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Intervertebral Disc Degeneration Is Associated With Aberrant Endplate Remodeling and Reduced Small Molecule Transport

https://doi.org/10.1002/jbmr.4009
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/jor.21513openalex-snapshot
Morphology of the human vertebral endplate
inferredcites →https://doi.org/10.1002/jor.22516openalex-snapshot
Influence of biochemical composition on endplate cartilage tensile properties in the human lumbar spine
inferredcites →https://doi.org/10.1002/jor.22716openalex-snapshot
Drug-induced changes to the vertebral endplate vasculature affect transport into the intervertebral disc in vivo
inferredcites →https://doi.org/10.1002/jsp2.1013openalex-snapshot
Discogenic cell transplantation directly from a cryopreserved state in an induced intervertebral disc degeneration canine model
inferredcites →https://doi.org/10.1002/jsp2.1026openalex-snapshot
Mechanotransduction and cell biomechanics of the intervertebral disc
inferredcites →https://doi.org/10.1002/jsp2.1037openalex-snapshot
Efficacy of administered mesenchymal stem cells in the initiation and co‐ordination of repair processes by resident disc cells in an ovine ( Ovis aries ) large destabilizing lesion model of experimental disc degeneration
inferredcites →https://doi.org/10.1002/jsp2.1055openalex-snapshot
Mesenchymal stem cell therapies for intervertebral disc degeneration: Consideration of the degenerate niche
inferredcites →https://doi.org/10.1002/mrm.20336openalex-snapshot
Gadodiamide T1 relaxivity in brain tissue in vivo is lower than in saline
inferredcites →https://doi.org/10.1002/mrm.25515openalex-snapshot
Classification of sodium MRI data of cartilage using machine learning
inferredcites →https://doi.org/10.1007/s00586-003-0616-xopenalex-snapshot
Effect of nutrient deprivation on the viability of intervertebral disc cells
inferredcites →https://doi.org/10.1007/s11657-018-0538-1openalex-snapshot
Correspondence between bone mineral density and intervertebral disc degeneration across age and sex
inferredcites →https://doi.org/10.1007/s40610-018-0105-yopenalex-snapshot
Contribution of the Endplates to Disc Degeneration
inferredcites →https://doi.org/10.1016/j.actbio.2016.12.036openalex-snapshot
Indentation across interfaces between stiff and compliant tissues
inferredcites →https://doi.org/10.1016/j.actbio.2017.02.043openalex-snapshot
Micromechanical anisotropy and heterogeneity of the meniscus extracellular matrix
inferredcites →https://doi.org/10.1016/j.actbio.2017.07.025openalex-snapshot
Translation of an injectable triple-interpenetrating-network hydrogel for intervertebral disc regeneration in a goat model
inferredcites →https://doi.org/10.1016/j.ejvs.2009.02.006openalex-snapshot
Atherosclerosis and Disc Degeneration/Low-Back Pain – A Systematic Review
inferredcites →https://doi.org/10.1016/j.jbiomech.2016.01.007openalex-snapshot
Human cartilage endplate permeability varies with degeneration and intervertebral disc site
inferredcites →https://doi.org/10.1016/j.joca.2016.08.006openalex-snapshot
A large animal model that recapitulates the spectrum of human intervertebral disc degeneration
inferredcites →https://doi.org/10.1016/j.joca.2019.01.013openalex-snapshot
Nutrient supply and nucleus pulposus cell function: effects of the transport properties of the cartilage endplate and potential implications for intradiscal biologic therapy
inferredcites →https://doi.org/10.1016/j.joca.2019.07.016openalex-snapshot
Multiscale and multimodal structure–function analysis of intervertebral disc degeneration in a rabbit model
inferredcites →https://doi.org/10.1016/j.spinee.2006.04.014openalex-snapshot
Intradiscal injections of osteogenic protein-1 restore the viscoelastic properties of degenerated intervertebral discs
inferredcites →https://doi.org/10.1016/j.spinee.2006.06.189openalex-snapshot
4:45149. Intradiscal Injections of Osteogenic Protein-1 Restore the Viscoelastic Properties of Degenerated Intervertebral Discs
inferredcites →https://doi.org/10.1016/j.spinee.2015.01.026openalex-snapshot
Establishment of intervertebral disc degeneration model induced by ischemic sub-endplate in rat tail
inferredcites →https://doi.org/10.1038/nprot.2012.113openalex-snapshot
Evaluation of bone regeneration using the rat critical size calvarial defect
inferredcites →https://doi.org/10.1038/nrrheum.2014.91openalex-snapshot
Intervertebral disc regeneration: do nutrients lead the way?
