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Metamizole (Dipyrone) and the Liver: A Review of the Literature

https://doi.org/10.1002/jcph.1512
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jama.1936.92770330003007bopenalex-snapshot
AGRANULOCYTIC LEUKOPENIA INDUCED BY A DRUG RELATED TO AMINOPYRINE
inferredcites →https://doi.org/10.1001/jama.1986.03380130077032openalex-snapshot
Risks of Agranulocytosis and Aplastic Anemia
inferredcites →https://doi.org/10.1001/jama.2019.1506openalex-snapshot
The True Cost of Measles Outbreaks During the Postelimination Era
inferredcites →https://doi.org/10.1002/14651858.cd011421.pub2openalex-snapshot
Single dose dipyrone (metamizole) for acute postoperative pain in adults
inferredcites →https://doi.org/10.1002/ajh.2830340216openalex-snapshot
Letter to the editor: “Mexican aspirin”—a derogatory term
inferredcites →https://doi.org/10.1002/ddr.1194openalex-snapshot
Dipyrone inhibits ethanol withdrawal and pentylenetetrazol‐induced seizures in rats
inferredcites →https://doi.org/10.1002/ejp.1194openalex-snapshot
Dipyrone is the preferred nonopioid analgesic for the treatment of acute and chronic pain. A survey of clinical practice in German‐speaking countries
inferredcites →https://doi.org/10.1002/hep.1840100214openalex-snapshot
Hepatitis during measles in young adults: Possible role of antipyretic drugs
inferredcites →https://doi.org/10.1002/hep.23696openalex-snapshot
Standardization of nomenclature and causality assessment in drug‐induced liver injury
inferredcites →https://doi.org/10.1002/jcph.1998.38.s1.55openalex-snapshot
Clinical Comparison of Dexketoprofen Trometamol and Dipyrone in Postoperative Dental Pain
inferredcites →https://doi.org/10.1002/pds.4622openalex-snapshot
Active surveillance of severe cutaneous adverse reactions: A case‐population approach using a registry and a health care database
inferredcites →https://doi.org/10.1007/bf00202178openalex-snapshot
The acetylation phenotype: does it contribute to the non-linearity of the metabolite pharmacokinetics of metamizol?
inferredcites →https://doi.org/10.1007/bf00278482openalex-snapshot
Formation and excretion of dipyrone metabolites in man
inferredcites →https://doi.org/10.1007/bf00314805openalex-snapshot
Pharmacokinetics of metamizol metabolites in healthy subjects after a single oral dose of metamizol sodium
inferredcites →https://doi.org/10.1007/bf00547371openalex-snapshot
Plasma protein binding of dipyrone metabolites in man
inferredcites →https://doi.org/10.1007/bf00549594openalex-snapshot
Plasma kinetics of dipyrone metabolites in rapid and slow acetylators
inferredcites →https://doi.org/10.1007/bf00558078openalex-snapshot
Effect of age on the pharmacokinetics of dipyrone
inferredcites →https://doi.org/10.1007/bf01061429openalex-snapshot
Influence of food on the pharmacokinetics of dipyrone
inferredcites →https://doi.org/10.1007/bf01534437openalex-snapshot
Analgesic and antiinflammatory effects of dipyrone in rat adjuvant arthritis model
inferredcites →https://doi.org/10.1007/s00228-002-0465-2openalex-snapshot
Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole)
inferredcites →https://doi.org/10.1007/s00228-013-1618-1openalex-snapshot
Drug-induced agranulocytosis in the Berlin case–control surveillance study
inferredcites →https://doi.org/10.1007/s00228-014-1781-zopenalex-snapshot
Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports
inferredcites →https://doi.org/10.1007/s00228-019-02635-yopenalex-snapshot
Severe reduction in tacrolimus concentrations with concomitant metamizole (dipyrone) therapy in transplant patients
inferredcites →https://doi.org/10.1007/s00228-019-02646-9openalex-snapshot
