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Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT 15 Genotypes: 2018 Update
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cpt.463openalex-snapshot
Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait
inferredcites →https://doi.org/10.1002/cpt.540openalex-snapshot
Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta‐Analysis of Three Genome‐Wide Association Studies
inferredcites →https://doi.org/10.1007/s00535-015-1142-4openalex-snapshot
NUDT15 R139C-related thiopurine leukocytopenia is mediated by 6-thioguanine nucleotide-independent mechanism in Japanese patients with inflammatory bowel disease
inferredcites →https://doi.org/10.1016/j.clpt.2003.12.001openalex-snapshot
Methylated metabolites of 6-mercaptopurine are associated with hepatotoxicity*1
inferredcites →https://doi.org/10.1016/s0022-3476(05)83063-xopenalex-snapshot
Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
inferredcites →https://doi.org/10.1016/s0140-6736(06)68340-2openalex-snapshot
Azathioprine dosed by thiopurine methyltransferase activity for moderate-to-severe atopic eczema: a double-blind, randomised controlled trial
inferredcites →https://doi.org/10.1016/s1470-2045(17)30154-7openalex-snapshot
DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a prospective substudy of a phase 3 trial
inferredcites →https://doi.org/10.1038/clpt.2008.154openalex-snapshot
Genetic Polymorphism of Inosine Triphosphate Pyrophosphatase Is a Determinant of Mercaptopurine Metabolism and Toxicity During Treatment for Acute Lymphoblastic Leukemia
inferredcites →https://doi.org/10.1038/leu.2008.316openalex-snapshot
Thiopurine methyltransferase activity is related to the risk of relapse of childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study
inferredcites →https://doi.org/10.1038/leu.2009.251openalex-snapshot
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
inferredcites →https://doi.org/10.1038/ng.3060openalex-snapshot
A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia
inferredcites →https://doi.org/10.1038/ng.3508openalex-snapshot
NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity
inferredcites →https://doi.org/10.1053/j.gastro.2006.01.048openalex-snapshot
American Gastroenterological Association Institute Technical Review on Corticosteroids, Immunomodulators, and Infliximab in Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1053/j.gastro.2015.06.002openalex-snapshot
Identification of Patients With Variants in TPMT and Dose Reduction Reduces Hematologic Events During Thiopurine Treatment of Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1086/301941openalex-snapshot
Pharmacogenetics of Cancer Therapy: Getting Personal
inferredcites →https://doi.org/10.1093/jnci/91.23.2001openalex-snapshot
Mercaptopurine Therapy Intolerance and Heterozygosity at the Thiopurine S-Methyltransferase Gene Locus
inferredcites →https://doi.org/10.1097/00007691-199608000-00003openalex-snapshot
Individualizing Therapy with 6-Mercaptopurine and 6-Thioguanine Related to the Thiopurine Methyltransferase Genetic Polymorphism
inferredcites →https://doi.org/10.1097/00007691-200404000-00018openalex-snapshot
Pharmacogenetics of Thiopurine S-Methyltransferase and Thiopurine Therapy
inferredcites →https://doi.org/10.1097/00043426-200009000-00011openalex-snapshot
Severe 6-Thioguanine-induced Marrow Aplasia in a Child With Acute Lymphoblastic Leukemia and Inherited Thiopurine Methyltransferase Deficiency
inferredcites →https://doi.org/10.1097/00054725-200402001-00008openalex-snapshot
Pharmacogenomics and IBD
inferredcites →https://doi.org/10.1097/01.fpc.0000114745.08559.dbopenalex-snapshot
Comprehensive analysis of thiopurine S-methyltransferase phenotype–genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants
inferredcites →https://doi.org/10.1097/fpc.0000000000000282openalex-snapshot
The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia
inferredcites →https://doi.org/10.1111/j.1365-2133.2004.06323.xopenalex-snapshot
Guidelines for prescribing azathioprine in dermatology
inferredcites →https://doi.org/10.1111/jcpt.12420openalex-snapshot
Further evidence that a variant of the geneNUDT15may be an important predictor of azathioprine-induced toxicity in Chinese subjects: a case report