inferredcites →https://doi.org/10.1038/srep27093openalex-snapshot
Excessive Activation of TGFβ by Spinal Instability Causes Vertebral Endplate Sclerosis
inferredcites →https://doi.org/10.1089/ten.teb.2009.0503openalex-snapshot
Use of Fluorochrome Labels in In Vivo Bone Tissue Engineering Research
inferredcites →https://doi.org/10.1097/00003086-198210000-00039openalex-snapshot
Nutrition of the Intervertebral Disc
inferredcites →https://doi.org/10.1097/00007632-198902000-00005openalex-snapshot
Biochemical and Structural Properties of the Cartilage End-Plate and its Relation to the Intervertebral Disc
inferredcites →https://doi.org/10.1097/00007632-199510001-00004openalex-snapshot
The Effect of Nicotine on Incorporation of Cancellous Bone Graft in an Animal Model
inferredcites →https://doi.org/10.1097/00007632-199601150-00003openalex-snapshot
Morphologic Differences of the Vascular Buds in the Vertebral Endplate
inferredcites →https://doi.org/10.1097/00007632-199602150-00003openalex-snapshot
Transport Properties of the Human Cartilage Endplate in Relation to Its Composition and Calcification
inferredcites →https://doi.org/10.1097/00007632-200212010-00002openalex-snapshot
Classification of Age-Related Changes in Lumbar Intervertebral Discs
inferredcites →https://doi.org/10.1097/01.brs.0000146499.97948.52openalex-snapshot
Nutrition of the Intervertebral Disc
inferredcites →https://doi.org/10.1097/01.brs.0000147573.88916.c6openalex-snapshot
Introduction
inferredcites →https://doi.org/10.1097/01.brs.0000148014.15210.64openalex-snapshot
ISSLS Prize Winner: A Study of Diffusion in Human Lumbar Discs: A Serial Magnetic Resonance Imaging Study Documenting the Influence of the Endplate on Diffusion in Normal and Degenerate Discs
inferredcites →https://doi.org/10.1097/01.brs.0000148048.15348.9bopenalex-snapshot
A Slowly Progressive and Reproducible Animal Model of Intervertebral Disc Degeneration Characterized by MRI, X-Ray, and Histology
inferredcites →https://doi.org/10.1097/01.brs.0000148152.04401.20openalex-snapshot
A Novel Rabbit Model of Mild, Reproducible Disc Degeneration by an Anulus Needle Puncture: Correlation Between the Degree of Disc Injury and Radiological and Histological Appearances of Disc Degeneration
inferredcites →https://doi.org/10.1097/01.brs.0000150833.93248.09openalex-snapshot
2004 Young Investigator Award Winner: Vertebral Endplate Marrow Contact Channel Occlusions and Intervertebral Disc Degeneration
inferredcites →https://doi.org/10.1097/01.brs.0000238681.71537.41openalex-snapshot
Nerve Fiber Ingrowth Into Scar Tissue Formed Following Nucleus Pulposus Extrusion in the Rabbit Anular-Puncture Disc Degeneration Model: Effects of Depth of Puncture
inferredcites →https://doi.org/10.1097/brs.0000000000001012openalex-snapshot
ISSLS Prize Winner
inferredcites →https://doi.org/10.1097/brs.0000000000002432openalex-snapshot
Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration
inferredcites →https://doi.org/10.1097/brs.0b013e318175cae7openalex-snapshot
Dynamic Compression Effects on Intervertebral Disc Mechanics and Biology
inferredcites →https://doi.org/10.1097/brs.0b013e31818043b7openalex-snapshot
Genetic and Environmental Effects on Disc Degeneration by Phenotype and Spinal Level
inferredcites →https://doi.org/10.1111/j.1469-7580.2007.00816.xopenalex-snapshot
Inhibition of vertebral endplate perfusion results in decreased intervertebral disc intranuclear diffusive transport
inferredcites →https://doi.org/10.1126/science.285.5426.409openalex-snapshot
An Allele of COL9A2 Associated with Intervertebral Disc Disease
inferredcites →https://doi.org/10.1126/scitranslmed.aau0670openalex-snapshot
Long-term mechanical function and integration of an implanted tissue-engineered intervertebral disc
