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LXR‐dependent and ‐independent effects of oxysterols on immunity and tumor growth

https://doi.org/10.1002/eji.201344292

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/eji.201242523openalex-snapshot

Converse regulation of CCR 7‐driven human dendritic cell migration by prostaglandin E 2 and liver X receptor activation

inferredcites →https://doi.org/10.1002/mc.21924openalex-snapshot

The oxysterol receptors lxrα and lxrβ suppress proliferation in the colon

inferredcites →https://doi.org/10.1016/j.cell.2004.09.032openalex-snapshot

LXR-Dependent Gene Expression Is Important for Macrophage Survival and the Innate Immune Response

inferredcites →https://doi.org/10.1016/j.cell.2005.12.022openalex-snapshot

Protein Sensors for Membrane Sterols

inferredcites →https://doi.org/10.1016/j.cell.2008.04.052openalex-snapshot

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

inferredcites →https://doi.org/10.1016/j.cell.2012.06.054openalex-snapshot

Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses

inferredcites →https://doi.org/10.1016/j.coph.2012.07.002openalex-snapshot

Cholesterol and its derivatives in Sonic Hedgehog signaling and cancer

inferredcites →https://doi.org/10.1016/j.coph.2012.07.003openalex-snapshot

Control of the immune system by oxysterols and cancer development

inferredcites →https://doi.org/10.1016/j.immuni.2009.06.018openalex-snapshot

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

inferredcites →https://doi.org/10.1016/j.tips.2012.03.013openalex-snapshot

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

inferredcites →https://doi.org/10.1016/s0959-437x(98)80013-0openalex-snapshot

The LXRs: a new class of oxysterol receptors

inferredcites →https://doi.org/10.1038/nature07202openalex-snapshot

Integration of metabolism and inflammation by lipid-activated nuclear receptors

inferredcites →https://doi.org/10.1038/nature10226openalex-snapshot

Oxysterols direct B-cell migration through EBI2

inferredcites →https://doi.org/10.1038/nature10280openalex-snapshot

Oxysterols direct immune cell migration via EBI2

inferredcites →https://doi.org/10.1038/nchembio.765openalex-snapshot

Oxysterols are allosteric activators of the oncoprotein Smoothened

inferredcites →https://doi.org/10.1038/ni.2555openalex-snapshot

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

inferredcites →https://doi.org/10.1038/ni.2681openalex-snapshot

Sterols and oxysterols in immune cell function

inferredcites →https://doi.org/10.1038/nm.2074openalex-snapshot

Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

inferredcites →https://doi.org/10.1038/nm820openalex-snapshot

Reciprocal regulation of inflammation and lipid metabolism by liver X receptors

inferredcites →https://doi.org/10.1038/nrc3239openalex-snapshot

The blockade of immune checkpoints in cancer immunotherapy

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Statin therapy and autoimmune disease: from protein prenylation to immunomodulation

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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells

inferredcites →https://doi.org/10.1038/nri3024openalex-snapshot

Neutrophils in the activation and regulation of innate and adaptive immunity

inferredcites →https://doi.org/10.1038/onc.2010.30openalex-snapshot

Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells

inferredcites →https://doi.org/10.1053/j.gastro.2013.02.005openalex-snapshot

Liver X Receptors Inhibit Proliferation of Human Colorectal Cancer Cells and Growth of Intestinal Tumors in Mice

inferredcites →https://doi.org/10.1073/pnas.0407749101openalex-snapshot

Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

inferredcites →https://doi.org/10.1073/pnas.0602852103openalex-snapshot

Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells

inferredcites →https://doi.org/10.1074/jbc.m110.188433openalex-snapshot

Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1

inferredcites →https://doi.org/10.1074/jbc.r700049200openalex-snapshot

Cholesterol, Reactive Oxygen Species, and the Formation of Biologically Active Mediators

inferredcites →https://doi.org/10.1074/jbc.r800006200openalex-snapshot

Oxidized Lipids Formed Non-enzymatically by Reactive Oxygen Species

inferredcites →https://doi.org/10.1084/jem.191.3.411openalex-snapshot

The Induction of Tolerance by Dendritic Cells That Have Captured Apoptotic Cells

inferredcites →https://doi.org/10.1084/jem.193.2.f5openalex-snapshot

Differentiation of T Regulatory Cells by Immature Dendritic Cells

inferredcites →https://doi.org/10.1084/jem.20051129openalex-snapshot

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin

inferredcites →https://doi.org/10.1084/jem.20130440openalex-snapshot

The oxysterol–CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils

inferredcites →https://doi.org/10.1093/carcin/bgp029openalex-snapshot

The oxysterol receptor LXR inhibits proliferation of human breast cancer cells

inferredcites →https://doi.org/10.1101/gad.14.2.121openalex-snapshot

The coregulator exchange in transcriptional functions of nuclear receptors

inferredcites →https://doi.org/10.1101/sqb.2007.72.058openalex-snapshot

Nuclear Receptors, Metabolism, and the Circadian Clock

inferredcites →https://doi.org/10.1126/science.1241908openalex-snapshot

27-Hydroxycholesterol Links Hypercholesterolemia and Breast Cancer Pathophysiology

inferredcites →https://doi.org/10.1128/mcb.21.22.7558-7568.2001openalex-snapshot

Autoregulation of the Human Liver X Receptor α Promoter

inferredcites →https://doi.org/10.1146/annurev-immunol-031210-101324openalex-snapshot