inferredcites →https://doi.org/10.1136/gut.48.5.591openalex-snapshot
Rational dosing of azathioprine and 6-mercaptopurine
inferredcites →https://doi.org/10.1136/gut.52.1.140openalex-snapshot
Safe treatment of thiopurine S-methyltransferase deficient Crohn’s disease patients with azathioprine
inferredcites →https://doi.org/10.1136/jcp.2009.069252openalex-snapshot
Thiopurine S-methyltransferase (TPMT) assessment prior to starting thiopurine drug treatment; a pharmacogenomic test whose time has come
inferredcites →https://doi.org/10.1158/0008-5472.can-06-3508openalex-snapshot
Differential Effects of Targeted Disruption of Thiopurine Methyltransferase on Mercaptopurine and Thioguanine Pharmacodynamics
inferredcites →https://doi.org/10.1182/blood-2005-08-3379openalex-snapshot
Thiopurine methyltransferase in acute lymphoblastic leukemia
inferredcites →https://doi.org/10.1200/jco.2001.19.8.2293openalex-snapshot
Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine
inferredcites →https://doi.org/10.1200/jco.2014.59.4671openalex-snapshot
Inherited NUDT15 Variant Is a Genetic Determinant of Mercaptopurine Intolerance in Children With Acute Lymphoblastic Leukemia
inferredcites →https://doi.org/10.1371/journal.pone.0029163openalex-snapshot
Thiopurine Methyltransferase Predicts the Extent of Cytotoxicty and DNA Damage in Astroglial Cells after Thioguanine Exposure
inferredcites →https://doi.org/10.1371/journal.pone.0188925openalex-snapshot
Measurements of 6-thioguanine nucleotide levels with TPMT and NUDT15 genotyping in patients with Crohn’s disease
inferredcites →https://doi.org/10.2217/pgs.09.155openalex-snapshot
Are Patients with Intermediate TPMT Activity at Increased Risk of Myelosuppression When Taking Thiopurine Medications?
inferredcites →https://doi.org/10.3324/haematol.2018.187658openalex-snapshot
Combination of common and novel rare NUDT15 variants improves predictive sensitivity of thiopurine-induced leukopenia in children with acute lymphoblastic leukemia
inferredcites →https://doi.org/10.7326/0003-4819-126-8-199704150-00003openalex-snapshot
Molecular Diagnosis of Thiopurine S-Methyltransferase Deficiency: Genetic Basis for Azathioprine and Mercaptopurine Intolerance
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Competing Benefits and Competing Hazards: The Benefit to Harm Balance in Individual Patients in Rational Therapeutics
inferred← citeshttps://doi.org/10.1007/s40272-020-00411-5openalex-snapshot
Thiopurines in Pediatric Inflammatory Bowel Disease: Current and Future Place
inferred← citeshttps://doi.org/10.1007/s40272-023-00560-3openalex-snapshot
Pharmacogenetic Aspects of Drug Metabolizing Enzymes and Transporters in Pediatric Medicine: Study Progress, Clinical Practice and Future Perspectives
inferred← citeshttps://doi.org/10.1007/s40273-026-01586-4openalex-snapshot
Economic Evaluation of Pre-emptive Pharmacogenetic Panel Testing versus No Genetic Testing in a Multi-ethnic Asian Population
inferred← citeshttps://doi.org/10.1007/s40291-021-00575-xopenalex-snapshot
The Value of Pharmacogenetics to Reduce Drug-Related Toxicity in Cancer Patients
inferred← citeshttps://doi.org/10.1007/s40291-023-00678-7openalex-snapshot
The Genetics of Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1007/s40472-026-00506-xopenalex-snapshot
Impact of Pharmacogenomics on Transplant Outcomes: Review of Recent Literature
inferred← citeshttps://doi.org/10.1007/s40487-026-00440-zopenalex-snapshot
Association of Variants in Candidate Pharmacogenes with Response to Mercaptopurine and Methotrexate in Pediatric Acute Lymphoblastic Leukemia: A Single-Center Experience from Croatia
inferred← citeshttps://doi.org/10.1007/s43440-020-00158-3openalex-snapshot
Pharmacogenetic determinants of thiopurines in an Indian cohort
inferred← citeshttps://doi.org/10.1007/s43440-021-00287-3openalex-snapshot
Genotyping NUDT15*3 rs1166855232 reveals higher frequency of potential adverse effects of thiopurines in Natives and Mestizos from Mexico
inferred← citeshttps://doi.org/10.1007/s43440-025-00818-2openalex-snapshot
The role of pharmacogenetics in the therapy regimen of acute lymphoblastic leukemia in children: recent discoveries and future perspectives
