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In vivo consequences of liver-specific interleukin-22 expression in mice: Implications for human liver disease progression

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/art.20965openalex-snapshot
Expression of interleukin‐22 in rheumatoid arthritis: Potential role as a proinflammatory cytokine
inferredcites →https://doi.org/10.1002/eji.200838655openalex-snapshot
IL‐22 and inflammation: Leukin' through a glass onion
inferredcites →https://doi.org/10.1002/hep.20184openalex-snapshot
Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation
inferredcites →https://doi.org/10.1002/hep.23273openalex-snapshot
Interleukin-17–Producing Cd4+ T Cells Increase With Severity of Liver Damage in Patients With Chronic Hepatitis B
inferredcites →https://doi.org/10.1002/hep.23837openalex-snapshot
Interleukin-22 Treatment Ameliorates Alcoholic Liver Injury in a Murine Model of Chronic-Binge Ethanol Feeding: Role of Signal Transducer and Activator of Transcription 3
inferredcites →https://doi.org/10.1007/s00018-010-0380-0openalex-snapshot
Structure and function of interleukin-22 and other members of the interleukin-10 family
inferredcites →https://doi.org/10.1007/s00109-009-0448-1openalex-snapshot
IL-22: A critical mediator in mucosal host defense
inferredcites →https://doi.org/10.1007/s00109-009-0457-0openalex-snapshot
IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-γ are not
inferredcites →https://doi.org/10.1007/s00281-009-0188-xopenalex-snapshot
Biology of interleukin-22
inferredcites →https://doi.org/10.1016/j.cyto.2007.11.016openalex-snapshot
The role of interleukin-22 in hepatitis C virus infection
inferredcites →https://doi.org/10.1016/j.cytogfr.2010.08.002openalex-snapshot
Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
inferredcites →https://doi.org/10.1016/j.immuni.2007.07.023openalex-snapshot
Interleukin-22 but Not Interleukin-17 Provides Protection to Hepatocytes during Acute Liver Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2008.03.004openalex-snapshot
The Biological Functions of T Helper 17 Cell Effector Cytokines in Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2008.11.003openalex-snapshot
Innate and Adaptive Interleukin-22 Protects Mice from Inflammatory Bowel Disease
inferredcites →https://doi.org/10.1016/j.jhep.2010.03.004openalex-snapshot
Amelioration of high fat diet induced liver lipogenesis and hepatic steatosis by interleukin-22
inferredcites →https://doi.org/10.1038/cmi.2010.5openalex-snapshot
Th17 cells and their associated cytokines in liver diseases
inferredcites →https://doi.org/10.1053/j.gastro.2009.08.066openalex-snapshot
Natural Killer Cells Are Polarized Toward Cytotoxicity in Chronic Hepatitis C in an Interferon-Alfa–Dependent Manner
inferredcites →https://doi.org/10.1053/j.gastro.2010.01.006openalex-snapshot
Activation of Natural Killer Cells During Acute Infection With Hepatitis C Virus
inferredcites →https://doi.org/10.1074/jbc.m511797200openalex-snapshot
Role of STAT3 in Type I Interferon Responses
inferredcites →https://doi.org/10.1126/science.1140485openalex-snapshot
Gender Disparity in Liver Cancer Due to Sex Differences in MyD88-Dependent IL-6 Production
inferredcites →https://doi.org/10.1172/jci0215841openalex-snapshot
Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS
inferredcites →https://doi.org/10.1172/jci15841openalex-snapshot
Opposing roles of STAT1 and STAT3 in T cell–mediated hepatitis: regulation by SOCS
inferredcites →https://doi.org/10.1172/jci33194openalex-snapshot
IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis
inferredcites →https://doi.org/10.1172/jci33263openalex-snapshot
IL-22 is required for Th17 cell–mediated pathology in a mouse model of psoriasis-like skin inflammation
inferredcites →https://doi.org/10.1182/blood-2010-05-285908openalex-snapshot
A novel role for IL-22R1 as a driver of inflammation
inferredcites →https://doi.org/10.4049/jimmunol.0904091openalex-snapshot
IL-22 Induces an Acute-Phase Response
inferredcites →https://doi.org/10.4049/jimmunol.164.4.1814openalex-snapshot
Cloning and Characterization of IL-10-Related T Cell-Derived Inducible Factor (IL-TIF), a Novel Cytokine Structurally Related to IL-10 and Inducible by IL-9
inferredcites →https://doi.org/10.4049/jimmunol.178.9.5973openalex-snapshot
IL-22 Induces Lipopolysaccharide-Binding Protein in Hepatocytes: A Potential Systemic Role of IL-22 in Crohn’s Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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The role of IL ‐22 in the resolution of sterile and nonsterile inflammation
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A catch‐22: Interleukin‐22 and cancer
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Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice
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Interleukin-22, Liver Progenitor Cells, and Liver Cancer
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Pathological functions of interleukin-22 in chronic liver inflammation and fibrosis with hepatitis B virus infection by promoting T helper 17 cell recruitment
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IL‐22 and IL‐22 binding protein (IL‐22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections
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NKp46+ natural killer cells attenuate metabolism‐induced hepatic fibrosis by regulating macrophage activation in mice
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P2X1‐regulated IL‐22 secretion by innate lymphoid cells is required for efficient liver regeneration
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Interleukin‐22 Ameliorates Neutrophil‐Driven Nonalcoholic Steatohepatitis Through Multiple Targets
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Metformin decreases IL ‐22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma
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Innate lymphoid cells involve in tumorigenesis
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Interleukin‐22 and intestinal homeostasis: Protective or destructive?
