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Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Lower kinetic limit to protein thermal stability: A proposal regarding protein stability in vivo and its relation with misfolding diseases
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Biophysical Characterization of Insoluble Aggregates of a Multi-Domain Protein: An Insight into the Role of the Various Domains
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Size-Exclusion Chromatography with On-Line Light-Scattering, Absorbance, and Refractive Index Detectors for Studying Proteins and Their Interactions
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Calculation of protein extinction coefficients from amino acid sequence data
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Amino acid sequence of the variable region of heavy chain in immunoglobulin (Mot) having unusual papain cleavage sites
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Effect of posttranslational modifications on the thermal stability of a recombinant monoclonal antibody
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Folding Mechanism of the CH2 Antibody Domain
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Domain Interactions in the Fab Fragment: A Comparative Evaluation of the Single-chain Fv and Fab Format Engineered with Variable Domains of Different Stability
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Design of humanized antibodies: From anti-Tac to Zenapax
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The Unfolding/Denaturation of Immunogammaglobulin of Isotype 2b and its Fab and Fc Fragments
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The Thermal Stability of Immunoglobulin: Unfolding and Aggregation of a Multi-Domain Protein
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Biophysical Properties of Human Antibody Variable Domains
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The influence of glycosylation on the thermal stability and effector function expression of human IgG1-Fc: properties of a series of truncated glycoforms
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Glycosylation of human IgG-Fc: influences on structure revealed by differential scanning micro-calorimetry
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Surprising similarities in structure comparison
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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
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Humanization of an anti-p185HER2 antibody for human cancer therapy.
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A Thermodynamic Study of Cooperative Structures in Rabbit Immunoglobulin G
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Methylglyoxal modified IgG generates autoimmune response in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2020.04.147openalex-snapshot
Enhancing the stability of adalimumab by engineering additional glycosylation motifs
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2026.151430openalex-snapshot
“Biophysical and colloidal properties govern anti-drug antibody generation: A case study using the tumoricidal murine-derived monoclonal antibody 4713”
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2011.03.064openalex-snapshot
Predicting solution aggregation rates for therapeutic proteins: Approaches and challenges
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2011.09.017openalex-snapshot
Impact of short range hydrophobic interactions and long range electrostatic forces on the aggregation kinetics of a monoclonal antibody and a dual-variable domain immunoglobulin at low and high concentrations
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2013.11.019openalex-snapshot
Comprehensive evaluation of etanercept stability in various concentrations with biophysical assessment
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2014.09.037openalex-snapshot
Evaluation of etanercept stability as exposed to various sugars with biophysical assessment
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2015.07.018openalex-snapshot
Evaluation of etanercept degradation under oxidative stress and potential protective effects of various amino acids
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2018.06.007openalex-snapshot
Effect of photo-degradation on the structure, stability, aggregation, and function of an IgG1 monoclonal antibody
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.101067openalex-snapshot
Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin
inferred← citeshttps://doi.org/10.1016/j.jbiotec.2013.03.019openalex-snapshot
Control of IgG LC:HC ratio in stably transfected CHO cells and study of the impact on expression, aggregation, glycosylation and conformational stability
inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.113727openalex-snapshot
Engineering IgG antibodies for intracellular targeting and drug delivery
inferred← citeshttps://doi.org/10.1016/j.jddst.2021.102765openalex-snapshot
Rational design of nanocarriers based on gellan gum/retrograded starch exploiting polyelectrolyte complexation and ionic cross-linking processes: A potential technological platform for oral delivery of bevacizumab
inferred← citeshttps://doi.org/10.1016/j.jddst.2026.108193openalex-snapshot
Effect of aggregate seeding on protein stability in solution
inferred← citeshttps://doi.org/10.1016/j.jmb.2009.08.032openalex-snapshot
The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators
inferred← citeshttps://doi.org/10.1016/j.jpba.2017.12.061openalex-snapshot
Influence of glycan modification on IgG1 biochemical and biophysical properties
inferred← citeshttps://doi.org/10.1016/j.jpba.2021.114309openalex-snapshot
Structural characterization of a monomethylauristatin-E based ADC that contains 8 drugs conjugated at interchain cysteine residues
inferred← citeshttps://doi.org/10.1016/j.msec.2020.111398openalex-snapshot
Novel hybrid lipid nanocapsules loaded with a therapeutic monoclonal antibody – Bevacizumab – and Triamcinolone acetonide for combined therapy in neovascular ocular pathologies
inferred← citeshttps://doi.org/10.1016/j.saa.2018.01.026openalex-snapshot
Structural and immunological characterization of hydroxyl radical modified human IgG: Clinical correlation in rheumatoid arthritis
inferred← citeshttps://doi.org/10.1016/j.vaccine.2020.09.070openalex-snapshot
IgA as a potential candidate for enteric monoclonal antibody therapeutics with improved gastrointestinal stability
inferred← citeshttps://doi.org/10.1016/j.xphs.2015.12.017openalex-snapshot
Acetate- and Citrate-Specific Ion Effects on Unfolding and Temperature-Dependent Aggregation Rates of Anti-Streptavidin IgG1
inferred← citeshttps://doi.org/10.1016/j.xphs.2016.01.004openalex-snapshot
Relating Protein–Protein Interactions and Aggregation Rates From Low to High Concentrations
inferred← citeshttps://doi.org/10.1016/j.xphs.2017.08.011openalex-snapshot
Effect of Polysorbate 20 and Polysorbate 80 on the Higher-Order Structure of a Monoclonal Antibody and Its Fab and Fc Fragments Probed Using 2D Nuclear Magnetic Resonance Spectroscopy
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.01.017openalex-snapshot
Understanding the Increased Aggregation Propensity of a Light-Exposed IgG1 Monoclonal Antibody Using Hydrogen Exchange Mass Spectrometry, Biophysical Characterization, and Structural Analysis
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.03.022openalex-snapshot
Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates
inferred← citeshttps://doi.org/10.1016/j.xphs.2018.07.024openalex-snapshot
Effect of Peroxide- Versus Alkoxyl-Induced Chemical Oxidation on the Structure, Stability, Aggregation, and Function of a Therapeutic Monoclonal Antibody
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.06.025openalex-snapshot
Characterization of a Novel Bispecific Antibody With Improved Conformational and Chemical Stability
inferred← citeshttps://doi.org/10.1016/j.xphs.2019.07.009openalex-snapshot
Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity
inferred← citeshttps://doi.org/10.1016/j.xphs.2020.01.029openalex-snapshot
Effect of Linker-Drug Properties and Conjugation Site on the Physical Stability of ADCs
inferred← citeshttps://doi.org/10.1016/j.xphs.2020.06.002openalex-snapshot
Deamidation in Moxetumomab Pasudotox Leading to Conformational Change and Immunotoxin Activity Loss
inferred← citeshttps://doi.org/10.1016/j.xphs.2021.05.023openalex-snapshot
Identification and Characterization of a Monoclonal Antibody Variant Species with a Clipping in the Complementarity Determining Region Isolated by Size Exclusion Chromatography Under Native Conditions
inferred← citeshttps://doi.org/10.1016/j.xphs.2021.09.005openalex-snapshot
Insights into the Conformation and Self-Association of a Concentrated Monoclonal Antibody using Isothermal Chemical Denaturation and Nuclear Magnetic Resonance
inferred← citeshttps://doi.org/10.1016/j.xphs.2022.06.014openalex-snapshot
Effect of the ADCC-Modulating Mutations and the Selection of Human IgG Isotypes on Physicochemical Properties of Fc
inferred← citeshttps://doi.org/10.1016/j.xphs.2022.10.017openalex-snapshot
Conformational Changes and Drivers of Monoclonal Antibody Liquid-Liquid Phase Separation
inferred← citeshttps://doi.org/10.1016/j.xphs.2023.08.002openalex-snapshot
Studying Intermolecular Interactions in an Antibody-Drug Conjugate Through Chemical Screening and Computational Modeling