inferredcites →https://doi.org/10.1155/2016/5952165openalex-snapshot
A Review of Animal Models of Intervertebral Disc Degeneration: Pathophysiology, Regeneration, and Translation to the Clinic
inferredcites →https://doi.org/10.1302/0301-620x.84b2.0840289openalex-snapshot
Intervertebral disc degeneration adjacent to a lumbar fusion
inferredcites →https://doi.org/10.1302/0301-620x.84b2.11937openalex-snapshot
Intervertebral disc degeneration adjacent to a lumbar fusion: An experimental rabbit model
inferredcites →https://doi.org/10.2106/00004623-200604002-00007openalex-snapshot
NUTRIENT SUPPLY AND INTERVERTEBRAL DISC METABOLISM
inferredcites →https://doi.org/10.3109/03008208909103905openalex-snapshot
Hierarchical Structure of the Intervertebral Disc
inferredcites →https://doi.org/10.3109/10520295009110996openalex-snapshot
A Rapid One-Step Mallory-Heidenhain Stain for Connective Tissue
inferredcites →https://doi.org/10.3109/10520298609110728openalex-snapshot
A Method for Preparing Whole-Body Sections Suitable for Autoradiographic, Histological and Histochemical Studies
inferredcites →https://doi.org/10.3109/17453677008991550openalex-snapshot
In Vitro Diffusion of DYE Through the End-Plates and the Annulus Fibrosus of Human Lumbar Inter-Vertebral Discs
inferredcites →https://doi.org/10.3390/data2010008openalex-snapshot
An Overview and Evaluation of Recent Machine Learning Imputation Methods Using Cardiac Imaging Data

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4638786openalex-extracted
Impact of Cartilaginous Endplate Degeneration on Quasi-Static Biomechanical Characteristics of Intervertebral Discs in Finite Element Models
inferred← citeshttps://doi.org/10.1002/advs.202507299openalex-snapshot
Piezo2 Mediates a Vicious Cycle of “Mechanical Homeostasis Imbalance—Inflammation” in Sensory Nerves and the Cartilage Endplate
inferred← citeshttps://doi.org/10.1002/advs.202522770openalex-snapshot
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
inferred← citeshttps://doi.org/10.1002/ame2.12501openalex-snapshot
A mouse coccygeal intervertebral disc degeneration model with tail‐looping constructed using a suturing method
inferred← citeshttps://doi.org/10.1002/cbf.4118openalex-snapshot
Research Progress on the Role of Cartilage Endplate in Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.1002/jbm.b.35532openalex-snapshot
Application of Self‐Healing Hydrogels in the Treatment of Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.1002/jcp.70140openalex-snapshot
Pathological Degeneration of Disc and Bone Is Associated With Chronic Low Back Pain in a Rat Model With Intradiscal Monosodium Iodoacetate
inferred← citeshttps://doi.org/10.1002/jor.25407openalex-snapshot
Level dependent alterations in human facet cartilage mechanics and bone morphometry with spine degeneration
inferred← citeshttps://doi.org/10.1002/jsp2.1147openalex-snapshot
Development of a standardized histopathology scoring system for intervertebral disc degeneration and regeneration in rabbit models‐An initiative of the ORS spine section
inferred← citeshttps://doi.org/10.1002/jsp2.1182openalex-snapshot
Panax notoginseng saponins attenuate intervertebral disc degeneration by reducing the end plate porosity in lumbar spinal instability mice
inferred← citeshttps://doi.org/10.1002/jsp2.1235openalex-snapshot
Controversies in spine research: Organ culture versus in vivo models for studies of the intervertebral disc
inferred← citeshttps://doi.org/10.1002/jsp2.1287openalex-snapshot
Mechanical crosstalk between the intervertebral disc, facet joints, and vertebral endplate following acute disc injury in a rabbit model
inferred← citeshttps://doi.org/10.1002/jsp2.1294openalex-snapshot