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Diverse immunological roles of liver‐resident immune cells in liver diseases
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Nonclinical safety assessment of a human interleukin‐22 FC IG fusion protein demonstrates in vitro to in vivo and cross‐species translatability
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Review on Liver Inflammation and Antiinflammatory Activity of Andrographis paniculata for Hepatoprotection
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Hepatic Immune System: Adaptations to Alcohol
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Clinical Implications of Hepatocyte Growth Factor, Interleukin-20, and Interleukin-22 in Serum and Bronchoalveolar Fluid of Patients with Non-Small Cell Lung Cancer
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Stem Cell Therapy for Liver Diseases
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Janus or Hydra: The Many Faces of T Helper Cells in the Human Tumour Microenvironment
inferred← citeshttps://doi.org/10.1007/978-3-030-55617-4_5openalex-snapshot
IL-22 Signaling in the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1007/978-3-030-57949-4_9openalex-snapshot
Hepatobiliary Tumors: Immunopathology and Immunotherapy
inferred← citeshttps://doi.org/10.1007/978-3-030-98950-7_12openalex-snapshot
Inflammatory Biomarkers for Cancer
inferred← citeshttps://doi.org/10.1007/978-3-0348-0522-3_4openalex-snapshot
Contributions of IL-22 to TH17 Responses: Repairing and Protecting Peripheral Tissues
inferred← citeshttps://doi.org/10.1007/978-3-319-02096-9_28openalex-snapshot
The Immunopathogenesis of Cirrhosis
inferred← citeshttps://doi.org/10.1007/978-3-319-39147-2_10openalex-snapshot
Inflammatory Biomarkers for Cancer
inferred← citeshttps://doi.org/10.1007/978-4-431-54442-5_6openalex-snapshot
Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells
inferred← citeshttps://doi.org/10.1007/978-94-017-9487-9_8openalex-snapshot
The Biology and Functions of Th22 Cells
inferred← citeshttps://doi.org/10.1007/s00109-016-1391-6openalex-snapshot
Biological and pathological activities of interleukin-22
inferred← citeshttps://doi.org/10.1007/s00281-021-00854-zopenalex-snapshot
The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies
inferred← citeshttps://doi.org/10.1007/s00281-022-00917-9openalex-snapshot
Th17 cells in the liver: balancing autoimmunity and pathogen defense
inferred← citeshttps://doi.org/10.1007/s10238-024-01548-0openalex-snapshot
Changes in CD4+ T cells subsets in patients with alcohol-related cirrhosis
inferred← citeshttps://doi.org/10.1007/s10616-021-00517-9openalex-snapshot
Th22/IL-22 mediates the progression of HBV-related hepatocellular carcinoma via STAT3
inferred← citeshttps://doi.org/10.1007/s10637-011-9791-5openalex-snapshot
Ent-11α-hydroxy-15-oxo-kaur-16-en-19-oic-acid inhibits hepatocellular carcinoma in vitro and in vivo via stabilizing IkBα
inferred← citeshttps://doi.org/10.1007/s10735-025-10622-0openalex-snapshot
Zhuyu pill mitigates NAFLD through activation of IL22/JAK1/STAT3 signaling pathway
inferred← citeshttps://doi.org/10.1007/s11033-018-04573-xopenalex-snapshot
IL-22 in hepatocyte’s survival of Pakistani patients with end stage liver disease: an insight into IL 22 mediated hepato-regenerative pathway
inferred← citeshttps://doi.org/10.1007/s11684-013-0256-4openalex-snapshot
Inflammation and liver tumorigenesis
inferred← citeshttps://doi.org/10.1007/s12016-014-8465-4openalex-snapshot
Cytokine-Mediated Immunopathogenesis of Hepatitis B Virus Infections
inferred← citeshttps://doi.org/10.1007/s12032-024-02481-8openalex-snapshot
The role of IL-22 in cancer
inferred← citeshttps://doi.org/10.1007/s12072-014-9516-xopenalex-snapshot
