On the public citation graph

Genotoxicity of pyrrolizidine alkaloids

https://doi.org/10.1002/jat.1504
0 signed · 349 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.
Claim with ORCID
Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.
See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/(sici)1098-2280(1997)29:1<91::aid-em12>3.0.co;2-copenalex-snapshot
Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid fromSenecio brasiliensis, in somatic cells ofDrosophila melanogaster
inferredcites →https://doi.org/10.1002/(sici)1098-2280(1997)29:1<91::aid-em12>3.3.co;2-1openalex-snapshot
Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster
inferredcites →https://doi.org/10.1002/(sici)1521-3773(19991203)38:23<3501::aid-anie3501>3.0.co;2-wopenalex-snapshot
Reductive Activation of a Hydroxylamine Hemiacetal Derivative of Dehydromonocrotaline: The First Reductively Activated Pyrrolizidine Alkaloid Capable of Cross-Linking DNA
inferredcites →https://doi.org/10.1002/em.2850210310openalex-snapshot
Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S‐phase synthesis, or micronuclei following in vivo treatment with multiple doses
inferredcites →https://doi.org/10.1002/path.1711070407openalex-snapshot
The chronic toxicity of retrorsine, a pyrrolizidine alkaloid, in vervet monkeys
inferredcites →https://doi.org/10.1002/tcm.1770080404openalex-snapshot
Somatic mutation induced by heliotrine in Drosophila
inferredcites →https://doi.org/10.1006/taap.1998.8552openalex-snapshot
Pyrrolizidine Alkaloids Crosslink DNA with Actin
inferredcites →https://doi.org/10.1007/bf00058454openalex-snapshot
In Vivo measurement of unscheduled DNA synthesis and S-phase synthesis as an indicator of hepatocarcinogenesis in rodents
inferredcites →https://doi.org/10.1007/bf01991912openalex-snapshot
Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea
inferredcites →https://doi.org/10.1016/0002-9343(89)90547-0openalex-snapshot
Comfrey herb tea-induced hepatic veno-occlusive disease
inferredcites →https://doi.org/10.1016/0006-2952(84)90721-4openalex-snapshot
Hepatic metabolism and pulmonary toxicity of monocrotaline using isolated perfused liver and lung
inferredcites →https://doi.org/10.1016/0009-2797(92)90088-3openalex-snapshot
Structure/activity relationships of the genotoxic potencies of sixteen pyrrolizidine alkaloids assayed for the induction of somatic mutation and recombination in wing cells of Drosophila melanogaster
inferredcites →https://doi.org/10.1016/0027-5107(69)90148-1openalex-snapshot
The mutagenic activity of the pyrrolizidine alkaloid heliotrine in Drosophila melanogaster II. Chromosome rearrangements
inferredcites →https://doi.org/10.1016/0027-5107(75)90227-4openalex-snapshot
Use of repair-deficient strains of escherichia coli and liver microsomes to detect and characterise DNA damage caused by the pyrrolizidine alkaloids heliotrine and monocrotaline
inferredcites →https://doi.org/10.1016/0027-5107(85)90167-8openalex-snapshot
The ability of bifunctional and monofunctional pyrrole compounds to induced sister-chromatid exchange (SCE) in human lymphocytes and mutations in Salmonella typhimurium
inferredcites →https://doi.org/10.1016/0027-5107(93)90048-kopenalex-snapshot
Micronuclei in adult and foetal mice exposed in vivo to heliotrine, urethane, monocrotaline and benzidine
inferredcites →https://doi.org/10.1016/0041-008x(86)90053-0openalex-snapshot
Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, A possible alkenal metabolite of the alkaloids, and related alkenals
inferredcites →https://doi.org/10.1016/0041-008x(91)90137-4openalex-snapshot
DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: Structure-activity relationships
inferredcites →https://doi.org/10.1016/0041-0101(94)90368-9openalex-snapshot
Toxicity and carcinogenicity of riddelliine following 13 weeks of treatment to rats and mice
inferredcites →https://doi.org/10.1016/0165-1110(76)90006-3openalex-snapshot
Naturally occurring mutagens
inferredcites →https://doi.org/10.1016/0165-1161(95)00033-xopenalex-snapshot
Evaluation studies on the in vitro rat hepatocyte micronucleus assay
inferredcites →https://doi.org/10.1016/0165-1218(79)90065-xopenalex-snapshot
Mutagenicity of alkaloids in the Salmonella/microsome system
inferredcites →https://doi.org/10.1016/0165-1218(79)90152-6openalex-snapshot
Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test
inferredcites →https://doi.org/10.1016/0165-1218(80)90027-0openalex-snapshot
Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids
inferredcites →https://doi.org/10.1016/0165-1218(90)90028-zopenalex-snapshot
The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells
inferredcites →https://doi.org/10.1016/0165-1218(92)90240-zopenalex-snapshot
Genotoxic action of an aqueous extract of Heliotropium curassavicum var. argentinum
inferredcites →https://doi.org/10.1016/0165-1218(93)90058-lopenalex-snapshot
Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells
inferredcites →https://doi.org/10.1016/0165-6147(87)90033-2openalex-snapshot
Chemistry and toxicology of pyrrolizidine alkaloids
inferredcites →https://doi.org/10.1016/0165-7992(85)90025-9openalex-snapshot
Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese hamster cells co-cultured with chick embryo hepatocytes
inferredcites →https://doi.org/10.1016/0165-7992(92)90050-ropenalex-snapshot
Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system
inferredcites →https://doi.org/10.1016/0165-7992(92)90091-uopenalex-snapshot
The clastogenic potential in vitro of pyrrolizidine alkaloids employing hepatocyte metabolism
inferredcites →https://doi.org/10.1016/0272-0590(90)90255-iopenalex-snapshot
The in vivo erythrocyte micronucleus test: Measurement at steady state increases assay efficiency and permits integration with toxicity studies
inferredcites →https://doi.org/10.1016/0278-6915(84)90131-5openalex-snapshot
Mutagenic activity of the pyrrolizidine alkaloids seneciphylline and senkirkine in drosophila and their transfer into rat milk
inferredcites →https://doi.org/10.1016/0304-3835(80)90034-8openalex-snapshot
Carcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata
inferredcites →https://doi.org/10.1016/0304-3835(82)90109-4openalex-snapshot
Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues
inferredcites →https://doi.org/10.1016/0304-3835(83)90048-4openalex-snapshot
Carcinogenic activity of Farfugium japonicum and Senecio cannabifolius
inferredcites →https://doi.org/10.1016/0378-4274(86)90119-0openalex-snapshot
Genotoxicity of the pyrrolizidine alkaloid jacobine in rats
inferredcites →https://doi.org/10.1016/0378-8741(81)90033-7openalex-snapshot
Studies on medicinal plants of Sri Lanka: Occurrence of pyrrolizidine alkaloids and hepatotoxic properties in some traditional medicinal herbs
inferredcites →https://doi.org/10.1016/0378-8741(85)90078-9openalex-snapshot
Studies on medicinal plants of sri lanka. part 14: toxicity of some traditional medicinal herbs
inferredcites →https://doi.org/10.1016/0378-8741(94)90112-0openalex-snapshot
Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae)
inferredcites →https://doi.org/10.1016/b978-0-7216-9540-2.50212-7openalex-snapshot
Pyrrolizidine Alkaloid Poisoning
inferredcites →https://doi.org/10.1016/j.canlet.2004.06.013openalex-snapshot
Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats
inferredcites →https://doi.org/10.1016/j.canlet.2004.11.039openalex-snapshot
Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo
inferredcites →https://doi.org/10.1016/j.canlet.2005.01.023openalex-snapshot
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine
inferredcites →https://doi.org/10.1016/j.toxicon.2009.07.007openalex-snapshot
Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells
inferredcites →https://doi.org/10.1016/j.toxlet.2004.11.010openalex-snapshot
Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid
inferredcites →https://doi.org/10.1016/j.toxlet.2008.02.008openalex-snapshot
Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine
inferredcites →https://doi.org/10.1016/s0009-2797(85)80152-6openalex-snapshot
In vivo covalent binding of retronecine-labelled [3H]seneciphylline and [3H]senecionine to dna of rat liver, lung and kidney
inferredcites →https://doi.org/10.1016/s0016-5085(85)80027-5openalex-snapshot
Hepatic Venocclusive Disease Associated With the Consumption of Pyrrolizidine Containing Dietary Supplements
inferredcites →https://doi.org/10.1016/s0031-3025(16)36534-5openalex-snapshot
Environmental Health Criteria 75
inferredcites →https://doi.org/10.1016/s0031-9422(00)86032-xopenalex-snapshot
Studies on Orchidaceae alkaloids—IV.