Cartilaginous endplates: A comprehensive review on a neglected structure in intervertebral disc research
inferred← citeshttps://doi.org/10.1002/jsp2.70045openalex-snapshot
Annulus Fibrosus Repair via Interpenetration of a Non‐Woven Scaffold Supports Tissue Integration and Prevents Re‐Herniation
inferred← citeshttps://doi.org/10.1002/jsp2.70076openalex-snapshot
In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.1007/978-981-19-3277-9_5openalex-snapshot
Mesenchymal Stem Cells Therapeutic Applications in Central Nervous System Disorders
inferred← citeshttps://doi.org/10.1007/s00586-022-07239-2openalex-snapshot
ISSLS Prize in Bioengineering Science 2022: low rate cyclic loading as a therapeutic strategy for intervertebral disc regeneration
inferred← citeshttps://doi.org/10.1007/s00586-026-10118-9openalex-snapshot
Comparison of the predictive value of mri-based cervical endplate bone quality (C-EBQ) score and cervical vertebral bone quality (C-VBQ) score for the progression of cervical disc degeneration
inferred← citeshttps://doi.org/10.1007/s00586-026-10189-8openalex-snapshot
Influence of endplate degeneration on fusion process in lateral lumbar interbody fusion
inferred← citeshttps://doi.org/10.1007/s10571-026-01668-zopenalex-snapshot
Ferroptosis in Spine-Related Diseases: Mechanistic Insights and Potential Therapeutic Targets
inferred← citeshttps://doi.org/10.1007/s11357-026-02513-3openalex-snapshot
The degenerating intervertebral disc leading to structural failure of the aging spine: from cellular pathways, risk factors, radiological diagnosis, to surgical management
inferred← citeshttps://doi.org/10.1007/s40122-024-00699-yopenalex-snapshot
A Long-Term Retrospective Observational Clinical Study Evaluating the Efficacy of Plasma Rich in Growth Factors (PRGF) in the Treatment of Back Pain
inferred← citeshttps://doi.org/10.1016/j.arr.2022.101733openalex-snapshot
The role of nerve fibers and their neurotransmitters in regulating intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102633openalex-snapshot
Implications of circadian disruption on intervertebral disc degeneration: The mediating role of sympathetic nervous system
inferred← citeshttps://doi.org/10.1016/j.bioactmat.2022.08.023openalex-snapshot
Ion elemental-optimized layered double hydroxide nanoparticles promote chondrogenic differentiation and intervertebral disc regeneration of mesenchymal stem cells through focal adhesion signaling pathway
inferred← citeshttps://doi.org/10.1016/j.ejphar.2026.179164openalex-snapshot
Vanillic acid protects vertebral endplate chondrocytes against oxidative stress and inflammation via Nrf-2/HO-1 pathway
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2022.08.018openalex-snapshot
Iron overload promotes intervertebral disc degeneration via inducing oxidative stress and ferroptosis in endplate chondrocytes
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e36509openalex-snapshot
Mapping knowledge structure and themes trends of non-surgical treatment in intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110159openalex-snapshot
Astaxanthin suppresses oxidative stress and calcification in vertebral cartilage endplate via activating Nrf-2/HO-1 signaling pathway
inferred← citeshttps://doi.org/10.1016/j.intimp.2023.110400openalex-snapshot
Understanding necroptosis and its therapeutic target for intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.jmpt.2025.10.029openalex-snapshot
Effect of Massage on Regulating Oxidative Stress in Intervertebral Disc Degeneration in a Rat Model
inferred← citeshttps://doi.org/10.1016/j.joca.2025.10.014openalex-snapshot
Excessive compression induces cartilage endplate degeneration via the Piezo1/NAT10/mTOR signaling axis