New drug targets for alcoholic liver disease
inferred← citeshttps://doi.org/10.1007/s12072-020-10082-6openalex-snapshot
Interleukin-22 in alcoholic hepatitis and beyond
inferred← citeshttps://doi.org/10.1007/s13277-015-4294-1openalex-snapshot
IL-22: a promising candidate to inhibit viral-induced liver disease progression and hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1007/s13770-023-00525-0openalex-snapshot
Immunomodulation for Tissue Repair and Regeneration
inferred← citeshttps://doi.org/10.1007/s40139-014-0053-zopenalex-snapshot
New Approaches for Studying Alcoholic Liver Disease
inferred← citeshttps://doi.org/10.1007/s40139-015-0088-9openalex-snapshot
Physiological and Pathological Properties of Interleukin-22 in Liver Diseases
inferred← citeshttps://doi.org/10.1016/b978-0-12-801121-8.00002-6openalex-snapshot
Interleukin-1 Superfamily and Cancer
inferred← citeshttps://doi.org/10.1016/b978-0-12-801121-8.00006-3openalex-snapshot
Interleukin-10 Superfamily and Cancer
inferred← citeshttps://doi.org/10.1016/b978-0-323-37591-7.00005-7openalex-snapshot
The Liver's Response to Injury
inferred← citeshttps://doi.org/10.1016/j.ajpath.2011.05.005openalex-snapshot
Hepatoprotective versus Oncogenic Functions of STAT3 in Liver Tumorigenesis
inferred← citeshttps://doi.org/10.1016/j.ajpath.2012.08.043openalex-snapshot
Protective and Pathological Properties of IL-22 in Liver Disease
inferred← citeshttps://doi.org/10.1016/j.ajpath.2012.12.010openalex-snapshot
Application of Interleukin-22 Mediates Protection in Experimental Acetaminophen-Induced Acute Liver Injury
inferred← citeshttps://doi.org/10.1016/j.ajpath.2025.03.010openalex-snapshot
An Update on IL-22 Therapies in Alcohol-Associated Liver Disease and Beyond
inferred← citeshttps://doi.org/10.1016/j.alit.2018.10.002openalex-snapshot
Bidirectional roles of IL-22 in the pathogenesis of allergic airway inflammation
inferred← citeshttps://doi.org/10.1016/j.antiviral.2022.105366openalex-snapshot
Long-term and efficient inhibition of hepatitis B virus replication by AAV8-delivered artificial microRNAs
inferred← citeshttps://doi.org/10.1016/j.biocel.2023.106503openalex-snapshot
IL-22 relieves hepatic ischemia-reperfusion injury by inhibiting mitochondrial apoptosis based on the activation of STAT3
inferred← citeshttps://doi.org/10.1016/j.biopha.2021.111372openalex-snapshot
The lignan-rich fraction from Sambucus Williamsii Hance ameliorates dyslipidemia and insulin resistance and modulates gut microbiota composition in ovariectomized rats
inferred← citeshttps://doi.org/10.1016/j.cellimm.2015.09.006openalex-snapshot
Characteristics of innate lymphoid cells (ILCs) and their role in immunological disorders (an update)
inferred← citeshttps://doi.org/10.1016/j.cellsig.2019.109388openalex-snapshot
IL-18/IL-18BP and IL-22/IL-22BP: Two interrelated couples with therapeutic potential
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A Randomized Phase II Study of Efmarodocokin Alfa, an interleukin-22 Agonist, Versus Vedolizumab in Patients With Ulcerative Colitis
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Emerging Pharmacologic Treatments for Alcohol-Associated Hepatitis
inferred← citeshttps://doi.org/10.1016/j.clim.2015.03.003openalex-snapshot
Up-regulation of interleukin-22 mediates liver fibrosis via activating hepatic stellate cells in patients with hepatitis C
inferred← citeshttps://doi.org/10.1016/j.clim.2023.109320openalex-snapshot
IL-22-producing CD3 + CD8- T cells increase in immune clearance stage of chronic HBV infection and correlate with the response of Peg-interferon treatment
inferred← citeshttps://doi.org/10.1016/j.clinre.2015.05.008openalex-snapshot
Combination therapy: New hope for alcoholic hepatitis?