Metamizole inhibits arachidonic acid-induced platelet aggregation after surgery and impairs the effect of aspirin in hospitalized patients
inferredcites →https://doi.org/10.1007/s002280050511openalex-snapshot
Cerebrospinal fluid and plasma concentrations of dipyrone metabolites after a single oral dose of dipyrone
inferredcites →https://doi.org/10.1007/s002280050659openalex-snapshot
The effect of short-term dipyrone administration on cyclosporin pharmacokinetics
inferredcites →https://doi.org/10.1007/s002280100341openalex-snapshot
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis-B virus does not occur in rapid acetylators
inferredcites →https://doi.org/10.1007/s00482-014-1490-7openalex-snapshot
Metamizol: Wirkmechanismen, Interaktionen und Agranulozytoserisiko
inferredcites →https://doi.org/10.1007/s00520-007-0327-7openalex-snapshot
Adjunct dipyrone in association with oral morphine for cancer-related pain: the sooner the better
inferredcites →https://doi.org/10.1016/0002-9343(83)90238-3openalex-snapshot
Acute toxicity of pyrazolones
inferredcites →https://doi.org/10.1016/0009-9236(95)90198-1openalex-snapshot
Dipyrone metabolism in liver disease*
inferredcites →https://doi.org/10.1016/0959-8049(94)90524-xopenalex-snapshot
Efficacy and tolerance of oral dipyrone versus oral morphine for cancer pain
inferredcites →https://doi.org/10.1016/j.bcp.2014.09.005openalex-snapshot
Gender and functional CYP2C and NAT2 polymorphisms determine the metabolic profile of metamizole
inferredcites →https://doi.org/10.1016/j.bmc.2011.11.028openalex-snapshot
Novel bioactive metabolites of dipyrone (metamizol)
inferredcites →https://doi.org/10.1016/j.cgh.2018.04.049openalex-snapshot
Development and Validation of a Test to Identify Drugs That Cause Idiosyncratic Drug-Induced Liver Injury
inferredcites →https://doi.org/10.1016/j.ejphar.2014.07.019openalex-snapshot
The analgesic effect of dipyrone in peripheral tissue involves two different mechanisms: Neuronal KATP channel opening and CB1 receptor activation
inferredcites →https://doi.org/10.1016/j.ejps.2018.05.003openalex-snapshot
N-demethylation of N-methyl-4-aminoantipyrine, the main metabolite of metamizole
inferredcites →https://doi.org/10.1016/j.forsciint.2016.02.033openalex-snapshot
The cutting of cocaine and heroin: A critical review
inferredcites →https://doi.org/10.1016/j.forsciint.2016.08.023openalex-snapshot
Analytical challenges in the confirmative identification of dipyrone as an adulterant in illicit drug samples
inferredcites →https://doi.org/10.1016/j.ijcard.2017.02.122openalex-snapshot
Analgesic medication with dipyrone in patients with coronary artery disease: Relation to MACCE
inferredcites →https://doi.org/10.1016/j.ijid.2013.06.014openalex-snapshot
Liver involvement in adults with measles
inferredcites →https://doi.org/10.1016/j.jped.2018.05.019openalex-snapshot
Suspected adverse drug reactions reported for Brazilian children: cross-sectional study
inferredcites →https://doi.org/10.1016/s0009-9236(97)90145-4openalex-snapshot
Impairment of the metabolism of dipyrone in asymptomatic carriers of the hepatitis B virus*
inferredcites →https://doi.org/10.1016/s0014-2999(98)00298-2openalex-snapshot
Metamizol potentiates morphine effects on visceral pain and evoked c-Fos immunoreactivity in spinal cord
inferredcites →https://doi.org/10.1016/s0140-6736(89)90349-8openalex-snapshot
DIPYRONE TRIALS IN THAILAND
inferredcites →https://doi.org/10.1016/s0379-0738(98)00102-9openalex-snapshot
Adulterants encountered in the illicit cocaine market
inferredcites →https://doi.org/10.1021/jm101208xopenalex-snapshot
Design, Synthesis, and Pharmacological Activity of Nonallergenic Pyrazolone-Type Antipyretic Analgesics
