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Carnitine palmitoyltransferase 1C reverses cellular senescence of MRC‐5 fibroblasts via regulating lipid accumulation and mitochondrial function
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The Kennedy pathway— De novo synthesis of phosphatidylethanolamine and phosphatidylcholine
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SIRT6 deacetylase transcriptionally regulates glucose metabolism in heart
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Effects of carnitine palmitoyltransferases on cancer cellular senescence
inferredcites →https://doi.org/10.1006/geno.2002.6845openalex-snapshot
A Novel Brain-Expressed Protein Related to Carnitine Palmitoyltransferase I
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Enhanced susceptibility of Cpt1c knockout mice to glucose intolerance induced by a high-fat diet involves elevated hepatic gluconeogenesis and decreased skeletal muscle glucose uptake
inferredcites →https://doi.org/10.1007/s00216-015-8484-xopenalex-snapshot
Comprehensive lipid profiling of plasma in patients with benign breast tumor and breast cancer reveals novel biomarkers
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Optimization of lipid extraction and analytical protocols for UHPLC-ESI-HRMS-based lipidomic analysis of adherent mammalian cancer cells
inferredcites →https://doi.org/10.1007/s10522-017-9710-zopenalex-snapshot
Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?
inferredcites →https://doi.org/10.1007/s12035-015-9238-7openalex-snapshot
The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions
inferredcites →https://doi.org/10.1016/0014-4827(61)90192-6openalex-snapshot
The serial cultivation of human diploid cell strains
inferredcites →https://doi.org/10.1016/0014-4827(65)90211-9openalex-snapshot
The limited in vitro lifetime of human diploid cell strains
inferredcites →https://doi.org/10.1016/j.arr.2009.03.003openalex-snapshot
The coordination of nuclear and mitochondrial communication during aging and calorie restriction
inferredcites →https://doi.org/10.1016/j.bbalip.2009.09.011openalex-snapshot
Mitochondrial dysfunction and lipotoxicity
inferredcites →https://doi.org/10.1016/j.bbr.2013.08.004openalex-snapshot
Carnitine palmitoyltransferase 1C deficiency causes motor impairment and hypoactivity
inferredcites →https://doi.org/10.1016/j.biochi.2017.05.005openalex-snapshot
Specific roles of phosphatidylglycerols in hosts and microbes
inferredcites →https://doi.org/10.1016/j.ccr.2007.04.001openalex-snapshot
HIF-1 Inhibits Mitochondrial Biogenesis and Cellular Respiration in VHL-Deficient Renal Cell Carcinoma by Repression of C-MYC Activity
inferredcites →https://doi.org/10.1016/j.cell.2005.02.003openalex-snapshot
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
inferredcites →https://doi.org/10.1016/j.cell.2007.07.003openalex-snapshot
Cellular Senescence in Cancer and Aging
inferredcites →https://doi.org/10.1016/j.cell.2012.02.035openalex-snapshot
Mitochondria: In Sickness and in Health
inferredcites →https://doi.org/10.1016/j.celrep.2018.02.047openalex-snapshot
ERRγ Promotes Angiogenesis, Mitochondrial Biogenesis, and Oxidative Remodeling in PGC1α/β-Deficient Muscle
inferredcites →https://doi.org/10.1016/j.cmet.2007.11.006openalex-snapshot
Conserved Metabolic Regulatory Functions of Sirtuins
inferredcites →https://doi.org/10.1016/j.exger.2010.01.018openalex-snapshot
Quantitative assessment of markers for cell senescence
inferredcites →https://doi.org/10.1016/j.jhep.2014.11.002openalex-snapshot
Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity
inferredcites →https://doi.org/10.1016/j.jpha.2020.04.004openalex-snapshot
Lipidomics reveals carnitine palmitoyltransferase 1C protects cancer cells from lipotoxicity and senescence
inferredcites →https://doi.org/10.1016/j.mad.2013.02.002openalex-snapshot
Metabolic changes during cellular senescence investigated by proton NMR-spectroscopy
inferredcites →https://doi.org/10.1016/j.mad.2014.03.004openalex-snapshot
The hallmarks of fibroblast ageing