inferred← citeshttps://doi.org/10.1016/j.clinre.2020.01.009openalex-snapshot
Interleukin 22 is related to development and poor prognosis of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1016/j.cyto.2016.08.023openalex-snapshot
Role of Interleukin-22 in chronic liver injury
inferred← citeshttps://doi.org/10.1016/j.cyto.2018.07.028openalex-snapshot
Type 3 cytokines in liver fibrosis and liver cancer
inferred← citeshttps://doi.org/10.1016/j.cyto.2024.156840openalex-snapshot
The protective effect of the vagus nerve-α7nAChR-IL-22 pathway on acute liver injury
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2014.04.005openalex-snapshot
The role of the IL-22/IL-22R1 axis in cancer
inferred← citeshttps://doi.org/10.1016/j.fbio.2023.102601openalex-snapshot
Lipidomics approach in alcoholic liver disease mice with sphingolipid metabolism disorder: Alleviation using sea cucumber phospholipids
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27578openalex-snapshot
IL-22 promotes liver regeneration after portal vein ligation
inferred← citeshttps://doi.org/10.1016/j.intimp.2020.106439openalex-snapshot
Janus kinase-dependent regulation of drug detoxifying protein expression by interleukin-22 in human hepatic cells
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111015openalex-snapshot
Liposomal IL-22 ameliorates liver fibrosis through miR-let7a/STAT3 signaling in mice
inferred← citeshttps://doi.org/10.1016/j.jaut.2015.10.005openalex-snapshot
AAV-IL-22 modifies liver chemokine activity and ameliorates portal inflammation in murine autoimmune cholangitis
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2020.10.017openalex-snapshot
PLANT PRODUCTION AND FUNCTIONAL CHARACTERIZATION OF CATFISH INTERLEUKIN 22 AS A NATURAL IMMUNE STIMULANT FOR AQUACULTURE
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2018.06.008openalex-snapshot
IL22 Inhibits Epithelial Stem Cell Expansion in an Ileal Organoid Model
inferred← citeshttps://doi.org/10.1016/j.jhep.2012.01.029openalex-snapshot
STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver
inferred← citeshttps://doi.org/10.1016/j.jhep.2015.02.004openalex-snapshot
Protective effect of Th22 cells and intrahepatic IL-22 in drug induced hepatocellular injury
inferred← citeshttps://doi.org/10.1016/j.jhep.2026.01.016openalex-snapshot
IL-22 supports long-term expansion of mouse and human hepatocytes
inferred← citeshttps://doi.org/10.1016/j.jhep.2026.03.034openalex-snapshot
IL-22 unlocks large-scale in vitro hepatocyte expansion via STAT3 activation
inferred← citeshttps://doi.org/10.1016/j.jhepr.2023.100962openalex-snapshot
Roles of innate lymphoid cells in metabolic and alcohol-associated liver diseases
inferred← citeshttps://doi.org/10.1016/j.kint.2023.09.020openalex-snapshot
IL-22 is secreted by proximal tubule cells and regulates DNA damage response and cell death in acute kidney injury
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.118677openalex-snapshot
Interleukin-22 regulating Kupffer cell polarization through STAT3/Erk/Akt crosstalk pathways to extenuate liver fibrosis
inferred← citeshttps://doi.org/10.1016/j.livres.2017.09.003openalex-snapshot
Interleukin-22 in the pathogenesis and potential treatment of liver diseases
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WITHDRAWN: IL-22 in liver inflammation, injury and repair
inferred← citeshttps://doi.org/10.1016/j.livres.2018.11.002openalex-snapshot
Alcoholic liver disease: A current molecular and clinical perspective
inferred← citeshttps://doi.org/10.1016/j.livres.2023.03.002openalex-snapshot
Current and emerging therapies for alcohol-associated hepatitis
inferred← citeshttps://doi.org/10.1016/j.molmed.2024.10.016openalex-snapshot
Harnessing IL-22 for metabolic health: promise and pitfalls
inferred← citeshttps://doi.org/10.1016/j.molmet.2024.101965openalex-snapshot
Lipid-encapsulated mRNA encoding an extended serum half-life interleukin-22 ameliorates metabolic disease in mice
inferred← citeshttps://doi.org/10.1016/j.pan.2018.02.014openalex-snapshot
Diverse effects of interleukin-22 on pancreatic diseases
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.06.007openalex-snapshot
Targeting inflammation for the treatment of alcoholic liver disease
inferred← citeshttps://doi.org/10.1016/j.semarthrit.2023.152165openalex-snapshot
Psoriatic disease and non-alcoholic fatty liver disease shared pathogenesis review
