021/jm000292eopenalex-snapshot
Prediction of Drug Absorption Using Multivariate Statistics
inferredcites →https://doi.org/10.1021/jm015507eopenalex-snapshot
Simple Selection Criteria for Drug-like Chemical Matter
inferredcites →https://doi.org/10.1021/jm020017nopenalex-snapshot
Molecular Properties That Influence the Oral Bioavailability of Drug Candidates
inferredcites →https://doi.org/10.1021/jm400887jopenalex-snapshot
Macrocyclic Drugs and Clinical Candidates: What Can Medicinal Chemists Learn from Their Properties?
inferredcites →https://doi.org/10.1021/jm901371vopenalex-snapshot
Physicochemical Space for Optimum Oral Bioavailability: Contribution of Human Intestinal Absorption and First-Pass Elimination
inferredcites →https://doi.org/10.1023/a:1008130001697openalex-snapshot
Property distribution of drug-related chemical databases*
inferredcites →https://doi.org/10.1038/srep42717openalex-snapshot
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
inferredcites →https://doi.org/10.1039/c1md00093dopenalex-snapshot
Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
inferredcites →https://doi.org/10.1093/nar/gkv951openalex-snapshot
PubChem Substance and Compound databases
inferredcites →https://doi.org/10.1093/nar/gkx1037openalex-snapshot
DrugBank 5.0: a major update to the DrugBank database for 2018
inferredcites →https://doi.org/10.1111/papr.12649openalex-snapshot
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Tissue Distribution and Elimination of Isavuconazole following Single and Repeat Oral-Dose Administration of Isavuconazonium Sulfate to Rats
inferredcites →https://doi.org/10.1136/heart.85.4.444openalex-snapshot
Pharmacodynamics and safety of lefradafiban, an oral platelet glycoprotein IIb/IIIa receptor antagonist, in patients with stable coronary artery disease undergoing elective angioplasty
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Effect of Moxisylyte Hydrochloride (α 1 -Blocker) on the Retinal Circulation of Patients with Diabetes mellitus
inferredcites →https://doi.org/10.1177/009127002401102803openalex-snapshot
Pharmacokinetics of GW433908, a Prodrug of Amprenavir, in Healthy Male Volunteers
inferredcites →https://doi.org/10.1186/1471-2105-14-257openalex-snapshot
KNIME-CDK: Workflow-driven cheminformatics
inferredcites →https://doi.org/10.1186/s13023-018-0990-4openalex-snapshot
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inferredcites →https://doi.org/10.1186/s13321-016-0187-6openalex-snapshot
A novel descriptor based on atom-pair properties
inferredcites →https://doi.org/10.1201/b16842openalex-snapshot
Basic Statistics and Pharmaceutical Statistical Applications
inferredcites →https://doi.org/10.1517/17460441.2014.913565openalex-snapshot
Advances in multiparameter optimization methods for de novo drug design
inferredcites →https://doi.org/10.2147/opth.s108213openalex-snapshot
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inferredcites →https://doi.org/10.2147/ott.s49187openalex-snapshot
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inferredcites →https://doi.org/10.2165/00003088-200645020-00002openalex-snapshot
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inferredcites →https://doi.org/10.2174/138920012799362864openalex-snapshot
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inferredcites →https://doi.org/10.33590/emjdermatol/10311121openalex-snapshot
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inferredcites →https://doi.org/10.3389/fphar.2016.00263openalex-snapshot
Profile of Antiemetic Activity of Netupitant Alone or in Combination with Palonosetron and Dexamethasone in Ferrets and Suncus murinus (House Musk Shrew)

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Cracking ERα Y537S Resistance: Explainable Machine Learning-Guided Discovery and Molecular Dynamics Validation of Stable Candidate Ligands
inferred← citeshttps://doi.org/10.3390/pharmaceutics14081749openalex-snapshot
Fluoroquinolones Hybrid Molecules as Promising Antibacterial Agents in the Fight against Antibacterial Resistance
inferred← citeshttps://doi.org/10.35516/jjps.v18i1.2537openalex-snapshot
In Silico Antioxidant Activity of Six Volatile Constituents in Capsella bursa-pastoris
inferred← citeshttps://doi.org/10.36656/jpfh.v6i2.1686openalex-snapshot
ANALISIS KETERKAITAN NETWORK PHAMACOLOGY SENYAWA METABOLIT SEKUNDER Abrus precatorius L. SECARA IN SILICO
inferred← citeshttps://doi.org/10.3892/br.2024.1825openalex-snapshot
Computational and in vitro analyses of the antibacterial effect of the ethanolic extract of Pluchea indica L. leaves
inferred← citeshttps://doi.org/10.48048/tis.2022.3918openalex-snapshot
Preliminary Computational Analysis of Pyrazinamide-Based Derivatives Reveals Possible Inhibition of SARS-CoV-2 RNA-Dependent RNA Polymerase, and Their Possible Use as Antiviral Agents
inferred← citeshttps://doi.org/10.58920/sciphar0304264openalex-snapshot
Druggability of Pharmaceutical Compounds Using Lipinski Rules with Machine Learning
inferred← citeshttps://doi.org/10.7124/bc.000a84openalex-snapshot
New polyfunctionalized 2-hydrazinoanthraquinone derivatives as potential antimicrobial agents
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