inferred← citeshttps://doi.org/10.1016/b978-0-12-816478-5.00005-4openalex-snapshot
Clinical Genetics and Referrals
inferred← citeshttps://doi.org/10.1016/b978-0-12-816478-5.00097-2openalex-snapshot
Pharmacogenomic Cases: Thiopurine for Acute Lymphoblastic Leukemia
inferred← citeshttps://doi.org/10.1016/b978-0-12-819869-8.00002-1openalex-snapshot
Pharmacogenomic mechanisms of drug toxicity
inferred← citeshttps://doi.org/10.1016/b978-0-12-819869-8.00016-1openalex-snapshot
Clinical pharmacogenetics
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00145-6openalex-snapshot
Translating Pharmacogenomic Research to Therapeutic Potentials (Bench to Bedside)
inferred← citeshttps://doi.org/10.1016/b978-0-12-820472-6.00159-6openalex-snapshot
Pharmacogenomics of Anti-Cancer Drugs
inferred← citeshttps://doi.org/10.1016/b978-0-12-820519-8.00010-7openalex-snapshot
Pharmacogenetics and personalized medicine
inferred← citeshttps://doi.org/10.1016/b978-0-12-822824-1.00029-8openalex-snapshot
Germline pharmacogenomics in cancer treatment
inferred← citeshttps://doi.org/10.1016/b978-0-12-822951-4.00012-6openalex-snapshot
Cardiovascular pharmacogenomics – Molecular basis of protective and adverse drug response
inferred← citeshttps://doi.org/10.1016/b978-0-12-824315-2.01077-0openalex-snapshot
Pharmacogenetics and toxicology
inferred← citeshttps://doi.org/10.1016/b978-0-323-95311-5.00004-xopenalex-snapshot
Pharmacogenomics – challenges and opportunities for precision medicine
inferred← citeshttps://doi.org/10.1016/b978-0-323-99133-9.00005-xopenalex-snapshot
The clinical relevance of metabolism
inferred← citeshttps://doi.org/10.1016/b978-0-443-11980-4.00012-xopenalex-snapshot
Therapeutics: Nonbiologics
inferred← citeshttps://doi.org/10.1016/b978-0-443-15717-2.00004-4openalex-snapshot
Childhood Acute Lymphoblastic Leukemia
inferred← citeshttps://doi.org/10.1016/b978-0-443-26472-6.00022-xopenalex-snapshot
Implementation of Pharmacogenomics in Clinical Pharmacy Practice
inferred← citeshttps://doi.org/10.1016/b978-0-443-26472-6.00063-2openalex-snapshot
Pharmacogenomics in the Community Setting
inferred← citeshttps://doi.org/10.1016/b978-0-443-26472-6.00165-0openalex-snapshot
Pharmacogenomics in Hospital Practice: Implementation, Clinical Applications and Future Perspectives
inferred← citeshttps://doi.org/10.1016/b978-0-443-29289-7.00021-7openalex-snapshot
Drug metabolism in liver transplant patients
inferred← citeshttps://doi.org/10.1016/b978-0-443-29289-7.00024-2openalex-snapshot
Drug metabolism in cancer patients
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2024.08.007openalex-snapshot
Circulating biomarkers for diagnosis and response to therapies in cancer patients
inferred← citeshttps://doi.org/10.1016/j.actpha.2022.03.010openalex-snapshot
La pharmacogénétique en oncologie, ce qu’il faut savoir à l’officine
inferred← citeshttps://doi.org/10.1016/j.anpede.2025.503936openalex-snapshot
Update on pharmacogenetics in pediatrics
inferred← citeshttps://doi.org/10.1016/j.anpedi.2025.503936openalex-snapshot
Actualización de farmacogenética en pediatría
inferred← citeshttps://doi.org/10.1016/j.aohep.2026.102439openalex-snapshot
Porto-sinusoidal vascular disorder and sinusoidal obstructive syndrome in patients treated with thiopurines: a systematic review
inferred← citeshttps://doi.org/10.1016/j.bcp.2019.04.020openalex-snapshot
Comprehensive study of thiopurine methyltransferase genotype, phenotype, and genotype-phenotype discrepancies in Sweden
inferred← citeshttps://doi.org/10.1016/j.bcp.2025.116809openalex-snapshot
Interactions between the intestinal microbiota and drug metabolism – Clinical implications and future opportunities
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.113901openalex-snapshot
DNA methylation of the TPMT gene and azathioprine pharmacokinetics in children with very early onset inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115706openalex-snapshot
Azathioprine dose tailoring based on pharmacogenetic information: Insights of clinical implementation
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.117893openalex-snapshot
Thiopurine S-methyltransferase – An important intersection of drug-drug interactions in thiopurine treatment