inferredcites →https://doi.org/10.1016/s0041-008x(03)00165-0openalex-snapshot
Chemical-specific alterations in ras, p53, and β-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years
inferredcites →https://doi.org/10.1016/s0090-9556(25)07642-1openalex-snapshot
The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine.
inferredcites →https://doi.org/10.1016/s0090-9556(25)07643-3openalex-snapshot
Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver.
inferredcites →https://doi.org/10.1016/s0090-9556(25)08583-6openalex-snapshot
Guinea pig and rat hepatic microsomal metabolism of monocrotaline.
inferredcites →https://doi.org/10.1016/s0140-6736(71)92618-3openalex-snapshot
ECONOMY IN TULLE DRESSINGS
inferredcites →https://doi.org/10.1016/s0140-6736(76)90726-1openalex-snapshot
AN OUTBREAK OF HEPATIC VENO-OCCLUSIVE DISEASE IN NORTH-WESTERN AFGHANISTAN
inferredcites →https://doi.org/10.1016/s0140-6736(76)90727-3openalex-snapshot
AN EPIDEMIC OF VENO-OCCLUSIVE DISEASE OF LIVER IN CENTRAL INDIA
inferredcites →https://doi.org/10.1016/s0140-6736(80)92566-0openalex-snapshot
TOXIC PYRROLIZIDINE ALKALOIDS IN COMFREY
inferredcites →https://doi.org/10.1016/s0140-6736(81)91638-xopenalex-snapshot
COMFREY AND LIVER DAMAGE
inferredcites →https://doi.org/10.1016/s0140-6736(83)91112-1openalex-snapshot
HEPATIC VENO-OCCLUSIVE DISEASE DUE TO TOXIC ALKALOID IN HERBAL TEA
inferredcites →https://doi.org/10.1016/s0140-6736(84)92057-9openalex-snapshot
RANDOMISED COMPARATIVE STUDY OF MEFLOQUINE, QINGHAOSU, AND PYRIMETHAMINE-SULFADOXINE IN PATIENTS WITH FALCIPARUM MALARIA
inferredcites →https://doi.org/10.1016/s0140-6736(89)92154-5openalex-snapshot
COMFREY HERB TEA AND HEPATIC VENO-OCCLUSIVE DISEASE
inferredcites →https://doi.org/10.1016/s0165-1218(97)00051-7openalex-snapshot
Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing
inferredcites →https://doi.org/10.1016/s0278-6915(99)00025-3openalex-snapshot
Comparative DNA Cross-linking by Activated Pyrrolizidine Alkaloids
inferredcites →https://doi.org/10.1016/s0304-3835(03)00045-4openalex-snapshot
Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F1 mice
inferredcites →https://doi.org/10.1016/s0378-4274(03)00240-6openalex-snapshot
Toxicity and carcinogenicity of riddelliine in rats and mice
inferredcites →https://doi.org/10.1016/s0378-4274(03)00293-5openalex-snapshot
Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine
inferredcites →https://doi.org/10.1016/s1383-5718(00)00051-6openalex-snapshot
Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells
inferredcites →https://doi.org/10.1016/s1383-5718(02)00008-6openalex-snapshot
Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years
inferredcites →https://doi.org/10.1016/s1383-5742(99)00010-1openalex-snapshot
Pyrrolizidine alkaloids in human diet
inferredcites →https://doi.org/10.1021/bi00491a017openalex-snapshot
Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogs of mitomycin C
inferredcites →https://doi.org/10.1021/jf00107a018openalex-snapshot
Pyrrolizidine alkaloids in honey from Echium plantagineum L
inferredcites →https://doi.org/10.1021/jf0114482openalex-snapshot
Honey from Plants Containing Pyrrolizidine Alkaloids: A Potential Threat to Health
inferredcites →https://doi.org/10.1021/jf8026099openalex-snapshot
Pyrrolizidine Alkaloids in Crotalaria Taxa from Northern Australia: Risk to Grazing Livestock
inferredcites →https://doi.org/10.1021/tx000150nopenalex-snapshot
Metabolic Activation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo
inferredcites →https://doi.org/10.1021/tx025605iopenalex-snapshot
Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine
inferredcites →https://doi.org/10.1021/tx030018yopenalex-snapshot
Identification of DNA Adducts Derived from Riddelliine, a Carcinogenic Pyrrolizidine Alkaloid
inferredcites →https://doi.org/10.1021/tx030030qopenalex-snapshot
Metabolic Formation of DHP-Derived DNA Adducts from a Representative Otonecine Type Pyrrolizidine Alkaloid Clivorine and the Extract of Ligularia hodgsonnii Hook
inferredcites →https://doi.org/10.1021/tx049955bopenalex-snapshot
Mutations Induced by the Carcinogenic Pyrrolizidine Alkaloid Riddelliine in the Liver cII Gene of Transgenic Big Blue Rats
inferredcites →https://doi.org/10.1038/183731a0openalex-snapshot
Mutagenic Activity of the Alkaloid Heliotrine in Drosophila
inferredcites →https://doi.org/10.1038/bjc.1950.39openalex-snapshot
Primary Liver Tumours in Rats following Feeding with Alkaloids of Senecio jacobaea
inferredcites →https://doi.org/10.1038/bjc.1954.49openalex-snapshot
Senecio Alkaloids: Primary Liver Tumours in Rats as a Result of Treatment with (1) A Mixture of Alkaloids from S. Jacobaea Lin.; (2) Retrorsine; (3) Isatidine
inferredcites →https://doi.org/10.1038/bjc.1957.65openalex-snapshot
Progression of Liver Lesions Produced in Rats by Temporary Treatment with Pyrrolizidine (Senecio) Alkaloids, and the Effects of Betaine and High Casein Diet
inferredcites →https://doi.org/10.1038/bjc.1967.55openalex-snapshot
Hepatocellular carcinoma in infancy and childhood in Ibadan, Western Nigeria.