inferred← citeshttps://doi.org/10.1016/j.jot.2024.03.005openalex-snapshot
HIF-2α/TFR1 mediated iron homeostasis disruption aggravates cartilage endplate degeneration through ferroptotic damage and mtDNA release: A new mechanism of intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.jot.2025.05.010openalex-snapshot
Activation of LAMP1-mediated lipophagy by sulforaphane inhibits cellular senescence and intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.mtbio.2025.102027openalex-snapshot
Deliver CEBPE via cartilage targeting Lipid nanoparticle to block CEBPE-LTF-STAT3 positive feedback loop for efficient treatment of cartilage endplate degeneration
inferred← citeshttps://doi.org/10.1016/j.peptides.2022.170867openalex-snapshot
Correlation between serum angiotensin-converting enzyme (ACE) levels and intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107119openalex-snapshot
Bioenergetic dysfunction in the pathogenesis of intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1016/j.spinee.2022.09.010openalex-snapshot
Disc degeneration contributes to the denser bone in the subendplate but not in the vertebral body in patients with lumbar spinal stenosis or disc herniation
inferred← citeshttps://doi.org/10.1016/j.yexmp.2020.104590openalex-snapshot
Effect of fibroblast growth factor 2 on degenerative endplate chondrocyte: From anabolism to catabolism
inferred← citeshttps://doi.org/10.1021/acsnano.6c02887openalex-snapshot
Platelet-Derived Growth Factor Receptor α-Targeted Cell Membrane-Camouflaged Nanotherapy Disrupts Fibrosis-Inflammation Coupling in Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.1038/s41413-021-00156-yopenalex-snapshot
3D assessment of intervertebral disc degeneration in zebrafish identifies changes in bone density that prime disc disease
inferred← citeshttps://doi.org/10.1038/s41413-024-00331-xopenalex-snapshot
Lumbar instability remodels cartilage endplate to induce intervertebral disc degeneration by recruiting osteoclasts via Hippo-CCL3 signaling
inferred← citeshttps://doi.org/10.1038/s41413-024-00355-3openalex-snapshot
Osteopontin deficiency promotes cartilaginous endplate degeneration by enhancing the NF-κB signaling to recruit macrophages and activate the NLRP3 inflammasome
inferred← citeshttps://doi.org/10.1038/s41467-023-39604-0openalex-snapshot
Innovative design of minimal invasive biodegradable poly(glycerol-dodecanoate) nucleus pulposus scaffold with function regeneration
inferred← citeshttps://doi.org/10.1038/s41598-026-36249-zopenalex-snapshot
Isorhamnetin inhibits mechanical stress-induced chondrocyte apoptosis through activation of the ROS/SRC/FOXO1 signaling pathway
inferred← citeshttps://doi.org/10.1038/s41598-026-42343-zopenalex-snapshot
Increased angiogenesis-osteogenesis coupling in the endplate at early stages of intervertebral disc degeneration
inferred← citeshttps://doi.org/10.1039/d2bm01343fopenalex-snapshot
Silk fibroin-based biomaterials for disc tissue engineering
inferred← citeshttps://doi.org/10.1089/ten.tea.2021.0226openalex-snapshot
Injectable Hydrogels for Articular Cartilage and Nucleus Pulposus Repair: Status Quo and Prospects
inferred← citeshttps://doi.org/10.1097/ms9.0000000000000829openalex-snapshot
Effectivity of puncture method for intervertebral disc degeneration animal models: review article
inferred← citeshttps://doi.org/10.1097/wnr.0000000000002241openalex-snapshot
Bone hypertrophy and reduced quality after nucleus pulposus aspiration induces low back pain-like behavior and neuronal hyperexcitability
inferred← citeshttps://doi.org/10.1111/jcmm.16440openalex-snapshot