inferred← citeshttps://doi.org/10.1016/j.xphs.2024.05.008openalex-snapshot
Understanding the Effects of Site-Specific Light Chain Conjugation on Antibody Structure Using Hydrogen Exchange-Mass Spectrometry (HX-MS)
inferred← citeshttps://doi.org/10.1016/j.xphs.2026.104468openalex-snapshot
Monoclonal antibody adsorption at fluid-fluid interfaces: Experimental and computational approaches for interfacial characterization
inferred← citeshttps://doi.org/10.1021/ac300535ropenalex-snapshot
Improved Protein Hydrogen/Deuterium Exchange Mass Spectrometry Platform with Fully Automated Data Processing
inferred← citeshttps://doi.org/10.1021/ac404003qopenalex-snapshot
Conformation and Dynamics of Interchain Cysteine-Linked Antibody-Drug Conjugates as Revealed by Hydrogen/Deuterium Exchange Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/ac404130aopenalex-snapshot
Understanding the Conformational Impact of Chemical Modifications on Monoclonal Antibodies with Diverse Sequence Variation Using Hydrogen/Deuterium Exchange Mass Spectrometry and Structural Modeling
inferred← citeshttps://doi.org/10.1021/ac9006254openalex-snapshot
Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody
inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03931openalex-snapshot
Structural Dynamics of a Thermally Stressed Monoclonal Antibody Characterized by Temperature-Dependent H/D Exchange Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.3c00317openalex-snapshot
Integration of NMR Spectroscopy in an Analytical Workflow to Evaluate the Effects of Oxidative Stress on Abituzumab: Beyond the Fingerprint of mAbs
inferred← citeshttps://doi.org/10.1021/acs.analchem.5b00764openalex-snapshot
Antibody Structural Integrity of Site-Specific Antibody-Drug Conjugates Investigated by Hydrogen/Deuterium Exchange Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.6b01958openalex-snapshot
Understanding the Impact of Methionine Oxidation on the Biological Functions of IgG1 Antibodies Using Hydrogen/Deuterium Exchange Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b00573openalex-snapshot
Signature of Antibody Domain Exchange by Native Mass Spectrometry and Collision-Induced Unfolding
inferred← citeshttps://doi.org/10.1021/acs.analchem.8b03452openalex-snapshot
PULSE SPR: A High Throughput Method to Evaluate the Domain Stability of Antibodies
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b04855openalex-snapshot
Probing the Impact of the Knob-into-Hole Mutations on the Structure and Function of a Therapeutic Antibody
inferred← citeshttps://doi.org/10.1021/acs.analchem.9b05748openalex-snapshot
Isothermal Chemical Denaturation: Data Analysis, Error Detection, and Correction by PARAFAC2
inferred← citeshttps://doi.org/10.1021/acs.biochem.6b01097openalex-snapshot
Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum
inferred← citeshttps://doi.org/10.1021/acs.biochem.8b00575openalex-snapshot
Structural Changes and Aggregation Mechanisms of Two Different Dimers of an IgG2 Monoclonal Antibody
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00286openalex-snapshot
Interconversion of Unexpected Thiol States Affects the Stability, Structure, and Dynamics of Antibody Engineered for Site-Specific Conjugation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.1c00572openalex-snapshot
Impact of Drug Conjugation on Thermal and Metabolic Stabilities of Aglycosylated and N-Glycosylated Antibodies
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.4c00259openalex-snapshot
Chemically Programmed Fc Protein as Antibody Mimetic to Targeting Carbonic Anhydrase IX
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00558openalex-snapshot
Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Phosphopantetheinyl Transferases
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5b00603openalex-snapshot
Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.5c00485openalex-snapshot
Photostability of Topoisomerase I Inhibitor Conjugated IgG1 Antibody–Drug Conjugates: Characterization Study and Degradation Mechanism Analysis
inferred← citeshttps://doi.org/10.1021/acs.chemrev.1c00857openalex-snapshot
Mass Spectrometry Methods for Measuring Protein Stability
inferred← citeshttps://doi.org/10.1021/acs.chemrev.2c00600openalex-snapshot
Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section
inferred← citeshttps://doi.org/10.1021/acs.chemrev.8b00294openalex-snapshot
Radioactive Main Group and Rare Earth Metals for Imaging and Therapy
inferred← citeshttps://doi.org/10.1021/acs.inorgchem.6c00216openalex-snapshot
Challenging the Macrocycle Paradigm: Four-Arm, High-Denticity Acyclic Chelators for Radiopharmaceuticals Incorporating Actinium and Lanthanides
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b00621openalex-snapshot