inferredcites →https://doi.org/10.1038/bjc.1970.4openalex-snapshot
Primary carcinoma of the liver in Ethiopia. A study of 38 cases proved at post-mortem examination
inferredcites →https://doi.org/10.1038/bjc.1975.49openalex-snapshot
Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide
inferredcites →https://doi.org/10.1038/bjc.1978.38openalex-snapshot
Malignant neoplasms in rats fed lasiocarpine
inferredcites →https://doi.org/10.1038/sj.bjc.6602420openalex-snapshot
Mutagenicity of comfrey (Symphytum Officinale) in rat liver
inferredcites →https://doi.org/10.1039/np9840100235openalex-snapshot
Pyrrolizidine alkaloids
inferredcites →https://doi.org/10.1056/nejm198610233151715openalex-snapshot
Toxicity of Comfrey–Pepsin Preparations
inferredcites →https://doi.org/10.1081/dmr-120028426openalex-snapshot
Pyrrolizidine Alkaloids—Genotoxicity, Metabolism Enzymes, Metabolic Activation, and Mechanisms
inferredcites →https://doi.org/10.1093/carcin/16.11.2691openalex-snapshot
Pyrrolizidine alkaloid-induced DNA-protein cross-links
inferredcites →https://doi.org/10.1093/carcin/8.3.415openalex-snapshot
Modulation of monocrotaline-induced hepatic genotoxicity in rats
inferredcites →https://doi.org/10.1093/carcin/9.8.1355openalex-snapshot
Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids
inferredcites →https://doi.org/10.1093/jnci/49.3.665openalex-snapshot
Brain and Spinal Cord Tumors in Rats Treated With Pyrrolizidine Alkaloids
inferredcites →https://doi.org/10.1093/jnci/53.5.1415openalex-snapshot
Brief Communication: Laslocarplne-Induced, Transplantable Squamous Cell Carcinoma of Rat Skin 2
inferredcites →https://doi.org/10.1093/jnci/56.4.787openalex-snapshot
Neoplastic Transformation in Tissues of Rats Exposed to Monocrotaline or Dehydroretronecine23
inferredcites →https://doi.org/10.1093/jnci/58.4.1155openalex-snapshot
Carcinogenic Activity of Petasitenine, a New Pyrrolizidine Alkaloid Isolated From Petasites japonicus Maxim2
inferredcites →https://doi.org/10.1093/jnci/61.1.85openalex-snapshot
Dehydroretronecine-Induced Skin Tumors in Mice23
inferredcites →https://doi.org/10.1093/jnci/61.3.865openalex-snapshot
Carcinogenic Activity of Symphytum officinale 2
inferredcites →https://doi.org/10.1093/jnci/63.2.469openalex-snapshot
Induction of Hepatic Tumors in Rats by Senkirkine and Symphytine 2
inferredcites →https://doi.org/10.1093/jnci/70.2.381openalex-snapshot
Neoplasia and Chronic Disease Associated With the Prolonged Administration of Dehydroheliotridine to Rats 2
inferredcites →https://doi.org/10.1093/nar/26.23.5441openalex-snapshot
Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks
inferredcites →https://doi.org/10.1093/toxsci/kfh262openalex-snapshot
DNA Cross-Linking by Dehydromonocrotaline Lacks Apparent Base Sequence Preference
inferredcites →https://doi.org/10.1097/00007691-200006000-00011openalex-snapshot
Clinical and Analytical Aspects of Pyrrolizidine Poisoning Caused by South African Traditional Medicines
inferredcites →https://doi.org/10.1111/j.1440-1746.1990.tb01827.xopenalex-snapshot
Hepatic veno‐occlusive disease associated with comfrey ingestion
inferredcites →https://doi.org/10.1111/j.1751-0813.1969.tb06635.xopenalex-snapshot
PYRROLIZIDINE ALKALOID POISONING IN A HORSE IN NEW SOUTH WALES
inferredcites →https://doi.org/10.1111/j.1751-0813.1974.tb14096.xopenalex-snapshot
RECTAL PROLAPSE IN CATTLE ASSOCIATED WITH PYRROLIZIDINE ALKALOID POISONING
inferredcites →https://doi.org/10.1111/j.1751-0813.1978.tb05536.xopenalex-snapshot
PYRROLIZIDINE ALKALOID POISONING OF HORSES
inferredcites →https://doi.org/10.1111/j.1751-0813.1987.tb09674.xopenalex-snapshot
Pyrrolizidine alkaloid poisoning of sheep in New South Wales
inferredcites →https://doi.org/10.1126/science.835011openalex-snapshot
Pyrrolizidine Alkaloids: Their Occurrence in Honey from Tansy Ragwort ( Senecio jacobaea L.)
inferredcites →https://doi.org/10.1136/bmj.295.6591.183openalex-snapshot
Veno-occlusive disease of the liver secondary to ingestion of comfrey.
inferredcites →https://doi.org/10.1136/gut.26.1.101openalex-snapshot
Herbal tea induced hepatic veno-occlusive disease: quantification of toxic alkaloid exposure in adults.
inferredcites →https://doi.org/10.1142/s0192415x89000127openalex-snapshot
The Identification of Pyrrolizidine Alkaloid-Containing Plants - A Study on 20 Herbs of the Compositae Family
inferredcites →https://doi.org/10.1142/s0192415x92000291openalex-snapshot
Pyrrolizidine Alkaloid Composition of Three Chinese Medicinal Herbs, Eupatorium cannabinum, E. japonicum and Crotalaria assamica
inferredcites →https://doi.org/10.1152/ajplung.1993.264.5.l517openalex-snapshot
Characterization of monocrotaline pyrrole-induced DNA cross-linking in pulmonary artery endothelium
inferredcites →https://doi.org/10.1177/019262337600400411openalex-snapshot
IARC Monograph of the Evaluation of Carcinogenic Risk of Chemicals to Man
inferredcites →https://doi.org/10.1177/0748233706071765openalex-snapshot
Formation of DHP-derived DNA adducts in vivo from dietary supplements and Chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids
inferredcites →https://doi.org/10.1177/0748233708093727openalex-snapshot
Metabolic activation of retronecine and retronecine N-oxide – formation of DHP-derived DNA adducts
inferredcites →https://doi.org/10.1177/096032718300200102openalex-snapshot
Effect of Calorie Restriction on the Fate of Hyperplastic Liver Nodules Induced by Concurrent Administration of Lasiocarpine and Thioacetamide
inferredcites →https://doi.org/10.1186/1471-2105-7-s2-s16openalex-snapshot
Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)
inferredcites →https://doi.org/10.1186/1471-2105-8-s7-s22openalex-snapshot
Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver
inferredcites →https://doi.org/10.1186/1471-2105-8-s7-s4openalex-snapshot
Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats
inferredcites →https://doi.org/10.1248/cpb.24.1120openalex-snapshot
Fukinotoxin, a new pyrrolizidine alkaloid from Petasites japonicus.
inferredcites →https://doi.org/10.2131/jts.9.143openalex-snapshot
Some toxic properties of a carcinogenic pyrrolizidine alkaloid, petasitenine.
inferredcites →https://doi.org/10.2527/jas1984.5851245xopenalex-snapshot
Mutagenic Responses of Tansy Ragwort (Senecio Jacobaea) Plant, Pyrrolizidine Alkaloids and Metabolites in Goat Milk with the Salmonella/Mammalian-Microsome Mutagenicity Test3
inferredcites →https://doi.org/10.2527/jas1988.6692343xopenalex-snapshot
Toxicity and Metabolism of Pyrrolizidine Alkaloids
inferredcites →https://doi.org/10.3109/00498257109041530openalex-snapshot
Hepatotoxic Effects due to Pyrrolizidine AlkaloidN-Oxides
inferredcites →https://doi.org/10.3390/ijerph2005010074openalex-snapshot
Metabolic Activation of the Tumorigenic Pyrrolizidine Alkaloid, Retrorsine, Leading to DNA Adduct Formation In Vivo
inferredcites →https://doi.org/10.38212/2224-6614.2394openalex-snapshot
The mutant frequencies and types of mutations induced by Comfrey in the lungs of transgenic big blue rats
inferredcites →https://doi.org/10.3891/acta.chem.scand.25-0349openalex-snapshot
Studies on Orchidaceae Alkaloids. XXIV. A Pyrrolizidine Alkaloid from Phalaenopsis cornu-cervi Rchb. f..