inferred← citeshttps://doi.org/10.1038/cmi.2015.97openalex-snapshot
Hepatocytes: a key cell type for innate immunity
inferred← citeshttps://doi.org/10.1038/icb.2016.107openalex-snapshot
Hypoxic modulation of hepatocyte responses to the cytokine interleukin‐22
inferred← citeshttps://doi.org/10.1038/nrc3611openalex-snapshot
Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms
inferred← citeshttps://doi.org/10.1038/nrd4176openalex-snapshot
Therapeutic opportunities of the IL-22–IL-22R1 system
inferred← citeshttps://doi.org/10.1038/nri3766openalex-snapshot
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
inferred← citeshttps://doi.org/10.1038/s41392-024-02104-8openalex-snapshot
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics
inferred← citeshttps://doi.org/10.1038/s41419-020-03176-4openalex-snapshot
IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling
inferred← citeshttps://doi.org/10.1038/s41423-018-0029-8openalex-snapshot
Safety, pharmacokinetics, and biomarkers of F-652, a recombinant human interleukin-22 dimer, in healthy subjects
inferred← citeshttps://doi.org/10.1038/s41423-018-0055-6openalex-snapshot
Interleukin-22 from bench to bedside: a promising drug for epithelial repair
inferred← citeshttps://doi.org/10.1038/s41423-020-00580-wopenalex-snapshot
Immunopathobiology and therapeutic targets related to cytokines in liver diseases
inferred← citeshttps://doi.org/10.1038/s41467-019-12540-8openalex-snapshot
Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23
inferred← citeshttps://doi.org/10.1038/s41586-020-2039-9openalex-snapshot
Feeding-dependent VIP neuron–ILC3 circuit regulates the intestinal barrier
inferred← citeshttps://doi.org/10.1038/s41598-017-04260-0openalex-snapshot
A tightly regulated IL-22 response maintains immune functions and homeostasis in systemic viral infection
inferred← citeshttps://doi.org/10.1038/s41598-020-80819-8openalex-snapshot
A subset of liver resident natural killer cells is expanded in hepatitis C-infected patients with better liver function
inferred← citeshttps://doi.org/10.1038/s41698-018-0048-zopenalex-snapshot
Role of nonresolving inflammation in hepatocellular carcinoma development and progression
inferred← citeshttps://doi.org/10.1042/cs20230522openalex-snapshot
Inflammatory liver diseases and susceptibility to sepsis
inferred← citeshttps://doi.org/10.1051/medsci/20163210016openalex-snapshot
Régénération hépatique
inferred← citeshttps://doi.org/10.1053/j.gastro.2011.06.051openalex-snapshot
A Proinflammatory Role for Interleukin-22 in the Immune Response to Hepatitis B Virus
inferred← citeshttps://doi.org/10.1053/j.gastro.2012.03.044openalex-snapshot
Interleukin-22 Promotes Proliferation of Liver Stem/Progenitor Cells in Mice and Patients With Chronic Hepatitis B Virus Infection
inferred← citeshttps://doi.org/10.1053/j.gastro.2012.07.031openalex-snapshot
Th17 Cells Regulate Liver Fibrosis by Targeting Multiple Cell Types: Many Birds With One Stone
inferred← citeshttps://doi.org/10.1053/j.gastro.2019.12.010openalex-snapshot
Interleukin 22 Signaling Regulates Acinar Cell Plasticity to Promote Pancreatic Tumor Development in Mice
inferred← citeshttps://doi.org/10.1055/s-0037-1601351openalex-snapshot
Update on the Mechanisms of Liver Regeneration
inferred← citeshttps://doi.org/10.1080/08830185.2025.2531820openalex-snapshot
Immune cells in liver regeneration: Current evidence and potential clinical targets
inferred← citeshttps://doi.org/10.1080/21645515.2018.1509649openalex-snapshot
Interleukin-22, a potent target for treatment of non-autoimmune diseases
inferred← citeshttps://doi.org/10.1080/2314808x.2023.2253601openalex-snapshot
Response to treatment of murine schistosomiasis with recombinant IL-22 under different circadian timing
inferred← citeshttps://doi.org/10.1089/ars.2012.4756openalex-snapshot
In Vivo Consequence of Vitamin C Insufficiency in Liver Injury: Vitamin C Ameliorates T-Cell-Mediated Acute Liver Injury in Gulo(−/−) Mice
inferred← citeshttps://doi.org/10.1089/cbr.2020.3794openalex-snapshot
Tumor Cells Interleukin-22 Expression Associates with Elevated Tumor-Associated Macrophages Infiltrating and Poor Prognosis in Patients with Breast Cancer
inferred← citeshttps://doi.org/10.1093/cei/uxae035openalex-snapshot
IL-22, a vital cytokine in autoimmune diseases
inferred← citeshttps://doi.org/10.1093/cid/cit714openalex-snapshot
HIV/Hepatitis C Virus-Coinfected Patients and Cirrhosis: How to Diagnose It and What to Do Next?