inferred← citeshttps://doi.org/10.1016/j.biopha.2025.118446openalex-snapshot
New insights into thiopurine toxicity: The contribution of rare XDH variants to myelotoxicity
inferred← citeshttps://doi.org/10.1016/j.bpg.2021.101756openalex-snapshot
Therapeutic drug monitoring of immunosuppressive drugs in hepatology and gastroenterology
inferred← citeshttps://doi.org/10.1016/j.bpg.2023.101877openalex-snapshot
Prognostic modelling in IBD
inferred← citeshttps://doi.org/10.1016/j.bulcan.2022.05.012openalex-snapshot
Modalités pratiques de prise en charge en cours de traitement d’entretien des leucémies aiguës lymphoblastiques pédiatriques : recommandations du Comité leucémies de la Société française de lutte contre les cancers et les leucémies de l’enfant et de l’adolescent (SFCE)
inferred← citeshttps://doi.org/10.1016/j.bulcan.2025.05.018openalex-snapshot
Pharmacogenetics in oncology: Unveiling its potential in treatment personalization and beyond
inferred← citeshttps://doi.org/10.1016/j.cgh.2024.07.032openalex-snapshot
Ancestral Diversity in Pharmacogenomics Affects Treatment for Hispanic/Latine Populations With Inflammatory Bowel Disease
inferred← citeshttps://doi.org/10.1016/j.clinbiochem.2021.02.007openalex-snapshot
NUDT15: A bench to bedside success story
inferred← citeshttps://doi.org/10.1016/j.clinsp.2023.100214openalex-snapshot
Pharmacogenetic testing for thiopurine drugs in Brazilian acute lymphoblastic leukemia patients
inferred← citeshttps://doi.org/10.1016/j.clinthera.2024.12.007openalex-snapshot
Comparison of Effects on 6-Thioguanine Nucleotides According to Mesalazine Formulation in Pediatric Patients with Ulcerative Colitis
inferred← citeshttps://doi.org/10.1016/j.cll.2026.07.007openalex-snapshot
The Role of Therapeutic Drug Monitoring in the Treatment of Childhood Leukemia
inferred← citeshttps://doi.org/10.1016/j.coph.2022.102225openalex-snapshot
Drug monitoring in systemic lupus erythematosus
inferred← citeshttps://doi.org/10.1016/j.coph.2025.102551openalex-snapshot
Recent innovations in clinical trial design for inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.coph.2026.102609openalex-snapshot
Pharmacological silence: Revisiting the clinical and molecular impact of inactive metabolites
inferred← citeshttps://doi.org/10.1016/j.cotox.2020.07.003openalex-snapshot
Precision medicine in drug safety
inferred← citeshttps://doi.org/10.1016/j.cpha.2022.10.013openalex-snapshot
What Is Precision Medicine?
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.104720openalex-snapshot
Pharmacogenomics in pediatric oncology patients with solid tumors related to chemotherapy-induced toxicity: A systematic review
inferred← citeshttps://doi.org/10.1016/j.critrevonc.2025.104977openalex-snapshot
The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review
inferred← citeshttps://doi.org/10.1016/j.ctarc.2026.101173openalex-snapshot
Optimizing mercaptopurine therapy in indian pediatric ALL: The role of TPMT and NUDT15 genetic polymorphisms
inferred← citeshttps://doi.org/10.1016/j.dmd.2025.100119openalex-snapshot
Establishment of a novel predictive model for thiopurine-induced leucopenia based on the polymorphisms in the DNA-thioguanine nucleotide metabolite pathway in Chinese patients with inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.dmpk.2021.100436openalex-snapshot
NUDT15 is a key genetic factor for prediction of hematotoxicity in pediatric patients who received a standard low dosage regimen of 6-mercaptopurine
inferred← citeshttps://doi.org/10.1016/j.dmpk.2022.100458openalex-snapshot
Intestinal microbiota-mediated biotransformations alter the pharmacokinetics of the major metabolites of azathioprine in rats after oral administration
inferred← citeshttps://doi.org/10.1016/j.ejcped.2023.100006openalex-snapshot
The heterozygous NUDT15 variant is not associated with the severity of 6-mercaptopurine-related side effects in early intensification therapy for childhood acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1016/j.ejcped.2025.100222openalex-snapshot
Curing using the minimal – Strategies for treatment reduction in childhood acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1016/j.ejcped.2025.100225openalex-snapshot
Therapeutic drug monitoring in the treatment of childhood acute lymphoblastic leukemia – A practical guideline