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4678749openalex-extracted
Degradation of Toxic Pyrrolidine Alkaloids in Drinking Water by Uv Activated Persulfate: Kinetics, Mechanism and Pathway
inferred← citeshttps://doi.org/10.1001/jamadermatol.2013.1495openalex-snapshot
Effect of Nutrient Supplementation on Atopic Dermatitis in Children
inferred← citeshttps://doi.org/10.1002/9781118992685.ch10openalex-snapshot
Pyrrolizidine Alkaloids in Food: Analytical, Toxicological and Health Considerations
inferred← citeshttps://doi.org/10.1002/9781119650034.ch5openalex-snapshot
Toxicology and Health Benefits of Plant Alkaloids
inferred← citeshttps://doi.org/10.1002/cbdv.202100631openalex-snapshot
Chemical Constituents and Biological Properties of Genus Doronicum (Asteraceae)
inferred← citeshttps://doi.org/10.1002/em.20645openalex-snapshot
MicroRNAs and their predicted target messenger RNAs are deregulated by Exposure to a Carcinogenic Dose of Comfrey in Rat Liver
inferred← citeshttps://doi.org/10.1002/jssc.201400314openalex-snapshot
Mass‐spectrometry‐directed analysis and purification of pyrrolizidine alkaloid cis/trans isomers in G ynura japonica
inferred← citeshttps://doi.org/10.1002/jssc.202000776openalex-snapshot
LC/MS study of the diversity and distribution of pyrrolizidine alkaloids in Crotalaria species growing in Colombia
inferred← citeshttps://doi.org/10.1002/lemi.202352223openalex-snapshot
Structure‐dependent relative toxic potencies of selected pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.1002/mnfr.201100165openalex-snapshot
Alkaloids in the human food chain – Natural occurrence and possible adverse effects
inferred← citeshttps://doi.org/10.1002/mnfr.201801206openalex-snapshot
Sensitization of Human Liver Cells Toward Fas‐Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine
inferred← citeshttps://doi.org/10.1002/mnfr.202100800openalex-snapshot
Organic Cation Transporter I and Na+/taurocholate Co‐Transporting Polypeptide are Involved in Retrorsine‐ and Senecionine‐Induced Hepatotoxicity in HepaRG cells
inferred← citeshttps://doi.org/10.1007/978-3-319-43806-1_9openalex-snapshot
Genotoxicity and Carcinogenicity of Herbal Products
inferred← citeshttps://doi.org/10.1007/978-3-319-66260-2_17openalex-snapshot
Genotoxicity and Biochemical Toxicity of Soil Antibiotics to Earthworms
inferred← citeshttps://doi.org/10.1007/978-3-319-96400-3_40openalex-snapshot
Pediatric Liver Disease in the African Continent
inferred← citeshttps://doi.org/10.1007/978-3-319-99235-8_5openalex-snapshot
Risk Factors for Cancer
inferred← citeshttps://doi.org/10.1007/978-94-017-9223-3_21openalex-snapshot
Metabolic Engineering of Selected Secondary Metabolites
inferred← citeshttps://doi.org/10.1007/s00204-019-02515-5openalex-snapshot
Prediction of in vivo genotoxicity of lasiocarpine and riddelliine in rat liver using a combined in vitro-physiologically based kinetic modelling-facilitated reverse dosimetry approach
inferred← citeshttps://doi.org/10.1007/s00204-020-02733-2openalex-snapshot
Mode of action-based risk assessment of genotoxic carcinogens
inferred← citeshttps://doi.org/10.1007/s00204-020-02853-9openalex-snapshot
In vitro biotransformation of pyrrolizidine alkaloids in different species: part II—identification and quantitative assessment of the metabolite profile of six structurally different pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.1007/s00204-022-03308-zopenalex-snapshot
Bioassay-directed analysis-based identification of relevant pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.1007/s00204-022-03394-zopenalex-snapshot
Genotoxicity of pyrrolizidine alkaloids in metabolically inactive human cervical cancer HeLa cells co-cultured with human hepatoma HepG2 cells
inferred← citeshttps://doi.org/10.1007/s00204-023-03482-8openalex-snapshot
Potency ranking of pyrrolizidine alkaloids in metabolically competent human liver cancer cells and primary human hepatocytes using a genotoxicity test battery
inferred← citeshttps://doi.org/10.1007/s00204-023-03591-4openalex-snapshot
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects
inferred← citeshttps://doi.org/10.1007/s00204-025-04182-1openalex-snapshot
Genotoxic carcinogenicity of pyrrolizidine alkaloids: relevance of potency factors for the risk assessment
inferred← citeshttps://doi.org/10.1007/s00204-025-04185-yopenalex-snapshot
The pyrrolizidine alkaloid lasiocarpine impairs cell cycle progression in vitro
inferred← citeshttps://doi.org/10.1007/s10565-021-09599-9openalex-snapshot
Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells
inferred← citeshttps://doi.org/10.1007/s10886-026-01689-4openalex-snapshot
Chemotaxonomy and Ecological Role of Pyrrolizidine Alkaloids: A Comprehensive Review of the Case Study of Africa
inferred← citeshttps://doi.org/10.1007/s11101-025-10070-4openalex-snapshot
Safety concern of drugs of herbal origin
inferred← citeshttps://doi.org/10.1007/s11306-011-0354-8openalex-snapshot
UPLC-MS based metabolomics study on Senecio scandens and S. vulgaris: an approach for the differentiation of two Senecio herbs with similar morphology but different toxicity
inferred← citeshttps://doi.org/10.1007/s44462-025-00021-9openalex-snapshot
Potential risks in tea and emerging monitoring technologies: a review
inferred← citeshttps://doi.org/10.1016/0378-4274(83)90239-4openalex-snapshot
Transfer of [3H]pyrrolizidine alkaloids from Senecio vulgaris L. and metabolites into rat milk and tissues
inferred← citeshttps://doi.org/10.1016/b978-0-08-046884-6.01026-5openalex-snapshot
Pyrrolizidine Alkaloid-Induced Hepatotoxicity
inferred← citeshttps://doi.org/10.1016/b978-0-12-405870-5.00010-4openalex-snapshot
Assessment of Safety and Quality Assurance of Herbal Dietary Supplements
inferred← citeshttps://doi.org/10.1016/b978-0-12-416041-5.00032-9openalex-snapshot
Plant Toxins
inferred← citeshttps://doi.org/10.1016/b978-0-12-801238-3.02114-0openalex-snapshot
Pyrrolizidine Alkaloid-Induced Hepatotoxicity
inferred← citeshttps://doi.org/10.1016/b978-0-12-802147-7.00062-0openalex-snapshot
Assessment of Genotoxic Effects of Selected Herbal Dietary Supplements**The information in this chapter is not a formal dissemination of information by the US Food and Drug Administration and does not represent agency position or policy.
