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Mps1 as a link between centrosomes and genomic instability

https://doi.org/10.1002/em.20476

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/978-1-4612-0411-4_18openalex-snapshot

Tumor Progression in Breast Cancer

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The Protein Protocols Handbook

inferredcites →https://doi.org/10.1007/s10549-004-1424-7openalex-snapshot

Genomic patterns of allelic imbalance in disease free tissue adjacent to primary breast carcinomas

inferredcites →https://doi.org/10.1016/j.ceb.2005.12.008openalex-snapshot

Controlling centrosome number: licenses and blocks

inferredcites →https://doi.org/10.1016/j.devcel.2007.07.002openalex-snapshot

Plk4-Induced Centriole Biogenesis in Human Cells

inferredcites →https://doi.org/10.1016/j.tcb.2007.03.003openalex-snapshot

Centrosome duplication: of rules and licenses

inferredcites →https://doi.org/10.1016/s0002-9440(10)65513-7openalex-snapshot

Altered Centrosome Structure Is Associated with Abnormal Mitoses in Human Breast Tumors

inferredcites →https://doi.org/10.1016/s0070-2153(99)49015-5openalex-snapshot

The role of the centrosome in the development of malignant tumors

inferredcites →https://doi.org/10.1016/s0092-8674(01)00410-xopenalex-snapshot

Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint

inferredcites →https://doi.org/10.1016/s0092-8674(01)00411-1openalex-snapshot

The Mouse Mps1p-like Kinase Regulates Centrosome Duplication

inferredcites →https://doi.org/10.1016/s0248-4900(99)80086-0openalex-snapshot

Centrosomes and cancer

inferredcites →https://doi.org/10.1016/s0955-0674(02)00385-xopenalex-snapshot

Centrosomes and tumour suppressors

inferredcites →https://doi.org/10.1016/s0960-9822(01)00094-xopenalex-snapshot

Kinetics and regulation of de novo centriole assembly

inferredcites →https://doi.org/10.1016/s1097-2765(02)00654-8openalex-snapshot

Duplicating Dangerously

inferredcites →https://doi.org/10.1016/s1470-2045(04)01653-5openalex-snapshot

Genomic instability in histologically normal breast tissues: implications for carcinogenesis

inferredcites →https://doi.org/10.1038/25292openalex-snapshot

Genetic instabilities in human cancers

inferredcites →https://doi.org/10.1038/nrc2249openalex-snapshot

Oncogenes and tumour suppressors take on centrosomes

inferredcites →https://doi.org/10.1038/nrc924openalex-snapshot

Centrosome aberrations: cause or consequence of cancer progression?

inferredcites →https://doi.org/10.1038/sj.onc.1210456openalex-snapshot

Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates

inferredcites →https://doi.org/10.1038/sj.onc.1210815openalex-snapshot

Ovarian hyperstimulation induces centrosome amplification and aneuploid mammary tumors independently of alterations in p53 in a transgenic mouse model of breast cancer

inferredcites →https://doi.org/10.1073/pnas.032479999openalex-snapshot

Centrosome amplification drives chromosomal instability in breast tumor development

inferredcites →https://doi.org/10.1073/pnas.0401139101openalex-snapshot

The Six1 homeoprotein stimulates tumorigenesis by reactivation of cyclin A1

inferredcites →https://doi.org/10.1073/pnas.2434156100openalex-snapshot

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

inferredcites →https://doi.org/10.1073/pnas.95.6.2950openalex-snapshot

Centrosome hypertrophy in human breast tumors: Implications for genomic stability and cell polarity

inferredcites →https://doi.org/10.1074/jbc.m002446200openalex-snapshot

Cell Cycle-regulated Phosphorylation of the Human SIX1 Homeodomain Protein

inferredcites →https://doi.org/10.1083/jcb.114.4.745openalex-snapshot

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.

inferredcites →https://doi.org/10.1083/jcb.132.1.111openalex-snapshot

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.