inferred← citeshttps://doi.org/10.1016/j.ejps.2024.106878openalex-snapshot
Genetic polymorphisms and their association with methotrexate polyglutamates during maintenance treatment in Korean children and young adults with acute lymphoblastic leukemia
inferred← citeshttps://doi.org/10.1016/j.ekir.2024.07.010openalex-snapshot
Pilot Study of Valganciclovir-Induced Leukopenia in Kidney Transplant Recipients With NUDT15 Genetic Variation
inferred← citeshttps://doi.org/10.1016/j.engappai.2026.113901openalex-snapshot
Micro ribonucleic acids-drug sensitivity prediction by variational graph auto-encoder and collaborative matrix factorization
inferred← citeshttps://doi.org/10.1016/j.gastre.2024.04.057openalex-snapshot
Personalised therapy in inflammatory bowel disease
inferred← citeshttps://doi.org/10.1016/j.gastrohep.2023.12.006openalex-snapshot
Terapia personalizada en la enfermedad inflamatoria intestinal
inferred← citeshttps://doi.org/10.1016/j.gim.2021.12.009openalex-snapshot
Clinical pharmacogenomic testing and reporting: A technical standard of the American College of Medical Genetics and Genomics (ACMG)
inferred← citeshttps://doi.org/10.1016/j.gimo.2025.103452openalex-snapshot
Pharmacogenomics in pediatric oncology: Australian adolescent or young adult and caregiver perspectives
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.126648openalex-snapshot
Physicochemical characterization and clinical evaluation of 3D-printed subdivided tablets of 6-Mercaptopurine with broad dosage variations
inferred← citeshttps://doi.org/10.1016/j.intimp.2026.116454openalex-snapshot
Drugs and natural bioactive products in modulation of inflammatory pathways in cancer: preclinical and clinical evidence of inflammasomes, cytokine networks, and macrophage polarization
inferred← citeshttps://doi.org/10.1016/j.isci.2026.115191openalex-snapshot
Pharmacogenomic diversity among Arab populations: A systematic review
inferred← citeshttps://doi.org/10.1016/j.japh.2019.06.008openalex-snapshot
Ready or not, here it comes: Direct-to-consumer pharmacogenomic testing and its implications for community pharmacists
inferred← citeshttps://doi.org/10.1016/j.jarlif.2026.100059openalex-snapshot
Utility of APOE testing for reducing ARIA under probabilistic stopping rates to treat with anti-amyloid therapy for ε4-homozygote patients: A simulation study
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100568openalex-snapshot
Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity
inferred← citeshttps://doi.org/10.1016/j.jmoldx.2022.03.008openalex-snapshot
Analytical Validation of a Computational Method for Pharmacogenetic Genotyping from Clinical Whole Exome Sequencing
inferred← citeshttps://doi.org/10.1016/j.jmoldx.2022.06.007openalex-snapshot
TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European…
inferred← citeshttps://doi.org/10.1016/j.jmoldx.2022.06.008openalex-snapshot
Characterization of Reference Materials for TPMT and NUDT15
inferred← citeshttps://doi.org/10.1016/j.jmoldx.2024.07.005openalex-snapshot
Genotype and Phenotype Correlation of the TPMT∗8 Allele in Thiopurine Metabolism
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2022.577904openalex-snapshot
Distinguishing CNS neurosarcoidosis from multiple sclerosis and an approach to “overlap” cases
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.114124openalex-snapshot
Methotrexate polyglutamate quantification for clinical application in patients with pediatric acute lymphoblastic leukemia in association with genetic polymorphisms
inferred← citeshttps://doi.org/10.1016/j.jpeds.2019.09.024openalex-snapshot
The Role of TPMT, ITPA, and NUDT15 Variants during Mercaptopurine Treatment of Swedish Pediatric Patients with Acute Lymphoblastic Leukemia
inferred← citeshttps://doi.org/10.1016/j.jtemb.2026.127952openalex-snapshot
Lead exposure decreases TPMT activity, highlighting the need for thiopurine dose adjustment in high-exposure individuals
inferred← citeshttps://doi.org/10.1016/j.lanwpc.2020.100001openalex-snapshot
Rapid whole-exome sequencing facilitates precision medicine in paediatric rare disease patients and reduces healthcare costs
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