inferred← citeshttps://doi.org/10.1016/b978-0-12-821038-3.00071-9openalex-snapshot
Genotoxicity evaluation of nutraceuticals
inferred← citeshttps://doi.org/10.1016/b978-0-323-95488-4.00098-xopenalex-snapshot
Pyrrolizidine Alkaloid-Induced Hepatotoxicity
inferred← citeshttps://doi.org/10.1016/b978-0-323-98367-9.00016-0openalex-snapshot
Importance of toxicity testing in drug discovery and research
inferred← citeshttps://doi.org/10.1016/b978-0-443-32932-6.00002-3openalex-snapshot
Genotoxic effects of different types of stresses on microbiome and plants
inferred← citeshttps://doi.org/10.1016/b978-0-443-45179-9.00003-3openalex-snapshot
Mutagenicity and carcinogenicity of African medicinal plants: an update
inferred← citeshttps://doi.org/10.1016/b978-0-443-45179-9.00015-xopenalex-snapshot
Toxic plants used in African traditional medicine: an update
inferred← citeshttps://doi.org/10.1016/b978-0-7020-5246-0.00009-7openalex-snapshot
Diseases of the Liver
inferred← citeshttps://doi.org/10.1016/j.agee.2016.04.018openalex-snapshot
The impact of different cutting regimes on population density of Jacobaea aquatica (Hill) G. Gaertn., B. Mey. & Scherb. and grassland vegetation
inferred← citeshttps://doi.org/10.1016/j.arabjc.2023.104655openalex-snapshot
Identification of pyrrolizidine alkaloids and flavonoid glycosides through HR-LCMS/MS analysis, biological screening, DFT and molecular docking studies on Heliotropium dasycarpum Ledeb.
inferred← citeshttps://doi.org/10.1016/j.biopha.2016.06.033openalex-snapshot
Activity of pyrrolizidine alkaloids against biofilm formation and Trichomonas vaginalis
inferred← citeshttps://doi.org/10.1016/j.biotechadv.2014.03.007openalex-snapshot
Improvement of hairy root cultures and plants by changing biosynthetic pathways leading to pharmaceutical metabolites: Strategies and applications
inferred← citeshttps://doi.org/10.1016/j.bjp.2014.03.006openalex-snapshot
Traditional use and safety of herbal medicines1
inferred← citeshttps://doi.org/10.1016/j.cbi.2018.11.007openalex-snapshot
Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells
inferred← citeshttps://doi.org/10.1016/j.cej.2024.151852openalex-snapshot
Treatment of emerging pyrrolizidine alkaloids in drinking water by UV/persulfate process: Kinetics, energy efficiency and degradation pathway
inferred← citeshttps://doi.org/10.1016/j.cois.2015.02.004openalex-snapshot
Molecular mechanisms of insect adaptation to plant secondary compounds
inferred← citeshttps://doi.org/10.1016/j.eujim.2019.101011openalex-snapshot
Medicinal plants used by traditional medicine practitioners to boost the immune system in people living with HIV/AIDS in Uganda
inferred← citeshttps://doi.org/10.1016/j.fct.2016.04.007openalex-snapshot
European medicinal and edible plants associated with subacute and chronic toxicity part I: Plants with carcinogenic, teratogenic and endocrine-disrupting effects
inferred← citeshttps://doi.org/10.1016/j.fct.2017.10.020openalex-snapshot
Wild edible plants: Nutritional and toxicological characteristics, retrieval strategies and importance for today's society
inferred← citeshttps://doi.org/10.1016/j.fct.2018.03.005openalex-snapshot
Risk assessment of pyrrolizidine alkaloids in food of plant and animal origin
inferred← citeshttps://doi.org/10.1016/j.fct.2018.04.009openalex-snapshot
The use of plants containing genotoxic carcinogens as foods and medicine
inferred← citeshttps://doi.org/10.1016/j.fct.2018.08.003openalex-snapshot
Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells
inferred← citeshttps://doi.org/10.1016/j.fct.2019.05.019openalex-snapshot
Human CYP3A4-mediated toxification of the pyrrolizidine alkaloid lasiocarpine
inferred← citeshttps://doi.org/10.1016/j.fct.2019.05.040openalex-snapshot
Determination of genotoxic potencies of pyrrolizidine alkaloids in HepaRG cells using the γH2AX assay
inferred← citeshttps://doi.org/10.1016/j.fct.2019.110868openalex-snapshot
In vitro metabolism of pyrrolizidine alkaloids – Metabolic degradation and GSH conjugate formation of different structure types
inferred← citeshttps://doi.org/10.1016/j.fct.2019.110923openalex-snapshot
Structure-dependent hepato-cytotoxic potencies of selected pyrrolizidine alkaloids in primary rat hepatocyte culture
inferred← citeshttps://doi.org/10.1016/j.fct.2019.111107openalex-snapshot
Pyrrolizidine alkaloids in food and phytomedicine: Occurrence, exposure, toxicity, mechanisms, and risk assessment - A review
inferred← citeshttps://doi.org/10.1016/j.fct.2020.111662openalex-snapshot
Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
inferred← citeshttps://doi.org/10.1016/j.fct.2021.112355openalex-snapshot
Micronucleus assays with the human derived liver cell line (Huh6): A promising approach to reduce the use of laboratory animals in genetic toxicology
inferred← citeshttps://doi.org/10.1016/j.fct.2022.113049openalex-snapshot
The chemical structure impairs the intensity of genotoxic effects promoted by 1,2-unsaturated pyrrolizidine alkaloids in vitro
inferred← citeshttps://doi.org/10.1016/j.fct.2025.115277openalex-snapshot
A proposed screening strategy for evaluating the genotoxicity potential of botanicals and botanical extracts
inferred← citeshttps://doi.org/10.1016/j.focha.2025.101139openalex-snapshot
Natural plant toxins in food: A comprehensive review of health implications, processing changes and regulatory challenges
inferred← citeshttps://doi.org/10.1016/j.foodchem.2015.04.067openalex-snapshot
Pyrrolizidine alkaloids in herbal teas for infants, pregnant or lactating women
inferred← citeshttps://doi.org/10.1016/j.foodchem.2020.127169openalex-snapshot
Echium plantagineum L. honey: Search of pyrrolizidine alkaloids and polyphenols, anti-inflammatory potential and cytotoxicity
inferred← citeshttps://doi.org/10.1016/j.foodcont.2013.09.037openalex-snapshot
Easy and rapid method for the quantitative determination of pyrrolizidine alkaloids in honey by ultra performance liquid chromatography-mass spectrometry: An evaluation in commercial honey
inferred← citeshttps://doi.org/10.1016/j.foodcont.2017.10.026openalex-snapshot
Contamination of hepatotoxic pyrrolizidine alkaloids in retail honey in China
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e17335openalex-snapshot
Toxic effect of Syzygium guineense ethanolic extract on female reproduction in rats: An evidence from a 10 week repeated-dose toxicity study
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e24055openalex-snapshot
Pyrrolizidine alkaloid contamination of food in Africa: A review of current trends and implications
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e26523openalex-snapshot
Effects of dietary exposure to plant toxins on bioaccumulation, survival, and growth of black soldier fly (Hermetia illucens) larvae and lesser mealworm (Alphitobius diaperinus)
inferred← citeshttps://doi.org/10.1016/j.ijdevneu.2014.05.007openalex-snapshot
Prenatal exposure to integerrimine N‐oxide impaired the maternal care and the physical and behavioral development of offspring rats
inferred← citeshttps://doi.org/10.1016/j.jchromb.2022.123273openalex-snapshot
Preparation of molecularly imprinted foam for selective extraction of toxic monocrotaline from herbs
inferred← citeshttps://doi.org/10.1016/j.jep.2017.08.009openalex-snapshot
Toxic pyrrolizidine alkaloids provide a warning sign to overuse of the ethnomedicine Arnebia benthamii
inferred← citeshttps://doi.org/10.1016/j.jep.2018.02.018openalex-snapshot
Development of an in vitro screening method of acute cytotoxicity of the pyrrolizidine alkaloid lasiocarpine in human and rodent hepatic cell lines by increasing susceptibility
inferred← citeshttps://doi.org/10.1016/j.jep.2019.112430openalex-snapshot
Medicinal and edible plants used by the Lhoba people in Medog County, Tibet, China
inferred← citeshttps://doi.org/10.1016/j.jfca.2023.105758openalex-snapshot
Comprehensive overview of the analytical methods for determining pyrrolizidine alkaloids and their derived oxides in foods
inferred← citeshttps://doi.org/10.1016/j.jfda.2015.06.001openalex-snapshot
Synthesis and phototoxicity of isomeric 7,9-diglutathione pyrrole adducts: Formation of reactive oxygen species and induction of lipid peroxidation
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.135142openalex-snapshot
Indirect photodegradation of typical pyrrolizidine alkaloids in water induced by triplet states of dissolved organic matter
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.11.028openalex-snapshot
The medical plant butterbur (Petasites): Analytical and physiological (re)view
inferred← citeshttps://doi.org/10.1016/j.jpba.2025.116675openalex-snapshot
Nano-zirconium-silicate solid-phase extraction method for the rapid quantification of pyrrolizidine alkaloids from plant extracts by UHPLC-QTOF-MS
inferred← citeshttps://doi.org/10.1016/j.mrfmmm.2015.05.006openalex-snapshot
Are effects of common ragwort in the Ames test caused by pyrrolizidine alkaloids?