inferredcites →https://doi.org/10.1083/jcb.149.2.317openalex-snapshot

The Respective Contributions of the Mother and Daughter Centrioles to Centrosome Activity and Behavior in Vertebrate Cells

inferredcites →https://doi.org/10.1083/jcb.200411126openalex-snapshot

The de novo centriole assembly pathway in HeLa cells

inferredcites →https://doi.org/10.1091/mbc.02-05-0074openalex-snapshot

Human MPS1 Kinase Is Required for Mitotic Arrest Induced by the Loss of CENP-E from Kinetochores

inferredcites →https://doi.org/10.1091/mbc.9.4.759openalex-snapshot

New Alleles of the YeastMPS1Gene Reveal Multiple Requirements in Spindle Pole Body Duplication

inferredcites →https://doi.org/10.1091/mbc.e04-10-0939openalex-snapshot

The Forkhead-associated Domain Protein Cep170 Interacts with Polo-like Kinase 1 and Serves as a Marker for Mature Centrioles

inferredcites →https://doi.org/10.1091/mbc.e07-03-0283openalex-snapshot

Preventing the Degradation of Mps1 at Centrosomes Is Sufficient to Cause Centrosome Reduplication in Human Cells

inferredcites →https://doi.org/10.1093/emboj/21.7.1723openalex-snapshot

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

inferredcites →https://doi.org/10.1097/01.coc.0000198740.33617.2fopenalex-snapshot

Biology of Ductal Carcinoma in Situ Classification Based on Biologic Potential

inferredcites →https://doi.org/10.1111/j.1365-2443.2007.01091.xopenalex-snapshot

Physical and functional interaction between mortalin and Mps1 kinase

inferredcites →https://doi.org/10.1126/science.273.5277.953openalex-snapshot

Activation of the Budding Yeast Spindle Assembly Checkpoint Without Mitotic Spindle Disruption

inferredcites →https://doi.org/10.1158/0008-5472.can-03-0110openalex-snapshot

The Cyclin-dependent Kinase Inhibitor CYC202 (R-Roscovitine) Inhibits Retinoblastoma Protein Phosphorylation, Causes Loss of Cyclin D1, and Activates the Mitogen-activated Protein Kinase Pathway

inferredcites →https://doi.org/10.1158/1078-0432.ccr-05-0903openalex-snapshot

Increased Expression of Mitotic Checkpoint Genes in Breast Cancer Cells with Chromosomal Instability

inferredcites →https://doi.org/10.1242/jcs.005231openalex-snapshot

Structure and duplication of the centrosome

inferredcites →https://doi.org/10.1242/jcs.115.9.1825openalex-snapshot

CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4185504openalex-extracted

inferred← citeshttps://doi.org/10.1002/cm.22032openalex-snapshot

Inactivation of the Catalytic Activity of Mps1 Kinase Prevents Its Own Degradation at Centrosomes

inferred← citeshttps://doi.org/10.1007/978-1-4419-0461-4_576openalex-snapshot

Monopolar Spindle 1 (Mps1)

inferred← citeshttps://doi.org/10.1007/978-1-62703-035-9_8openalex-snapshot

Many Pathways to Destruction: The Role of the Centrosome in, and Its Control by Regulated Proteolysis

inferred← citeshttps://doi.org/10.1007/978-3-030-23173-6_17openalex-snapshot

Breaking Bad: Uncoupling of Modularity in Centriole Biogenesis and the Generation of Excess Centrioles in Cancer

inferred← citeshttps://doi.org/10.1007/978-3-319-67199-4_576openalex-snapshot

Monopolar Spindle 1 (Mps1)

inferred← citeshttps://doi.org/10.1016/j.bmc.2017.02.030openalex-snapshot

Novel pyrrolopyrimidines as Mps1/TTK kinase inhibitors for breast cancer

inferred← citeshttps://doi.org/10.1016/j.canlet.2013.05.029openalex-snapshot

Oncogenic B-RafV600E abrogates the AKT/B-Raf/Mps1 interaction in melanoma cells

inferred← citeshttps://doi.org/10.1016/j.ejmech.2019.04.047openalex-snapshot

Molecular design and anticancer activities of small-molecule monopolar spindle 1 inhibitors: A Medicinal chemistry perspective

inferred← citeshttps://doi.org/10.1016/j.ejmech.2020.113023openalex-snapshot

Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114887openalex-snapshot

Design, Synthesis and Biological Evaluation of a New Class of 7H-Pyrrolo[2,3-D]Pyrimidine Derivatives as Mps1 Inhibitors for the Treatment of Breast Cancer

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116504openalex-snapshot

Hijacking monopolar spindle 1 (MPS1) for various cancer types by small molecular inhibitors: Deep insights from a decade of research and patents