inferred← citeshttps://doi.org/10.1093/jac/dkr595openalex-snapshot
Plasma IL-6 and IL-9 predict the failure of interferon- plus ribavirin therapy in HIV/HCV-coinfected patients
inferred← citeshttps://doi.org/10.1093/procel/pwaf027openalex-snapshot
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside
inferred← citeshttps://doi.org/10.1097/hc9.0000000000000528openalex-snapshot
Modulating intestinal neuroimmune VIPergic signaling attenuates the reduction in ILC3-derived IL-22 and hepatic steatosis in MASLD
inferred← citeshttps://doi.org/10.1097/hc9.0000000000000614openalex-snapshot
Hepatocyte-derived liver progenitor-like cells attenuate liver cirrhosis via induction of apoptosis in hepatic stellate cells
inferred← citeshttps://doi.org/10.1097/hep.0000000000000986openalex-snapshot
Alcohol-associated liver disease: Emerging therapeutic strategies
inferred← citeshttps://doi.org/10.1097/md.0000000000008329openalex-snapshot
Increased circulating Th22 cells in patients with acute gouty arthritis
inferred← citeshttps://doi.org/10.1097/tp.0b013e3182449136openalex-snapshot
Interleukin-22
inferred← citeshttps://doi.org/10.1101/2023.06.08.544134openalex-snapshot
IL-22 promotes acute kidney injury through activation of the DNA damage response and cell death in proximal tubule cells
inferred← citeshttps://doi.org/10.1101/346577openalex-snapshot
Interleukin 22 mediates interleukin 23-induced pathology in newborn mice by disrupting the function of pancreatic and intestinal cells
inferred← citeshttps://doi.org/10.1101/cshperspect.a028548openalex-snapshot
Targeting IL-10 Family Cytokines for the Treatment of Human Diseases
inferred← citeshttps://doi.org/10.1101/cshperspect.a030304openalex-snapshot
Innate Lymphoid Cells (ILCs): Cytokine Hubs Regulating Immunity and Tissue Homeostasis
inferred← citeshttps://doi.org/10.1111/bph.12196openalex-snapshot
IL ‐22 in tissue‐protective therapy
inferred← citeshttps://doi.org/10.1111/febs.15711openalex-snapshot
Rationalizing heptadecaphobia: TH17 cells and associated cytokines in cancer and metastasis
inferred← citeshttps://doi.org/10.1111/hepr.12287openalex-snapshot
Serum levels of interleukin‐22 and hepatitis B core‐related antigen are associated with treatment response to entecavir therapy in chronic hepatitis B
inferred← citeshttps://doi.org/10.1111/imm.13340openalex-snapshot
Temporal overexpression of IL‐22 and Reg3γ differentially impacts the severity of experimental autoimmune encephalomyelitis
inferred← citeshttps://doi.org/10.1111/j.1440-1746.2011.07003.xopenalex-snapshot
Hepatoprotective and anti‐inflammatory cytokines in alcoholic liver disease
inferred← citeshttps://doi.org/10.1111/j.1478-3231.2012.02764.xopenalex-snapshot
Pivotal roles of the interleukin‐23/T helper 17 cell axis in hepatitis B
inferred← citeshttps://doi.org/10.1111/jgh.12032openalex-snapshot
Hepatoprotective and anti‐fibrotic functions of interleukin‐22: Therapeutic potential for the treatment of alcoholic liver disease
inferred← citeshttps://doi.org/10.1111/jgh.16991openalex-snapshot
Navigating the Paradox of IL‐22: Friend or Foe in Hepatic Health?
inferred← citeshttps://doi.org/10.1111/liv.12594openalex-snapshot
Infiltrating neutrophils aggravate metabolic liver failure in fah‐deficient mice
inferred← citeshttps://doi.org/10.1111/liv.15545openalex-snapshot
Potential therapies for acute‐on‐chronic liver failure
inferred← citeshttps://doi.org/10.1111/liv.15619openalex-snapshot
Novel treatment of acute and acute‐on‐chronic liver failure: Interleukin‐22
inferred← citeshttps://doi.org/10.1128/aem.00312-24openalex-snapshot
Development of a Limosilactobacillus reuteri therapeutic delivery platform with reduced colonization potential
inferred← citeshttps://doi.org/10.1128/iai.01268-15openalex-snapshot
Therapeutic Role of Interleukin 22 in Experimental Intra-abdominal Klebsiella pneumoniae Infection in Mice
inferred← citeshttps://doi.org/10.1136/gutjnl-2018-317232openalex-snapshot
Bacteria engineered to produce IL-22 in intestine induce expression of REG3G to reduce ethanol-induced liver disease in mice
inferred← citeshttps://doi.org/10.1136/gutjnl-2019-318372openalex-snapshot
Rilpivirine attenuates liver fibrosis through selective STAT1-mediated apoptosis in hepatic stellate cells
inferred← citeshttps://doi.org/10.1146/annurev-immunol-032414-112123openalex-snapshot
Interleukin-22: Immunobiology and Pathology
inferred← citeshttps://doi.org/10.1146/annurev-nutr-072610-145138openalex-snapshot
Inflammation in Alcoholic Liver Disease
inferred← citeshttps://doi.org/10.1152/ajpgi.00200.2014openalex-snapshot
Cytotoxic T lymphocytes and natural killer cells display impaired cytotoxic functions and reduced activation in patients with alcoholic hepatitis
inferred← citeshttps://doi.org/10.1152/ajprenal.00005.2015openalex-snapshot
Interleukin-22 in kidney injury and regeneration
inferred← citeshttps://doi.org/10.1155/2016/2148129openalex-snapshot
How Does Interleukin-22 Mediate Liver Regeneration and Prevent Injury and Fibrosis?