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2014.12.008openalex-snapshot
Micronucleus induction in rat liver and bone marrow by acute vs. repeat doses of the genotoxic hepatocarcinogen monocrotaline
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2020.503305openalex-snapshot
Genotoxicity of selected pyrrolizidine alkaloids in human hepatoma cell lines HepG2 and Huh6
inferred← citeshttps://doi.org/10.1016/j.otc.2022.06.005openalex-snapshot
Allergies and Natural Alternatives
inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2020.08.005openalex-snapshot
Fanconi anemia-independent DNA inter-strand crosslink repair in eukaryotes
inferred← citeshttps://doi.org/10.1016/j.phymed.2015.03.020openalex-snapshot
Detection of pyrrolizidine alkaloids in German licensed herbal medicinal teas
inferred← citeshttps://doi.org/10.1016/j.phytochem.2010.12.014openalex-snapshot
Evolutionary recruitment of a flavin-dependent monooxygenase for stabilization of sequestered pyrrolizidine alkaloids in arctiids
inferred← citeshttps://doi.org/10.1016/j.phytochem.2014.09.006openalex-snapshot
Diversity of pyrrolizidine alkaloids in native and invasive Senecio pterophorus (Asteraceae): Implications for toxicity
inferred← citeshttps://doi.org/10.1016/j.phytochem.2024.114107openalex-snapshot
Dihydrostilbenes and flavonoids from whole plants of Jacobaea vulgaris
inferred← citeshttps://doi.org/10.1016/j.rvsc.2014.06.011openalex-snapshot
Effects of dietary Crotalaria pallida seeds on the health and performance of laying hens and evaluation of residues in eggs
inferred← citeshttps://doi.org/10.1016/j.sajb.2023.08.011openalex-snapshot
Hepatic phytotoxins in herbal medicines: A review of Africa's pyrrolizidine alkaloid-containing plants, their traditional uses, contamination pathways and associated health risks
inferred← citeshttps://doi.org/10.1016/j.talanta.2022.123645openalex-snapshot
Electrochemiluminescence sensor for point-of-care detection of pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.1016/j.tox.2014.04.007openalex-snapshot
Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity
inferred← citeshttps://doi.org/10.1016/j.tox.2022.153101openalex-snapshot
Kupffer cells play a crucial role in monocrotaline-induced liver injury by producing TNF-α
inferred← citeshttps://doi.org/10.1016/j.toxlet.2016.05.002openalex-snapshot
Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines
inferred← citeshttps://doi.org/10.1016/j.toxrep.2021.03.032openalex-snapshot
Sub-chronic toxicity of ethanol leaf extract of Syzygium guineense on the biochemical parameters and histopathology of liver and kidney in the rats
inferred← citeshttps://doi.org/10.1016/j.yrtph.2015.01.012openalex-snapshot
Genotoxicity and subchronic toxicity of Sophorae radix in rats: Hepatotoxic and genotoxic potential
inferred← citeshttps://doi.org/10.1016/j.yrtph.2015.09.024openalex-snapshot
Risk assessment on the use of herbal medicinal products containing pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.1016/j.yrtph.2016.08.006openalex-snapshot
A 28-day oral toxicity study of echimidine and lasiocarpine in Wistar rats
inferred← citeshttps://doi.org/10.1016/j.yrtph.2019.01.027openalex-snapshot
A comprehensive toxicological safety assessment of an extract of Ageratum conyzoides
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c01995openalex-snapshot
Broad-Spectrum Aptamer Selection of Challenging Retronecine-Type Hepatotoxic Pyrrolizidine Alkaloids for Biosensor Construction
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00157openalex-snapshot
Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.1c00384openalex-snapshot
1,2-Dehydropyrrolizidine Alkaloids: Their Potential as a Dietary Cause of Sporadic Motor Neuron Diseases
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.2c00292openalex-snapshot
From Structural Alerts to Signature Fragment Alerts: A Case Study on Pyrrolizidine Alkaloids
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.5b00253openalex-snapshot
Species-Specific Differences in thein VitroMetabolism of Lasiocarpine
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00297openalex-snapshot
Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation
inferred← citeshttps://doi.org/10.1021/jacs.3c03422openalex-snapshot
Charting the Evolution of Chemoenzymatic Strategies in the Syntheses of Complex Natural Products
inferred← citeshttps://doi.org/10.1021/jf403647uopenalex-snapshot
Pyrrolizidine Alkaloids in the Food Chain: Development, Validation, and Application of a New HPLC-ESI-MS/MS Sum Parameter Method
inferred← citeshttps://doi.org/10.1021/tx5002964openalex-snapshot
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3H-Pyrrolizin-7-yl)methanol
inferred← citeshttps://doi.org/10.1021/tx500403topenalex-snapshot
Pyrrolizidine Alkaloids: Potential Role in the Etiology of Cancers, Pulmonary Hypertension, Congenital Anomalies, and Liver Disease
inferred← citeshttps://doi.org/10.1038/s41598-020-76586-1openalex-snapshot
The invasive butterbur contaminates stream and seepage water in groundwater wells with toxic pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.1038/s41598-022-26087-0openalex-snapshot
Qualitative and quantitative phytochemical screening of Nerium oleander L. extracts associated with toxicity profile
inferred← citeshttps://doi.org/10.1039/bk9781837675036-00099openalex-snapshot
Bioactivation of Natural Products and Biological Assay of Carcinogens
inferred← citeshttps://doi.org/10.1055/s-0038-1623090openalex-snapshot
Pyrrolizidinalkaloide und die Seneciose bei Tieren
inferred← citeshttps://doi.org/10.1079/9781786390981.0063openalex-snapshot
Bugs, ants, wasps, moths and other insect species.