inferredcites →https://doi.org/10.1021/tx00044a007openalex-snapshot
Oxidation of Aminopyrine by Hypochlorite to a Reactive Dication: Possible Implications for Aminopyrine-Induced Agranulocytosis
inferredcites →https://doi.org/10.1023/a:1016088925786openalex-snapshot
High-Performance Liquid Chromatographic Analysis of Dipyrone Metabolites to Study Their Formation in Human Liver Microsomes
inferredcites →https://doi.org/10.1023/a:1021077810548openalex-snapshot
Gastrointestinal Tolerability of Metamizol, Acetaminophen, and Diclofenac in Subchronic Treatment in Rats
inferredcites →https://doi.org/10.1034/j.1398-9995.1999.00953.xopenalex-snapshot
Combined immediate‐ and delayed‐type hypersensitivity to metamizole
inferredcites →https://doi.org/10.1034/j.1600-0676.2002.01718.xopenalex-snapshot
Allergic cholestatic hepatitis and exanthema induced by metamizole: verification by lymphocyte transformation test
inferredcites →https://doi.org/10.1038/sj.clpt.6100138openalex-snapshot
Selective Induction of Human Hepatic Cytochromes P450 2B6 and 3A4 by Metamizole
inferredcites →https://doi.org/10.1038/srep23845openalex-snapshot
Pyrazolones metabolites are relevant for identifying selective anaphylaxis to metamizole
inferredcites →https://doi.org/10.1039/c6ay01157hopenalex-snapshot
Determination of cocaine and its main adulterants in seized drugs from Rio Grande do Sul, Brazil, by a Doehlert optimized LC-DAD method
inferredcites →https://doi.org/10.1055/s-2008-1067871openalex-snapshot
Nachweis der allergischen Genese einer akuten Hepatitis durch den Lymphozytentransformationstest
inferredcites →https://doi.org/10.1096/fj.06-8061comopenalex-snapshot
Dipyrone elicits substantial inhibition of peripheral cyclooxygenases in humans: new insights into the pharmacology of an old analgesic
inferredcites →https://doi.org/10.1097/00000421-199804000-00019openalex-snapshot
A Comparison of Two Nonsteroidal Antiinflammatory Drugs (Diflunisal Versus Dipyrone) in the Treatment of Moderate to Severe Cancer Pain
inferredcites →https://doi.org/10.1097/00007611-199606000-00011openalex-snapshot
Agranulocytosis and Near Fatal Sepsis Due to ‘Mexican Aspirin’ (Dipyrone)
inferredcites →https://doi.org/10.1097/00008571-199602000-00005openalex-snapshot
Genetic factors and risk of agranulocytosis from metamizol
inferredcites →https://doi.org/10.1097/01.smj.0000233020.68212.8fopenalex-snapshot
Metamizole Use Among Hispanics in Miami: Report of a Survey Conducted in a Primary Care Setting
inferredcites →https://doi.org/10.1097/eja.0000000000000275openalex-snapshot
Use of metamizole in children and the risk of agranulocytosis
inferredcites →https://doi.org/10.1111/bcp.12505openalex-snapshot
In vitrotesting for diagnosis of idiosyncratic adverse drug reactions: Implications for pathophysiology
inferredcites →https://doi.org/10.1111/bcp.12565openalex-snapshot
Drug‐induced liver injury: results from the hospital‐based B erlin Case–Control Surveillance Study
inferredcites →https://doi.org/10.1111/bcp.12628openalex-snapshot
Effects of food on pharmacokinetics of immediate release oral formulations of aspirin, dipyrone, paracetamol and NSAIDs – a systematic review
inferredcites →https://doi.org/10.1111/bph.12717openalex-snapshot
Dipyrone metabolite 4‐ MAA induces hypothermia and inhibits PGE 2‐dependent and ‐independent fever while 4‐ AA only blocks PGE 2‐dependent fever
inferredcites →https://doi.org/10.1111/j.1365-2036.2007.03338.xopenalex-snapshot
Risk of acute liver injury associated with the use of drugs: a multicentre population survey
inferredcites →https://doi.org/10.1111/j.1365-2125.1980.tb01813.xopenalex-snapshot
Kinetics and metabolism of pyrazolones (propyphenazone, aminopyrine and dipyrone).