inferred← citeshttps://doi.org/10.1155/2018/5241526openalex-snapshot
Enhanced Regeneration and Hepatoprotective Effects of Interleukin 22 Fusion Protein on a Predamaged Liver Undergoing Partial Hepatectomy
inferred← citeshttps://doi.org/10.1155/2018/6716529openalex-snapshot
Zhuang Gu Guan Jie Wan: Reasonable Application Can Alleviate the Liver Injury for Osteoarthritis Treatment
inferred← citeshttps://doi.org/10.1155/2022/7794890openalex-snapshot
Serum Interleukins as Potential Prognostic Biomarkers in HBV-Related Acute-on-Chronic Liver Failure
inferred← citeshttps://doi.org/10.1158/1535-7163.mct-23-0726openalex-snapshot
Inflammation and Immunity in Liver Neoplasms: Implications for Future Therapeutic Strategies
inferred← citeshttps://doi.org/10.11606/d.17.2017.tde-06062017-162609openalex-snapshot
Papel da IL-22 na imunopatologia da asma experimental
inferred← citeshttps://doi.org/10.1177/1091581819898399openalex-snapshot
Beyond Metabolism: Role of the Immune System in Hepatic Toxicity
inferred← citeshttps://doi.org/10.1186/1471-2407-11-506openalex-snapshot
STAT3 activation in monocytes accelerates liver cancer progression
inferred← citeshttps://doi.org/10.1186/1471-2407-13-59openalex-snapshot
IL-22 is related to development of human colon cancer by activation of STAT3
inferred← citeshttps://doi.org/10.1186/1741-7015-10-102openalex-snapshot
Interleukin-22 predicts severity and death in advanced liver cirrhosis: a prospective cohort study
inferred← citeshttps://doi.org/10.1186/s12933-017-0498-6openalex-snapshot
Serum levels of interleukin-22, cardiometabolic risk factors and incident type 2 diabetes: KORA F4/FF4 study
inferred← citeshttps://doi.org/10.1186/s12985-019-1224-7openalex-snapshot
Tumor necrosis factor-α-induced protein 8-like 2 mRNA in peripheral blood mononuclear cells is associated with the disease progression of chronic hepatitis B virus infection
inferred← citeshttps://doi.org/10.1186/s13048-023-01236-9openalex-snapshot
Opportunities and challenges: interleukin-22 comprehensively regulates polycystic ovary syndrome from metabolic and immune aspects
inferred← citeshttps://doi.org/10.1186/s13578-015-0015-0openalex-snapshot
Biologically active, high levels of interleukin-22 inhibit hepatic gluconeogenesis but do not affect obesity and its metabolic consequences
inferred← citeshttps://doi.org/10.1186/s13578-024-01267-9openalex-snapshot
New advances in drug development for metabolic dysfunction-associated diseases and alcohol-associated liver disease
inferred← citeshttps://doi.org/10.1189/jlb.0212083openalex-snapshot
Th17 cells: critical mediators of host responses to burn injury and sepsis
inferred← citeshttps://doi.org/10.12659/aot.890977openalex-snapshot
Preoperative Interleukin-22 Values Add Valuable Information for Outcome Prediction Following Orthotopic Liver Transplantation: A Preliminary Study
inferred← citeshttps://doi.org/10.1371/journal.pone.0023737openalex-snapshot
High Fat Diet Induces Formation of Spontaneous Liposarcoma in Mouse Adipose Tissue with Overexpression of Interleukin 22
inferred← citeshttps://doi.org/10.1371/journal.pone.0055101openalex-snapshot
Highest Frequencies of Interleukin-22-Producing T Helper Cells in Alcoholic Hepatitis Patients with a Favourable Short-Term Course
inferred← citeshttps://doi.org/10.1371/journal.pone.0107454openalex-snapshot
Immune Modulatory Effects of IL-22 on Allergen-Induced Pulmonary Inflammation
inferred← citeshttps://doi.org/10.1371/journal.pone.0154419openalex-snapshot
Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
inferred← citeshttps://doi.org/10.1371/journal.pone.0224318openalex-snapshot
Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
inferred← citeshttps://doi.org/10.14218/jcth.2013.00013openalex-snapshot
Emerging Role of Interleukin 22 in Hepatitis B Virus Infection: a Double-edged Sword
inferred← citeshttps://doi.org/10.14309/ctg.0000000000000197openalex-snapshot
Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression
inferred← citeshttps://doi.org/10.1515/sjecr-2015-0011openalex-snapshot
Innate Lymphoid Cells: Roles In Tumour Genesis And Progression
inferred← citeshttps://doi.org/10.1586/1744666x.2014.930665openalex-snapshot
Immunological basis of stem cell therapy in liver diseases
inferred← citeshttps://doi.org/10.1681/asn.2013060611openalex-snapshot
IL-22 Ameliorates Renal Ischemia-Reperfusion Injury by Targeting Proximal Tubule Epithelium
inferred← citeshttps://doi.org/10.17219/acem/94062openalex-snapshot
The clinical significance of intrahepatic Th22 cells in liver cirrhosis
inferred← citeshttps://doi.org/10.18632/oncotarget.12275openalex-snapshot
Immune cells in liver regeneration
inferred← citeshttps://doi.org/10.18632/oncotarget.23266openalex-snapshot
Dual roles of IL-22 at ischemia-reperfusion injury and acute rejection stages of rat allograft liver transplantation
inferred← citeshttps://doi.org/10.21037/tlcr.2018.09.04openalex-snapshot
Targeting IL22: a potential therapeutic approach for Kras mutant lung cancer?