Natural Innate and Adaptive Immunity to Cancer

inferredcites →https://doi.org/10.1146/annurev.immunol.18.1.593openalex-snapshot

The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses

inferredcites →https://doi.org/10.1146/annurev.immunol.21.120601.141040openalex-snapshot

Tolerogenic Dendritic Cells

inferredcites →https://doi.org/10.1146/annurev.immunol.26.021607.090254openalex-snapshot

Migration of Dendritic Cell Subsets and their Precursors

inferredcites →https://doi.org/10.1146/annurev.physiol.68.033104.152158openalex-snapshot

LXRS AND FXR: The Yin and Yang of Cholesterol and Fat Metabolism

inferredcites →https://doi.org/10.1158/0008-5472.can-04-2332openalex-snapshot

Antiproliferative Effect of Liver X Receptor Agonists on LNCaP Human Prostate Cancer Cells

inferredcites →https://doi.org/10.1158/2159-8290.cd-11-0102openalex-snapshot

An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

inferredcites →https://doi.org/10.1172/jci0216388openalex-snapshot

Do oxysterols control cholesterol homeostasis?

inferredcites →https://doi.org/10.1172/jci16388openalex-snapshot

Do oxysterols control cholesterol homeostasis?

inferredcites →https://doi.org/10.1172/jci38911openalex-snapshot

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

inferredcites →https://doi.org/10.1172/jci42974openalex-snapshot

Liver X receptor (LXR) mediates negative regulation of mouse and human Th17 differentiation

inferredcites →https://doi.org/10.1172/jci58393openalex-snapshot

Coordinate regulation of neutrophil homeostasis by liver X receptors in mice

inferredcites →https://doi.org/10.1182/blood-2001-11-0017openalex-snapshot

Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells

inferredcites →https://doi.org/10.1182/blood-2006-08-043422openalex-snapshot

Liver X receptors regulate dendritic cell phenotype and function through blocked induction of the actin-bundling protein fascin

inferredcites →https://doi.org/10.1189/jlb.0411198openalex-snapshot

Metabolism, LXR/LXR ligands, and tumor immune escape

inferredcites →https://doi.org/10.1189/jlb.1008663openalex-snapshot

Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes

inferredcites →https://doi.org/10.1371/journal.pgen.1003483openalex-snapshot

Liver X Receptors Protect from Development of Prostatic Intra-Epithelial Neoplasia in Mice

inferredcites →https://doi.org/10.1371/journal.ppat.1000981openalex-snapshot

PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy

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Nuclear hormone receptors put immunity on sterols

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Metabolomics in Autoimmunity, Infections, and Physiological Diseases

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Immune Cell Metabolism in Tumor Microenvironment

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Lipid Metabolism and Tumor Antigen Presentation

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The administration of drugs inhibiting cholesterol/oxysterol synthesis is safe and increases the efficacy of immunotherapeutic regimens in tumor-bearing mice

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Oxysterols in Cell Viability, Phospholipidosis and Extracellular Vesicles Production in a Lung Cancer Model

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Oxysterols and mesenchymal stem cell biology

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22(R)-hydroxycholesterol induces HuR-dependent MAP kinase phosphatase-1 expression via mGluR5-mediated Ca2+/PKCα signaling

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Beyond the membrane: lipid rafts and oxysterols establish cholesterol as a dynamic signaling hub while underlying the cholesterol paradox in cancer

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Lipid metabolism and lipophagy in cancer

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Lipoproteins and cancer: The role of HDL-C, LDL-C, and cholesterol-lowering drugs

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Implication of oxysterols in chronic inflammatory human diseases

inferred← citeshttps://doi.org/10.1016/j.bmcl.2016.09.029openalex-snapshot

Fluoro analogs of bioactive oxy-sterols: Synthesis of an EBI2 agonist with enhanced metabolic stability

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Metabolic reprogramming of macrophages during infections and cancer

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An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles

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Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol

inferred← citeshttps://doi.org/10.1016/j.coph.2017.05.004openalex-snapshot

Leukocyte trafficking in tumor microenvironment

inferred← citeshttps://doi.org/10.1016/j.cyto.2016.12.003openalex-snapshot

Liver X receptors agonists suppress NLRP3 inflammasome activation

inferred← citeshttps://doi.org/10.1016/j.cytogfr.2017.06.005openalex-snapshot

Tumor-derived factors affecting immune cells

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HNE and cholesterol oxidation products in colorectal inflammation and carcinogenesis

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Metabolic Reprogramming of Immune Cells in Cancer Progression

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Oxysterols in tumor immune microenvironment (TIME)

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Emerging role of 7-Ketocholesterol and hydroxylated 7-Ketocholesterol in the pathophysiology of disease

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