inferredcites →https://doi.org/10.1111/j.1398-9995.2007.01553.xopenalex-snapshot
Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption
inferredcites →https://doi.org/10.1111/j.1476-5381.1983.tb10528.xopenalex-snapshot
Differential effect of acetylsalicylic acid and dipyrone on prostaglandin production in human fibroblast cultures
inferredcites →https://doi.org/10.1111/jcpt.12422openalex-snapshot
Safety of metamizole: a systematic review of the literature
inferredcites →https://doi.org/10.1111/jvp.12484openalex-snapshot
Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs
inferredcites →https://doi.org/10.1111/pan.13257openalex-snapshot
The use of dipyrone (metamizol) as an analgesic in children: What is the evidence? A review
inferredcites →https://doi.org/10.1111/pan.13341openalex-snapshot
The use of dipyrone (metamizol) as an analgesic in children: what is the evidence? A review
inferredcites →https://doi.org/10.1111/papr.12467openalex-snapshot
Metamizole (Dipyrone) as an Alternative Agent in Postoperative Analgesia in Patients with Contraindications for Nonsteroidal Anti‐Inflammatory Drugs
inferredcites →https://doi.org/10.1136/bmj.f4366openalex-snapshot
India's health ministry bans pioglitazone, metamizole, and flupentixol-melitracen
inferredcites →https://doi.org/10.1136/bmj.l634openalex-snapshot
Measles cases in Europe tripled from 2017 to 2018
inferredcites →https://doi.org/10.1177/0269216316655746openalex-snapshot
Metamizole/dipyrone for the relief of cancer pain: A systematic review and evidence-based recommendations for clinical practice
inferredcites →https://doi.org/10.1177/096032719601500108openalex-snapshot
Immunohistochemical properties of dipyrone-induced cytochromes P450 in rats
inferredcites →https://doi.org/10.1179/135100006x116637openalex-snapshot
Dipyrone and aminopyrine are effective scavengers of reactive nitrogen species
inferredcites →https://doi.org/10.1182/asheducation-2017.1.187openalex-snapshot
Non–chemotherapy drug–induced neutropenia: key points to manage the challenges
inferredcites →https://doi.org/10.1186/s12913-017-2086-6openalex-snapshot
Changes over time in prescription practices of pain medications in Switzerland between 2006 and 2013: an analysis of insurance claims
inferredcites →https://doi.org/10.1371/journal.pone.0122918openalex-snapshot
Metamizole-Associated Adverse Events: A Systematic Review and Meta-Analysis
inferredcites →https://doi.org/10.1371/journal.pone.0214329openalex-snapshot
Analgesic use among the Brazilian population: Results from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM)
inferredcites →https://doi.org/10.1371/journal.pone.0229039openalex-snapshot
Correction: Analgesic use among the Brazilian population: Results from the National Survey on Access, Use and Promotion of Rational Use of Medicines (PNAUM)
inferredcites →https://doi.org/10.1517/14740338.6.3.323openalex-snapshot
Non-chemotherapy drug-induced agranulocytosis
inferredcites →https://doi.org/10.15171/apb.2015.080openalex-snapshot
Simultaneous Determination of Metamizole, Thiamin and Pyridoxin Using UV-Spectroscopy in Combination with Multivariate Calibration
inferredcites →https://doi.org/10.15386/cjmed-413openalex-snapshot
Safety issues of current analgesics: an update
inferredcites →https://doi.org/10.1542/peds.109.6.e98openalex-snapshot
Metamizole Use by Latino Immigrants: A Common and Potentially Harmful Home Remedy
inferredcites →https://doi.org/10.1590/1980-5497201600030010openalex-snapshot
Uso de medicamentos prescritos e automedicação em homens
inferredcites →https://doi.org/10.1590/s0100-879x2001001100017openalex-snapshot
Limited-sampling strategy models for estimating the pharmacokinetic parameters of 4-methylaminoantipyrine, an active metabolite of dipyrone
inferredcites →https://doi.org/10.1590/s0103-50532007000400026openalex-snapshot
A simplified reflectometric method for the rapid determination of dipyrone in pharmaceutical formulations
inferredcites →https://doi.org/10.1590/s1516-31802005000300001openalex-snapshot