Carbohydrate sulfotransferase 3 (CHST3) overexpression promotes cartilage endplate‐derived stem cells (CESCs) to regulate molecular mechanisms related to repair of intervertebral disc degeneration by rat nucleus pulposus
inferred← citeshttps://doi.org/10.1111/jcmm.16898openalex-snapshot
A novel rat model of vertebral inflammation–induced intervertebral disc degeneration mediated by activating cGAS/STING molecular pathway
inferred← citeshttps://doi.org/10.1111/jcmm.18267openalex-snapshot
LTF ameliorates cartilage endplate degeneration by suppressing calcification, senescence and matrix degradation through the JAK2/STAT3 pathway
inferred← citeshttps://doi.org/10.1111/joa.13349openalex-snapshot
Degeneration alters structure‐function relationships at multiple length‐scales and across interfaces in human intervertebral discs
inferred← citeshttps://doi.org/10.1111/os.14209openalex-snapshot
The Role of Microvascular Variations in the Process of Intervertebral Disk Degeneration and Its Regulatory Mechanisms: A Literature Review
inferred← citeshttps://doi.org/10.1152/ajpheart.00886.2024openalex-snapshot
Transport across the thoracic aortic wall: implications for aneurysm pathobiology, diagnosis, and treatment
inferred← citeshttps://doi.org/10.1155/2022/2948090openalex-snapshot
circ_0072464 Shuttled by Bone Mesenchymal Stem Cell‐Secreted Extracellular Vesicles Inhibits Nucleus Pulposus Cell Ferroptosis to Relieve Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.1155/2022/6326677openalex-snapshot
Hydroxysafflor Yellow A (HSYA) Protects Endplate Chondrocytes Against IL-1β-Induced Injury Through Promoting Autophagy
inferred← citeshttps://doi.org/10.1155/2022/8709075openalex-snapshot
Deep Learning-Based Magnetic Resonance-Ultrashort Time of Echo Imaging for Analyzing Degeneration of Intervertebral Disc Cartilage Endplate and Rehabilitation Nursing
inferred← citeshttps://doi.org/10.1155/carm/5383659openalex-snapshot
Assessing Intervertebral Disk Tissue Mechanics Using Dual‐Actuator Multifrequency Magnetic Resonance Elastography: Case Reports
inferred← citeshttps://doi.org/10.1172/jci.insight.164883openalex-snapshot
GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc
inferred← citeshttps://doi.org/10.1186/s13018-022-03374-0openalex-snapshot
Age-related radiographic parameters difference between the degenerative lumbar spinal stenosis patients and healthy people and correlation analysis
inferred← citeshttps://doi.org/10.1186/s13018-026-06908-yopenalex-snapshot
Association between lumbar vertebral body bone quality and cranial/caudal endplate bone quality with intervertebral disc degeneration: a retrospective study of 2018 patients
inferred← citeshttps://doi.org/10.1186/s40001-025-02455-0openalex-snapshot
Association of dyslipidemia with intervertebral disc degeneration: a case–control study
inferred← citeshttps://doi.org/10.12669/pjms.40.7.8762openalex-snapshot
Comparing contribution of bony and cartilaginous endplate changes to intervertebral disc degeneration
inferred← citeshttps://doi.org/10.12998/wjcc.v11.i1.17openalex-snapshot
Endplate role in the degenerative disc disease: A brief review
inferred← citeshttps://doi.org/10.14245/ns.2244366.183openalex-snapshot
Extra Cellular Matrix Remodeling: An Adjunctive Target for Spinal Cord Injury and Intervertebral Disc Degeneration
inferred← citeshttps://doi.org/10.21203/rs.3.rs-10709039/v1openalex-snapshot
Prediction of non-surgical spinal decompression efficacy in lumbar disc herniation patients is based on pre-treatment paravertebral muscle MRI radiomics and clinical factors in a two-center study with external validation.
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2031014/v1openalex-snapshot
Do different endplate region injuries affect the prognosis of post- operative patients with thoracolumbar fractures?