inferred← citeshttps://doi.org/10.1080/01480545.2025.2527176openalex-snapshot
Acute and subacute toxicity of ethanol leaf extract of Urtica simensis Hochst. ex A. Rich in rats
inferred← citeshttps://doi.org/10.1080/02648725.2022.2027628openalex-snapshot
An innovative approach of bioremediation in enzymatic degradation of xenobiotics
inferred← citeshttps://doi.org/10.1080/09168451.2019.1691913openalex-snapshot
In vitroandin vivoevaluation of antioxidant activity ofPetasites japonicusMaxim. flower buds extracts
inferred← citeshttps://doi.org/10.1080/10408444.2019.1686456openalex-snapshot
Risk assessment of herbal supplements containing ingredients that are genotoxic and carcinogenic
inferred← citeshttps://doi.org/10.1080/10590501.2015.1096882openalex-snapshot
Blood Pyrrole-Protein Adducts—A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans
inferred← citeshttps://doi.org/10.1080/10937404.2010.509013openalex-snapshot
Metabolism, Genotoxicity, annd Carcinogenicity of Comfrey
inferred← citeshttps://doi.org/10.1080/11263504.2015.1054449openalex-snapshot
Seasonal variability in pyrrolizidine alkaloids in Senecio inaequidens from the Val Venosta (Northern Italy)
inferred← citeshttps://doi.org/10.1080/13880209.2016.1207089openalex-snapshot
Oxidant effects and toxicity ofCroton campestrisinDrosophila melanogaster
inferred← citeshttps://doi.org/10.1080/17512433.2019.1638251openalex-snapshot
A closer look at the spectrum of drug-induced liver injury in sub-Saharan Africa
inferred← citeshttps://doi.org/10.1080/19440049.2010.547519openalex-snapshot
Pyrrolizidine alkaloid toxicity in livestock: a paradigm for human poisoning?
inferred← citeshttps://doi.org/10.1080/19440049.2011.555085openalex-snapshot
The ecological context of pyrrolizidine alkaloids in food, feed and forage: an overview
inferred← citeshttps://doi.org/10.1080/19440049.2017.1319579openalex-snapshot
Investigation of pyrrolizidine alkaloids including their respective N-oxides in selected food products available in Hong Kong by liquid chromatography electrospray ionisation mass spectrometry
inferred← citeshttps://doi.org/10.1080/19440049.2018.1468929openalex-snapshot
Uncertainties in the determination of pyrrolizidine alkaloid levels in naturally contaminated honeys and comparison of results obtained by different analytical approaches
inferred← citeshttps://doi.org/10.1080/19440049.2023.2178828openalex-snapshot
Risk assessment of short-term intake of pyrrolizidine alkaloids in food: derivation of an acute reference dose
inferred← citeshttps://doi.org/10.1080/22221751.2025.2574305openalex-snapshot
Rinderine suppresses African swine fever virus replication in porcine alveolar macrophages by dual targeting of membrane-associated profilin 1 and phosphatidylethanolamine
inferred← citeshttps://doi.org/10.1080/26896583.2020.1738161openalex-snapshot
Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes
inferred← citeshttps://doi.org/10.1080/26896583.2021.1954460openalex-snapshot
Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloidN-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts
inferred← citeshttps://doi.org/10.1093/mutage/ger060openalex-snapshot
MicroRNA expression profiles distinguish the carcinogenic effects of riddelliine in rat liver
inferred← citeshttps://doi.org/10.1093/toxsci/kfaf004openalex-snapshot
A perspective review on factors that influence mutagenicity in medicinal plants and their health implications
inferred← citeshttps://doi.org/10.1093/toxsci/kfx187openalex-snapshot
Editor’s Highlight: Identification of Any Structure-Specific Hepatotoxic Potential of Different Pyrrolizidine Alkaloids Using Random Forests and Artificial Neural Networks
inferred← citeshttps://doi.org/10.1097/md.0000000000036860openalex-snapshot
Analysis of potential risks of clinical application of Yi Dian Hong and its proprietary Chinese medicines: A review
inferred← citeshttps://doi.org/10.1111/1750-3841.70777openalex-snapshot
Evaluating Echimidine Impact on Food Safety and the Health of Living Organisms
inferred← citeshttps://doi.org/10.1111/1751-2980.12112openalex-snapshot
T usanqi and hepatic sinusoidal obstruction syndrome
inferred← citeshttps://doi.org/10.1111/eva.70114openalex-snapshot
Geographic Range Size Predicts Butterfly Species' Tolerance to Heavy Metals More Than Evolutionary History With Toxic Larval Diets
inferred← citeshttps://doi.org/10.1134/s2079059713050031openalex-snapshot
The genotoxicology of plant compounds
inferred← citeshttps://doi.org/10.1155/2023/9947841openalex-snapshot
Naturally Occurring Plant Food Toxicants and the Role of Food Processing Methods in Their Detoxification
inferred← citeshttps://doi.org/10.11606/d.9.2012.tde-25022013-143518openalex-snapshot
Estudos comportamentais e bioquímicos da exposição perinatal ao Senecio brasiliensis na prole de ratos
inferred← citeshttps://doi.org/10.1177/1091581811401046openalex-snapshot
A Three-Stage-Integrative Approach for the Identification of Potential Hepatotoxic Compounds From Botanical Products
inferred← citeshttps://doi.org/10.1186/1472-6882-14-264openalex-snapshot
Cytotoxicity of Eupatorium cannabinum L. ethanolic extract against colon cancer cells and interactions with Bisphenol A and Doxorubicin
inferred← citeshttps://doi.org/10.1201/9781315371443-5openalex-snapshot
Food Chemical Carcinogens: Sources and Mechanism of Exogenous DNA Adduct Formation
inferred← citeshttps://doi.org/10.12677/jocr.2024.122012openalex-snapshot
Research Progress in the Synthesis of Pyroriliidine Alkaloids
inferred← citeshttps://doi.org/10.12705/663.7openalex-snapshot
Sex, drugs and pupusas: Disentangling relationships in Echiteae (Apocynaceae)
inferred← citeshttps://doi.org/10.1371/journal.pone.0041737openalex-snapshot
Traditional Herbal Medicine Use Associated with Liver Fibrosis in Rural Rakai, Uganda
inferred← citeshttps://doi.org/10.14218/fim.2026.00017openalex-snapshot
Stratified Safety Evaluation Framework for Natural Products Based on New Approach Methodologies in Integrative Medicine: A Narrative Review
inferred← citeshttps://doi.org/10.1515/9783111469713-020openalex-snapshot
681Chapter 20 Genotoxic effects of medicinal and aromatic plants
inferred← citeshttps://doi.org/10.15389/agrobiology.2024.1.54engopenalex-snapshot
POISONOUS PLANTS AND PHYTOTOXICOSES IN HORSES (review)
inferred← citeshttps://doi.org/10.17268/sci.agropecu.2022.007openalex-snapshot
Methanolic extract of Crotalaria longirostrata: Identification of secondary metabolites and insecticidal effect
inferred← citeshttps://doi.org/10.17816/ecogen10341-52openalex-snapshot
Genotoxicology of plant compounds
inferred← citeshttps://doi.org/10.18174/303126openalex-snapshot
New concepts for risk and safety assessment of botanicals and botanical preparations including plant food supplements (PFS)
inferred← citeshttps://doi.org/10.18174/478360openalex-snapshot
Alternative testing strategy to quantify inter-species, inter-ethnic, and inter-individual variation in bioactivation and toxicity of food-borne alkenylbenzenes and pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.18174/496159openalex-snapshot