Dipyrone and blood dyscrasia revisited: "non-evidence based medicine"
inferredcites →https://doi.org/10.1590/s1518-8787.2016050006117openalex-snapshot
Prevalence of self-medication in Brazil and associated factors
inferredcites →https://doi.org/10.2174/1874210601812010347openalex-snapshot
Self-medication Among Myofascial Pain Patients: A Preliminary Study
inferredcites →https://doi.org/10.2174/1874473711666180911091846openalex-snapshot
Pain-Prescription Differences - An Analysis of 500,000 Discharge Summaries
inferredcites →https://doi.org/10.2478/pjvs-2014-0030openalex-snapshot
Pharmacological characteristics of metamizole
inferredcites →https://doi.org/10.3109/02841869709109238openalex-snapshot
Ketorolac Tromethamine in Cancer Pain
inferredcites →https://doi.org/10.3389/fpubh.2018.00213openalex-snapshot
Metamizole Utilization and Expenditure During 6-Year Period: Serbia vs. Croatia
inferredcites →https://doi.org/10.4414/smw.2017.14438openalex-snapshot
Leucopenia associated with metamizole: a case-control study
inferredcites →https://doi.org/10.5414/cpp40322openalex-snapshot
Bioavailability of two metamizole (dipyrone) solutions as single doses of 2 g versus metamizole capsules
inferredcites →https://doi.org/10.5504/bbeq.2012.0089openalex-snapshot
Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part I: Pharmaceutical and Nonclinical Profile
inferredcites →https://doi.org/10.5504/bbeq.2012.0135openalex-snapshot
Metamizole: A Review Profile of a Well-Known “Forgotten” Drug. Part II: Clinical Profile
inferredcites →https://doi.org/10.7326/0003-4819-146-9-200705010-00009openalex-snapshot
Systematic Review: Agranulocytosis Induced by Nonchemotherapy Drugs

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4671052openalex-extracted
inferred← citeshttps://doi.org/10.1002/bcp.70101openalex-snapshot
Pharmacology and relevant drug interactions of metamizole
inferred← citeshttps://doi.org/10.1002/cmdc.202300063openalex-snapshot
5‐Alkoxy‐1‐aryl‐3‐polyfluoroalkylpyrazoles with Antinociceptive Activity: Partial Agonists of TRPV1 Ion Channels
inferred← citeshttps://doi.org/10.1007/s00115-025-01799-6openalex-snapshot
Metamizolhaltige Arzneimittel in der Psychiatrie – wie steht es um die Pharmakokinetik?
inferred← citeshttps://doi.org/10.1007/s00210-024-03240-2openalex-snapshot
Safety of metamizole (dipyrone) for the treatment of mild to moderate pain—an overview of systematic reviews
inferred← citeshttps://doi.org/10.1007/s00414-021-02717-6openalex-snapshot
Analytical findings in a non-fatal intoxication with the synthetic cannabinoid 5F-ADB (5F-MDMB-PINACA): a case report
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Dental recommendation and prescribing patterns for systemic analgesics – a cross-sectional study
inferred← citeshttps://doi.org/10.1007/s10309-025-00753-5openalex-snapshot
Tonisch-klonischer Anfall unter Lamotrigin und Metamizol
inferred← citeshttps://doi.org/10.1007/s13738-026-03516-9openalex-snapshot
Recent advances in pyrazolone chemistry: synthetic strategies and therapeutic frontiers
inferred← citeshttps://doi.org/10.1007/s40264-021-01049-zopenalex-snapshot
Liver Injury Associated with Metamizole Exposure: Features of an Underestimated Adverse Event
inferred← citeshttps://doi.org/10.1007/s40264-021-01087-7openalex-snapshot
Is There an Increased Risk of Hepatotoxicity with Metamizole? A Comparative Cohort Study in Incident Users
inferred← citeshttps://doi.org/10.1007/s40266-024-01151-8openalex-snapshot
Pharmacological Pain Treatment in Older Persons
inferred← citeshttps://doi.org/10.1007/s40268-023-00415-9openalex-snapshot
Case Report: Simultaneously Induced Neutropenia and Hemolysis After a Single Metamizole Dose
inferred← citeshttps://doi.org/10.1016/j.bpa.2022.12.003openalex-snapshot
Adjuvants for balanced anesthesia in ambulatory surgery
inferred← citeshttps://doi.org/10.1016/j.cca.2020.09.034openalex-snapshot
Accidental ingestion of methyl ethyl ketone peroxide: N-acetylcysteine treatment and toxicological analysis