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3075503/v1openalex-snapshot
Association of dyslipidemia with lumbar disc herniation: A case-control study
inferred← citeshttps://doi.org/10.21203/rs.3.rs-6808577/v1openalex-snapshot
TgA86 Mice overexpressing transmembrane TNF display an unexpected absence of thoracolumbar disc degeneration
inferred← citeshttps://doi.org/10.2147/ijn.s529127openalex-snapshot
Nano-Drug Delivery System Targeting the Oxidative Stress Microenvironment: A Prospective Strategy for Intervertebral Disc Degeneration Treatment
inferred← citeshttps://doi.org/10.22203/ecm.v041a24openalex-snapshot
Intervertebral disc degeneration and regeneration: a motion segment perspective
inferred← citeshttps://doi.org/10.23736/s0393-3660.23.05369-xopenalex-snapshot
Assessing endplate damage and modic changes for predicting degenerative intervertebral discs in patients with low back pain: a comparative analysis
inferred← citeshttps://doi.org/10.3348/kjr.2021.0950openalex-snapshot
Diurnal Variation in Hydration of the Cervical Intervertebral Disc Assessed Using T2 Mapping of Magnetic Resonance Imaging
inferred← citeshttps://doi.org/10.3389/fbioe.2021.766087openalex-snapshot
Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration
inferred← citeshttps://doi.org/10.3389/fbioe.2026.1751565openalex-snapshot
Glucose concentration modulates bovine intervertebral disc response under physiological loading
inferred← citeshttps://doi.org/10.3389/fcell.2022.853688openalex-snapshot
Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice
inferred← citeshttps://doi.org/10.3389/fcell.2025.1683282openalex-snapshot
Proteolytic enzyme models as tunable preclinical platforms for investigating intervertebral disc degeneration
inferred← citeshttps://doi.org/10.3389/fcell.2026.1811737openalex-snapshot
Metabolic reprogramming in intervertebral disc degeneration: mechanisms and therapeutic opportunities
inferred← citeshttps://doi.org/10.3389/fendo.2022.1042060openalex-snapshot
Ferroptosis: A potential target for the intervention of intervertebral disc degeneration
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1806060openalex-snapshot
Restoring immune homeostasis in the spinal microenvironment: targeting mechano-inflammation and immunometabolic reprogramming
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1862921openalex-snapshot
Blood and lymphatic vascular remodeling in intervertebral disc degeneration
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1906279openalex-snapshot
From Modic changes to the disc-endplate-bone marrow complex: imaging stratification, immune remodeling, and translational implications in intervertebral disc degeneration
inferred← citeshttps://doi.org/10.3389/fphar.2022.937502openalex-snapshot
Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway
inferred← citeshttps://doi.org/10.3389/fphar.2023.1150835openalex-snapshot
Natural products can modulate inflammation in intervertebral disc degeneration
inferred← citeshttps://doi.org/10.3389/fphar.2025.1606912openalex-snapshot
The therapeutic potential of icariin in the intervention of bone and joint diseases through multiple pathways: a narrative review
inferred← citeshttps://doi.org/10.3390/bioengineering9040137openalex-snapshot
The Endplate Role in Degenerative Disc Disease Research: The Isolation of Human Chondrocytes from Vertebral Endplate—An Optimised Protocol
inferred← citeshttps://doi.org/10.3390/cells11213508openalex-snapshot
Targeting Ferroptosis Holds Potential for Intervertebral Disc Degeneration Therapy
inferred← citeshttps://doi.org/10.3390/cells14080613openalex-snapshot
REDOX Imbalance and Oxidative Stress in the Intervertebral Disc: The Effect of Mechanical Stress and Cigarette Smoking on ER Stress and Mitochondrial Dysfunction
inferred← citeshttps://doi.org/10.3390/cells15020148openalex-snapshot
Impact of Menopause and Associated Hormonal Changes on Spine Health in Older Females: A Review
inferred← citeshttps://doi.org/10.3390/ijms21228717openalex-snapshot
The Potential Role of Hepatocyte Growth Factor in Degenerative Disorders of the Synovial Joint and Spine
inferred← citeshttps://doi.org/10.3390/ijms242316592openalex-snapshot
Achilles’ Heel—The Significance of Maintaining Microenvironmental Homeostasis in the Nucleus Pulposus for Intervertebral Discs
inferred← citeshttps://doi.org/10.3390/metabo14030146openalex-snapshot
Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging
inferred← citeshttps://doi.org/10.3390/metabo16090673openalex-snapshot
Causal Effects of Plasma Metabolites on Intervertebral Disc Degeneration and Low Back Pain: A Mendelian Randomization Study
inferred← citeshttps://doi.org/10.3390/neurolint16060129openalex-snapshot
Animal Models of Intervertebral Disc Diseases: Advantages, Limitations, and Future Directions
inferred← citeshttps://doi.org/10.3390/vetsci10090540openalex-snapshot
Development and Degeneration of the Intervertebral Disc—Insights from Across Species
inferred← citeshttps://doi.org/10.3892/etm.2022.11544openalex-snapshot
Knockdown of triggering receptor expressed on myeloid cells 1 (TREM1) inhibits endoplasmic reticulum stress and reduces extracellular matrix degradation and the apoptosis of human nucleus pulposus cells
inferred← citeshttps://doi.org/10.3892/ijmm.2023.5339openalex-snapshot
Nrf2 protects against cartilage endplate degeneration through inhibiting NCOA4‑mediated ferritinophagy
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