Novel strategies for risk assessment of pyrrolizidine alkaloids
inferred← citeshttps://doi.org/10.20883/medical.e760openalex-snapshot
Genotoxic and chemopreventive potentials of ethanol leaves extract of Annona muricata on N-Ethyl-N-Nitrosourea-induced pro-leukaemia carcinogen in mice model by bone marrow micronucleus assay
inferred← citeshttps://doi.org/10.2131/jts.46.391openalex-snapshot
Metabolic profiles for the pyrrolizidine alkaloid neopetasitenine and its metabolite petasitenine in humans extrapolated from rat in vivo and in vitro data sets using a simplified physiologically based pharmacokinetic model
inferred← citeshttps://doi.org/10.2174/1389200221666201202101715openalex-snapshot
CYP2C and CYP2B Mediated Metabolic Activation of Retrorsine in Cyp3a Knockout Mice
inferred← citeshttps://doi.org/10.2174/1872312801666211220110055openalex-snapshot
Plasma Concentration Profiles for Hepatotoxic Pyrrolizidine Alkaloid Senkirkine in Humans Extrapolated from Rat Data Sets Using a Simplified Physiologically Based Pharmacokinetic Model
inferred← citeshttps://doi.org/10.22271/phyto.2020.v9.i5aj.12734openalex-snapshot
Effects of Senecio selloi (Spreng.) DC flower extract on mitochondrial membrane peroxidation and enzyme activities
inferred← citeshttps://doi.org/10.2478/jvetres-2026-0046openalex-snapshot
Liquid chromatography–tandem mass spectrometry analysis of pyrrolizidine alkaloids in polish honey
inferred← citeshttps://doi.org/10.2903/j.efsa.2011.2406openalex-snapshot
Scientific Opinion on Pyrrolizidine alkaloids in food and feed
inferred← citeshttps://doi.org/10.30574/gscbps.2019.6.2.0003openalex-snapshot
Plant toxins: alkaloids and their toxicities
inferred← citeshttps://doi.org/10.3109/00498254.2012.679978openalex-snapshot
Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates
inferred← citeshttps://doi.org/10.3164/jcbn.20-58openalex-snapshot
Antioxidant compounds of Petasites japonicus and their preventive effects in chronic diseases: a review
inferred← citeshttps://doi.org/10.32473/edis-vm180-2011openalex-snapshot
Pasture-associated Liver Disease in Horses
inferred← citeshttps://doi.org/10.3389/fphar.2021.708050openalex-snapshot
A Comparison of Nine Machine Learning Mutagenicity Models and Their Application for Predicting Pyrrolizidine Alkaloids
inferred← citeshttps://doi.org/10.3389/fphar.2023.1301154openalex-snapshot
Ethnopharmacology and therapeutic potential of Anchusa strigosa: a comprehensive review
inferred← citeshttps://doi.org/10.3390/foods10051114openalex-snapshot
The Food Contaminants Pyrrolizidine Alkaloids Disturb Bile Acid Homeostasis Structure-Dependently in the Human Hepatoma Cell Line HepaRG
inferred← citeshttps://doi.org/10.3390/foods11040532openalex-snapshot
Identification of microRNAs Implicated in Modulating Senecionine-Induced Liver Toxicity in HepaRG Cells
inferred← citeshttps://doi.org/10.3390/foods11182828openalex-snapshot
Food-Borne Chemical Carcinogens and the Evidence for Human Cancer Risk
inferred← citeshttps://doi.org/10.3390/foods11192946openalex-snapshot
Risk Assessment of (Herbal) Teas Containing Pyrrolizidine Alkaloids (PAs) Based on Margin of Exposure Approach and Relative Potency (REP) Factors
inferred← citeshttps://doi.org/10.3390/foods13040536openalex-snapshot
Levels, Toxic Effects, and Risk Assessment of Pyrrolizidine Alkaloids in Foods: A Review
inferred← citeshttps://doi.org/10.3390/horticulturae12040417openalex-snapshot
Vertical Distribution of Pyrrolizidine Alkaloids in PA-Producing Weeds and Its Relevance for Chamomile (Matricaria recutita L.) Contamination Under Field Conditions
inferred← citeshttps://doi.org/10.3390/ijerph192214824openalex-snapshot
Cytotoxicity and Genotoxicity of Senecio vulgaris L. Extracts: An In Vitro Assessment in HepG2 Liver Cells
inferred← citeshttps://doi.org/10.3390/ijms19061668openalex-snapshot
Pyrrolizidine Alkaloids: Chemistry, Pharmacology, Toxicology and Food Safety
inferred← citeshttps://doi.org/10.3390/ijms22010202openalex-snapshot
Pyrrolizidine Alkaloids Induce Cell Death in Human HepaRG Cells in a Structure-Dependent Manner
inferred← citeshttps://doi.org/10.3390/ijms22083821openalex-snapshot
Active Transport of Hepatotoxic Pyrrolizidine Alkaloids in HepaRG Cells
inferred← citeshttps://doi.org/10.3390/ijms23169214openalex-snapshot
Structure-Dependent Toxicokinetics of Selected Pyrrolizidine Alkaloids In Vitro
inferred← citeshttps://doi.org/10.3390/ijms242316972openalex-snapshot
Pyrrolizidine Alkaloids—Pros and Cons for Pharmaceutical and Medical Applications
inferred← citeshttps://doi.org/10.3390/molecules24030498openalex-snapshot
Pyrrolizidine Alkaloids: Biosynthesis, Biological Activities and Occurrence in Crop Plants
inferred← citeshttps://doi.org/10.3390/molecules24061077openalex-snapshot
Simultaneous Determination and Risk Assessment of Pyrrolizidine Alkaloids in Artemisia capillaris Thunb. by UPLC-MS/MS Together with Chemometrics
inferred← citeshttps://doi.org/10.3390/molecules26040896openalex-snapshot
Genotoxicity of Water Extract from Bark-Removed Rhus verniciflua Stokes
inferred← citeshttps://doi.org/10.3390/molecules26061498openalex-snapshot
CRISPR/Cas9-Mediated Genome Editing in Comfrey (Symphytum officinale) Hairy Roots Results in the Complete Eradication of Pyrrolizidine Alkaloids
inferred← citeshttps://doi.org/10.3390/molecules26071970openalex-snapshot
Current Knowledge and Perspectives of Pyrrolizidine Alkaloids in Pharmacological Applications: A Mini-Review
inferred← citeshttps://doi.org/10.3390/molecules26113464openalex-snapshot
Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar
inferred← citeshttps://doi.org/10.3390/molecules30071594openalex-snapshot
Decarboxylation-Driven Double Annulations: Innovative Multi-Component Reaction Pathways
inferred← citeshttps://doi.org/10.3390/molecules31203590openalex-snapshot
Simplifying PA Quantification: A Unified Enrichment and Reduction Workflow for Retronecine-Based Quantification of Pyrrolizidine Alkaloids in Phyto Samples
inferred← citeshttps://doi.org/10.3390/ph18111618openalex-snapshot
A Review of the Main Biologically Active Compounds of the Genus Echium L., Naturally Distributed in Bulgaria, and Their Pharmacological Potential
inferred← citeshttps://doi.org/10.3390/toxins12100664openalex-snapshot
Toxin Degradation by Rumen Microorganisms: A Review
inferred← citeshttps://doi.org/10.3390/toxins12110707openalex-snapshot
Plant and Fungal Hepatotoxicities of Cattle in Australia, with a Focus on Minimally Understood Toxins
inferred← citeshttps://doi.org/10.3390/toxins16020079openalex-snapshot
Pyrrolizidine Alkaloids in Foods, Herbal Drugs, and Food Supplements: Chemistry, Metabolism, Toxicological Significance, Analytical Methods, Occurrence, and Challenges for Future
inferred← citeshttps://doi.org/10.3390/toxins16120538openalex-snapshot
Repair of Retrorsine-Induced DNA Damage in Rat Livers: Insights Gained from Transcriptomic and Proteomic Studies
inferred← citeshttps://doi.org/10.3390/toxins7124892openalex-snapshot
Toxicosis by Plant Alkaloids in Humans and Animals in Colombia
showing the first 200 of 217 · page through all 217
Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.