inferred← citeshttps://doi.org/10.1016/j.clinre.2020.11.002openalex-snapshot
Metamizole-induced acute liver failure in a boy
inferred← citeshttps://doi.org/10.1016/j.jece.2022.107740openalex-snapshot
Anaerobic biodegradation of dipyrone: Determination of transformation products by LC-HRMS and ecotoxicity assessment using target organisms and QSAR model
inferred← citeshttps://doi.org/10.1016/j.molstruc.2023.136807openalex-snapshot
Emerging insights into pyrazoline motifs: A comprehensive exploration of biological mechanisms and prospects for future advancements
inferred← citeshttps://doi.org/10.1016/j.rvsc.2023.105034openalex-snapshot
Pharmacotherapeutic monitoring of dipyrone in northeastern Brazilian donkeys (Equus asinus)
inferred← citeshttps://doi.org/10.1016/j.talanta.2024.126753openalex-snapshot
Preparation of monoclonal antibodies recognizing pharmacologically active metabolites of metamizole based on rational hapten design and their application in the detection of animal-derived food
inferred← citeshttps://doi.org/10.1016/j.transproceed.2022.04.028openalex-snapshot
Liver Transplantation for Metamizole induced Acute Liver Failure
inferred← citeshttps://doi.org/10.1021/acs.joc.4c02484openalex-snapshot
Regioselective Synthesis of N-Aryl Pyrazoles from Alkenyl Sulfoxonium Ylides and Aryl Diazonium Salts
inferred← citeshttps://doi.org/10.1021/acsomega.4c10957openalex-snapshot
Electrochemical Determination of Dipyrone Using a Cold-Plasma-Treated Graphite Sheet Electrode
inferred← citeshttps://doi.org/10.1039/d3ob01932bopenalex-snapshot
A protocol for directly accessing geminal C-4 diarylated pyrazol-5(4 H )-ones via tandem C–H aryne insertion and their inceptive neurobiological evaluation
inferred← citeshttps://doi.org/10.1080/10406638.2022.2157026openalex-snapshot
Design, Spectroscopic, and Crystal Structural Characterization of New Pyrazolone-Based Schiff Bases: Molecular Docking Investigations against SARS-Covid-19 Main Proteases (PDB Ids: 6LU7 and 7TLL)
inferred← citeshttps://doi.org/10.1080/15287394.2021.1942355openalex-snapshot
Assessment of the cytoprotective effect of the homeopathic compound Canova® on African green monkey kidney (VERO) cell line exposed to the drug dipyrone sodium
inferred← citeshttps://doi.org/10.1080/17425255.2021.1840551openalex-snapshot
Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review
inferred← citeshttps://doi.org/10.1088/2050-6120/abc13copenalex-snapshot
Non-covalent binding and selective fluorescent sensing of dipyrone with a carbocyanine dye and cetyltrimethylammonium bromide
inferred← citeshttps://doi.org/10.1093/infdis/jiae025openalex-snapshot
Prediction Models for Adverse Drug Reactions During Tuberculosis Treatment in Brazil
inferred← citeshttps://doi.org/10.1097/fpc.0000000000000432openalex-snapshot
NAT2 polymorphisms as a cause of metamizole-induced agranulocytosis
inferred← citeshttps://doi.org/10.1111/bcp.14473openalex-snapshot
Further evidence for the hepatotoxic potential of metamizole
inferred← citeshttps://doi.org/10.1111/bcp.15720openalex-snapshot
Time course of CYP3A activity during and after metamizole (dipyrone) in healthy volunteers
inferred← citeshttps://doi.org/10.1111/bcpt.13633openalex-snapshot
Effects of dipyrone and acetylsalicylic acid on contractions of distal cauda epididymis duct, serum testosterone and sperm count in rats
inferred← citeshttps://doi.org/10.1111/jvp.70073openalex-snapshot
Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs
inferred← citeshttps://doi.org/10.1111/liv.70012openalex-snapshot
Drug‐Induced Liver Injury Caused by Metamizole: Identification of a Characteristic Injury Pattern
inferred← citeshttps://doi.org/10.1111/myc.70173openalex-snapshot
Impact of Concomitant Metamizole Treatment on the Exposure of Mould‐Active Triazoles
inferred← citeshttps://doi.org/10.1116/6.0002367openalex-snapshot
Dipyrone tablet analyzed by x-ray photoelectron spectroscopy
inferred← citeshttps://doi.org/10.1134/s1068162024050236openalex-snapshot