inferredcites →https://doi.org/10.1016/j.mad.2014.11.002openalex-snapshot
Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans
inferredcites →https://doi.org/10.1016/j.mad.2016.02.003openalex-snapshot
Regulation of SIRT1 in aging: Roles in mitochondrial function and biogenesis
inferredcites →https://doi.org/10.1016/j.mam.2004.06.004openalex-snapshot
Carnitine palmitoyltransferases 1 and 2: biochemical, molecular and medical aspects
inferredcites →https://doi.org/10.1016/j.plipres.2015.11.004openalex-snapshot
Carnitine palmitoyltransferase 1C: From cognition to cancer
inferredcites →https://doi.org/10.1038/cdd.2012.168openalex-snapshot
Depletion of the novel p53-target gene carnitine palmitoyltransferase 1C delays tumor growth in the neurofibromatosis type I tumor model
inferredcites →https://doi.org/10.1038/nature06322openalex-snapshot
mTOR controls mitochondrial oxidative function through a YY1–PGC-1α transcriptional complex
inferredcites →https://doi.org/10.1038/nature10600openalex-snapshot
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
inferredcites →https://doi.org/10.1038/nm.4000openalex-snapshot
Cellular senescence in aging and age-related disease: from mechanisms to therapy
inferredcites →https://doi.org/10.1038/s41418-017-0013-3openalex-snapshot
Carnitine palmitoyltransferase 1C regulates cancer cell senescence through mitochondria-associated metabolic reprograming
inferredcites →https://doi.org/10.1038/s41598-018-25485-7openalex-snapshot
CPT1C promotes human mesenchymal stem cells survival under glucose deprivation through the modulation of autophagy
inferredcites →https://doi.org/10.1039/c6mb00842aopenalex-snapshot
Regulation of lipids is central to replicative senescence
inferredcites →https://doi.org/10.1073/pnas.0602205103openalex-snapshot
The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis
inferredcites →https://doi.org/10.1073/pnas.1415279111openalex-snapshot
PGC-1β promotes enterocyte lifespan and tumorigenesis in the intestine
inferredcites →https://doi.org/10.1074/jbc.m111.337493openalex-snapshot
Ceramide Levels Regulated by Carnitine Palmitoyltransferase 1C Control Dendritic Spine Maturation and Cognition
inferredcites →https://doi.org/10.1074/jbc.m414670200openalex-snapshot
SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes
inferredcites →https://doi.org/10.1074/jbc.m707965200openalex-snapshot
CPT1c Is Localized in Endoplasmic Reticulum of Neurons and Has Carnitine Palmitoyltransferase Activity
inferredcites →https://doi.org/10.1080/10715762.2018.1549732openalex-snapshot
Emerging role of SIRT3 in mitochondrial dysfunction and cardiovascular diseases
inferredcites →https://doi.org/10.1093/carcin/bgx023openalex-snapshot
PPARα regulates tumor cell proliferation and senescence via a novel target gene carnitine palmitoyltransferase 1C
inferredcites →https://doi.org/10.1097/01.ico.0000247206.47897.92openalex-snapshot
Cellular Senescence as a Stress Response
inferredcites →https://doi.org/10.1101/gad.1467506openalex-snapshot
Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
inferredcites →https://doi.org/10.1101/gad.1987211openalex-snapshot
Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
inferredcites →https://doi.org/10.1111/j.1471-4159.2008.05255.xopenalex-snapshot
Brain‐specific carnitine palmitoyl‐transferase‐1c: role in CNS fatty acid metabolism, food intake, and body weight
inferredcites →https://doi.org/10.1111/j.1745-7254.2006.00345.xopenalex-snapshot
Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid1
inferredcites →https://doi.org/10.1146/annurev-pathol-121808-102144openalex-snapshot
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
inferredcites →https://doi.org/10.1152/physrev.00025.2007openalex-snapshot
Transcriptional Paradigms in Mammalian Mitochondrial Biogenesis and Function
inferredcites →https://doi.org/10.1155/2017/4829180openalex-snapshot
Ethanolamine and Phosphatidylethanolamine: Partners in Health and Disease
inferredcites →https://doi.org/10.1158/1078-0432.ccr-11-3281openalex-snapshot