inferred← citeshttps://doi.org/10.2147/ott.s572872openalex-snapshot
Research Progress on the Molecular Mechanism of Metformin Regulating AMPK Signaling Pathway in Inhibiting Liver Cancer
inferred← citeshttps://doi.org/10.21608/jesp.2019.68066openalex-snapshot
HISTOPATHOLOGICAL STUDY ON MICE EXPERIMENTALLY INFECTED WITH S. MANSONI AND TREATED BY NEEM AND MIRAZID
inferred← citeshttps://doi.org/10.2174/1574885519666230915103206openalex-snapshot
A Sustainable Approach Towards Prevention and Treatment of Hepatic and Other Disorders Associated with Alcohol Consumption
inferred← citeshttps://doi.org/10.2217/fvl.12.58openalex-snapshot
In Vitro Antigen-Specific Induction of IL-22 in Human Subjects that Resolved HCV Infection
inferred← citeshttps://doi.org/10.24966/ghr-2566/100001openalex-snapshot
Different Cell Types Involved in Mediating Concanavalin A Induced Liver Injury: A Comprehensive Overview
inferred← citeshttps://doi.org/10.3109/08830185.2015.1008631openalex-snapshot
Pivotal Roles of ILCs in Hepatic Diseases
inferred← citeshttps://doi.org/10.3349/ymj.2016.57.3.652openalex-snapshot
Comparative Analysis of Liver Injury-Associated Cytokines in Acute Hepatitis A and B
inferred← citeshttps://doi.org/10.33696/immunology.3.087openalex-snapshot
IL-22-mediates Cross-talk between Tumor Cells and Immune Cells Associated with Favorable Prognosis in Human Colorectal Cancer
inferred← citeshttps://doi.org/10.3389/fimmu.2012.00346openalex-snapshot
CD161+CD4+ T cells are enriched in the liver during chronic hepatitis and associated with co-secretion of IL-22 and IFN-γ
inferred← citeshttps://doi.org/10.3389/fimmu.2013.00018openalex-snapshot
Pro-Inflammatory Signaling by IL-10 and IL-22: Bad Habit Stirred Up by Interferons?
inferred← citeshttps://doi.org/10.3389/fimmu.2014.00142openalex-snapshot
Recognition Strategies of Group 3 Innate Lymphoid Cells
inferred← citeshttps://doi.org/10.3389/fimmu.2015.00662openalex-snapshot
IL-22-Expressing Murine Lymphocytes Display Plasticity and Pathogenicity in Reporter Mice
inferred← citeshttps://doi.org/10.3389/fimmu.2017.00301openalex-snapshot
Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration
inferred← citeshttps://doi.org/10.3389/fimmu.2018.01155openalex-snapshot
The Interleukin-20 Cytokine Family in Liver Disease
inferred← citeshttps://doi.org/10.3389/fimmu.2020.01500openalex-snapshot
Roles of Hepatic Innate and Innate-Like Lymphocytes in Nonalcoholic Steatohepatitis
inferred← citeshttps://doi.org/10.3389/fimmu.2020.02013openalex-snapshot
Abnormal Innate Immunity in Acute-on-Chronic Liver Failure: Immunotargets for Therapeutics
inferred← citeshttps://doi.org/10.3389/fimmu.2020.02148openalex-snapshot
A Double Edged Sword Role of Interleukin-22 in Wound Healing and Tissue Regeneration
inferred← citeshttps://doi.org/10.3389/fimmu.2022.846923openalex-snapshot
Signaling Pathways Tuning Innate Lymphoid Cell Response to Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3389/fimmu.2022.951107openalex-snapshot
The role of interleukin-22 in lung health and its therapeutic potential for COVID-19
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