Synthesis of Some Novel (E)-1,5-Dimethyl-2-phenyl-4-(((2-arylimidazo[1,2-a]pyridin-3-yl)-methylene)amino)-1,2-dihydro-3H-pyrazol-3-one Derivatives: Exploring Their Antimicrobial Activity
inferred← citeshttps://doi.org/10.1136/bcr-2019-231133openalex-snapshot
Acute intermittent porphyria: analgesia can be dangerous
inferred← citeshttps://doi.org/10.1155/ianc/9944493openalex-snapshot
Quantification of the Active Metabolites 4‐Methylaminoantipyrine and 4‐Aminoantipyrine of Dipyrone From Human Plasma by LC–MS/MS
inferred← citeshttps://doi.org/10.1159/000545507openalex-snapshot
LKM Immunofluorescence Is Associated with DILI, Especially after Metamizole Intake
inferred← citeshttps://doi.org/10.11606/t.46.2021.tde-26102022-111633openalex-snapshot
Characterization of the electrochemical behaviour of antiinflammatory and antipsychotic drugs and their interaction with biomolecules within their respective pathways
inferred← citeshttps://doi.org/10.1177/20420986241275255openalex-snapshot
Assessing potential risk factors for metamizole-induced leukopenia
inferred← citeshttps://doi.org/10.1177/2050313x261439208openalex-snapshot
A clinical case and pharmacokinetic analysis of an inadvertent overdose of dipyrone (metamizole) without clinical toxicity: A case report
inferred← citeshttps://doi.org/10.1186/s12884-025-07872-xopenalex-snapshot
Adverse effects of dipyrone (Metamizole) use during pregnancy on offspring health: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.1186/s40360-024-00780-4openalex-snapshot
Adverse effects of metamizole on heart, lung, liver, kidney, and stomach in rats
inferred← citeshttps://doi.org/10.12890/2022_003349openalex-snapshot
Metamizole as a Rare Cause of Drug-Induced Liver Injury
inferred← citeshttps://doi.org/10.1371/journal.pone.0264440openalex-snapshot
The antipyretic effectiveness of dipyrone in the intensive care unit: A retrospective cohort study
inferred← citeshttps://doi.org/10.1515/ohe-2025-0075openalex-snapshot
In search of the world’s most popular painkiller: An infodemiological analysis of Google Trend statistics from 2004 to 2023
inferred← citeshttps://doi.org/10.1590/0102-311xen093125openalex-snapshot
Dipyrone use in Brazil: clinical conditions, sociodemographic characteristics, population attitudes and perceptions
inferred← citeshttps://doi.org/10.17147/asu-2111-8358openalex-snapshot
Mit Schmerzen und der Schmerzmitteleinnahme assoziierte Faktoren bei deutschen Rettungskräften: Eine Post-hoc-Analyse
inferred← citeshttps://doi.org/10.17816/ptors627283openalex-snapshot
Current concepts in the diagnosis and management of acute pain in children
inferred← citeshttps://doi.org/10.20527/jps.v10i1.13920openalex-snapshot
Pengaruh Penyakit Penyerta terhadap Toksisitas Obat Metamizole
inferred← citeshttps://doi.org/10.20986/resed.2023.4025/2022openalex-snapshot
Problemas y reacciones adversas relacionados con dipirona en Colombia
inferred← citeshttps://doi.org/10.21149/11193openalex-snapshot
Factores clínicos y demográficos asociados con la mortalidad por dengue en Colombia: estudio de casos y controles
inferred← citeshttps://doi.org/10.2174/0113852728360592250214110907openalex-snapshot
Recent Advancements in the Synthesis of Pyrazole Derivative for the Treatment of Alzheimer's Disease
inferred← citeshttps://doi.org/10.2174/0115680266339816241212081205openalex-snapshot
Pyrazoline and Pyrazoline Derivatives as Anti-Cancer Agents: Synthesis and Biological Activities: A Compressive Review
inferred← citeshttps://doi.org/10.2174/1574886317666220606150721openalex-snapshot
Unmasking of Metamizole-induced Liver Injury by Simult aneous Development of Characteristic Agranulocytosis
inferred← citeshttps://doi.org/10.22141/2224-0551.20.4.2025.1856openalex-snapshot
Management of pain syndrome in children (literature review)
inferred← citeshttps://doi.org/10.2217/pmt-2021-0094openalex-snapshot
An Overview of the use and Misuse/Abuse of Opioid Analgesics in Different World Regions and Future Perspectives
inferred← citeshttps://doi.org/10.2298/jsc220907001aopenalex-snapshot