Molecular Pathways: Tumor Cells Co-opt the Brain-Specific Metabolism Gene CPT1C to Promote Survival
inferredcites →https://doi.org/10.1159/000369731openalex-snapshot
Effects of Nicotinamide N-Methyltransferase on PANC-1 Cells Proliferation, Metastatic Potential and Survival Under Metabolic Stress
inferredcites →https://doi.org/10.11613/bm.2019.030501openalex-snapshot
Hallmarks of senescence and aging
inferredcites →https://doi.org/10.1172/jci64098openalex-snapshot
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
inferredcites →https://doi.org/10.1194/jlr.r066597openalex-snapshot
Oxidative stress and lipotoxicity
inferredcites →https://doi.org/10.1210/er.2008-0017openalex-snapshot
Transcriptional Control of Energy Homeostasis by the Estrogen-Related Receptors
inferredcites →https://doi.org/10.1371/journal.pgen.1002493openalex-snapshot
Down-Regulating Sphingolipid Synthesis Increases Yeast Lifespan
inferredcites →https://doi.org/10.1371/journal.pone.0074341openalex-snapshot
Plasma Lipid Profiling Shows Similar Associations with Prediabetes and Type 2 Diabetes
inferredcites →https://doi.org/10.3389/fphys.2012.00143openalex-snapshot
Function and Regulation of Lipid Biology in Caenorhabditis elegans Aging
inferredcites →https://doi.org/10.3389/fphys.2014.00282openalex-snapshot
Mitochondrial and cellular mechanisms for managing lipid excess
inferredcites →https://doi.org/10.7150/jca.21148openalex-snapshot
Cpt1c regulated by AMPK promotes papillary thyroid carcinomas cells survival under metabolic stress conditions
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4780205openalex-extracted
Benefits and Costs: Understanding the Influence of Heavy Metal Pollution on Environmental Adaptability in Anura Through an Energy Budget Perspective
inferred← citeshttps://doi.org/10.1016/j.arr.2024.102294openalex-snapshot
Lipids and lipid metabolism in cellular senescence: Emerging targets for age-related diseases
inferred← citeshttps://doi.org/10.1016/j.bcp.2024.116422openalex-snapshot
The YY1-CPT1C signaling axis modulates the proliferation and metabolism of pancreatic tumor cells under hypoxia
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.124388openalex-snapshot
Benefits and costs: Understanding the influence of heavy metal pollution on environmental adaptability in Strauchbufo raddei tadpoles through an energy budget perspective
inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108154openalex-snapshot
Fenofibrate targets PPARα-CPT1C axis to reverse aging by regulating lipid metabolism and mitochondrial function
inferred← citeshttps://doi.org/10.1038/s41419-023-05599-1openalex-snapshot
To be or not to be a fat burner, that is the question for cpt1c in cancer cells
inferred← citeshttps://doi.org/10.1111/acel.14184openalex-snapshot
PAR2‐mediated cellular senescence promotes inflammation and fibrosis in aging and chronic kidney disease
inferred← citeshttps://doi.org/10.1186/s13018-023-03872-9openalex-snapshot
l-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway
inferred← citeshttps://doi.org/10.21037/jtd-22-886openalex-snapshot
Molecular mechanisms of alveolar epithelial cell senescence and idiopathic pulmonary fibrosis: a narrative review
inferred← citeshttps://doi.org/10.3389/fnins.2021.747229openalex-snapshot
Quality of Life and a Surveillant Endocannabinoid System
inferred← citeshttps://doi.org/10.3389/fphys.2022.796850openalex-snapshot
Lipids as Regulators of Cellular Senescence
inferred← citeshttps://doi.org/10.3390/genes15091121openalex-snapshot
Exploration of Genes Related to Intramuscular Fat Deposition in Xinjiang Brown Cattle
inferred← citeshttps://doi.org/10.3390/ijms24020946openalex-snapshot
Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer
inferred← citeshttps://doi.org/10.3892/mmr.2022.12861openalex-snapshot
Transcriptional regulation of CDKN2A/p16 by sirtuin 7 in senescence
inferred← citeshttps://doi.org/10.7150/ijbs.80822openalex-snapshot
Metabolic Flux Analysis Reveals the Roles of Stearate and Oleate on CPT1C-mediated Tumor Cell Senescence
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