Osmolyte Effects on Monoclonal Antibody Stability and Concentration-Dependent Protein Interactions with Water and Common Osmolytes
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b03878openalex-snapshot
Effects of Protein Conformation, Apparent Solubility, and Protein–Protein Interactions on the Rates and Mechanisms of Aggregation for an IgG1Monoclonal Antibody
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6b05473openalex-snapshot
Kinetics of Antibody Aggregation at Neutral pH and Ambient Temperatures Triggered by Temporal Exposure to Acid
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00370openalex-snapshot
Biophysical Characterization of Binary Therapeutic Monoclonal Antibody Mixtures
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c01138openalex-snapshot
Suppression of Electrostatic Mediated Antibody Liquid–Liquid Phase Separation by Charged and Noncharged Preferentially Excluded Excipients
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5b00387openalex-snapshot
Mapping the Aggregation Kinetics of a Therapeutic Antibody Fragment
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5b00643openalex-snapshot
Viscosity-Lowering Effect of Amino Acids and Salts on Highly Concentrated Solutions of Two IgG1 Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5c00591openalex-snapshot
Bayesian Optimization for Efficient Multiobjective Formulation Development of Biologics
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5c01398openalex-snapshot
Deconvoluting Biophysical Factors that Influence Long-Term Aggregation Rates of High-Concentration Monoclonal Antibody Formulations
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.6c00433openalex-snapshot
Properties of Drug Linkers Affecting Hydrophobic Interaction Chromatography for Determining the Drug-to-Antibody Ratio of Antibody-Drug Conjugates
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00690openalex-snapshot
Submicron Aggregation of Chemically Denatured Monoclonal Antibody
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.8b00867openalex-snapshot
Developability Assessment of Engineered Monoclonal Antibody Variants with a Complex Self-Association Behavior Using Complementary Analytical and in Silico Tools
inferred← citeshttps://doi.org/10.1021/bc400182xopenalex-snapshot
Investigation into Temperature-Induced Aggregation of an Antibody Drug Conjugate
inferred← citeshttps://doi.org/10.1021/bc400439xopenalex-snapshot
Auristatin Antibody Drug Conjugate Physical Instability and the Role of Drug Payload
inferred← citeshttps://doi.org/10.1021/bc900434copenalex-snapshot
Physicochemical Stability of the Antibody−Drug Conjugate Trastuzumab-DM1: Changes due to Modification and Conjugation Processes
inferred← citeshttps://doi.org/10.1021/bi101549nopenalex-snapshot
Thermal Induction of an Alternatively Folded State in Human IgG-Fc
inferred← citeshttps://doi.org/10.1021/bi400232popenalex-snapshot
Effects of Salts from the Hofmeister Series on the Conformational Stability, Aggregation Propensity, and Local Flexibility of an IgG1 Monoclonal Antibody
inferred← citeshttps://doi.org/10.1021/bi900853vopenalex-snapshot
Physical Instability of a Therapeutic Fc Fusion Protein: Domain Contributions to Conformational and Colloidal Stability
inferred← citeshttps://doi.org/10.1021/bk-2015-1202.ch005openalex-snapshot
Characterization of Monoclonal Antibody Aggregates and Emerging Technologies
inferred← citeshttps://doi.org/10.1021/jp411185dopenalex-snapshot
Gauging Colloidal and Thermal Stability in Human IgG1–Sugar Solutions through Diffusivity Measurements
inferred← citeshttps://doi.org/10.1021/mp200404copenalex-snapshot
Advancements in High Throughput Biophysical Technologies: Applications for Characterization and Screening during Early Formulation Development of Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1021/mp400666bopenalex-snapshot
Examination of Thermal Unfolding and Aggregation Profiles of a Series of Developable Therapeutic Monoclonal Antibodies
inferred← citeshttps://doi.org/10.1021/mp500614popenalex-snapshot
Approaches to Interchain Cysteine-Linked ADC Characterization by Mass Spectrometry
inferred← citeshttps://doi.org/10.1038/s41467-025-66805-6openalex-snapshot
Development of ACE2-tropic-betacoronavirus therapeutics for future pandemic preparedness
inferred← citeshttps://doi.org/10.1038/s41598-017-12616-9openalex-snapshot
Sequence composition predicts immunoglobulin superfamily members that could share the intrinsically disordered properties of antibody CH1 domains
inferred← citeshttps://doi.org/10.1038/s41598-019-51233-6openalex-snapshot
Coupling Multi-Angle Light Scattering to Reverse-Phase Ultra-High-Pressure Chromatography (RP-UPLC-MALS) for the characterization monoclonal antibodies
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