Microwave-assisted synthesis of a series of 4,5-dihydro-1H-pyrazoles endowed with selective COX-1 inhibitory potency
inferred← citeshttps://doi.org/10.2460/ajvr.24.04.0118openalex-snapshot
Antinociceptive and anesthetic-sparing effects of levomethadone/fenpipramide cannot be enhanced by coadministration of metamizole in awake and anesthetized Beagles
inferred← citeshttps://doi.org/10.30895/2312-7821-2022-10-4-396-410openalex-snapshot
Sodium Metamizole: Regulatory Status around the World, Safety Problems and Medication Errors
inferred← citeshttps://doi.org/10.3238/arztebl.m2025.0214openalex-snapshot
Metamizole: Indications and risks
inferred← citeshttps://doi.org/10.33448/rsd-v11i13.35570openalex-snapshot
A bibliographic analysis on the use of Dipyrone and Agranulocytosis
inferred← citeshttps://doi.org/10.3389/fmed.2023.1125754openalex-snapshot
Case report: Generalized bullous fixed drug eruption mimicking epidermal necrolysis
inferred← citeshttps://doi.org/10.3389/fped.2023.1127020openalex-snapshot
Analysis of umbilical cord tissue as an indicator of in utero exposure to toxic adulterating substances
inferred← citeshttps://doi.org/10.3389/fphar.2025.1624044openalex-snapshot
Pharmacogenetics of metamizole-induced agranulocytosis: a systematic review and drug regulation implications
inferred← citeshttps://doi.org/10.3389/fphys.2026.1810607openalex-snapshot
Evaluating the analgesic effect of metamizole in the mouse model for DSS-induced acute colitis
inferred← citeshttps://doi.org/10.3390/ani14060929openalex-snapshot
Tramadol and M1 Bioavailability Induced by Metamizole Co-Administration in Donkeys (Equus asinus)
inferred← citeshttps://doi.org/10.3390/ani15111666openalex-snapshot
Pharmacokinetic Profile of Two Active Dipyrone Metabolites, 4-Methylaminoantipyrine (MAA) and 4-Aminoantipyrine (AA), Following Intravenous Administration in Dogs: A Preliminary Study
inferred← citeshttps://doi.org/10.3390/ijms24021633openalex-snapshot
Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?
inferred← citeshttps://doi.org/10.3390/jcm11195628openalex-snapshot
Positive Patient Postoperative Outcomes with Pharmacotherapy: A Narrative Review including Perioperative-Specialty Pharmacist Interviews
inferred← citeshttps://doi.org/10.3390/laboratories1030012openalex-snapshot
Rectal Prolapse in Laboratory-Housed Macaques: Assessing Prevalence, Risk Factors, and Enhanced Treatment Modality
inferred← citeshttps://doi.org/10.3390/molecules27217434openalex-snapshot
Pain Management and Analgesics Used in Small Mammals during Post-Operative Period with an Emphasis on Metamizole (Dipyrone) as an Alternative Medication
inferred← citeshttps://doi.org/10.3390/molecules30010017openalex-snapshot
Effects of Metamizole, 4-Methylaminoantipyrine, and 4-Aminoantipyrine on LX-2 Liver Cell Line Viability and Apoptosis
inferred← citeshttps://doi.org/10.3390/ph16081084openalex-snapshot
Parenteral Ready-to-Use Fixed-Dose Combinations Including NSAIDs with Paracetamol or Metamizole for Multimodal Analgesia—Approved Products and Challenges
inferred← citeshttps://doi.org/10.36290/far.2021.015openalex-snapshot
Metamizole (dipyrone)
inferred← citeshttps://doi.org/10.38031/slovpediatr-2020-4-03openalex-snapshot
AKUTNI PANKREATITIS IN HEPATITIS OB OKUŽBI Z VIRUSOM INFLUENCE B: PREDSTAVITEV PRIMERA
inferred← citeshttps://doi.org/10.38031/slovpediatr-2020-4-03enopenalex-snapshot
ACUTE PANCREATITIS AND HEPATITIS CAUSED BY INFLUENZA B VIRUS INFECTION: CASE REPORT
inferred← citeshttps://doi.org/10.5114/ceh.2025.151745openalex-snapshot
To use or not to use: Safety of selected painkillers in patients with chronic liver diseases
inferred← citeshttps://doi.org/10.56238/devopinterscie-096openalex-snapshot
A bibliographic analysis on the use of dipyrone and agranulocytosis
inferred← citeshttps://doi.org/10.57187/s.3535openalex-snapshot
Use of metamizole and other non-opioid analgesics in Switzerland between 2014 and 2019: an observational study using a large health insurance claims database
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