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00963openalex-snapshot

Development of MPS1 Inhibitors: Recent Advances and Perspectives

inferred← citeshttps://doi.org/10.1038/mp.a000882.01openalex-snapshot

Mps1

inferred← citeshttps://doi.org/10.1038/onc.2012.94openalex-snapshot

Phosphorylation of Mps1 by BRAFV600E prevents Mps1 degradation and contributes to chromosome instability in melanoma

inferred← citeshttps://doi.org/10.1073/pnas.1607421113openalex-snapshot

Modular elements of the TPR domain in the Mps1 N terminus differentially target Mps1 to the centrosome and kinetochore

inferred← citeshttps://doi.org/10.1074/jbc.m110.140905openalex-snapshot

Degradation of the Human Mitotic Checkpoint Kinase Mps1 Is Cell Cycle-regulated by APC-cCdc20 and APC-cCdh1 Ubiquitin Ligases*

inferred← citeshttps://doi.org/10.1091/mbc.e10-04-0281openalex-snapshot

Antizyme Restrains Centrosome Amplification by Regulating the Accumulation of Mps1 at Centrosomes

inferred← citeshttps://doi.org/10.1091/mbc.e10-04-0298openalex-snapshot

Mps1 Phosphorylation Sites Regulate the Function of Centrin 2 in Centriole Assembly

inferred← citeshttps://doi.org/10.1091/mbc.e14-07-1248openalex-snapshot

Centrin 3 is an inhibitor of centrosomal Mps1 and antagonizes centrin 2 function

inferred← citeshttps://doi.org/10.1158/1541-7786.mcr-14-0462-topenalex-snapshot

Targeting MPS1 Enhances Radiosensitization of Human Glioblastoma by Modulating DNA Repair Proteins

inferred← citeshttps://doi.org/10.1186/1747-1028-6-9openalex-snapshot

Centriole assembly and the role of Mps1: defensible or dispensable?

inferred← citeshttps://doi.org/10.1186/1747-1028-9-3openalex-snapshot

Differential expression of centrosome regulators in Her2+ breast cancer cells versus non-tumorigenic MCF10A cells

inferred← citeshttps://doi.org/10.1371/journal.pone.0067822openalex-snapshot

CDC25B Overexpression Stabilises Centrin 2 and Promotes the Formation of Excess Centriolar Foci

inferred← citeshttps://doi.org/10.18632/oncotarget.6432openalex-snapshot

Whole-genome duplication increases tumor cell sensitivity to MPS1 inhibition

inferred← citeshttps://doi.org/10.18632/oncotarget.6552openalex-snapshot

Mps1 is SUMO-modified during the cell cycle

inferred← citeshttps://doi.org/10.24275/uami.2r36tx79mopenalex-snapshot

Análisis de la participación de MPS1 en la inducción de amplificación de centrosomas por mutantes de P53 en líneas celulares de cáncer

inferred← citeshttps://doi.org/10.3389/fonc.2013.00277openalex-snapshot

Centrosome Dysfunction Contributes to Chromosome Instability, Chromoanagenesis, and Genome Reprograming in Cancer

inferred← citeshttps://doi.org/10.3892/ijmm.2014.1961openalex-snapshot

Effects of ornithine decarboxylase antizyme 1 on the proliferation and differentiation of human oral cancer cells

inferred← citeshttps://doi.org/10.3892/ol.2019.9924openalex-snapshot

Mps1 is associated with the BRAFV600E mutation and predicts poor outcome in patients with colorectal cancer

inferred← citeshttps://doi.org/10.4137/cin.s6631openalex-snapshot

In silico Analysis of Combinatorial microRNA Activity Reveals Target Genes and Pathways Associated with Breast Cancer Metastasis

inferred← citeshttps://doi.org/10.4161/cc.10.5.14955openalex-snapshot

Mip1 associates with both the Mps1 kinase and actin, and is required for cell cortex stability and anaphase spindle positioning

inferred← citeshttps://doi.org/10.4161/cc.21927openalex-snapshot

VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes

inferred← citeshttps://doi.org/10.4161/cc.23824openalex-snapshot

VDAC3 and Mps1 negatively regulate ciliogenesis

inferred← citeshttps://doi.org/10.5772/intechopen.87547openalex-snapshot

Ubiquitin - Proteasome Pathway

inferred← citeshttps://doi.org/10.5772/intechopen.92623openalex-snapshot

Ubiquitin-Independent Proteasomal Degradation Mediated by Antizyme

inferred← citeshttps://doi.org/10.70675/2ae3e010zff79z4dd2zadfez7f3daabd476bopenalex-snapshot

Phosphoregulation of Mps1 kinase activity

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